National Congress of the Italian Society of Immunology, Clinical Immunology and Allergology Abano Terme (Padova), 25-28 May 2016 Pietro d'Abano Congress Center SECRETARIAT Rita Repizzi Tel. +39 333 4398196 [email protected]www.siica.org ORGANIZING SECRETARIAT Viale G. Matteotti, 7 50121 Florence, Italy Tel. +39 055 50351 Fax +39 055 5001912 [email protected]Congress Venue Pietro d'Abano Congress Center Largo Marconi, 16 - 35031 Abano Terme (PD), Italy Tel. +39 049 8666111 Fax + 39 049 8666113 Congress President Paola Zanovello Local Organizing Committee Alberto Amadori Gianpietro Semenzato Paola Zanovello Scientific Committee Alberto Amadori Francesco Annunziato Flavia Bazzoni Ennio Carbone Raffaele De Palma Francesca Di Rosa Cecilia Garlanda Francesca Granucci Vito Pistoia Angela Santoni Gianpietro Semenzato Angelo Vacca Paola Zanovello PRELIMINARY SCIENTIFIC PROGRAM
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National Congress of theItalian Society of Immunology,Clinical Immunology and Allergology
Abano Terme (Padova), 25-28 May 2016Pietro d'Abano Congress Center
National Congress of the Italian Society of Immunology, Clinical Immunology and AllergologyAbano Terme (Padova) 25-28 May 2016
14.00 AUDITORIUM15.00 OPENING CEREMONY & WELCOME ADDRESSES LECTUREL1 The golden age of Medicine in Padova during Renaissance G. Thiene (Italy)
15.00 AUDITORIUM17.00 PLENARY SYMPOSIUM 1 - SIICA-FOCIS JOINT SYMPOSIUM IMMUNODEFICIENCY Chairpersons: C. Agostini (Italy), R. De Palma (Italy)
PS1.1 Pathogenesisofprimaryantibodydeficiencies I. Quinti (Italy)
PS1.2 Monogenic disorders of regulatory T cells: mechanisms and therapies T. Chatila (USA)
PS1.3 Functional SCID caused by LOF mutation in the CAR11 gene T. Giese (Germany)
PS1.4 Clinicalwholeexomesequencingfromprimaryimmunodeficiencies,experiencesfromStockholm O. Winqvist (Sweden)
PS1.5 ClinicalassociationsofbiallelicandmonoallelicTNFRSF13BvariantsinItalianprimaryantibodydeficiencysyndromes F. Pulvirenti, R. Zuntini, C. Milito, F. Specchia, G. Spadaro, M.G. Danieli, A. Pession, I. Quinti, S. Ferrari (Italy)
17.00 SPONSORED SYMPOSIUM18.00
18.00 AUDITORIUM19.00 EFIS LECTURE Chairperson: L. Moretta (Italy)
L2 Immune response to tuberculosis: how to control the most successful pathogen on earth S.H.E. Kaufmann (Germany)
THURSDAY 26 MAY 2016
4
National Congress of the Italian Society of Immunology, Clinical Immunology and AllergologyAbano Terme (Padova) 25-28 May 2016
8.30 AUDITORIUM10.30 PLENARY SYMPOSIUM 2 CELL DEVELOPMENT AND REGULATION Chairperson: G. Matarese (Italy)
PS2.1 T lymphocyte differentiation, migration and immune regulation F. Sallusto (Switzerland)
PS2.2 New insights about the regulation of human Th17 cell response F. Annunziato (Italy)
PS2.3 IL-10regulationofcytokineexpression:focusonepigeneticmechanisms F. Bazzoni (Italy)
PS2.4 Deconstructing the pathway to memory B cell generation and maintenance in humans R. Carsetti (Italy)
PS2.5 iNKTcelldevelopmentrequiresmicroRNA-dependentmodulationofTGF-β signaling M. Fedeli, M. Riba, J.M. Garcia Manteiga, L. Tian*, V. Viganò, G. Rossetti, M. Pagani, A. Liston*, S. Abrignani, D. Cittaro, P. Provero, P. Dellabona, G. Casorati (Italy, *Belgium)
10.30 BREAK & POSTER VIEWING11.30
11.30 AUDITORIUM13.00 WORKSHOP 1 INNATE IMMUNITY 1 Chairpersons: G. Casorati (Italy), G. Ferlazzo (Italy)
W1.1 Characterizationandimmunomodulatoryroleofmultiplemyelomacell-derivedexosomesonhumanNKcell-mediatedfunctions:roleofTLR2 E. Vulpis, F. Cecere, R. Molfetta, G. Caracciolo, L. Digiacomo, G. Peruzzi, L. Masuelli, L. Simonelli, U. D’Oro, A. Soriani, C. Fionda, R. Paolini, M. Cippitelli, A. Santoni, A. Zingoni (Italy)
W1.2 Tolerogenic plasmacytoid dendritic cells migrate via afferent lymph to secondary lymphoid organs I. Bonaccorsi, S. Campana, C. De Pasquale, D. Oliveri, R. Conte, B. Morandi, R. Iemmo, G. Ferlazzo (Italy)
W1.3 Down-regulationofatypicalchemokinereceptorACKR2expressionbyhematopoieticprogenitorspromotesmyeloid cell mobilization and differentiation O. Bonavita, N. Caronni, B. Savino, M. Massara, L. Crisafulli, F. Ficara, A. Mantovani, M. Locati, R. Bonecchi (Italy)
W1.4 TherapeuticimmunostimulationmediatedbyRIG-Ipathwayactivation J. Hiscott (Italy)
W1.5 DendriticcellsproduceVEGF-Ainhumaninflamedsecondarylymphoidorgans V. Gianello, V. Salvi, W. Vermi, S. Lonardi, V. Gagliostro, A. Naldini, S. Sozzani, D. Bosisio (Italy)
13.00 LUNCH SYMPOSIA/MEET THE EXPERT & POSTER VIEWING14.30
THURSDAY 26 MAY 2016
5
National Congress of the Italian Society of Immunology, Clinical Immunology and AllergologyAbano Terme (Padova) 25-28 May 2016
14.30 AUDITORIUM16.30 PLENARY SYMPOSIUM 3 - SIICA-MIT JOINT SYMPOSIUM IMMUNO-RHEUMATOLOGY AND AUTOIMMUNITY Chairpersons: I. Kacskovics (Hungary), L. Punzi (Italy)
PS3.1 New advances in the management of SLE A. Doria (Italy)
PS3.2 Myeloidcellsignallinginautoimmuneinflammation A. Mocsai (Hungary)
PS3.3 Pathogeneticmolecularandimmunologicalmechanismsoffibrosis:thesystemicsclerosisparadigm A. Gabrielli (Italy)
PS3.4 Citrullination and autoimmunity G. Valesini (Italy)
17.30 AUDITORIUM19.00 WORKSHOP 4 INNATE IMMUNITY 2 Chairpersons: A. Rubartelli (Italy), P. Zanovello (Italy)
W4.1 Proton-pumpinhibitorsprotectmicefromacutesystemicinflammationandinducelongtermcross-tolerance A. Rubartelli, S. Carta, E. Balza, P. Piccioli, R. Lavieri, M. Gattorno, C. Semino, P. Castellani (Italy)
W4.2 Theabundantnaturalkiller(NK)cellsinmultiplemyelomapatientsareenrichedinproliferatingCD56dim-CD94low highly cytotoxic NK cell subset C. Barberi, S. Campana, C. De Pasquale, A. Allegra, G. Ferlazzo (Italy)
W4.3 The long pentraxin PTX3 and the alternative complement pathway cooperate in the immune response to Aspergillus fumigatus R. Parente, F. Petroni, M. Sironi, S. Valentino, B. Bottazzi, A. Mantovani, A. Inforzato (Italy)
W4.4 Interleukin-1receptor8(IL-1R8)playsacrucialroleinnaturalkillercelldifferentiationandfunction M. Molgora, E. Bonavita, A. Ponzetta, M. Barbagallo, N. Polentarutti, S. Jaillon, F. Riva, E. Magrini, G. Benigni, G. Bernardini, A. Santoni, A. Mantovani, C. Garlanda (Italy)
W4.5 Human BDCA1+ dendritic cells are potent activator of tonsillar ILC3 S. Campana, D. Oliveri, C. Barberi, C. De Pasquale, R. Cavaliere, G. Ferlazzo (Italy)
