National Cancer Institute HIV/AIDS Cancer Programs Mostafa Nokta, MD Ph.D. Chief, AIDS Cancer Clinical Program Office of HIV and AIDS Malignancy National Cancer Institute N a t i o n a l C a n c e r I n s t i t u t e U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health
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National Cancer Institute HIV/AIDS Cancer Programs Mostafa Nokta, MD Ph.D. Chief, AIDS Cancer Clinical Program Office of HIV and AIDS Malignancy National.
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Change in Incidence of Cancers in HIV in the cART Era in USA
Kaposi’s sarcoma CNS Lymphoma Lymphoma (NHL and CNS) Lymphoma (HD) Anal Cancer Lung Cancer Cervical Cancer Breast Hepatoma
Patel P et al, Ann Intern Med 2008;148:728-736
Dual Burden of KSHV and HIV Infection in Africa Fuel an Epidemic of Kaposi’s Sarcoma
HIV KS KS Incidence
Office of HIV & AIDS Malignancy
AIDS Malignancy Program
AIDS Cancer Clinical Program
• CFAR• WIHS• MACS• IeDEA• AITRP
• AIDS Malignancy Consortium (AMC)• ACSR•INCTR•ACTG• SPOREs (Lung, Lymphoma, Head & Neck)
AIDS Malignancy Clinical Trials Consortium
AIDS Malignancy Consortium (AMC)
Evaluate clinical interventions for the treatment and prevention of malignancies in people with HIV
Investigate the biology of these malignancies in the context of clinical trials
Conduct Phase I, II and III clinical trials Address issues of international importance in HIV
associated malignancies Contribute specimens and clinical data to the
ACSR
AMC International Objectives
Assist with capacity building in developing nations for international HIV-related cancers
Develop AMC-sponsored and co-sponsored collaborative studies with emphasis on trials that:
- Employ hypothesis-driven, scientifically sound, locally relevant and feasible therapies
- Address important pathogenesis-based questions - Utilize the unique scientific expertise of the AMC
Current International Protocols
Protocol Project Site(s) CommentAMC 049 Sunitinib in AIDS KS Uganda, Kenya Active
AMC 050 KSHV viral transcription Brazil Active
AMC 054 Quadrivalent HPV vaccine IndiaLocal Gov
Review
AMC 055 Indinavir endemic KS Uganda Active
AMC 056 Indinavir endemic KS ZimbabweCTEP/IRB
review
AMC/ACTG 5263/5264
Treatment of early and late KS
Several sites in Africa
In development
AMCOral chemo and Modified
CHOP for AIDS NHLTBD In development
AMC International Sites
Uganda, Kampala Kenya, Nairobi Zimbabwe, Harare India, Mumbai, Chennai, Tamil Nadu Brazil, Sao Paulo Australia, Darling Hurst, NSW Dr. Mostafa Nokta, [email protected]
International Network for Cancer Treatment and Research
• The INCTR is a non for profit, non governmental organization dedicated to helping to build capacity for cancer treatment and research in countries with limited resources.
• Capacity building, Palliative care and educational programs• Disease interests: NH lymphoma, cervical cancer
Dr. Ian Magrath, PIhttp://www.inctr.org/
NCI/OHAM Cofunded Programs
MACS, Multicenter AIDS Cohort Study WIHS, The Women's Interagency HIV Study CFARs, Centers for AIDS Research IeDEA, International Epidemiologic Databases
to Evaluate AIDS AITRP, AIDS International Training
RFA: Strengthening Capacity for HIV-Associated Malignancies in Africa
PI from a US institution and an African Institution
Will support training in all disciplines from basic to clinical research to lay the foundation for the African/US investigators to seek future independent research grants on AIDS-related cancers
International Conference on Malignancies in AIDS & Other Acquired Immunodeficiencies