rd 3 National Conference of Institute of Pharmacy (NCIP) - 2019 “Integrating Natural and Modern Medicines in Drug Discovery and Development” NCIP 2019 NCIP 2019 January 24 - 25, 2019 ORGANIZED BY Institute of Pharmacy, Nirma University S. G. Highway, Chharodi, Ahmedabad – 382481, Gujarat, INDIA Phone : +91-079-3062715 • Fax : +91-2717-241916 • Website : http://www.ncip.in Supported by:
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rd3 National Conference of Institute of Pharmacy (NCIP) - 2019
“Integrating Natural and Modern Medicines in Drug Discovery and Development”
NCIP 2019NCIP 2019
January 24 - 25, 2019
ORGANIZED BYInstitute of Pharmacy, Nirma University
S. G. Highway, Chharodi, Ahmedabad – 382481, Gujarat, INDIAPhone : +91-079-3062715 • Fax : +91-2717-241916 • Website : http://www.ncip.in
Supported by:
MISSION
Nirma University emphasizes the all-round
development of its students. It aims at
producing not only good professionals, but also
good and worthy citizens of a great country,
aiding in its overall progress and development.
It endeavors to treat every student as an
individual, to recognize their potential and to
ensure that they receive the best preparation
and training for achieving their career
ambitions and life goals.
VISION
Shaping a better future for mankind
by developing effective and socially
responsible individuals and
organizations
QUALITY STATEMENT
To develop high quality professionals who reflect and demonstrate values that the University stands
for, through innovation and continuous improvement in facilitation of learning, research and
extension activities.
I
II
rd3 National Conference of Institute of Pharmacy
We are heartily thankful to
Science and Engineering Research BoardDepartment of Science and Technology
Department of Biotechnology
Defence Research and Development Organisation
Gujarat Council on Science and Technology
Shri Nitinbhai PatelDy. Chief Minister of Gujarat
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III
Shri Bhupendrasinh ChudasamaEducation Minister,
Government of Gujarat
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IV
Prof. B. SureshPresident,
Pharmacy Council of India
V
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Vaidya Rajesh KotechaSecretary, AYUSH
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VI
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VII
Shri K. K. PatelVice-
Nirma UniversityPresident,
MESSAGE
I am gratified to welcome all invited guests and participants at Nirma University for
National Conference of Institute of Pharmacy (NCIP – 2019) on “Integrating
Natural and Modern Medicines in Drug Discovery and Development” from
January 24-25, 2017.
All the diseases are different and unique, require different drugs for treatment.
Research is the best defense against all the challenges faced in development of safe
and efficacious treatment of diseases. Currently, the nation’s investment in drug
development is also increasing which is definitely helping the young researchers for
new drug development by integrating natural and modern medicines.
In light of this, organization of such a conference will serve the purpose of nurturing
innovations in the field of drug, discovery & development and help in exchange of
research ideas amongst the budding scientists from academia and industries.
I heartily acknowledge the efforts of Institute of Pharmacy, Nirma University for
organizing such event that provides a common platform for all stakeholders to put
forward their views and opinions. I extend my best compliments to Institute of
Pharmacy for a grand success of this conference and we hope that the Institute
continues to fill the void in the pharmaceutical sector by arranging many more
conferences and workshops in future.
Dr. Anup K. SinghDirector GeneralNirma University
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VIII
MESSAGE
I am delighted to learn that Institute of Pharmacy, Nirma University is organizing a National Conference for the third time - National Conference of Institute of Pharmacy (NCIP – 2019) on “Integrating Natural and Modern Medicines in Drug Discovery and Development” from January 24-25, 2019. It’s my honor and privilege to welcome all the eminent speakers and delegates to the exquisite campus of Nirma University, Ahmedabad.
Designing new leads against various life threatening diseases has been an integral part of drug discovery process. New drug discovery is facing serious challenges due to reduction in success rats of new chemical entities as well as excessive high cost. This scenario has prompted researchers to come out with a novel approach of integrated drug discovery. Combining the principles of natural medicines with refined modern chemical technology can help in the development of more economical, environmental friendly and effective drug discovery process. Such conferences will help spread the awareness as well as a stage to discuss all the global isssues in integrating Natural and Modern Medicines in Drug Discovery and Development.
I appreciate the efforts of Institute of Pharmacy for taking lead in fostering innovations in drug discovery by organizing a conference on such sought after theme and to offer common platform for the researchers from various parts of the country. I wish from the bottom of my heart that this conference serves as a medium to bring together eminent personalities across the nation to share their experience in the field of drug discovery and innovation.
I once again welcome all the dignitaries, delegates and participants at Nirma University for the conference and wish Institute of Pharmacy to have a grand and successful event.
CONTENTS
SR. TITLE PAGE
No. NO.
1 About Nirma University & Institute of Pharmacy 03
2 Advisory Committee 10
3 Organizing Committee 11
4 Students Task Force 13
5 Scientific Schedule at a Glance 14
6 Inauguration, Valedictory and Key note address 16
7 Plenary Sessions 21
8 Panel Discussion 33
Institute of Pharmacy, Nirma University
FROM THE DESK OF ORGANIZERS
With the great privilege on behalf of the Organizing Committee, it is our honor to invite all the delegates,
invitees and students to the 3rd National Conference of Institute of Pharmacy (NCIP-2019) on “Integrating
natural and modern medicines in drug discovery and development” to be held during January 24-25, 2019.
The pharmaceutical science is a group of interdisciplinary fields involved in the design, discovery,
development, delivery and disposition of the drugs. With the advent of numerous novel drug discovery and
development techniques, natural medicines still hold great promise to offers holistic approach for better
management of various diseases. Successful Integration Of traditional and evidence based medicine can be
possible with each being separately recognized as legitimate forms of health care within the same framework
and by the combined effort of public and government sector. This integrated approach will help in the
development of more economical and effective therapeutics but at the same time faces numerous
challenges. In view of this, the 3rd National conference is organized with the present theme to provide an
open forum for the academicians, researchers, physicians and professionals of pharmaceutical field to enrich
their knowledge about the cutting edge advances and research related to drug discovery & development by
integration of natural and modern medicines.
