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AG-45B-0012-KI01 96 wells Assay Range: 7.8 to 500 pg/ml. Sensitivity: 7 pg/ml. Sample Type: Cell Culture Supernatant, Plasma, Serum. Colorimetric sandwich assay. APRIL is implicated in the regulation of tumor cell growth, is involved in monocyte/macrophage-mediated immunological processes and functions as an important survival factor for plasmablasts and bone marrow plasma cells. Manual
APRIL/BAFF (human) Tandem ELISA Kit
AG-45B-4501-KI02 2 x 96 wells Assay Range: 7.8 to 500 pg/ml for APRIL (human) ELISA Kit; 15.6 – 500 pg/ml for BAFF (human) ELISA Kit. Sensitivity: 7 pg/ml for APRIL (human) ELISA Kit; 8 pg /ml for BAFF (human) ELISA Kit. Sample Type: Cell Culture Supernatant, Plasma, Serum. Assay Type: Sandwich.The new Tandem format includes 1 x BAFF (human) ELISA kit (AG-45B-0001) and 1 x APRIL (human) ELISA (AG-45B-0012) kit that can be used to measure both BAFF (human) and APRIL (human) in biological fluids. Manual
Asprosin (human) Matched Pair Detection Set
AG-46B-0011-KI01 1 Set Assay Range: 0.156 to 10 ng/ml. Sensitivity: 150 pg/ml. Sample Type: Cell Culture Supernatant. Detection Type: Colorimetric. Assay Type: Sandwich. Asprosin function could serve as a potentially unique therapeutic target against obesity, diabetes or metabolic diseases. Manual
CD40L (human) ELISA Kit
AG-45B-0018-KI01 96 wells Assay Range: 0.03125 to 2 ng/ml. Sensitivity: 20 pg/ml. Sample type: Cell Culture Supernatant, Plasma, Serum. Colorimetric sandwich assay. CD40-CD40L interactions are crucially involved in development of autoimmune disease and have also impact on growth regulation of certain carcinomas. Manual
Erythroferrone (human) ELISA Kit
AG-45B-0014-KI01 96 wells Assay Range: 0.3125 to 20 ng/ml. Sensitivity: 270 pg/ml. Sample type: Cell Culture Supernatant, Plasma, Serum. Colorimetric sandwich assay. Erythroferrone is a biomarker for different types of anemia, for cardiology and potentially also for metabolic diseases. Manual
FGL1 (human) ELISA Kit
AG-45B-0022-KI01 96 wells Assay Range: 7.8 to 500pg/ml. Sensitivity: 1.8pg/ml. Sample Type: Cell Culture Supernatant, Plasma, Serum. Colorimetric sandwich assay. Fibrinogen-like protein 1 was initially identified as an overexpressed transcript in hepatocyte carcinoma and as a transcript enriched in regenerating liver. FGL1 is expressed at lower levels in brown and white adipose in the setting of liver injury. Recently, FGL1 has also been shown to be upregulated in human cancers and FGL1 is a major functional ligand of LAG-3. Manual
Gasdermin D (mouse) ELISA Kit
AG-45B-0011-KI01 96 wells Assay Range: 15.6 to 1000 pg/ml. Sensitivity: 14pg/ml Sample Type: Cell Culture Supernatant, Cell Lysate. Colorimetric sandwich assay. Detects full-length and cleaved mouse Gasdermin D (C-terminus). The cleavage of the intracellular gasdermin D by caspases leads to a particular form of inflammatory cell death called pyroptosis. Manual
ICOSL (B7-H2/CD275) (human) ELISA Kit
AG-45B-0017-KI01 96 wells Assay Range: 0.0625 to 4 ng/ml. Sensitivity: 55 pg/ml. Sample type: Cell Culture Supernatant, Plasma, Serum. Colorimetric sandwich assay. ICOSL sheds from the cell membrane and the soluble form of ICOSL (sICOSL), found in plasma and sera, can be a potential biomarker for autoimmune diseases and some cancers. Manual
IL-36alpha (human) ELISA Kit
AG-45B-0013-KI01 96 wells Assay Range: 7.8 to 500pg/ml. Sensitivity: 4 pg/ml. Sample type: Cell Culture Supernatant, Plasma, Serum. Colorimetric sandwich assay. Detects natural and recombinant human IL-36alpha (IL-1F6). IL-36 family members may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination. Manual
IL-36alpha/IL-36gamma (human) Tandem ELISA