19.00 SIICA ASSEMBLY20.00
THURSDAY 26 MAY 2016
6
National Congress of the Italian Society of Immunology, Clinical Immunology and AllergologyAbano Terme (Padova) 25-28 May 2016
11.30 ROOM PIETRO D'ABANO13.00 WORKSHOP 2 EPIGENETICS Chairpersons: S. Indraccolo (Italy), M. Locati (Italy)
W2.1 Long noncoding RNAs: new players in plasticity and new therapeutic opportunities in human immune system I. Panzeri, M. Lorenzo, P. Gruarin, A. Dardanelli, S. Marchesi, V. Ranzani, A. Arrigoni, R.J.P. Bonnal, G. Rossetti, S. Abrignani, M. Pagani (Italy)
W2.2 IdentificationandcharacterizationofLongnon-codingRNAsinprimaryhumanmonocytesandneutrophils B. Mariotti, M. Castellucci, F.M.A. Bianchetto, N. Tamassia, M.A. Cassatella, F. Bazzoni (Italy)
W2.3 DoesepigeneticsplayaroleinIL-10productionbyBlymphocytes? S. Tonon, F. Mion, J. Dong*, H.-D. Chang*, A. Radbruch*, M. Colombo, S. Canevari, M. Dugo, D. Cesselli, C.E.M. Pucillo (Italy, *Germany)
W2.4 Differential expression of DNA repeats in human CD4+ T cell subsets F. Marasca, S. Sinha, E. Provasi, S. Abrignani, M. Pagani, B. Bodega (Italy)
17.30 ROOM PIETRO D'ABANO19.00 WORKSHOP 5 NEUROIMMUNOLOGY Chairpersons: R. Furlan (Italy), A. Uccelli (Italy)
W5.1 InvariantnaturalkillerTcellsinsecondaryprogressivemultiplesclerosispatientsdisplaypro-inflammatoryprofiles E. Bianchini, S. De Biasi, A.M. Simone, M. Nasi, D. Ferraro, F. Vitetta, L. Gibellini, M. Pinti, C. Del Giovane, P. Sola, A. Cossarizza (Italy)
W5.2 CCRL2 regulates M1/M2 polarization during EAE recovery phase A. Del Prete, C. Mazzon, L. Zanotti, L. Wang, E. Fontana, V. Salvi, P.L. Poliani, S. Sozzani (Italy)
W5.3 Estrogenreceptor-α (ERα) expression in human lymphocytes of multiple sclerosis patients before and after pregnancy M. Lo Pizzo, G. Di Liberto, D. Di Liberto, P. Ragonese, S. Realmuto, G. Salemi, F. Dieli (Italy)
W5.4 CD8+Tcellreactivityagainstapoptoticself-epitopesinmultiplesclerosis I. Cammarata, C. Martire, A. Citro, M. Albanese, C. Buscarinu, M. Salvetti, D. Centonze, V. Barnaba (Italy)
W5.5 Selectiverecognitionofviralandself-antigensbyTh1-andTh1/17-cellsinmultiplesclerosisrevealsdistinctrolesinCNSimmune-surveillanceandrelapses M. Paroni, V. Maltese, M. De Simone, V. Ranzani, P. Larghi, C. Fenoglio, A. Pietroboni, M. De Riz, D. Galimberti, M. Pagani, E. Scarpini, S. Abrignani, J. Geginat (Italy)
THURSDAY 26 MAY 2016
7
National Congress of the Italian Society of Immunology, Clinical Immunology and AllergologyAbano Terme (Padova) 25-28 May 2016
11.30 ROOM ASTROLABIO13.00 WORKSHOP 3 AUTOIMMUNITY AND TOLERANCE Chairpersons: V. Barnaba (Italy), C. Pucillo (Italy)
W3.1 TheroleofIL-1:fromautoimmunitytoauto-inflammation P. Sfriso (Italy)
W3.2 ImmunologicaltolerancemechanismscontrollinghumanautoreactiveCD8+Tcellsinhealthyandautoimmune conditions C. Martire, I. Cammarata, A. Citro, G. Peruzzi, F. Guerrieri, R. Scrivo, G. Valesini, V. Barnaba (Italy)
W3.3 Decreased function of Fas and variations of the perforin gene in adult patients with primary immune thrombocytopenia E. Boggio, C.L. Gigliotti, N. Clemente, G. Gaidano, A. Chiocchetti, R. Fanin, U. Dianzani, F. Zaja (Italy)
W3.4 Inflammatorymicroenvironmentinhibitstype-1regulatorycellsimmunomodulatorypropertiesinIntestinalbowel disease P. Larghi, S. Alfen, F. Facciotti, N. Gagliani*, M. Paroni, C. Ciafardini, S. Maglie, M. Moro, M.C. Crosti, D. Conte, F. Caprioli, S. Abrignani, R.F. Flavell*, J. Geginat (Italy, *USA)
17.30 ROOM ASTROLABIO19.00 WORKSHOP 6 ONCO-HEMATOLOGY 1 Chairpersons: I. Airoldi (Italy), G. Semenzato (Italy)
W6.1 IMiDs:immunostimulationandcytotoxicityinfirstlineandrelapsedmultiplemyeloma R. Zambello (Italy)
W6.2 Autophagy,assurvivalmachinery,isrelatedtobortezomib-resistanceinbonemarrowfibroblastsfrommultiple myeloma patients V. Desantis, L. Di Marzo, D. Vergara, K. De Veirman*, E. Menu*, M. Maffia, K. Vanderkerken*, A. Vacca, M.A. Frassanito (Italy, *Belgium)
W6.3 Reducedp66Shcexpressioninchroniclymphocyticleukemia(CLL)BcellsenhancesCXCR4/CCR7recyclingand impairs S1P1 expression promoting their lymph node accumulation L. Patrussi, N. Capitani, V. Martini, V. Trimarco, F. Frezzato, M. Pizzi, F. Marino, G. Semenzato, L. Trentin, C.T. Baldari (Italy)
W6.4 Identificationofgranulocyticmyeloid-derivedsuppressorcells(G-MDSCs)intheperipheralbloodofHodgkinandnon-Hodgkinlymphomapatients O. Marini, C. Spina, E. Mimiola, A. Cassaro, G. Malerba, G. Todeschini, O. Perbellini, M.T. Scupoli, G. Carli, D. Facchinelli, M.A. Cassatella, P. Scapini, C. Tecchio (Italy)
W6.5 Geneticcharacterizationofimmunoglobulineheavyvariable,diversityandjoininggenesin471patientswithchroniclymphocyticleukemia A. Visentin, M. Facco, E. Pagnin, V. Martini, F. Frezzato, V. Trimarco, F. Severin, S. Teolato, S. Imbergamo, F. Raggi, L. Martinello, E. Scomazzon, G. Semenzato, L. Trentin (Italy)
W6.6 Expressionofthep66ShcproteinadaptorisregulatedbytheactivatoroftranscriptionSTAT4innormalandCLL B cells F. Cattaneo, L. Patrussi, N. Capitani, L. Trentin, G. Semenzato, C.T. Baldari (Italy)
FRIDAY 27 MAY 2016
8
National Congress of the Italian Society of Immunology, Clinical Immunology and AllergologyAbano Terme (Padova) 25-28 May 2016
8.30 AUDITORIUM10.30 PLENARY SYMPOSIUM 4 TISSUE AND MUCOSAL IMMUNOLOGY Chairperson: A. Cavani (Italy)
PS4.1 NewinsightsintothefunctionofIGD:aroleinallergenprotection? A. Cerutti (Spain)
PS4.2 The gut vascular barrier: a new anatomical structure M. Rescigno (Italy)
PS4.3 Reinstalling immunoregulatory tryptophan catabolism in autoimmune diabetes U. Grohmann (Italy)
PS4.4 DeterminantsofhepaticeffectorCD8+Tcelldynamics L. Guidotti (Italy)
PS4.5 Differentialcytokinesandphenotypeprofilesinintestinalmucosabetweenpediatricpatientswithovertorpotential celiac disease S. Vitale, V. Santarlasci, S. Picascia, R. Auricchio, F. Liotta, L. Cosmi, F. Annunziato, R. Troncone, C. Gianfrani (Italy)
10.30 BREAK & POSTER VIEWING11.30
11.30 AUDITORIUM13.00 WORKSHOP 7 TUMOR IMMUNOLOGY 1 Chairpersons: P. Allavena (Italy), M. Cippitelli (Italy)
W7.1 Neutrophils are protective in cancerogenesis by altering tumor microenvironment and controlling intestinal microbiota A. Ponzetta, M.R. Galdiero, M. Barbagallo, M. Molgora, E. Magrini, E. Bonavita, C. Garlanda, A. Mantovani, S. Jaillon (Italy)