The organizing committee, under the valuable support and guidance of management of Nirma University as
well as advisory committee members will be able to give this shape of the conference and ensure you great
learning experience at conference. Discussions will be led by experts from the industries, respectable
academia and health care practitioners through plenary sessions and panel discussion. Poster sessions in
various areas of traditional medicines and pharmaceutical sciences will provide an ideal platform to represent
and exchange the ideas from budding researchers.
We acknowledge financial support received from Department of Biotechnology (DBT), Department of Science
& Technology (DST), Defense Research and Development Organization (DRDO) and Gujarat Council on
Science & Technology (GUJCOST) as well as various industries.
We are deeply thankful to all the resource persons who have travelled far distance to participate and interact
with the young researchers.
All these efforts undertaken by the organizing and technical committees has led to a high quality technical
conference program for all the attendees to add great value in ongoing research in various fields of
pharmaceutical sciences.
Welcome to NCIP 2019 and wish you all a good stay and memorable time in this conference.
We are looking forward for your valuable cooperation and dynamic participation to make this conference a
grand success.
02
Dr. Niyati Acharya
Organizing Secretary, NCIP-2019
Dr. Manjunath Ghate
Convener, NCIP-2019
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ABOUT NIRMA UNIVERSITY
03
Nirma University was established by the initiative of the Nirma Education and Research Foundation. The
University was established in the year 2003 as a statutory university under a special act passed by the Gujarat
State Legislative Assembly. It is recognized by the University Grants Commission (UGC) under Section 2 (f) of
the UGC Act. The University is duly accredited by National Assessment and Accreditation Council (NAAC) with
'A' grade. The University is a member of Association of Indian Universities (AIU) and the Association of
Commonwealth Universities (ACU).
Functioning under the aegis of NERF, the University consists of Faculty of Technology and Engineering,
Faculty of Management, Faculty of Pharmacy, Faculty of Law, Faculty of Science, Faculty of Doctoral Studies
and Research, Faculty of Architecture & Planning, Faculty of Commerce and Department of Design.
Innovation, excellence, and quality are the driving forces on the campus and this has translated the vision of
these institutions into a reality over a short period of time. Today the campus vibrates with not only world
class curricular activities but also with myriad activities like international conventions, symposia, conferences,
student competitions, conclaves, short-term industry relevant programs, cultural activities, etc.
The University is identified with cutting edge research, robust academic program, quality teaching learning
process and over-all personality development interventions of its students. The 125 acres sprawling state of
art campus provides refreshing environment and stimulates intellectual growth and creativity.
The University in the year 2015 has been recognized as among the leading Universities in the Country by
India Today. In the year 2018, it has been ranked as the 94th university in India by NIRF India Rankings.
The University has been awarded under the category of 'Excellence in Technology for Education Delivery'
during the FICCI Education Awards 2015, as a part of the Eleventh FICCI Higher Education Summit 2015 held
during November 3-4, 2015 organized by FICCI in association with the Ministry of Human Resource
Development, Government of India.
In addition to above the University has also been accorded recognition as Scientific and Industrial Research
Organization by the Department of Scientific and Industrial Research (DSIR), Department of Science and
Technology, Government of India in 2014.
The seven constituent institutes being run under the faculties are: Institute of Technology, Institute of
Management, Institute of Pharmacy, Institute of Science, Institute of Law, Institute of Architecture & Planning
and Institute of Commerce. The under-graduate, post-graduate and doctoral level programmes offered by
these institutes are rated highly by accreditation agencies, industry, business magazines and students.
Institute of Pharmacy, Nirma University
Institute of Pharmacy established in the year 2003, is a leading institute in the western region of the country
imparting quality pharmacy education at under graduate, post graduate and doctoral levels. Institute of
Pharmacy, Nirma University has been ranked 18th best pharmacy institute among pharmacy institutions of
the country by National Institutional Ranking Framework, Ministry of Human Resource Development, Govt. of
India.
Institute of Pharmacy prepares the students to meet the challenges in the area of pharmaceutical
manufacturing and research and development. The Institute houses state-of-art research facility and
infrastructure to support pharmaceutical education and research. The Institute offers B. Pharm, M. Pharm and
Full time and External Ph.D. Programmes in Pharmaceutical Sciences. The Institute has adopted Outcome
Based Education (OBE) to further advance the development of professional knowledge, inculcate
employability skills in addition to development of character and social responsibility. To achieve the same
objective, vision & mission of the institute was also defined in line of University's vision & mission. Further,
the programme educational objectives and programme outcomes are also well defined & available on
www.nirmauni.ac.in/ipnu
The Institute has dynamic curriculum, robust and talented pool of faculty members, and state of the art
infrastructure in all the departments. It is well known for imparting quality education, doing active research
and also in nurturing students for holistic development, achieved through students' engagement tools like
continuous evaluation, blended learning, active use of Massive Open Online Course, credit-based systems,
departmental electives, institute electives, university and non-university courses, industrial visits & training,
industrial and hospital projects, expert lectures, special training in communication skills, yoga classes and
many more.
OBJECTIVES :
1. To develop a centre of excellence in imparting graduate, postgraduate, doctoral and postdoctoral level
education in pharmaceutical sciences.
2. To cater to the human resource needs of the rapidly expanding pharmaceutical industry, educational
institutions and research laboratories in Gujarat State and in the country at large.
3. To promote research in high tech emerging and thrust areas of medicine and human healthcare and
contribute towards fulfilling the national objectives in pharmaceutical education and technology.
4. To establish excellent industry academy interactions and undertake collaborative professional
programmes in the areas of pre-clinical toxicity studies, pharmacokinetics and drug metabolism,
formulation and development studies.
5. To undertake research projects sponsored by the government, various funding agencies and the
pharmaceutical industries.
