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COURSE MBT 401: Nanobiotechnology: Elective Course I4 Credits,
Level II, 3 L, 1T)
Unit 1 15L1. Introduction to nanoscience
Introduction to nanoscience; History and scope,
interdisciplinary nature,
structure of nanomaterials, length scales de Broglie wavelength
& exciton
Bohr radius, quantum wires, quantum dots, fullerenes, graphite,
carbon
nanotubes, inorganic nanowires, nanoparticles, core-shell
nanoparticles2. Nanomaterials synthesis
Top-down and bottom-up approaches, chemical precipitation, vapor
deposition,
hydrothermal method, pyrrolysis, Sputtering, laser ablation,
electric-arc, sol-gel
processing, lithography, natural synthesis in organism, natural
inorganic,
micelle, bio-based protocol
Unit 2 15L1. Nanomaterials characterization
Electron microscopy SEM, TEM, EDAX, X-ray diffraction atomic
force
microscopy, confocal microscopy, UV-Visible spectroscopy,
photoluminescence
spectroscopy, FTIR spectroscopy, UV and X-ray photoelectron
spectroscopy,
particle size analysis, charge distribution analysis (charge on
the surface,
estimation).
2. Nanotechnology Applications Materials domainNanoscale
materials, fabrication at the nanoscale, Molecular Beam
Epitaxy,
Nano transfer printing, Scanning probe based techniques for
nanomaterial
synthesis, MEMS and NEMS, selforganization, nanoscale
(opto)electronics and
magnetic Fullerenes, Nanosensors: characterization,
perception,
electrochemical sensors, physical sensors, thin-films nanoscale
devices
Transistors, FETs, quantum dots, lasers and others,
Microfluidics, Nanofuel
cell, Nanoemulsions and coatings, Microcastings
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Unit 3 15L1. Nanotechnology Applications Biology domain
Bionanomachines composed of protein, nucleic acids, lipids,
polysaccharides,
recombinant DNA technology, protein folding, self assembly,
biomolecular
motors, traffic across membranes, biomolecular sensing, self
replication,
nanobiosensors, nanoimplants, biorobotics, functionalization of
nanoparticles
for biological applications.
2. Applications of AFM, SEM and Raman Spectroscopy in
biologyScanning tunneling microscopy, atomic force microscopy,
magnetic- force
microscopy (MFM), scanning near field optical microscopy (SNOM),
etc.
Applications: microscopy, AFM/FFM and various measurement
techniques,
friction and adhesion, self assembled monolayers
Unit 4 15L1. Applications in cancer biology
Characteristics of tumor tissues, drug delivery to tumors,
physicochemical
properties of nanoparticles in cancer therapy, surface treatment
of coating of
nanoparticle polymers for encapsulation, site specific delivery
of
chemotherapeutic agents using nanoparticles, passive targeting,
targeting
lymph nodes with nanoparticles, increasing bioavailability of a
compound,
active targeting, magnetically directed targeting to tumor
tissue, ligand
directed active targeting, targeted drug delivery using magnetic
nanoparticles,
nanoviral gene therapy, hyperthermia, computer aided drug
design, anti-AIDS
drugs, general medicine to personalized medicine,
immunotoxinstargeted cell
killers, drugs delivered with liposomes, artificial blood, gene
therapy
2. Applications in Food IndustryNano-food, food processing,
packaging and safety, nano-capsules and
nanocomposites used in food industry.
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3. Applications in Environment ProtectionEnvironmental benefits
of nanotechnology, nanotechnology in water treatment.
4. Applications in MicrobiologyMicrobial synthesis of
nanoparticles, nanomaterial enabled microbial control,
application of nanotechnology in the study of cell structure;
bacteria and virus.
5. Applications in AgricultureCrop improvement,
nanoagrochemicals, nanosensors for on-farm monitoring,
plant disease monitoring, plant disease diagnosis.
References1. T. Pradeep, Nano, The Essentials, Understanding
Nanoscience and
Nanotechnology, Tata McGraw-Hill Publishing Company Limited,
2007
2. J. W. M. Bulte, M.M.J. Modo, Nanoparticles in Biomedical
Imaging: EmergingTechnologies and Applications, Springer Science
Business Media, LLC, 2008
3. C.A. Mirkin and C.M. Niemeyer, Nanobiotechnology- II, More
Concepts andApplications, WILEY-VCH, Verlag Gmb H&Co, 2007
4. V. Renugopalakrishnan and R. V. Lewis Eds.
BionanotechnologyProteins toNanodevices, Springer.
5. D. S. Goodsell, Bionanotechnology Lessons from Nature John
Wiley & Sons,Inc
6. Bhushan Ed.,Handbook of nanotechnology, Springer.7. A C. Yih
and I. Talpasanu Eds. Micro and Nano Manipulations for
Biomedical
Applications
8. Tuan VoDinh. Ed. Nanotechnology in Biology and Medicine:
methods, deviceand applications. CRC Press.