W7.2 Transcriptionallandscapeofhumantissuelymphocytesunveilsuniquenessoftumor-infiltratingTregulatory cells M. De Simone, A. Arrigoni, G. Rossetti, P. Gruarin, V. Ranzani, C. Politano, R.J.P. Bonnal, I. Panzeri, V. Vaira, S. Bosari, A. Palleschi, L. Santambrogio, G. Bovo, N. Zucchini, M. Totis, L. Gianotti, J. Geginat, S. Abrignani, M. Pagani (Italy)
W7.3 InvolvementofiNKTcellsinthecontrolandprognosisofchroniclymphocyticleukemia F. Gorini, L. Azzimonti, L. Scarfò, M. Ponzoni, C. Tripodo, A. Gulino, F. Caligaris Cappio, P. Ghia, M. Bellone, P. Dellabona, G. Casorati, C. de Lalla (Italy)
W7.4 EarlytriggeringofnaturalkilleranddendriticcellduringtheantitumortherapeuticresponseinducedbyTNFa tumor vessel delivery and melphalan E. Balza, S. Zanellato, A. Poggi, D. Reverberi, A. Rubertelli, L. Mortara (Italy)
W7.5 Residualtumormicro-fociandoverwhelmingregulatoryTlymphocyteinfiltrationarethecausesofbladdercancer recurrence G. Filaci, D. Fenoglio, A. Parodi, F. Kalli, F. Ferrera, G. Nasi, M. Curto, G. Conteduca, S. Tardito, C. Bernardi, P. Traverso, L. Mastracci (Italy)
FRIDAY 27 MAY 2016
9
National Congress of the Italian Society of Immunology, Clinical Immunology and AllergologyAbano Terme (Padova) 25-28 May 2016
13.00 LUNCH SYMPOSIA/MEET THE EXPERT & POSTER VIEWING14.30
14.30 AUDITORIUM16.30 PLENARY SYMPOSIUM 5 - SIICA-NIBIT JOINT SYMPOSIUM TUMOR IMMUNOLOGY Chairpersons: P.F. Conte (Italy), V. Russo (Italy)
PS5.1 RedirectingandimprovingCytokine-InducedKiller(CIK)cellactivityagainstsolidtumor A. Rosato (Italy)
PS5.2 Reprogramming of myeloid cells in cancer therapy A. Sica (Italy)
PS5.3 Microbiome and multiple myeloma progression M. Bellone (Italy)
PS5.4 Epigeneticreprogrammingofcancercellstoimprovetheefficacyofimmunotherapy M. Maio (Italy)
PS5.5 Hematopoieticexpressionoftheatypicalchemokinereceptor2inhibitstherecruitmentofanti-metastaticneutrophils M. Massara, O. Bonavita, B. Savino, N. Caronni, C. Recordati, M. Sironi, A. Mantovani, M. Locati, R. Bonecchi (Italy)
16.30 BREAK & POSTER VIEWING17.30
17.30 AUDITORIUM19.00 WORKSHOP 10 TUMOR IMMUNOLOGY 2 Chairpersons: V. Bronte (Italy), P. Dellabona (Italy)
W10.1 ImmunometaboliccheckpointsofTregperformanceincancer I. Pacella, C. Focaccetti, E. Timperi, V. Barnaba, S. Piconese (Italy)
W10.2 C1qasapotentialnewtherapeuticaltargetinmalignantpleuralmesothelioma C. Agostinis, R. Vidergar, M. Confalonieri, P. Geri, U. Kishore*, R. Bulla (Italy, *United Kingdom)
W10.3 Naturalkillercellscontrolthebreastcancerandrelatedcancerstemcellshematologicalspreading R. Tallerico, L. Conti, S. Lanzardo, R. Sottile*, C. Garofalo, A.K. Wagner*, M.H. Johansson*, C.M. Cristiani, K. Kärre*, E. Carbone, F. Cavallo (Italy, *Sweden)
W10.4 Phenotypicandfunctionaladaptationoftumorinfiltratinglymphocytesinnon-smallcelllungcancer E. Timperi, C. Focacetti, A. Grimaldi, D. Gallerano, F. Facciolo, M. Panetta, P. Nisticò, V. Barnaba (Italy)
microenvironment T. Gulic, I. Laface, A. Inforzato, M. Sironi, R. Leone, C. Lage Crespo, F. Grizzi, B. Bottazzi, P. Allavena, D. Rukavina* (Italy, *Croatia)
FRIDAY 27 MAY 2016
10
National Congress of the Italian Society of Immunology, Clinical Immunology and AllergologyAbano Terme (Padova) 25-28 May 2016
19.00 AUDITORIUM20.00 KEYNOTE LECTURE 1 Chairperson: A. Vacca (Italy)
KL1 Imaging immunity: creating a spatiotemporal understanding of host defense R. Germain (USA)
11.30 ROOM PIETRO D'ABANO13.00 WORKSHOP 8 MUCOSAL IMMUNITY Chairpersons: C. Gianfrani (Italy), F. Granucci (Italy)
W8.1 Non-IPEXautoimmuneenteropathyisassociatedwithuncontrolledIL-17productionbyintraepitheliallymphocytes M. Paroni, A. Magarotto, S. Tartari, G. Nizzoli, P. Larghi, U. Gianelli, M. Pagani, L. Elli, S. Abrigani, D. Conte, F. Caprioli, J. Geginat (Italy)
W8.2 PrimaryandchronicHIVinfectiondifferentlymodulatesmucosalVdelta1andVdelta2T-cellsdifferentiationprofileandeffectorfunctions E. Cimini, C. Agrati, G. D’Offizi, C. Vlassi, R. Casetti, A. Sacchi, R. Lionetti, V. Bordoni, N. Tumino, P. Scognamiglio, F. Martini (Italy)
W8.3 Cooperativeeffectsofbacterialbioproductsandfungionmastcellactivation M. De Zuani, B. Frossi, T. Zelante, A. Arzese, G. Paolicelli, V. Oikonomou, L. Romani, C. Pucillo (Italy)
W8.4 slan/M-DC8+cellsconstituteadistinctsubsetofdendriticcellsinhumantonsils A. Micheletti, G. Finotti, F. Calzetti, W. Vermi, M.A. Cassatella (Italy)
17.30 ROOM PIETRO D'ABANO19.00 WORKSHOP 11 IMMUNOREGULATION Chairpersons: A. Amadori (Italy), S. Mandruzzato (Italy)
W11.1 Unexpectedrelationshipbetweenferritinheavychainandeukaryoticcellsimmunogenicity R. Sottile, F. Trecroci*, M.C. Faniello*, B. Quaresima*, R. Tallerico*, C. Garofalo*, A. Anichini*, G. Cuda*, A. Cozzi*, S. Levi*, K. Kärre, F.S. Costanzo*, E. Carbone* (Sweden, *Italy)
W11.2 IL-10producedbyhumanCD1c+DCshapesCD8+T-cellprimingandpromoteshomeostaticproliferationofCD8+memoryT-cells G. Nizzoli, P. Larghi, M. Paroni, R. De Francesco, M. Pagani, S. Abrignani, J. Geginat (Italy)
W11.3 ISG15 protects regulatory T cells from IFNα-inducedcelldeath S. Piconese, I. Pacella, M. Severa, F. Rizzo, E.M. Coccia, V. Barnaba (Italy)
W11.4 Clinical response and analysis of regulatory T cells/t helper 17 cell ratio in patients with active systemic
Lupus erythematosus on treatment with belimumab V. Desantis, A. Venturelli, L. Di Marzo, V. Racanelli, M. Prete, F. Dammacco, A. Vacca, M.A. Frassanito (Italy)
W11.5 Arginase1presidesoverimmunoregulatorysignalingmediatedbyindoleamine2,3-dioxygenase1indendritic cells G. Mondanelli, M.T. Pallotta, A. Iacono, S. Ugel, V. Bronte, C. Volpi, U. Grohmann (Italy)
FRIDAY 27 MAY 2016
11
National Congress of the Italian Society of Immunology, Clinical Immunology and AllergologyAbano Terme (Padova) 25-28 May 2016
11.30 ROOM ASTROLABIO13.00 WORKSHOP 9 ADAPTIVE IMMUNITY Chairpersons: F. Dieli (Italy), S. Piconese (Italy)
W9.1 IdentificationofhumanfollicularhelperTcellsspecificmiRNAskeytodifferentiationandfunction M. Lorenzo, A. Ripamonti, E. Provasi, M. De Simone, G. Rossetti, S. Curti, V. Ranzani, A. Arrigoni, R.J.P. Bonnal, S. Torretta, L. Pignataro, M. Pagani, S. Abrignani (Italy)