AG-45B-4502-KI02 2 x 96 wells Assay Range: 7.8 to 500 pg/ml for IL-36α (human) ELISA Kit; 3.9 – 250 pg/ml for IL-36γ (human) ELISA Kit. Sensitivity: 4 pg/ml for IL-36α (human) ELISA Kit; 3 pg /ml for IL-36γ (human) ELISA Kit. Sample type: Cell Culture Supernatant, Serum. Colorimetric sandwich assay. The new Tandem format includes 1 x IL-36alpha (human) ELISA kit (AG-45B-0013) and 1 x IL-36gamma ELISA kit (AG-45B-0008) that can be used to measure both IL-36alpha (human) and IL-36gamma (human) in biological fluids. Manual
PD-1 (human) ELISA Kit
AG-45B-0015-KI01 96 wells Assay Range: 3.125 to 200 pg/ml. Sensitivity: 1.6 pg/ml. Sample Type: Cell Culture Supernatant, Plasma, Serum. Assay Type: Sandwich. Soluble checkpoints, such as sPD-1 or sPD-L1, are involved in positive or negative immune regulation and changes in their serum/plasma levels affect the development, prognosis and treatment of cancer. Manual
Species reactivity: Human Range: 15.6 to 500 pg/mlSensitivity: 8 pg/ml Sample type: Serum, Plasma, Cell Culture Supernatant
baff, Soluble (human) Matched Pair Detection Set AG-46B-0001 Reagents to perform 5 x 96 wells
Species reactivity: Human Range: 16 to 1000 pg/ml Sensitivity: 16 pg/ml Sample type: Serum, Plasma, Cell Culture Supernatant
High Quality ELISA Kits Developed & Manufactured by
• Extensively validated • High Specificity, Sensitivity & Accuracy • Reproducible Results with low Inter- and Intra-Assay Variation• Many Citations in Peer-reviewed Key Literature References
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Species reactivity: Human / Monkey / Mouse / Rat Range: 0.001 to 5 µg/mlSensitivity: 1 ng/ml Sample type: Serum, Plasma, Cell Culture Supernatant
LIT: Irisin, a novel myokine is an independent predictor for sarcopenia and carotid atherosclerosis in dialysis patients: M.J. Lee, et al.; Atheroscler. 242, 476 (2015) • Irisin levels in the progression of diabetes in sedentary women: I.D. Duran, et al.; Clin. Biochem. 48, 1268 (2015) • Chronic CNS oxytocin signaling preferentially induces fat loss in high-fat diet-fed rats by enhancing satiety responses and increasing lipid utilization: J.E. Blevins, et al.; Am. J. Physiol. 310, R640 (2016) • Eicosapentaenoic acid regulates brown adipose tissue metabolism in high-fat-fed mice and in clonal brown adipocytes: M. Pahlavanni, et al.; J. Nutr. Bioche. 39, 101 (2017)
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The B cell-stimulating molecules, BAFF (B cell activating factor also known as BLyS; TALL-1; CD257 or TNFSF13B) and APRIL (a prolif-eration-inducing ligand, also known as CD256 or TNFSF13), are critical factors in the maintenance of the B cell pool and humoral im-munity. They are implicated in several human autoimmune diseases with autoreactive B cell involvement, including systemic lupus erythematosus (SLE), Sjogren’s syndrome (SS), IgA nephropathy (IgAN) and rheumatoid arthritis (RA). APRIL might also function in enhancing proliferation of some tumor cells, especially B cell malignancies and BAFF levels are increased in some lymphoid cancers.
The APRIL (human) ELISA Kit (Prod. No. AG-45B-0012) is a sandwich ELISA for specific quantitative determination of human APRIL in serum, plasma and cell culture supernatants. This ELISA Kit shows both high specificity and high sensitivity, which is a clear advantage compared to other APRIL (human) ELISA Kits from key competitors.
The BAFF, Soluble (human) ELISA Kit (Prod. No. AG-45B-0001) is a sandwich ELISA for specific quantitative determination of human BAFF in serum, plasma and cell culture supernatants. This ELISA Kit does not cross-react with mouse BAFF and has been chosen by sev-eral CROs for its high specificity and high sensitivity.
