• Neoadjuvante chemoradiatie: surgery when needed (preSANO) • Neoadjuvante chemoradiatie: targeted treatment (TRAP) • Neoadjuvante/definitieve chemoradiatie: surgery if possible (TOR) • Definitieve chemoradiatie: dosisintensificatie (ART-DECO) • Dataregistratie (POCOP) Blik op de toekomst: lopende en geplande DOCG studies Dr. Hanneke W.M. van Laarhoven Medische Oncologie Academisch Medische Centrum
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Neoadjuvante chemoradiatie: surgery when needed (preSANO) Neoadjuvante chemoradiatie: targeted treatment (TRAP) Neoadjuvante/definitieve chemoradiatie:
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• Neoadjuvante chemoradiatie: surgery when needed (preSANO)
• Neoadjuvante chemoradiatie: targeted treatment (TRAP)• Neoadjuvante/definitieve chemoradiatie: surgery if
possible (TOR)• Definitieve chemoradiatie: dosisintensificatie (ART-DECO)• Dataregistratie (POCOP)
Blik op de toekomst: lopende en geplande DOCG studies
Dr. Hanneke W.M. van LaarhovenMedische OncologieAcademisch Medische Centrum
preSANOpre- Surgery As Needed for Oesophageal carcinoma
A single-arm feasibility trial
Primary endpoint•Correlation between the clinical response during CRE-I and CRE-II and the final pathological response in the resection specimen
Secondary endpoints•Serious complications during endoscopic and endosonographic tissue sampling •R0-resection rates for all included patients that undergo resection
TRAPChemoradiation, TRAstuzumab and Pertuzumab in resectable
HER2+ esophageal carcinomaA single arm feasibility study
Acknowledgments• Joel Shapiro, Bas Wijnhoven, Jan van Lanschot (preSANO)• Maarten Anderegg, Mark van Berge Henegouwen (TOR)• Maarten Hulshof (ART-DECO)• Leonie Haverkamp, Jelle Ruurda (Oesofagus/maag parel)