W9.2 Pro-resolvinglipidmediatorsD-seriesresolvinsandmaresin1arecriticalinmodulatingTcellresponses:anovelroleforregulationofcell-mediatedadaptiveimmunity V. Chiurchiu, A. Leuti, J. Dalli*, M. Maccarrone, C. Serhan* (Italy, *USA)
W9.3 Bcellsincancerimmunology:theeffectsofintestinalcanceronsetonIL-10-producingBcells F. Mion, S. Vetrano, S. Tonon, A. Burocchi, A. Piontini, L. Petti, M. Colombo, C.E. Pucillo (Italy)
W9.4 CharacterizationofCD8andCD4T-cellsresponsetotheQuantiFERON-TB-Plusantigens E. Petruccioli, T. Chiacchio, I. Pepponi, V. Vanini, G. Gualano, G. Cuzzi, D. Cirillo, F. Palmieri, D. Goletti (Italy)
W9.5 Antigen B multiepitope peptides for the diagnosis of Cystic echinococcosis L. Petrone, V. Vanini, M. Amicosante, A. Corpolongo, E. Busi Rizzi, A. Ludovisi, G. Ippolito, E. Pozio, A. Teggi, D. Goletti (Italy)
17.30 ROOM ASTROLABIO19.00 WORKSHOP 12 ONCO-HEMATOLOGY 2 Chairpersons: V. Pistoia (Italy), L. Trentin (Italy)
W12.1 Thetranscriptionalco-repressorSin3AcontributestotheoncogenicpotentialofSTAT3inALK+ALCL G. Gambi, L. Icardi, V. Basso, M. Ponzoni, A. Mondino (Italy)
W12.2 Cortactin:acheckpointmoleculeformigrationandinvasioninchroniclymphocyticleukemicBcells V. Martini, C. Gattazzo, F. Frezzato, V. Trimarco, G. Chiodin, F. Severin, F. Raggi, L. Martinello, M. Pizzi, A. Visentin, E. Scomazzon, F. Marino, M. Facco, G. Semenzato, L. Trentin (Italy)
W12.3 NOTCH1inhibitionregulatesevolutionaryconservedmiRNAsinT-celllymphoblasticleukemia V. Saccomani, E. Piovan, A. Grassi, J. Yu*, F. Bordin, S. Minuzzo, V. Tosello, P. Zanovello (Italy, *USA)
W12.4 Inhibitionofjanuskinases2/signaltransducersandactivatorsoftranscription3pathwayleadstoapopto-sisinchroniclymphocyticleukemiacells F. Severin, F. Frezzato, V. Martini, V. Trimarco, F. Raggi, L. Martinello, A. Visentin, E. Scomazzon, G. Chiodin, M. Facco, G. Semenzato, L. Trentin (Italy)
W12.5 Prevalenceandriskfactorsofautoimmunediseasesinpatientswithchroniclymphocyticleukemia A. Visentin, S. Imbergamo, F. Frezzato, C. Gurrieri, V. Martini, V. Trimarco, F. Severin, E. Scomazzon, F. Raggi, L. Martinello, M. Facco, G. Semenzato, L. Trentin (Italy)
SATURDAY 28 MAY 2016
12
National Congress of the Italian Society of Immunology, Clinical Immunology and AllergologyAbano Terme (Padova) 25-28 May 2016
PS6.3 Differentiationofhumangroup3innatelymphoidcells E. Montaldo (Italy)
PS6.4 Regulationofinnatelymphoidcells M. Colonna (USA)
PS6.5 IFNαenhancestheproductionofIL-6byhumanneutrophilsactivatedviaTLR8 M. Zimmermann, F. Arruda-Silva, C. Lunardi, M.A. Cassatella, N. Tamassia (Italy)
10.30 BREAK & POSTER VIEWING11.30
11.30 AUDITORIUM13.00 WORKSHOP 13 VACCINE AND IMMUNOTHERAPY Chairpersons: F. Cavallo (Italy), P. De Berardinis (Italy)
W13.1 IdentificationofaHLA-A*0201-restrictedimmunogenicepitopefromtheuniversaltumorantigenDEPDC1 A. Tosi, R. Sommaggio, E. Cappuzzello, P. Zanovello, A. Rosato (Italy)
W13.2 Microvescileasnovelimmunogenformulationforanti-tumorvaccines:impactonantigencross-processingand presentation in dendritic cells F. Battisti, I.G. Zizzari, C. Napoletano, H. Rahimi Koshkaki, M. Nuti, A. Rughetti (Italy)
W13.3 Man’sbestfriend:areal-lifemodelfortestinggeneticcancervaccines J. Impellizeri, S. Bandini*, L. Luberto*, A. Gavazza*, G. Lubas*, E. Greissworth, D. Jemiolo, G. Ciliberto*, L. Aurisicchio* (USA, *Italy)
W13.4 Mouse breast tumor growth and metastasis inhibition via immunotargeting of the cancer stem cell antigen xCT S. Lanzardo, L. Conti, R. Rooke*, R. Ruiu, G. Donofrio, F. Pericle**, E. Bolli, V. Rolih, A. Laroche, I. Merighi, R. Calogero, F. Cavallo (Italy, *France, **USA)
W13.5 NoveladjuvantAlum-TLR7agreatlypotentiatesimmuneresponsetoglyconjugatevaccines C. Buonsanti, C. Balocchi, C. Harfouche, F. Corrente, L. Galli Stampino, F. Mancini, P. Malyala*, S. Bufali, B. Baudner, E. De Gregorio, N. Valiante*, D. O’Hagan*, R. Rappuoli, U. D’Oro (Italy, *USA)
SATURDAY 28 MAY 2016
13
National Congress of the Italian Society of Immunology, Clinical Immunology and AllergologyAbano Terme (Padova) 25-28 May 2016
13.00 AUDITORIUM14.00 KEYNOTE LECTURE 2 Chairperson: A. Santoni (Italy)
KL2 Memory-likeNKcellsgeneratedduringviralinfection A. Moretta (Italy)
11.30 ROOM PIETRO D'ABANO13.00 WORKSHOP 14 - SIICA-SIAAIC JOINT WORKSHOP ALLERGIC INFLAMMATION Chairpersons: R. Paolini (Italy), M. Triggiani (Italy)
W14.1 MolecularmechanismsregulatingFcepsilonRIendocytictraffickinginmastcells R. Paolini (Italy)
W14.2 Proinflammatoryandvasoactivemediatorsinchronicurticaria M. Triggiani (Italy)
W14.3 Characterization of mast cell derived exosomes: role of FcεRI-IgEcomplexes R. Molfetta, L. Quatrini, M. Lecce, B. Zitti, A. Zingoni, L. Masuelli, L. Simonelli, G. Caracciolo, S. Palchetti, A. Santoni, R. Paolini (Italy)
W14.4 ModulatingallergicresponsebyunlockingthestructureofthemajorParietariaallergens D. Di Blasi, A. Bonura, F. Gervasi, C. Uasuf, M.R. Melis, P. Colombo, M.A. Ragusa (Italy)
W14.5 DendriticcellsdifferentiationismodulatedbythenematodeparasiteAnisakispegreffii C. Napoletano, S. Mattiucci, A. Colantoni, M. Nuti, A. Rughetti (Italy)
11.30 ROOM ASTROLABIO13.00 WORKSHOP 15 CELL SIGNALLING Chairpersons: A. Leonardi (Italy), G. Natoli (Italy)
W15.1 MusculinisexpressedbyhumanTh17cellsanddown-regulatestheirresponsetoIL-2byinhibitingSTAT5serine 193 phosphorylation V. Santarlasci, A. Mazzoni, M. Capone, M.C. Rossi, L. Maggi, G. Montaini, R. De Palma, F. Liotta, L. Cosmi, F. Annunziato (Italy)
W15.2 RoleofIP3R3inCD14-NFATpathwayactivation L. Marongiu, M. Di Gioia, V. Poli, L. Sironi, M. Collini, I. Zanoni, F. Granucci (Italy)
W15.3 Phosphatidylinositol4-phosphate5-kinase αisacriticalregulatorofCD28signalingfunctions N. Porciello, M. Kunkl, M. Muscolini, C. Camperio, S. Caristi, C. Capuano, A. Viola, R. Galandrini, L. Tuosto (Italy)
W15.4 Acomparisonbetweenasecondandthird-generationchimericantigenreceptorrevealsapotentialdetrimental effect of hyperstimulation G. Zuccolotto (Italy)
W15.5 Insightsintointerleukin-10-activatedSTAT3transcriptionalfunctionviagenome-widechromatinoccupancyand gene expression analysis M. Castellucci, B. Mariotti, M. Mokry*, M. Rossato*, T. Radstake*, F. Bianchetto, N. Tamassia, M. Cassatella, F. Bazzoni (Italy, *The Netherlands)