UNIQUE
Specificity: Serum from a healthy patient is left untreated or treated with 1 µg/ml of the APRIL receptor, TACI (human):Fc (human) (Prod. No. AG-40B-0079). APRIL levels were measured using the APRIL (human) ELISA Kit (Prod. No. AG-45B-0012).
Specificity: Serum from a healthy patient or patient with multiple sclerosis is left untreated or treated with 0.5 μg/ml of a BAFF receptor, TACI (human):Fc (human) (AG-40B-0079). BAFF levels are measured using the BAFF, Soluble (human) ELISA Kit (hypersensitive) (AG-45B-0001).
Erythroferrone (human) ELISA Kit The only Specific & Sensitive Assay on the Market!
Erythroferrone (also called Myonectin, CTRP15, Fam132B or ERFE) is a hormone produced by erythroblasts in the
bone marrow in response to erythropoietin controlling iron storage release or is a myokine abundantly expressed in
skeletal muscle tissue, upregulated by voluntary exercise. Erythroferrone/Myonectin is a potential clinical biomarker
for assessing erythropoiesis in patients with blood disorders, to study iron homeostasis for cardiovascular/heart
protection, and potentially for metabolic disorders.
NEW Erythroferrone (human) ELISA Kit
AG-45B-0014 96 wells
Sensitivity: 270 pg/ml
Range: 0.3125 to 20 ng/ml
Sample: Cell Culture Supernatant, Plasma, Serum
This Erythroferrone (human) ELISA Kit is a Sandwich assay
based on two antibodies and is to be used for the in vitro
quantitative determination of human Erythroferrone in
cell culture supernatants, serum and plasma. Levels of
Erythroferrone measured by this ELISA kit in serum and
plasma correspond to mouse protein levels (~ 500 ng/ml).
J U S T RELEASED
FEATURES OF THIS ASSAY
4 High Specificity
4 High Sensitivity
4 High Reproducibility
4 Tested & Validated on many Samples
4 Swiss Quality Guarantee
MANUFACTURED IN SWITZERLANDMANUFACTURED IN SWITZERLANDMANUFACTURED IN SWITZERLAND
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Gasdermin D Signaling & Inflammasome Research
Gasdermin D (mouse) ELISA Kit
Gasdermin D (mouse) ELISA KitAG-45B-0011 96 wells
Detects full-length and cleaved C-terminal mouse Gasdermin D in cell culture superna-tants and cell extracts. Does not cross-react with human Gasdermin D.
NEW
Pyroptosis is an inflammatory programmed cell death that is initiated in response to pathogen- or host-derived perturbations of the cytosol. In human and mice pyroptosis is induced by inflammatory caspases, such as caspase-1 and -11 that are activated by inflammasomes. Gasdermin D (GSDMD) is a central mediator of pyroptotic cell death. It contains a functional N-terminal domain and an inhibitory C-terminal domain. Upon caspase-1/11 cleavage of the linker located between the two domains of Gasdermin D, the cleaved N-terminal fragment of Gasdermin D oligomerizes and forms pores on the host cell membrane, leading to cell death called pyroptosis.
AdipoGen Life Sciences is the leading manufacturer and supplier of inflammasome signaling research reagents. The validated high quality inflammasome research tools are used and published daily by the experts in the inflammasome research field.
The Gasdermin D (mouse) ELISA Kit (Prod. No. AG-45B-0011) is a sandwich ELISA for quantitative determination of mouse Gasder-min D in cell culture supernatants and in cell extracts. This ELISA is specific for the measurement of natural and recombinant mouse Gasdermin D (full-length and C-terminus cleaved fragment). It does not detect human Gasdermin D.
UNIQUE
FIGURE 1 FIGURE 2Specificity:
Gasdermin D is tested from supernatants of Bone Marrow-Derived Macrophages cells (BMDMs)transfected with LPS from different knockout mice strains (see Figure 1). Only the supernatants from WT and NLRP3-/- strains contain the protein Gasdermin D. Gasdermin D is also tested from cell extracts (lysed with a Triton X-100 buffer) of Bone Marrow-Derived Macrophages cells from WT and Gasdermin D knockout mice strains (see Figure 2).
A New Tool to Measure Pyroptosis:
Sensitivity: 14 pg/ml
Range: 15.6 to 1000 pg/ml
Sample: Cell Culture Supernatant, Cell Lysate
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• high Specificity, Sensitivity & accuracy• reproducible results with low inter- and intra-assay Variation• Very competitive Prices• developed by the leading antibody & Protein Manufacturer