NEURO-ONCOLOGY - Insights · PDF filenervous system (CNS), peripheral nerve sheath (PNS) and pituitary tumors. Our world renown neuro-oncology ... Comprehensive Neuro-oncology Panel

NEURO-ONCOLOGY

M A Y O M E D I C A L L A B O R A T O R I E S . C O M 8 0 0 - 5 3 3 - 1 7 1 0 o r + 5 0 7 - 2 6 6 - 5 7 0 0

CONSULTATIVE SERVICE

70012 Pathology Consultation (appropriate stains and ancillary testing may be performed in order to render an accurate diagnosis)

The Mayo Clinic Deparment of Laboratory Medicine and Pathology offers a broad menu of testing for central nervous system (CNS), peripheral nerve sheath (PNS) and pituitary tumors. Our world renown neuro-oncology experts in pathology and genetics provide an integrated approach for testing and interpretation of results.

GLIOMA / GLIOBLASTOMAATRX Immunostain

BRAF V600E Immunostain

Glial Fibrillary Acidic Protein (GFAP) Immunostain

IDH1 Mutation (R132H) Immunostain

Ki67 (MIB-1) Immunostain

Olig2 Immunostain

p53 Immunostain

S-100 Protein Immunostain

1p/19q Deletion in Gliomas, FISH, Tissue*,+ [ID: GLIOF]

BRAF Mutation Analysis (V600E), Tumor* [ID: BRAFT]

Chromosomal Microarray, Tumor, FFPE*,+ [ID: CMAPT]

IDH1/2, Mutation Analysis* [ID: IDH]

MGMT Promoter Methylation, Tumor* [ID: MGMT]

Comprehensive Neuro-oncology Panel by NGS (coming in 2016)

NEURONAL / EMBRYONAL / MEDULLOBLASTOMAINI1/BAF47 Immunostain

Medulloblastoma panel: Beta catenin, YAP and GAB1 Immunostains

Neu-N Immunostain

Neurofilament (NF) Immunostain

Synaptophysin (SYNAPTO-B) Immunostain

Medulloblastoma, FISH, Ts (MYCN amplification, MYC ampification, chromosome 6 monosomy)* [ID: MEDF]

ATRX immunostain - loss of expression in astrocytoma cells

Pleomorphic xanthoastrocytoma (H&E image) Mutant IDH1 immunostain FISH: 1p deletion (oligodendroglioma)

*individually orderable+microarray is the preferred test but for small specimens 1p/19q FISH can be ordered

OncoScan Array PatternTriple Positive Glioma (IDH mut, TERT mut, 1p/19q codel)Eckel-Passow et al. NEJM 2015; 372:2499-2508

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MOLECULAR PATHOLOGY

ROBERT B. JENKINS, M.D., PH.D. BENJAMIN R. KIPP, PH.D.

CONSULTANTS

ANATOMIC PATHOLOGY

CATERINA GIANNINI, M.D., PH.D

MARK E. JENTOFT, M.D.

JOSEPH E. PARISI, M.D.

ADITYA RAGHUNATHAN, M.D.

01/2016

PITUITARY TUMORSAdrenocorticotropin Hormone (ACTH) Immunostain

Alpha Follicle Stimulating Hormone (FSH) Immunostain

Beta FSH Immunostain

Beta LH Immunostain

Beta Thyroid Releasing Hormone (TSH) Immunostain

Growth Hormone (GH) Immunostain

Prolactin Immunostain

OTHER PRIMARY CNS TUMORS (INCLUDING GERM CELL, CNS LYMPHOMA AND PERIPHERAL NERVE TUMORS)

Alpha-1-Fetoprotein (AFP) Immunostain

Alpha-B Crystallin Immunostain

BCL2 Immunostain

BCL6 Immunostain

CD3 Immunostain

CD20 Immunostain

CD 117, (c-Kit) Immunostain

CD56 (NCAM) Immunostain

OTHER PRIMARY CNS TUMORS (CONT’D)

Collagen IV Immunostain

Chromogranin Immunostain

Epithelial Membrane Antigen (EMA) Immunostain

Human Chorionic Gonadotropin (Beta-hCG) Immunostain

Inhibin Immunostain

Ki67 (MIB-1) Immunostain

MUM1 Immunostain

Placental Alkaline Phosphatase (PLAP) Immunostain

OCT-4 Immunostain

SOX-10 Immunostain

STAT6 immunostain

Epstein-Barr Virus (EBV) RNA Detection by In Situ Hybridization* [ID: 80786]

Germ Cell Tumor (GCT), Isochromosome 12p, FISH, Tissue* [ID: GCTF]

MYD88, L265P, Somatic Gene Mutation, DNA Allele-Specific PCR* [ID: 70138]

*individually orderable