POSTER SESSIONS
14
National Congress of the Italian Society of Immunology, Clinical Immunology and AllergologyAbano Terme (Padova) 25-28 May 2016
POSTER AREA POSTER SESSION I - THURSDAY 26 MAY
P1 - INNATE IMMUNITY
P1.1 Differentialbiologicalactivitiesofswineinterferon-alphasubtypes C. Zanotti, E. Razzuoli, H. Crooke*, O. Soule*, G. Pezzoni, M. Ferraris, A. Ferrari, M. Amadori (Italy, *United Kingdom)
P1.2 Roleofneutrophilsinanimiquimod-inducedmousemodelofpsoriasis D. Bevilacqua, S. Costa, M.A. Cassatella, G. Girolomoni, P. Scapini (Italy)
P1.3 Molecularmechanismsregulatingvincristine-mediatedNKG2D(ULBP-1andMICA)andDNAM-1(PVR)ligandinductionon multiple myeloma cells C. Borrelli, B. Ricci, A. Zingoni, R. Molfetta, C. Fionda, R. Paolini, M. Cippitelli, M.P. Abruzzese, M.R. Ricciardi, M.T. Petrucci, A. Soriani, A. Santoni (Italy)
P1.4 TLR4 activation elicits a functionally discrete subset of TSLPR+ human monocytes F. Borriello, R. Iannone, V. Vastolo, G. Petrosino, S. Di Somma, F. Visconte, M. Raia, G. Scalia, S. Loffredo, F. Granata, L. Del Vecchio, G. Portella, G. Marone (Italy)
P1.5 Pro-lymphangiogenicpropertiesofIFN-g-activateddendriticcells D. Bosisio, V. Gagliostro, P. Seeger, V. Salvi, E. Garrafa, R. Bresciani, S. Sozzani (Italy)
P1.6 Ratioofmonocytestolymphocytesinperipheralbloodofpatientswithtuberculosis:anoldbiomarkerrevisited N. Caccamo, M.P. La Manna, V. Orlando, T. Prezzemolo, F. Dieli, G. Cuzzi, D. Goletti (Italy)
P1.7 NK cells and human cytomegalovirus: role of viral immediate early proteins and of the DNA damage response pathway intheexpressionofligandsoftheNKG2DandDNAM-1activatingreceptors B. Pignoloni, C. Fionda, V. Dell’Oste, A. Luganini, M. Cippitelli, A. Zingoni, S. Landolfo, G. Gribaudo, A. Santoni, C. Cerboni (Italy)
P1.8 PersistentintrahepaticVgamma9Vdelta2T-cellsimpairmentinchronicHCV-infectedpatients E. Cimini, V. Bordoni, U. Visco-Comandini, M. Montalbano, R. Lionetti, A. Sacchi, R. Casetti, N. Tumino, G. D’Offizi, M.R. Capobianchi, F. Martini, C. Agrati (Italy)
P1.9 HepatitisBVirusaffectsdendriticcellactivationandtheircross-talkwithnaturalkillercells C. De Pasquale, S. Campana, C. Barberi, T. Pollicino, G. Ferlazzo (Italy)
P1.10 Predominanceoftype1innatelymphoidcellsintherectalmucosaofpatientswithnon-celiacwheatsensitivity:reversalafterawheat-freediet D. Di Liberto, P. Mansueto, A. D’Alcamo, M. Lo Pizzo, E. Lo Presti, G. Geraci, F. Fayer, G. Guggino, G. Iacono, F. Dieli, A. Carroccio (Italy)
P1.11 Anautocrinesurvivalloopmediatedbystemcellfactor/c-kitinmousedendriticcells A. Barroeta Seijas, S. Simonetti, D. Runci, S. Vitale, A. Quinci, A. Soriani, M. Criscuoli, I. Filippi, A. Naldini, A. Santoni, F. Di Rosa (Italy)
P1.12 Endogenously produced TNFαcontributestotheexpressionofCXCL10inIFNλ3-activatedplasmacytoiddendriticcells G. Finotti, N. Tamassia, F. Calzetti, M.A. Cassatella (Italy)
P1.13 MicroRNAprofilinginhumanneutrophilsduringactivation S. Ghasemi, B. Mariotti, N. Tamassia, F. Bianchetto, M.A. Cassatella, F. Bazzoni (Italy)
P1.14 GammadeltaTcellsareexpandedinperipheralbloodandsynovialfluidofPsApatientsandareactivatedthroughIL9Rand IL23R transduction signalling G. Guggino, F. Ciccia, D. Di Liberto, M. Lo Pizzo, P. Ruscitti, P. Cipriani, J.J. Fournie*, R. Giacomelli, F. Dieli, G. Triolo (Italy, *France)
P1.15 ExpressionofCD206oncirculatingmonocytescorrelateswithactivetuberculosis M.P. La Manna, B. Tamburini, V. Orlando, N. Caccamo, F. Dieli (Italy)
POSTER SESSIONS
15
National Congress of the Italian Society of Immunology, Clinical Immunology and AllergologyAbano Terme (Padova) 25-28 May 2016
P1.16 ActivationandselectiveIL-17responseofhumanVγ9Vδ2TlymphocytesbyTLR-activatedplasmacytoiddendriticcells E. Lo Presti, N. Caccamo, V. Orlando, F. Dieli, S. Meraviglia (Italy)
P1.17 Human circulating group 2 innate lymphoid cells can express CD154 and promote IgE production L. Maggi, G. Montaini, A. Mazzoni, M. Capone, M.C. Rossi, V. Santarlasci, F. Liotta, O. Rossi, E. Maggi, L. Cosmi, F. Annunziato (Italy)
P1.18 ConservedresponsetoIL-12/IL-15andnaturalcytotoxicityreceptorInducibilityofNKcellsareahallmarkofefficientcontrol of circulating HIV DNA reservoir in HIV infected patients F. Marras, F. Bozzano, A. Di Biagio, L. Nicolini, L. Tarmasso, C. Dentone, E. Pontali, G. Orofino, M. Setti, L. Moretta, C. Orlandi, A. Casabianca, M. Magnani, A. De Maria (Italy)
P1.19 NCR expression/inducibility on NK cells is associated to different levels of control of HIV infection in Virologically discordant non progressor (VDNP) and in HIV controller (HIC) patients F. Marras, F. Bozzano, A. Di Biagio, L. Nicolini, L. Tarmasso, M. Setti, C. Dentone, E. Pontali, G. Orofino, E. Mantia, L. Moretta, C. Orlandi, A. Casabianca, M. Magnani, A. De Maria (Italy)
P1.20 Humancirculatinggroup2innatelymphoidcellscanbeinducedtoproduceIFN-γbyIL-12 G. Montaini, L. Maggi, A. Mazzoni, M. Capone, M.C. Rossi, V. Santarlasci, E. Maggi, F. Liotta, L. Cosmi, F. Annunziato (Italy)
P1.21 PhenotypicandfunctionalcharacterizationofCD56lowCD16lowNKcellsubsetinbonemarrowandperipheralbloodofpediatricleukemicpatientsafterTcell-depletedhematopoieticstemcelltransplantation P. Nisti, H. Stabile, S. Morrone, D. Pagliara, A. Bertaina, F. Locatelli, A. Santoni, A. Gismondi (Italy)
P1.22 NKcellsimmunoprofilinginaHIVpositive,elitecontrollerpatient E. Palella, C. Torti, C. Garofalo, M. Mazzitelli, R. Tallerico, R. Sottile*, G.S. Barreca, L. Galati, A. Focà, E. Carbone (Italy, *Sweden)
P1.23 Assessingtheautophagicfluxinprimarycellsfrompatientswithtuberculosis I. Pepponi, E. Petruccioli, A. Romagnoli, G. Cuzzi, G.M. Fimia, D. Goletti (Italy)
P1.24 RoleoftheclassicalandlectincomplementpathwaysinthePTX3-mediatedimmuneresponsetoAspergillus fumigatus F. Petroni, R. Parente, M. Sironi, S. Valentino, B. Bottazzi, A. Mantovani, A. Inforzato (Italy)
P1.25 Hypoxiareprogramshumanmacrophagestowardsaproinflammatorydirection:roleofTREM-1 F. Raggi, S. Pelassa, D. Pierobon, M. Giovarelli, L. Varesio, M.C. Bosco (Italy)
P1.26 HIVinfectionofmonocytes-deriveddendriticcellsinhibitsVgamma9Vdelta2Tcellsfunctions A. Sacchi, A. Rinaldi, N. Tumino, R. Casetti, C. Agrati, F. Turchi, V. Bordoni, E. Cimini, F. Martini (Italy)
