Neural Stem Cells in Treating Diseases of the CNS Brooke McCarthy BME 281 Fall 2011.

Neural Stem Cells in Treating Diseases of the CNSBrooke McCarthyBME 281Fall 2011

Stem Cells

Undifferentiated cells

Types

Cell division

Induced to become specialized cellsPhysiologically

Experimentally

Neural Stem Cells

Most fundamental cell of the nervous system

Divides to createNeurons

Astrocytes

Oligodendroglia

CNS

Malignant glioblastomas

Multiple sclerosis

Niemann-Pick’s disease

Current treatments

NSC Therapy

Inject

Migrate

Surround

Results

Multiple sclerosis

Niemann-Pick’s disease

Still too early

Pros

Best results

Injection

Either type of stem cell

Problems

Risks

BTSC

Mutation of NSC

Largest part of brain tumors

Resists treatments

Genetic engineering

Future

Genetic engineering

Cellular origins

Other diseases

ResourcesAchanta, P. "Gliomagenesis and the Use of Neural Stem Cells in Brain Tumor Treatment." Anticancer Agents Med Chem.(2010): 121-30. Pubmed. Web. 17 Sept. 2011.

“Glioblastoma Multiforme.” Medscape. Web. 14 Sept. 2011. <http:// emedicine.medscape.com/article/283252-overview#showall>.

Taupin, P. "Potential of Neural Stem Cells for the Treatment of Brain Tumors." Clinical Medicine: Oncology. (2008): 451-54. PubMed. Web. 17 Sept. 2011.

“Stem Cell Information.” The National Institutes of Health. Web. 14 Sept. 2011. <http://stemcells.nih.gov/info/basics/basics1.asp>.

“What are Stem Cells?” Medical News Today. Web. 14 Sept. 2011.