6. To regularly conduct continuing education programmes for the pharmaceutical scientists and
academicians
ABOUT INSTITUTE OF PHARMACY
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PROGRAMMES OFFERED BY THE INSTITUTE INCLUDE:
1. B. Pharm. (Eight semester programme)*
2. M. Pharm. (Four semester programme)*
a. Pharmaceutics
b. Pharmacology
c. Pharmaceutical Chemistry
d. Regulatory Affairs
e. Pharmaceutical Analysis
3. Ph. D. in Pharmaceutical Sciences (Full time & External)**
*With Industrial Training, **With Course Work
THE CAMPUS
The Institute of Pharmacy is situated on the sprawling 125 acre green campus of Nirma University. It has all
the modern facilities like Sophisticated Instruments, State of the art Labs, Excellent Computing & IT
infrastructure including latest software, Rich Library, canteen, playgrounds, indoor games and gymnasium.
The campus provides an ambience that motivates the students to grow. The Institute building has modern
amenities, with enough space and replenished with modernity and grandeur. The post graduate laboratories
are independently developed for M.Pharm. and Ph.D. students. In addition the campus has sports facilities
and the overall ambience is distinguishable by its serenity, which is conducive for intellectual pursuits.
CLASS ROOMS
The classrooms are spacious, ventilated and equipped with multimedia and audiovisual equipments to
facilitate effective learning. The classrooms are designed to provide maximum interaction between the faculty
and students.
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Institute of Pharmacy, Nirma University
COMPUTER CENTRE
The central computer facilities consist of 24 servers and more than 1500 systems, which are interconnected
by fiber optic cables and 256 Mbps, leased line internet connectivity. Computing facilities for students include
a laboratory equipped with 42 computers for U.G. and P.G. students. The students have an easy access to the
internet. The campus is equipped with Wi-Fi network.
LEARNING RESOURCES CENTRE (LIBRARY)
At Institute of Pharmacy, it is a belief to facilitate production and dissemination of knowledge, information,
insights & intellect in all scientific communities. The Library plays a vital role in the collection development
and dissemination of scientific information and includes a wide range of volumes of different branches of
Pharmaceutical Sciences and allied subjects and also provides extensive access to leading Indian and
international research journals.
The Library at Institute of Pharmacy houses more than 9,062 volumes of books selectively chosen for
reading and reference, 365 CDs, 1,835 Bound Volumes, 831 Project Reports (B.Pharm), 540 Research Project
Reports (M.Pharm), 70 PhD Theses and subscribes about 21 printed national, 3 international periodicals, 15
magazines and 9 newspapers. Library is also providing Web access to 113 e-journals: Science Direct:
Institute has very high intellect faculty members who are actively involved in research, consultancy, testing
and are supported financially with sponsored projects from different government as well as private
organizations.
Many full time PhD research scholars have received the prestigious fellowships from DST-INSPIRE (Innovation
in Science Pursuit for Inspired Research), Women Scientist Fellowship from the DST, Senior Research
Fellowship from ICMR and CSIR, Prime Minister Fellowship Government of India and from Confederation of
Indian Industries (CII).
Many M. Pharm students and research guides from the department of Medicinal Chemistry, Pharmaceutical
Technology & Bio-pharmaceutics, Pharmacology, Pharmacognosy and Pharmaceutical Analysis have received
national recognition for “R. V. Patel Competition for Best Thesis at Masters Program” supported by DST,
Government of India and Troikaa Pharmaceuticals Ltd. Faculty members have been awarded with P. D. Sethi
08
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awards, N. S. Dhalla Young Scientist award and APTI awards for publishing the best research papers and
presentations during symposiums and conferences. Faculties received best principal of the year 2017-2018
award and women of the year award from Association of Pharmaceutical Teachers of India (APTI). Faculty
members have contributed in innovative pharmaceutical research by solving web based challenges floated by
the Innocentive. Inc. USA.
The graduate students have been awarded for securing the highest grade in B.Pharm Examinations and
many students performed well to achieve All India rank in GPAT and secured admissions at reputed institutes
like IITs, NIPER and other PG centres of India and also abroad. The post graduate students have been placed
at reputed academic institutions and industries of India.
Different departments of Institute have received support from government organizations like ICMR, DST,
AICTE, ISTE, GUJCOST, DBT, DRDO, INSA and CSIR in organizing various workshops, conferences and
symposia of national and international level on recent advances in pharmaceutical sciences.
COLLABORATION WITH RESEARCH INSTITUTIONS / INDUSTRIES
The University, recognizing research as the main drive of success in an academic setting, has established a
distinct Faculty of Doctoral Studies and Research to initiate research programmes independently or in
collaboration with National Laboratories that have the potential in terms of infrastructure and expertise. As a
beginning such collaboration exists with institutions like-
• Piramal Drug Development Services Ltd., Ahmedabad
• Physical Research Laboratory (PRL), Ahmedabad
• B. V. Patel Pharmaceutical Education and Research Centre, Ahmedabad
• Cadila Pharmaceutical Research Centre, Ahmedabad
• Intas Pharmaceuticals Ltd., Ahmedabad
• Directorate of Forensic Science, Government of Gujarat
• Space Application Centre (ISRO), Ahmedabad
• Ayurlab Herbal Pvt. Ltd., Vadodara
• Appollo Hospitals International Ltd., Ahmedabad
• CII (Confederation of Indian Industry), Ahmedabad
• Beiersdorf (Nivea), Germany
• Eris Life Sciences, Ahmedabad
• Quantys Clinical Pvt Ltd., Gandhidham
• Sushen Medicamentos Pvt Ltd., Ahmedabad
• Chemical Shoppe Pvt Ltd., Ahmedabad
• Indian Institute of Chemical Technology, Hyderabad
• Finecure Pharmaceuticals Limited, Ahmedabad
• Contract Pharmacal Corp. (CPC), Ahmedabad
• Synchron Research Services Pvt Ltd., Ahmedabad
• Massachusetts College of Pharmacy and Health Science (MCPHS) University, Boston, USA.