P1.27 Arylhydrocarbonreceptor:anoveltargetfortheanti-inflammatoryactivityofstatintherapy A. Turco, M. Pirro, M. Gargaro, G. Scalisi, F. Fallarino (Italy)
P1.28 AnalysisofBAFFandAPRILexpressioninmastcells:novelactorsintheB/MCcrosstalk A.A. Ceccaroni, F. Mion, I. Catacchio, V. Valeri, F. D’Incà, E. Betto, A. Tardivel*, P. Schneider*, A. Vacca, C.E.M. Pucillo (Italy, *Switzerland)
P2- ADAPTIVE IMMUNITY
P2.1 Presentationofbacterialandviralantigensbyantigen-presentingTcells:characterizationofT-APCscells V. Boccasavia, B. Alarcón (Spain)
P2.2 Characterization of the immunomodulatory activities of an Ascidian derived peptide in human PBMC A. Bonura, A. Vizzini, A. Longo, S. Vlah, F. Gervasi, M.R. Melis, P. Colombo (Italy)
P2.3 DifferentmodulationofpolyfunctionalCD8TcellresponsebycARTinprimaryandchronicHIVinfection R. Casetti, G. De Simone, C. Pinnetti, F. Besi, A. Sacchi, I. Abbate, G. Rozera, P. Pierro, C. Agrati, E. Cimini, V. Bordoni, N. Tumino, D. Viola, M.R. Capobianchi, A. Antinori, F. Martini, A. Ammassari (Italy)
P2.4 Chitinase3-Like-1isproducedbyhumanTh17cells A. Mazzoni, L. Maggi, V. Santarlasci, M. Capone, M.C. Rossi, G. Montaini, R. Cimaz, R. De Palma, E. Maggi,
POSTER SESSIONS
16
National Congress of the Italian Society of Immunology, Clinical Immunology and AllergologyAbano Terme (Padova) 25-28 May 2016
S. Romagnani, F. Liotta, L. Cosmi, F. Annunziato (Italy)
P2.5 Th1-inducedCD106expressionmediatesleukocytesadhesiononsynovialfibroblastsfromjuvenileidiopathicarthritispatients M.C. Rossi, L. Maggi, F. Margheri, C. Luciani, M. Capone, V. Santarlasci, A. Mazzoni, G. Montaini, R. Cimaz, F. Liotta, E. Maggi, L. Cosmi, M. Del Rosso, F. Annunziato (Italy)
P3 - IMMUNIDEFICIENCY
P3.1 Th1andTh17pro-inflammatoryprofilescharacterizeinvariantNKTcellsinvirologicallysuppressedHIV+patientswithlowCD4/CD8ratio E. Bianchini, S. De Biasi, M. Nasi, M. Digaetano, L. Gibellini, V. Borghi, M. Pinti, C. Mussini, A. Cossarizza (Italy)
P3.2 CD34+hematopoieticprogenitorcellsfromHIV-infectedpatientsshowanimpairedTcelldifferentiationinvitro,relatedtoautocrinepro-inflammatorycytokinesreleaseandTLR8triggering V. Bordoni, M. Bibas, D. Viola, A. Sacchi, C. Agrati, N. Tumino, E. Cimini, R. Casetti, A. Amendola, A. Ammassari, F. Martini (Italy)
P3.3 ImpactofARTonCD4+andCD8+T-cell-specificresponsetocommoncopathogensinHIV-TBcoinfectedsubjects T. Chiacchio, E. Petruccioli, V. Vanini, G. Cuzzi, C. Pinnetti, A. Sampaolesi, A. Antinori, F. Palmieri, E. Girardi, D. Goletti (Italy)
P3.4 CD4+naïveTcellsfromHIVpatientswithsuppressedviremiacontainlessproviralDNAandmoresjTREC+cellscompared to central or effector memory lymphocytes M. Nasi, S. De Biasi, E. Bianchini, M. Digaetano, S. Pecorini, M. Pinti, L. Gibellini, V. Borghi, C. Mussini, A. Cossarizza (Italy)
P3.5 Self-administeredhyaluronidasefacilitatedsubcutaneousimmunoglobulintherapyinsevereprimaryantibodydeficiencies F. Pulvirenti, M.G. Danieli, R. Morariu, V. Rocchi, C. Milito, I. Quinti (Italy)
P4 - IMMUNOREGULATION
P4.1 Bone-marrow-residentCD34+DNAM-1brightCXCR4+committedlymphoidprecursorsduringchronicinfectionandinflammationsupportsinnateandadaptiveimmuneresponses F. Bozzano, F. Marras, M.L. Ascierto*, C. Cantoni, G. Cenderello, C. Dentone, A. Di Biagio, G. Orofino, E. Mantia, S. Boni, P. De Leo, A. Picciotto, F. Braido, F. Antonini, E. Wang*, F. Marincola*, L. Moretta, A. De Maria (Italy, *USA,**Qatar)
P4.2 Casereport:effectivetreatmentofhypeRIgDsyndromewiththeinhibitionoftheenzymeHMG-CoAreductase E. Cillari, M.S. Leto Barone, F. Arcoleo, M. Lo Pizzo (Italy)
P4.3 Diet-relatedinflammationandimmunedysfunctioninobesity:potentialriskfactorsforcolorectalcancer G. Donninelli, M. D’Archivio, L. Conti, M. Del Cornò, B. Scazzocchio, R. Varì, B. Varano, S. Giammarioli, M. Pierdominici, R. Masella, S. Gessani (Italy)
P4.4 IL-27mediatestheexpressionofIDOandPD-L1inhumantumorcellsthroughSTAT1/3signaling G. Carbotti, G. Barisione, I. Airoldi, D. Mezzanzanica, A. Petretto, M. Fabbi, S. Ferrini (Italy)
P4.5 ICOS-ligandtriggeringimpairsosteoclastdifferentiationinvitroandinvivo C.L. Gigliotti, E. Boggio, N. Clemente, E. Toth, A. Chiocchetti, C. Dianzani, M. Bosetti, U. Dianzani (Italy)
P4.6 Theinvitroanti-inflammatoryandanti-toxiceffectsofnutraceuticals A. Giovazzino, A. Di Cerbo, G. Guidetti, V. Rubino, A.T. Palatucci, S. Centenaro, E. Fraccaroli, L. Cortese, G. Ruggiero, S. Canello, G. Terrazzano (Italy)
P4.7 A novel immunotherapy for heart failure M. Kallikourdis, E. Martini, P. Carullo, C. Sardi, C. Greco, G.G. Stirparo, G. Roselli, F. Riva, A. Ormbostad Berre*, T.O. Stølen*, G. Faggian, E. Di Pasquale, L. Elia, C. Rumio, D. Catalucci, R. Papait, G. Condorelli (Italy,*Norway)
POSTER SESSIONS
17
National Congress of the Italian Society of Immunology, Clinical Immunology and AllergologyAbano Terme (Padova) 25-28 May 2016
P4.8 HumanamnioticmesenchymaltissuecellsaffectbothM1andM2macrophagesinvitro M. Magatti, E. Vertua, S. De Munari, A. Silini, O. Parolini (Italy)
P4.9 Immunotherapies for cardiovascular diseases E. Martini, P. Carullo, C. Sardi, G. Roselli, G.G. Stirparo, F. Bonacina, D. Vignali, F. Riva, A.M. Ormbostad Berre*, T.O. Stølen*, G. Faggian, C. Rumio, E. Di Pasquale, G.D. Norata, L. Elia, R. Papait, D. Catalucci, G. Condorelli, M. Kallikourdis (Italy, *Norway)
P4.10 CD3+CD56+cells,anovelregulatorysubsetthatmodulatestheeffectorfunctionofhumanCD8+Tcells V. Rubino, M. Santopaolo, A. Giovazzino, A.T. Palatucci, C. La Rocca, E. Mozzillo, S. De Simone, A. Franzese, G. Matarese, G. Ruggiero, M. Galgani, G. Terrazzano (Italy)
P4.11 Myeloid derived suppressor cells increase during the early phases of primary HIV infection N. Tumino, F. Turchi, C. Pinnetti, R. Casetti, V. Bordoni, E. Cimini, C. Agrati, A. Antinori, A. Ammassari, F. Martini, A. Sacchi (Italy)
P4.12 InHIV-positivepatients,myeloid-derivedsuppressorcellsinduceT-cellanergybysuppressingCD3zetaexpressionthroughELF-1inhibition N. Tumino, F. Turchi, S. Meschi, E. Lalle, V. Bordoni, R. Casetti, C. Agrati, E. Cimini, C. Montesano, V. Colizzi, F. Martini, A. Sacchi (Italy)
P5 - NEUROIMMUNOLOGY
P5.1 Increasedadipokineslevelsinnormal-weightmultiplesclerosispatients M. Reale, E. Costantini, C. D’Angelo, L. Pasquali (Italy)
