Nanotechnology - Center for Cancer Research · What is Nano? Nanotechnology: Alliance Na%technology Characterization Laboratory Research and technology development at the atomic,

Nanotechnology

Outline

3

What is nano?

Nanoparticles

4

Nanoparticles in daily life

5

Nanoparticles in medical applications

6

Nanoparticle type

7

Nanotechnology

8

Benefits

Reduced toxicity

Immunotherapy

Vaccines

Lymphatic delivery

Toxicity

Toxicity

Immune system

Bidirectional communication

Particle size

Protein binding

Bidistribution

MPS uptake

Hemolysis

Hemolysis

Coagulation system

Undesirable effects

Platelets

Zeta potential

Platelets

Leukocyte

Endothelial cells

Allergenicity

Allerginicity

Complement activation

Allergenicity

Cytokine storm

Cytokine storm

IL-8

Oxidative stress

IL-1

IL-1

Immunogenicity

Immunogenicity

Immune system

Take home message