• Plovdic University, Bulgaria
• Changwon National University, South Korea
• The University of Southern California, Los Angeles, California, USA.
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Institute of Pharmacy, Nirma University
ADVISORY COMMITTEE
1. Dr. Anamik Shah, Vice Chancellor, Gujarat Vidhyapith, Ahmedabad
2. Dr. Manish Nivsarkar, Director, B. V. Patel PERD Center, Ahmedabad
3. Dr. Kiran Marthak, Director - Management, Lambda Therapeutic Research Limited, Ahmedabad
4. Dr. Lal Hingorani, CMD, Pharmanza Herbal Health, Dharmaj
5. Dr. Rakesh Rawal, Professor, Department of Life Sciences, Gujarat University, Ahmedabad
6. Mr. S. B. Dangayach, Founder Trustee of Innovative Thought Forum, Ahmedabad
7. Prof. Bhaswat S. Chakraborty, Emeritus Professor, Institute of Pharmacy, Nirma University
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CHIEF PATRON
VARIOUS COMMITTEES
CONVENER
Scientific & Abstract book
Committee
Prof. Tejal A. Mehta
Dr. Bhoomika M. Patel
Dr. Nagja V. Tripathi
Dr. Nrupesh R. Patel
Ms. Palak K. Parikh
Dr. Mohit P. Shah
Mr. Shreyas Bhuva
Mr. Mukeshbhai Patel
Printing and Souvenir
Committee
Dr. Shital Butani
Dr. Snehal S. Patel
Dr. Bhagwati Saxena
Mr. Jignesh Patel
ORGANIZING COMMITTEE
Shri K. K. Patel
Vice-President, Nirma University
Dr. Anup K. Singh
Director General, Nirma University
Dr. Niyati Acharya
Head, Department of Pharmacognosy, Institute of Pharmacy
Nirma University
Prof. Manjunath D. Ghate
Director
Institute of Pharmacy
Nirma University
ORGANIZING SECRETARY
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Institute of Pharmacy, Nirma University
Finance Committee
Prof. Priti J. Mehta
Dr. Bhumika D. Patel
Mr. Dinesh Patel
Mr. Devendrabhai Vaghela
Registration & Correspondence
Prof. Jigna S. Shah
Dr. Shital Panchal
Dr. Charmy S. Kothari
Dr. Vidhi Shah
Ms. Pooja Pandey
Ms. Jigisha Patel
Mr. Chetan Patel
Transport, Accommodation
& Logistics
Dr. Hardik G. Bhatt
Dr. Vivek Vyas
Mr. Shailesh Patel
Venue Management
Dr. Jigar N. Shah
Mr. Mukesh Patel
Mr. Kiran Parmar
Catering
Dr. Mayur M. Patel
Mr. Rohitbhai Patel
Mr. Hasmukhbhai Rathod
Mr. Virendra Goswami
Hospitality & Reception
Dr. Jignasha K. Savjani
Dr. Dipal M. Gandhi
Ms. Drashtiben Patel
Ms. Dhartiben Patel
Website Management
Dr. Dhaivat C. Parikh
Ms. Jaya Dabhi
Media Publicity
Mr. Tushar Patel
Ms. Sima Ahire
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STUDENTS TASK FORCE
Scientific & Abstract book
Committee
Chetan Dhal
Manan Shah
Tripti Halder
Kirti Vishwakarma
Khushali Parekh
Harshita Gupta
Ankita Mehta (M. Pharm.)
Jigisha Chauhan (M. Pharm.)
Diksha Pandey (M. Pharm.)
Silvi Singh (M. Pharm.)
Shivangi Panchal (M. Pharm.)
Printing and Souvenir committee
Vishal Chavda
Harshita Gupta
Trisha Bhatt (M.Pharm.)
Finance Committee
Dhara Bhayani
Registration & Correspondence
Chintan Pansara
Parmi Patel
Krunal Prajapati
Misari Patel
Priyanshi Shah (M.Pharm.)
Riya Chitral (M.Pharm.)
Vidhi Patel (M.Pharm.)
Swapnil Shah (M.Pharm.)
Jimmy Patel (M.Pharm.)
Vraj Mehta (M.Pharm.)
Transport, Accommodation &
Logistics
Udit Chaube
Namdev Dhas
Piyush Gediya
Arpit Bana
Jaydeep Chavda (M. Pharm.)
Kevin Shah (M.Pharm.)
Venue Management
Vishal Chavda
Jayanta Kumar Maji
Vimal Gupta (M. Pharm.)
Vismay Saraiya (M. Pharm.)
Mitali Thakur (M. Pharm.)
Harshil Shah (M.Pharm.)
Catering
Kartik Hariharan
Hemil Pandit (M.Pharm.)
Harsh Maru (M.Pharm.)
Riyaz Momin (M.Pharm.)
Karanpalsingh Chaudhary (M.Pharm.)
Hospitality & Reception
Kartik Hariharan
Shruti Rawal
Manasi Patel
Dattatreya Yadav
Karan Rathod (M.Pharm.)
Sapana Bhati (M.Pharm.)
Dhruvi Gandhi (M.Pharm.)
Shreya Mehta (M.Pharm.)