POSTER AREA POSTER SESSION II - FRIDAY 27 MAY - SATURDAY 28 MAY
P6 - AUTOIMMUNITY AND TOLERANCE
P6.1 Anti-tumournecrosisfactor-αdrugsdifferentlyaffecttumournecrosisfactor-α/solubletumournecrosisfactor-receptorsystem and monocyte subsets in patients with psoriasis E. Bianchini, L. Gibellini, S. De Biasi, R. Bartolomeo, A. Fabiano, M. Manfredini, F. Ferrari, G. Albertini, T. Trenti, G. Carnevale, M. Nasi, M. Pinti, G. Pellacani, A. Cossarizza (Italy)
P6.2 ClinicalphenotypemodificationaftertreatmentwithsofosbuvirintwopatientswithhepatitisCvirus-relatedmixedcryoglobulinemia: a monocentric experience R. Capecchi, G. Di Colo, F. Petrelli, P. Colombatto, M.R. Brunetto, P. Migliorini, A.G. Tavoni (Italy)
P6.3 SerumlevelsofCXCL13refinethepredictiveabilityofautoantibodiestoidentifyunstableremissioninearlyrheumatoidarthritis A. Manzo, S. Bugatti, B. Vitolo, F. Benaglio, R. Caporali, C. Montecucco (Italy)
P6.4 ShortglutenchallengewithwheatflourextensivehydrolyzedbyLactobacilli and Fungal proteases does not recall gliadinspecificT-cellsintheperipheralbloodofceliacdiseasepatients S. Picascia, R. Mandile, C. Parrella, L. Greco, M. Gobbetti, R. Auricchio, C. Gianfrani (Italy)
P6.5 TheancientwheatspeciesTriticum monococcum has a reduced in vivo immunotoxicity: implication for celiac disease prevention S. Picascia, A. Camarca, R. Auricchio, S. Vitale, R. Mandile, R. Troncone, S. Auricchio, G. Mamone, C. Gianfrani (Italy)
P6.6 ExpressionanalysisofHLAallelesassociatedtotype1diabetes L. Pisapia, A. Zimbardo, S. Picascia, P. Barba, M. Strazzullo, E. Mozzillo, A. Franzese, C. Gianfrani, G. Del Pozzo (Italy)
P6.7 TcellresponsetopeptidesoftheVregionofInfliximabisdetectableintreatedpatients S. Pratesi, F. Nencini, F. Zanieri, E. Maggi, A. Matucci, A. Vultaggio (Italy)
POSTER SESSIONS
18
National Congress of the Italian Society of Immunology, Clinical Immunology and AllergologyAbano Terme (Padova) 25-28 May 2016
P6.8 CirculatingTcellsubsetsincutaneouspsoriasis:correlationwithdiseaseseverityandsystemicinflammation F. Sgambelluri, M. Diani, A. Altomare, E. Frigerio, L. Drago, F. Granucci, G. Banfi, G. Altomare, E. Reali (Italy)
P6.9 InstallingFVIII-specifictoleranceInhemophiliaAviathearylhydrocarbonreceptoroperatedbytryptophanderivatives G. Scalisi, M. Gargaro, D. Matino, C. Santoro, M.G. Mazzucconi, P. Puccetti, A. Iorio, F. Fallarino (Italy)
P6.10 TheinterplaybetweenHLA-B*27andERAP1inankylosingspondylitis:afocusonprocessingandpresentationofunpredicted viral epitopes C. Vitulano, V. Tedeschi, F. Paladini, A. Cauli, A. Mathieu, R. Sorrentino, M.T. Fiorillo (Italy)
P7 - ONCO-HEMATOLOGY
P7.1 microRNAsprofileinbonemarrowfibroblastsfrompatientswithmultiplemyeloma L. Di Marzo, V. Desantis, I. Craparotta, L. Beltrame, S. Marchini, M. D’Incalci, A. Vacca, M.A. Frassanito (Italy)
P8 - TRANSPLANTATION
P8.1 5-azacytidineandrapamycin:differentandsynergisticeffectonexvivoexpansionofnaturalhumanTregulatorycells G. Conteduca, G. Ehx, M. Hannon, Y. Beguin, F. Baron (Belgium)
P9 - TUMOR IMMUNOLOGY
P9.1 Phenotypic and functional alterations in the T cell compartment of Diffuse Large B Cell Lymphoma (DLBCL) patients at diagnosis,andlong-termtherapy-inducemodifications S. Battella, M.C. Cox, R. La Scaleia, S. Pelliccia, A. Di Napoli, A. Porzia, F. Mainiero, L. Ruco, B. Monarca, A. Santoni, G. Palmieri (Italy)
P9.2 Lurbinectedinreducestumor-associatedmacrophagesandtheproductionofinflammatorycytokines,chemokinesandangiogenic factors in preclinical models C. Belgiovine, M. Liguori, E. Bello, R. Frapolli, C.M. Galmarini*, M. D’Incalci, P. Allavena (Italy,*Spain)
P9.3 HarnessingCD1c-restrictedTcellsfortheimmunotherapyofleukemia M. Consonni, C. Garavaglia, C. de Lalla, I. Boemi, M. Lepore*, G. De Libero*, L. Mori*, F. Ciceri, P. Dellabona, G. Casorati (Italy, *Switzerland)
P9.4 AnalysisofnaturalkillercellresponseinperipheralbloodofstageIIandIIImelanomapatients C.M. Cristiani, R. Tallerico, M. Capone, G. Madonna, D. Mallardo, C. Garofalo, E. Palella, E. Simeone, A.M. Grimaldi, G. Del Zotto, A. Moretta, P.A. Ascierto, E. Carbone (Italy)
P9.5 InvariantnaturalkillerTcellscontrolcancerprogressionbyrestrainingpro-angiogenictumorinfiltratingmacrophages F. Cortesi, G. Delfanti, A. Calcinotto, F. Gorini, F. Pucci*, M. Grioni, M. De Palma**, M. Bellone, G. Casorati, P. Dellabona (Italy, *USA, **Switzerland)
P9.6 Mastcell-derivedexosomespromotecoloncancercellproliferation F. D’Incà, F. Mion, B. Frossi, C. Pucillo (Italy)
P9.7 Highplasmalevelsofinterleukin-31andthymicstromallymphopoietinareassociatedwithclinicalcharacteristicofprognosticrelevanceinpatientswithclassicalHodgkin’slymphoma E. Ferretti, S. Hohaus, B. Belmonte, A. Di Napoli, E. Cupelli, E. Galli, A. Cuccaro, G. Fraternali-Orcioni, V. Pistoia, A. Corcione (Italy)
P9.8 Humanprimarycelllinesfromtumorandnon-tumortissueforthestudyofcolorectalcancerimmunity D. Gallerano, E. Timperi, C. Focaccetti, L. Sacco, F. Lancellotti, K. Fazzi, E. Manzi, M.G. Diodoro, S. Brozzetti, G.L. Grazi, P. Chirletti, V. Barnaba (Italy)
POSTER SESSIONS
19
National Congress of the Italian Society of Immunology, Clinical Immunology and AllergologyAbano Terme (Padova) 25-28 May 2016
P9.9 WakingupNKcellsrecognitionofhumantumorcellsbynanoparticlesassisteddeliveryofsmalldrugsreactivatingP53 C. Garofalo, E. Palella, R. Tallerico, C.M. Cristiani, R. Sottile*, G. Selivanova*, E. Carbone (Italy, *Sweden)
P9.10 Occurrenceandsignificanceoftumor-associatedneutrophilsinpatientswithcolorectalcancer M.R. Galdiero, P. Bianchi, F. Grizzi, G. Di Caro, G. Basso, A. Ponzetta, E. Bonavita, M. Barbagallo, S. Tartari, N. Polentarutti, A. Malesci, G. Marone, M. Roncalli, L. Laghi, C. Garlanda, A. Mantovani, S. Jaillon (Italy)
P9.11 CD8Tcellregulationbybonemarrowendothelialcellsinmultiplemyeloma P. Leone, A. Ferrucci, I. Catacchio, V. Racanelli, A. Vacca (Italy)
P9.12 Role of complement in murine cancer development and its translational relevance E. Magrini, S. Di Marco, E. Bonavita, S. Gentile, M.L. Barbagallo, A. Ponzetta, A. Mantovani, C. Garlanda (Italy)
P9.13 PVR expression in multiple myeloma cells is regulated by sumoylation R. Molfetta, B. Zitti, L. Quatrini, C. Fionda, H. Stabile, V. de Turris, M.R. Ricciardi, M.T. Petrucci, M. Cippitelli, A. Gismondi, A. Santoni, R. Paolini (Italy)
