Definition: Non-Neoplastic mass of edematous nasal/sinus submucosaforms when the oedematous stroma ruptures and herniates through the basement membrane Theory (not proven):the exact etiology is not known yet Fibrosiscausing lymphatic obstruction Histopathology: 1.marked edemaof the connective tissue stroma2.Inflammatory mediators such a: s histamine, prostaglandins and leukotrienes. 3.marked eosinophilic and histiocytic infiltrate 4.epithelium displays gobletcell hyperplasia5.lining mucosa is ciliated columnarbut due to atmospheric irritation it may undergo squamouscell metaplasia Features: 1. Bilateral: simple inflammatory polyp usually are bilateral2. soft3. gelatinous4.initially sessile then Pedunculated 5. pale6. do not bleed on probing / do not shrink with the use of vasoconstrictor 7. insensitive to pain8. Long-standing cases present with broadeningof noseand increased intercanthal distance(frog face deformity) Features suggestive of malignancy in a polyp: 1.Unilateral2.Fleshy3.ulcerated4.Produce bloody discharge 5.Cause pain6.Cervical metastasisNasal Polyp
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Non -Neoplastic mass of edematous nasal/sinus submucosa forms when theoedematous stroma ruptures and herniates through the basement membrane
Theory (not proven):the exact etiology is not known yet
Fibrosis causing lymphatic obstruction
Histopathology:
1. marked edema of the connective tissue stroma 2. Inflammatory mediators such a: s histamine, prostaglandins and leukotrienes.3. marked eosinophilic and histiocytic infiltrate4. epithelium displays goblet cell hyperplasia 5. lining mucosa is ciliated columnar but due to atmospheric irritation it may
undergo squamous cell metaplasia
Features:
1. Bilateral: simple inflammatory polyp usually are bilateral 2. soft 3. gelatinous 4. initially sessile then Pedunculated5. pale 6. do not bleed on probing / do not shrink with the use of vasoconstrictor 7. insensitive to pain 8. Long-standing cases present with broadening of nose and increased intercanthal
distance (frog face deformity)
Features suggestive of malignancy in a polyp:
1. Unilateral 2. Fleshy 3. ulcerated 4. Produce bloody discharge 5. Cause pain 6. Cervical metastasis
Always arise from the lateral wall of nose (ethmoid sinus). Common sites are uncinate process, bulla ethmoidalis, ostia of sinuses, medialsurface and edge of middle turbinate.
Allergic nasal polypi almost never arise from the septum or the floor of nose
Polypi are seen in chronic rhinosinusitis of both allergic and non-allergicorigin. Non-allergic rhinitis with eosinophilia syndrome (NARES) is aform of chronic rhinitis associated with polyp.
2. Allergic fungal sinusitis : Almost all cases of fungal sinusitis form nasal polyp.
3. Asthma : 7% of pt with asthma will develop polyp
4. Aspirin intolerance: 36% of the patients with aspirin intolerance may show polypi. Sampter's triad consists of:
1. nasal polypi2. asthma3. aspirin intolerance. Have more sever symptoms Higher risk of recurrence post surgery
May benefit from low Salicylate diet (avoid potato,olive oil,wine)
5. Churg-Strauss syndrome : Consists of asthma, fever, eosinophilia, vasculitis and granuloma.
6. Cystic fibrosis: 20% of patients with CF form polyp. It is due to abnormal mucus .
7. Kartagener's syndrome : consists of bronchiectasis ,sinusitis, situs inversus and ciliary dyskinesis.
8. Young's syndrome : It consists of sinopulmonary disease and azoospermia.
9. Nasal mastocytosis : It is a form of chronic rhinitis in which nasal mucosa is infiltrated with
mast cells but few eosinophils. Skin tests for allergy and IgE levels are normal .
DiagnosisDiagnosis can be easily made on clinical examination.
CT scan of paranasal sinuses is essential to exclude the bony erosion and expansionsuggestive of neoplasia
1. topical corticosteroids decrease capillary permeability decrease excretion in response to cholinergic stimulation suppress cytokine synthesis in eosinophil, basophil and
lymphocytes inhibit influx of eosinophil and basophil into nasal epithelium anddecrease
production of inflammatory mediators arachidonic acid production
2. oral corticosteroids used for recurrent conditions short high burst with rapid taper