Media Publicity
Nisith Raval
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Institute of Pharmacy, Nirma University
SCIENTIFIC SCHEDULE OF NCIP-2019 AT A GLANCE
10:00 am to 10:45 am Dr. P. R. Vavia Professor of Pharmaceutics & Dean, Role of excipient functionality in
Academic Programme, Institute of Chemical drug deliveryTechnology, Mumbai
Plenary Lecture-1
2:00 pm to 2:45 pm Dr. Anil K MishraScientist "G", Molecular Imaging and Non-Invasive Imaging Probes Research Centre, Institute of Nuclear for Life ImagingMedicine and Allied Sciences, Delhi
2.45 pm to 3:30 pm Prof. K. S. Laddha Plenary Lecture-3Professor of Pharmacognosy, Integrating herbals into
Institute of Chemical Technology, Mumbai modern medicine
Plenary Lecture-2
3:45 pm to 4:30 pm Dr. Kiran MarthakDirector - Management, Lambda Therapeutic AYUSH and its Regulations
Research Ltd., Ahmedabad and GCP
4:30 pm to 5:15 pm Prof. A. K. Chakraborti Plenary lecture-5Professor and Head, Department of New chemistries in the quest for
Medicinal Chemistry, and Dean, novel anti-inflammatory scaffoldsNational Institute of Pharmaceutical
Education and Research (NIPER), Mohali
Plenary lecture-4
"Integrating natural and modern medicines in drug discovery and development"th th
24 - 25 January, 2019
thDAY 1: 24 JANUARY 2019 (THURSDAY)
9:15 am to 10:00 am Registration and Breakfast
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Venue: Auditorium, Institute of Management, Nirma University, Ahmedabad
10.45 am to INAUGURATION
12:00 noon Chief Guest: Dr. G . N. Singh
Secretary-cum-Scientific Director, Indian Pharmacopoeia Commission
Ministry of Health & Family Welfare, Govt. of India
Guest of Honour: Dr. Gopal Kundu
Director (I/c), National Centre for Cell Science, Pune
12.00 noon Key Note Address
to 1:00 pm Dr. Gopal Kundu, Director (I/c), National Centre for Cell Science, Pune
Title: Role of Osteopontin In Tumor Microenvironment:
A New Paradigm In Cancer Therapy
1:.00 pm to 2:00 pm Lunch Break
Chairperson: Dr. Gopal Kundu, Director (I/c), NCCS, Pune
3.30 pm to 3.45 pm Tea- Coffee and Networking
Chairperson: Dr. Anil K Mishra, Scientist "G",
Molecular Imaging and Research Centre, INMAS, Delhi
rd3 National Conference of Institute of Pharmacy
1.15 pm to 2:00 pm Prof. Javed AliProfessor (Pharmaceutics), Nanopharmaceuticals: challenges and
School of Pharmaceutical Education and opportunities for phytotherapeuticsResearch (Formerly Faculty of Pharmacy),
Jamia Hamdard, New Delhi
2:00 pm to 2:45 pm Dr. Jyoti Paliwal Plenary Lecture-9Director, PHAEX Consulting, ADME Studies for Rational Integration
Dr. Suresh Patankar, Chairman, Department of Urology, ACE Hospital and Research Center, Pune
Panelist:
Prof. Krishnapriya Mohanraj, Vice Principal (Administration and Strategy)Professor, Department of Pharmaceutical Analysis, Bombay College of Pharmacy, Mumbai
Mr. S. B. Dangayach, Founder Trustee, Innovative Thought Forum, Ahmedabad
Dr. Jyoti Paliwal, Director, PHAEX Consulting, Gurugram
Dr. Rakesh Rawal, Professor, Department of Life Sciences, Gujarat University, Ahmedabad
Dr. Sarat Dalai, Director, Institute of Science, Nirma University, Ahmedabad
Dr. Shivprakash Rathnam, Managing Director, Synchron Research Services Pvt. Ltd., Ahmedabad
9:30 am to 10:15 am Dr. Suresh PatankarChairman, Department of Urology, Lab to patent to patient
ACE Hospital and Research Center, Pune
10:15 am to 11:00 am Prof. Krishnapriya Mohanraj Plenary Lecture-7Vice Principal (Administration and Strategy) Drug Discovery from Natural
Professor, Department of Pharmaceutical Sources- Challenges and Case studiesAnalysis, Bombay College of Pharmacy,
Mumbai
Plenary lecture-6
thDAY 2: 25 JANUARY 2019 (FRIDAY)
9:00 am to 9:30 am Registration and Breakfast
Chairperson: Dr. Bhaswat Chakraborty,
Professor Emeritus, Institute of Pharmacy, Nirma University
11.00am to 12.30pm Poster Session (All tracks) • Venue: Institute of Pharmacy
12.30 pm to 1.15 pm Lunch Break
Chairperson: Dr. Manish Nivsarkar, Director, B. V. Patel PERD Centre
2:45 pm to 3.00 pm Tea- Coffee and Networking
3:00 pm to 4:00 pm PANEL DISCUSSION
Integrating natural and modern medicines in drug development life cycle for
better health outcomes: Need or Mandate?
Institute of Pharmacy, Nirma University
Inauguration, Valedictory and Key note address
16
Dr. G. N. Singh
Secretary-cum-Scientific Director
Indian Pharmacopoeia Commission
& Former Drugs Controller General (India)
Central Drugs Standard Control Organization (CDSCO)
Ministry of Health & Family Welfare, Govt. of India
BIODATA
Dr. G.N Singh did his doctorate in Pharmaceutical Sciences from Banaras Hindu University in 1987 and MBA
from University of Hull, U.K in the year 1997. He is a man of humble beginning having qualities of excellent
leadership, dedication and commitment to raise the quality of drug regulatory system in the country. Dr. has
got established Indian Pharmacopoeia Commission (IPC) in the year 2009 with aim to set and promote
quality standards for drugs and pharmaceuticals. Dr. G. N. Singh, the first Secretary-cum-Scientific Director of
the Commission has been discharging the functions and duties of Chief Scientific and Executive Officer.
Under his leadership, IPC publishes Indian Pharmacopoeia (IP) and its Addenda at regular time interval,
ensures availability of IP Reference Substances (IPRS) and Impurity standards. The Indian Pharmacopoeial
laboratory is accredited as WHO pre-qualified (first among government laboratories) and NABL accredited to
ensure compliance of ISO:IEC 17025:2005. To promote rational use of drugs, IPC publishes National
Formulary of India (NFI) at regular time intervals. IPC also acts as National Coordinating Centre (NCC) for
Pharmacovigilance programme of India (PvPI) with the aim to monitor the safety of the drugs and devices in
the country. NCC-PvPI works through ADR monitoring centres in the country and also contributes to WHO
Programme for International Drug Monitoring.