P9.14 Elevated expression of mTGFβ on Treg cells in men with early diagnosed prostatic cancer S. Occhipinti, E. Lombardi, A. Zitella, P. Gontero, M. Giovarelli (Italy)
P9.15 Myeloid-derivedsuppressorcell-activatedTcellinteraction:mechanismsunderlyingimmunosuppression L. Pinton, S. Solito, E. Masetto, M. Vettore, V. Damuzzo, S. Francescato, A. Pozzuoli, A. Berizzi, S. Mocellin, C.R. Rossi, P. Zanovello, V. Bronte, S. Mandruzzato (Italy)
P9.16 IL-17inhibitionimprovestheantigen-specificanti-tumorresponsesinducedbyDNAvaccinationinpancreaticcancer C. Roux, R. Curto, G. Mucciolo, G. Barutello, F. Novelli, P. Cappello (Italy)
P9.17 Comparativetranscriptomicsoftriplenegativebreastcancerstemcellsanddifferentiatedtumorcellsidentifiesteneurin-4asapotentialtargetforimmunotherapy R. Ruiu, M. Arigoni, F. Riccardo, L. Conti, S. Lanzardo, C. Musiu, R.A. Calogero, F. Cavallo (Italy)
P9.18 RegulatoryTcellsshowingphenotypical,epigeneticandfunctionalfeaturesofimmunesuppressionareenrichedinhuman colorectal cancer E. Timperi, I. Pacella, V. Schinzari, L. Sacco, F. Farelli, F. Longo, A. Ciardi, P. Chirletti, V. Barnaba, S. Piconese (Italy)
P9.19 Naturalkillercellsfrompatientswitheithermalignantorinflammatorypleuraleffusionsdisplaydecreasedcytotoxiccapacityanddecidual-likephenotype S. Zanellato, A. Musco, A. Bruno, B. Bassani, M. Cattoni, C. Sampietro, A. Imperatori, A. Albini, D.D.M. Noonan, L. Mortara (Italy)
P9.20 TheMICA-129dimorphismandsolubleMICAareassociatedwiththeprogressionofmultiplemyeloma A. Zingoni, F. Cecere, D. Fuerst*, T. Saribekyan*, I. Nardone, E. Vulpis, M.P. Abruzzese, M.T. Petrucci, E. Lisi, M.R. Ricciardi, A. Soriani, C. Fionda, M. Cippitelli, A. Santoni (Italy, *Germany)
P10 - ALLERGIC INFLAMMATION
P10.1 RoleofnuclearfactorofactivatedTcells(NFAT)pathwayactivationininnateimmunecellsinacutetransplantrejection C. Cigni, F. Mingozzi, R. Marzi, M. Colombo, D. Prosperi, I. Zanoni*, F. Granucci (Italy, USA)
P11 - VACCINES AND IMMUNOTHERAPY
P11.1 Maternal immunization delays tumor progression in offspring prone to neuroblastoma G. Barutello, C. Voena, F. Riccardo, L. Consolino, R. Chiarle, F. Cavallo (Italy)
P11.2 ImmunosuppressiveactivityofabataceptoncirculatingThelperlymphocytesfromjuvenileidiopathicarthritispatients M. Capone, L. Maggi, R. Cimaz, V. Santarlasci, M.C. Rossi, A. Mazzoni, G. Montaini, F. Liotta, E. Maggi, F. Annunziato, L. Cosmi (Italy)
P11.3 Enhancingcytokine-inducedkillercellactivitywithHer2-specificFc-engineeredantibodiesandantibodyderivatives E. Cappuzzello, C. Kellner*, A. Rosato, M. Peipp* (Italy, *Germany)
POSTER SESSIONS
20
National Congress of the Italian Society of Immunology, Clinical Immunology and AllergologyAbano Terme (Padova) 25-28 May 2016
P11.4 VaccinatingagainstHER2-positivebreastcancerwithanewnaturalpolymeractingasaTLRagonist D. Carpanese, I.M. Montagner, A. Dalla Pietà, G. Pasut, A. Mero, P. Zanovello, A. Rosato (Italy)
P11.5 Alum-TLR7enhancesexpansionofmemoryBcellcompartment T.M.H. Vo, S. Sammicheli, M. Tortoli, F. Corrente, M. Iannacone, U. D’Oro, D. Piccioli (Italy)
P11.6 NaturalpolymerX:anoveladjuvanttoexplorenewvaccinationstrategies I.M. Montagner, A. Dalla Pietà, D. Carpanese, G. Pasut, A. Mero, P. Zanovello, A. Rosato (Italy)
P11.7 “T cell interrogation system”: validation of immunogenic cell death and discovery of lung tumor antigens C. Focaccetti, A. Grimaldi, G. Peruzzi, G. Del Bene, S. Spada, F. Longo, P. Nisticò, V. Barnaba (Italy)
P11.8 Cytokineinducedkillercells(CIK)effectivelykillBRAFinhibitor-resistantmelanomacancerstemcells L. Gammaitoni, L. Giraudo, M. Macagno, V. Leuci, G. Mesiano, V. Coha, A. Zaccagna, A. Pisacane, S. Gallo, F. Carnevale-Schianca, M. Aglietta, D. Sangiolo (Italy)
P11.9 Chemotherapy enhances humoral and cellular responses against tumor associated antigens in pancreatic cancer G. Mandili, M. Principe, E. Mazza, S. Bulfamante, D. Giordano, P. Cappello, F. Novelli (Italy)
P11.10 ImmuneresponseinmiceimmunizedwithaClostridium perfringens beta2 recombinant toxin M. Pellegrini, A. Serroni, P. Pasquali, B. Chirullo, S. Corneli, K. Forti, L. Anzalone, G. Curina, M. Cagiola, A. De Giuseppe, G. Severi (Italy)
P11.11 Theinterplaybetweenanti-CD20therapeuticantibodiesandhumannaturalkillercells:impactofantibodyFcengeneering C. Pighi, C. Capuano, R. Molfetta, R. Paolini, A. Santoni, R. Galandrini (Italy)
P11.12 PreclinicalinvestigationoftherapeuticstrategiescombiningtumorvasculatureremodelingandGD2-CARTcellbasedimmunotherapy for human neuroblastoma P. Bocca, M. Cilli, L. Emionite, I. Caruana, B. De Angelis, C. Quintarelli, E. Di Carlo, A. Pezzolo, F. Morandi, F. Locatelli, V. Pistoia, I. Prigione (Italy)
P11.13 A chimeric DNA vaccine against CSPG4 for the treatment of malignant melanoma: an effective way to overcome immune tolerance in humans and dogs F. Riccardo, M. Arigoni, G. Barutello, V. Rolih, S. Occhipinti, E. Quaglino, G. Donofrio, S. Lanzardo, S. Mayayo, D. Giacobino, E. Lardone, S. Ferrone*, P. Buracco, F. Cavallo (Italy,*USA)
P11.14 Bovineherpesvirus4-basedvectorsencodingforchimericHER2antigeniseffectiveininducingapotentanti-tumorresponse against HER2+ mammary cancer V. Rolih, S. Jacca, V. Franceschi, E. Bolli, A. Ballatore, I.F. Merighi, G. Donofrio, F. Cavallo, E. Quaglino (Italy)
P11.15 Electro-gene-transfer:asolidplatformformonoclonalantibodygeneration E. Pavoni, A. Muzi, F.F. Ferrara, M. Cappelletti, E. Marra, G. Ciliberto, L. Aurisicchio, G. Roscilli (Italy)
P11.16 Immunomonitoringpredictisclinicaloutcomesofmelanomapatientsreceivingipilimumab S. Solito, V. Damuzzo, L. Pinton, S. Valpione, J. Pigozzo, V. Chiarion-Sileni, E. Carrozzo, R. Arboretti Giancristofaro, S. Mandruzzato (Italy)
P11.17 AnalysisofnaturalkillerandTcellsubsetsandtheirprognosticvalueinmelanomapatientstreatedwithIpilimumab(anti-CTLA-4) R. Tallerico, C.M. Cristiani, E. Staaf*, C. Garofalo, E. Palella, M. Capone, Y. Pico de Coaña*, G. Madonna, R. Sottile*, D. Mallardo, V. Carannante*, E. Simeone, A.M. Grimaldi, S. Johansson*, E. Gulletta, A. Anichini, F. Colucci, G. Ciliberto, R. Kiessling*, K. Kärre*, P.A. Ascierto, E. Carbone (Italy, Sweden)