Narcolepsy Indira Gurubhagavatula, MD, MPH 1 Narcolepsy Indira Gurubhagavatula, MD, MPH Associate Professor Director, Sleep Disorders Clinic Crescenz VA Medical Center Director, Occupational Sleep Medicine University of Pennsylvania Medical Center March 29, 2019 Conflict of Interest Disclosures for Speakers 1. I do not have any potential conflicts to disclose. 2. I wish to disclose the following potential conflicts of interest: Type of Potential Conflict Details of Potential Conflict Grant/Research Support BluTech, Inc., AASM Foundation Consultant Speakers’ Bureaus Financial support Other 3. The material presented in this lecture has no relationship with any of these potential conflicts, OR 4. This talk presents material that is related to one or more of these potential conflicts, and the following objective references are provided as support for this lecture: 1. 2. 3. X X Outline • History • Definition • Clinical presentation • Classification • Etiology • Diagnostic testing • Treatment • Future work
This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
Transcript
NarcolepsyIndira Gurubhagavatula, MD, MPH
1
Narcolepsy
Indira Gurubhagavatula, MD, MPH
Associate Professor
Director, Sleep Disorders Clinic
Crescenz VA Medical Center
Director, Occupational Sleep Medicine
University of Pennsylvania Medical Center
March 29, 2019
Conflict of Interest Disclosures for Speakers
1. I do not have any potential conflicts to disclose.
2. I wish to disclose the following potential conflicts of interest:
Type of Potential Conflict Details of Potential Conflict
Grant/Research Support BluTech, Inc., AASM Foundation
Consultant
Speakers’ Bureaus
Financial support
Other
3. The material presented in this lecture has no relationship with any of these potential conflicts, OR
4. This talk presents material that is related to one or more of these potential conflicts, and the following objective references are provided as support for this lecture:
1.
2.
3.
X
X
Outline
• History
• Definition
• Clinical presentation
• Classification
• Etiology
• Diagnostic testing
• Treatment
• Future work
NarcolepsyIndira Gurubhagavatula, MD, MPH
2
“a rare neurosis...characterized by an urgent necessity to sleep, sudden and of short duration, which recurred
at intervals more or less long”
Galineau, 1878
1877• First description
1902• Cataplexy
1935• Amphetamine
1959• SOREMs
1970• MSLT
1973• Canine
1992• HLA-DQB1*0602
1998• HCRT receptor
1999• HCRT mutation: mice, dogs
2000
• HCRT deficiency
• Canine gene cloned
2010s
• H1N1
• Autoimmune hypothesis
2015
• NT2
• Idiopathic hypersomnia
History
Narcolepsy
• excessive daytime sleepiness (EDS)
• hypnagogic hallucinations
• sleep paralysis
• cataplexy
• disrupted nocturnal sleep
• PSG: without other sleep disorder
• MSLT: SL <=8 minutes and SOREM >=2 without other explanation