Dr. Singh was holding additional charge as Drugs Controller General (India) of the Ministry of Health and
Family Welfare, Govt. of India from 21st February, 2012 to 20th February, 2018. Dr. Singh within the span of 6
years was able to give new directions to the Central Drugs Standard Control Organisation (CDSCO). He was
instrumental in bringing out swift changes in the drug regulatory landscape of the country by means of
simplification of rules, and procedures using cutting-edge technological platforms.
Dr. Singh also served/serving as a member of various national and international committees, to name few-
Drugs Technical Advisory Board, Drugs Consultative Committee, Expert Core Committee of National List of
Essential Medicines, Pharmacy Council of India, Expert Core Committee of National List of Essential Medicines
and Investigational New Drug approval committee etc of Govt. of India and also in advisory boards of various
academic institutions. The United States Pharmacopoeia convention recognized the services of Dr. Singh and
appointed him as voting delegate for Indian Pharmacopoeia Commission in the USP convention. Dr. Singh is
at Research Council of CDRI, Lucknow and IIIM, Jammu of CSIR, New Delhi.
The vision of Dr. Singh is to bridge the gap within the Industry – Academia - National Institutions - Public for
better health care system in India.
17
Chief Guest – Inaugural Function
Institute of Pharmacy, Nirma University
Role of Osteopontin In Tumor Microenvironment:
A New Paradigm In Cancer Therapy
Dr. Gopal Kundu,
Director (I/C),
National Centre for Cell Science, Pune
BIODATA
Dr. Gopal Kundu has obtained his Ph.D. in chemistry from Bose Institute, Kolkata, India (1989). He did his
post-doctoral research in US from 1989 to 1998. He joined as Scientist-D at National Centre for Cell Science
(NCCS) in 1998 and at present he is Scientist-G. His area of research at NCCS is tumor biology, cancer stem
cells, angiogenesis, cancer therapeutics and nanomedicine. He has received several awards including Fellows
Award for Research Excellence from USA; National Bioscience Award; Shanti Swarup Bhatnagar Prize;
International Award in Oncology, Greece; International Young Investigator Award, USA and 7th National
Grassroots Innovation Award, Rashtrapati Bhavan, India. He is Fellow of National Academy of Sciences and
Indian Academy of Sciences. He has published 81 papers including Nature Medicine, Science, PNAS, Cancer
Research, J. of Invest. Dermatology, JBC, TCB, Oncogene, Nanomedicine etc and one US patent. He serves as
Editorial Board Member of Current Molecular Medicine, Molecular Medicine Reports, American Journal of
Cancer Research and Associate Editor of Molecular Cancer. Dr. Kundu is acting as Visiting Professor at Curtin
University, Perth, Australia. Dr. Kundu is also Director (I/c) at National Centre for Cell Science, Pune.
KEY NOTE ADDRESS
Tumor microenvironment play important role in determining the invasive and metastatic potential of breast
and other cancers. Analysis of microenvironment in patients with different solid tumors reveals that the
majority of tumors showed infiltration of T cells, macrophages, fibroblasts, dendritic cells etc. Intratumoral
heterogeneity contributes significantly to the effectiveness of cancer treatment and outcome. Substantial
advances in cancer treatments have resulted in significant decrease in mortality. However, existing cancer
therapies often result in high toxicity and nonspecific side effects. Therefore, better targeted delivery and
increased efficacy of drugs are crucial to overcome these effects. Osteopontin, a chemokine like protein plays
crucial role in regulating the oncogenic and angiogenic potential of various cancers including breast. Several
groups have demonstrated the role of Osteopontin in regulating the cell signaling that ultimately controls
tumor progression and metastasis covering all the hallmarks of cancer. During last several years, we have
demonstrated that both tumor and stroma-derived Osteopontin regulate tumor growth and angiogenesis
through induction of pro-angiogenic and metastasis associated genes. Recent data has shown that
circulating Osteopontin acts as predictive marker in development of hepatocellular carcinoma in a large
European population. It has been also reported that knocking down of Osteopontin in combination with PD-
L1 in macrophages suppresses lung adenocarcinoma cell migration. We have demonstrated that Osteopontin
signaling upregulates cyclooxygenase-2 expression in tumor-associated macrophages leading to enhanced
angiogenesis and melanoma growth via α9β1 integrin. Our earlier data showed that Osteopontin controls
HIF-1alpha dependent VEGF expression and breast tumor angiogenesis in response to hypoxia. Our recent
data revealed that Osteopontin transactivates normal fibroblasts to myofibroblasts and support breast tumor
progression in tumor microenvironment. Thus targeting Osteopontin and its regulated signaling network
could be novel therapeutic strategies for the management of breast and other cancers.
18
rd3 National Conference of Institute of Pharmacy
Guest of Honor– Inaugural Function
Prof. N. R. Sheth
Vice Chancellor,
Gujarat Technological University, Ahmedabad
BIODATA
Prof. (Dr.) Navin Sheth took over as the Vice-Chancellor of the Gujarat Technological University on December
31, 2016. A renowned educationist and administrator, Prof. Sheth started his academic career way back in
1979 and during the course of time, emerged as a tireless academician and herbal scientist. Born in Modasa
town of Aravalli district of Gujarat, Prof. Sheth had his early education in his hometown. He obtained his
B.Pharm. and M. Pharm degrees from L. M. College of Pharmacy, Gujarat University, Ahmedabad. He was
awarded the National Merit Scholarship for his graduation studies. He obtained Ph.D. degree from the
Saurashtra University, Rajkot. He started his academic career in 1979 as an Assistant lecturer at the B. K. Mody
Government Pharmacy College, Rajkot and was gradually promoted as the Lecturer, Reader and Principal
there. In 2007, he joined the Department of Pharmaceutical Sciences, Saurashtra University, Rajkot as the
Professor and Head. He has also served the Saurashtra University under various capacities like the Dean,
Faculty of Pharmacy, the Chairman, Board of Pharmaceutical Sciences, the Member of the Senate and the
Academic Council. A distinguished academician, staunch disciplinarian and an efficient administrator, Prof.
Sheth has also been the Member of the Peer Teams of the National Assessment and Accreditation Council -
NAAC and NBA. He has also served as the Member and Chairman of the various Committees of UGC/ AICTE
/DST/ GUJCOST and several Universities in India. He had been the Advisor and later on, Member of the GPSC.
In 2016, he took over as the Chairman of the Board of Pharmacy Education, AICTE. Prof. Sheth has attended
many national and international conferences in India and abroad. His research interests include Traditional
Drugs, Herbal Drugs and Standardization, Herbal formulations. His exuberant involvement in R&D has been
recognized by his 100+ publications including 65 technical papers in renowned research journals, 42 papers
in National Conferences 21 papers in the International Conferences. Till 2017, 20 research scholars had
successfully completed their doctoral research under his guidance. At present, 8 research scholars are
pursuing their Ph.D. under his supervision. About 21 of his former PG students are occupying key positions in
the various fields of Pharmacy. Prof. Sheth is awarded by Life Time Achievement Award at KLE University,
Karnataka during 20th National Conference of ISP at Belgaum, Karnataka, Indian Society of Pharmacognosy
2017 at Aurangabad and World Education Convention 2017 at New Delhi. Prof. Sheth has been associated
with various national and international associations and professional bodies as a member or a life member;
these include Indian Society of Technical Education, Indian Pharmaceutical Association, Indian Society for
Pharmacognosy, the Association of Pharmaceutical Teachers of India, All India Council Of Technical Education
(AICTE), Pharmacy Council Of India (PCI), Indian Institute of Management-Ahmedabad, Gujarat Forensic
Sciences University and B. V. Patel Pharmaceutical Education & Research Development (PERD) Centre. His
dream, vision, mission and efforts are directed towards making the Gujarat Technological University to a
world class University in the field of Science and Technology.
19
Chief Guest – Valedictory Function
Institute of Pharmacy, Nirma University
Dr. Anamik Shah
Vice Chancellor, Gujarat Vidyapith, Ahmedabad
President, Indian Society of Chemists & Biologists
In charge, Centre of Excellence for Drug Discovery
Former Professor, Department of Chemistry, Saurashtra University, Rajkot
BIODATA
Prof. Anamik Shah is a Vice-Chancellor of Gujarat Vidyapith, Ahmedabad; founded by Mahatma Gandhi in
1920. Currently, he is looking after it’s various activities of education (Naitalim), higher education, constructive
social and extension programme at various level across Gujarat. He did his M.Sc (Chemistry) and Ph.D.
(Medicinal Chemistry) from Saurashtra University, Rajkot. He has 33 years of teaching and research
experience at Saurashtra University. He has published more than 205 papers in International and National
peer reviewed journals. His research area includes Synthetic Organic Chemistry, Analytical Environmental
Chemistry, Medicinal Chemistry, Natural products chemistry, Isolation & screening of marine based natural
products, QSAR, anticancer, anti-tubercular drug research, MDR reverter development and Analytical Method
Developments of Active Pharma Intermediates. He has worked as a Principal Investigator with No. Of Projects
related to Medicinal Chemistry, Anti-HIV, Anti-Cancer, MDR Revrters, Anti TB, Aromatase Inhibitors, Non
Nucleoside Reverse Transcriptase Inhibitors etc. funded by NIH (USA), DST, DBT, UGC, CSIR, DAE, MSME worth
Rs. 25 Crore. He has also completed several pharma related projects with industries like Alembic Limited,
AstraZeneca USA, Claris Life Sciences Ltd, Dabur Research Foundation and Primal Life Sciences. He has given
proven technology to Claris Life Sciences and Created National Facility for Drug Discovery Center, Centre of
Excellence (In drug delivery funded by Government of Gujarat, Government of India worth Rs.20crore in two
phases) at Saurashtra University, Rajkot, Gujarat, India. He has visited several countries like Singapore,
Malaysia, Taiwan, Netherlands, Germany, France, Italy, Switzerland, Greece, U.K., United States of
America/Mexico, Macao, China, Hong Kong for Scientific Purpose. He has supervised more than 60 PhD
Scholars and several M. Sc and M. Pharm (Ayurved) students for their Dissertation work.
He is also serving as Chairman - Gujarat Vidyapith Trust, President - Indian Society of Chemists and Biologists
(ISCB – Lucknow), Principal Investigator - Centre of Excellence (Saurashtra University, Rajkot), Trustee - Kaba
Gandhi no Delo (Rajkot), Trustee - Rashtriya Shala (Rajkot), Chairman - ‘Vishwamangalam
Trust’(Sabarkantha), Sardar Vallabhbhai Smarak Trust (Rajkot), Editor - ‘Vidyapith’ Research Journal, Board of
Director of ‘Anuvad Foundation’ (Non-profit organization), Chairman - Tribal Research and Training Institute
(TRTI - Gujarat Vidyapith) and Board of Directors, Vikram Sarabhai Science Centre.
20
rd3 National Conference of Institute of Pharmacy
Guest of Honor – Valedictory Function
Plenary Sessions
21
Role of Excipient Functionality in Drug Delivery
Prof. P. R. VaviaProfessor of Pharmaceutics & Dean, Academic Programme,
Institute of Chemical Technology, Mumbai
BIODATA
Prof. P. R. Vavia is a Professor in Pharmaceutics at The Institute of Chemical Technology, Mumbai. Currently, he
is the Dean of academic programmes at Institute of Chemical Technology. He has more than 29 years of
teaching experience to undergraduate, postgraduate and doctoral students. So far, Prof. Vavia has guided
over 55 Master students and 43 Ph.D. students who are placed at key positions in leading pharmaceutical
organizations. Presently, his research group comprises 5 masters and 15 Ph.D. students. Till date, he has 137
peer reviewed scientific publications in national and international journals to his credit, with more than 2745
citations and H-index of 27. Prof. Vavia has given more than 250 research presentations at national and
international levels. He has 8 granted patents, 38 complete patent specifications and 3 PCT applications filed
in the area of drug delivery.
ABSTRACT
Excipients are important part in formulation development that decide final dosage form as well as
pharmacokinetics and pharmacodynamics of drug being delivered. Over the past few years there has been
considerable interest in using polymers from various natural resources as a carrier in nanoparticle drug
delivery systems due to their multifaceted therapeutic benefits. These polymers with various functionality
can effectively deliver the drug into the target site which provides better therapeutic effect. Many plant
polysaccharides have been extensively investigated for their use in the development of novel carrier system
for drug delivery. Present talk is focusing on some of the important case studies where natural excipients are
successfully utilized in formulation development. Case studies focusing on successful delivery of natural
bioactives with novel drug delivery approach would also be discussed.
22
rd3 National Conference of Institute of Pharmacy
Non-Invasive Imaging Probes for Life Imaging
Dr. Anil K. MishraScientist "G",
Molecular Imaging and Research Centre
Institute of Nuclear Medicine and Allied Sciences, Delhi
BIODATA
Dr. A.K. Mishra is working as a Scientist at Institute of Nuclear Medicine and Allied Sciences, Defence
Research and Development Organization, Ministry of Defence, Govt. of India. He obtained his M.S.
(Chemistry) from Gorakhpur University, Gorakhpur, and Ph.D. (Chemistry) from Banaras Hindu University,
Varanasi. During his career, he held positions as Post-doctorate fellow at Universite de Bourgogne, Dijon,
France; Research Scientist at University of California, Davis, USA; Senior Scientist at INSERM U-463, Nantes,
France, and Visiting Professor at MaxPlanck Institute, Germany. Dr. Mishra has published more than 284
papers, in various journals of international repute. Dr Mishra is granted US, European and Indian patents. He
has received several awards and most prestigious one is DRDO-Young scientist by Prime Minister (Shri Atal
Bihari Vajpayee) of India in 1999. He is also serving as Honorary Professor at Deakin University [Australia],
Task force member [DBT and DST], Core Member of Radiopharmaceutical of India [DCGI], Associate Editor
[Frontiers in Nuclear Medicine] and Expert IAEA, Vienna. His Research Interest includes Molecular Imaging
Probes (SPECT-PET-MR-OI), Radiochemistry, Coordiantion chemistry, Synthetic chemistry and Bioconjugate
chemistry.
ABSTRACT
The tracing and extraction of biochemical of plant origin using non-invasive way is still in infancy stage.
However, all the biochemical of important nature to isolate and characterize required invasive or by
sacrificing the plants with laborious dissections by hand or to depend on less sensitive and non-specific
techniques. To overcome associated strenuous process, we have directed our efforts to develop smart and
specific agent to investigate in vivo topography, and connections and titration of biochemical's non-invasively
using imaging techniques. Our present study opens a new avenue to design and development of multimodal
molecular imaging probe of broad interest in development of affinity based probes. Imaging probes are a
special class of tracers that are used in conjunction with imaging techniques such as MRI, CT, and nuclear
imaging (PET and SPECT), allowing healthcare practitioners to see disease and injuries in a non-invasive way.
In the post genomics era, there is the opportunity to advance probes to the point where they can target
specific biochemical signatures associated with disease. Because changes in biochemistry occur before
diseases reach an advanced stage, molecular imaging probes will foster earlier and more personalized
diagnosis of disease. Our Lab is focused on bringing the power of modern synthesis to bear on the
development of molecular imaging probes and agents. These probes and agents are being developed to
visualize specific molecular targets and pathways in live cells, tissues and organism (from plants, mouse to
human). The specific aim is to 1) design and synthesize new imaging probes/agents, 2) develop and use
novel amplification schemes for the development of 'next generation' imaging probes, 3) optimize
pharmacokinetics and 'imagability', 4) efficiently synthesize and produce complex and diverse small
molecules, and test their ability as imaging agents. To design and synthesis the next generation of imaging
probes/agents for MRI, PET and SPECT, and optical imaging is the core mandate of our research lab.
23
Institute of Pharmacy, Nirma University
Integrating Herbals into Modern Medicine
Prof. K. S. LaddhaProfessor of Pharmacognosy and Phytochemistry,
Institute of Chemical Technology, Mumbai
BIODATA
K. S. Laddha, Ph.D. (Tech.) is a Professor in Pharmacognosy and Phytochemistry at Dept. of Pharmaceutical
Sciences and Technology, Institute of Chemical Technology, Matunga, Mumbai. He has 29 years of Academic
experience and 4 years of industrial experience at different levels. His fields of specialization include
Extraction, isolation and characterization of phytoconstituents, Development of large scale extraction
technologies, Standardization of Ayurvedic/herbal drugs and formulations, Development of Ayurvedic/herbal
drug formulations, Chemical modification of phytoconstituents, Scientific studies on shodhan prakriya of
toxic plants in Ayurveda. He has published more than 100 papers, authored 7 books and 2 patents to his
credit. He has also published 58 monographs in 'Quality Standards of Indian Medicinal Plants' Volume 11
(2013), 12 (2014), 13 (2015), 14 (2016), 15 (2017), 16 (2018) published by Indian Council of Medical Research,
New Delhi. He has guided more than 20 Ph.D. scholars and 70 master's students. He has completed 23
sponsored projects including 8 from govt agencies such as MOFPI, DAE, AICTE, UGC, ICAR, AYUSH, ICMR,
RGSTC and 16 from industry such as Gufic Ltd, Mumbai; Colgate Palmolive, Mumbai; Kukadeshwar, Pune;