FORMULATION APPROACHES AND DEVELOPMENT OF NANOSTRUCTURED LIPID CARRIER Presented By Mr. Rahul S. Dalvi M. Pharm. (SEM – II) Dept. of Pharmaceutics Guided By Dr. A. J. Shinde Asso. Professor Dept. of Pharmaceut BHARATI VIDYAPEETH COLLEGE OF PHARMACY, KOLHAPUR 2015-2016 Date:12/03/ 2016 1
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FORMULATION APPROACHES AND DEVELOPMENT OF NANOSTRUCTURED
LIPID CARRIER
Presented By
Mr. Rahul S. DalviM. Pharm. (SEM – II)Dept. of Pharmaceutics
Guided By
Dr. A. J. ShindeAsso. Professor Dept. of Pharmaceutics
BHARATI VIDYAPEETH COLLEGE OF PHARMACY, KOLHAPUR
2015-2016
Date:12/03/2016
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Contents Introduction
Types of NLC
Composition
Method of preparation
Characterization methods
Marketed products
Conclusion
References
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Introduction Lipid nanoparticles.
Second generation lipid nanoparticles.
Produced from blends of solid lipids and liquid lipids.
The blends obtained are also solid at room temperature and body
temperature.
Solid lipids are mixed with liquid lipids preferably in the ratio of
70:30 up to a ratio of 99.9:0.1.
Has lipid matrix with a special nanostructure which improve drug
loading and firmly incorporate the drug during storage.
Can be administered via oral, ocular, topical and intravenous
route.
Nanostructured Lipid Carrier ( NLC )
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Limitations Poor drug loading capacity.
Drug expulsion after polymeric transition during storage.
Relatively high water content of the dispersions (70-99.9%)
The low capacity to load water soluble drugs due to
partitioning effects during the production process.
NLC overcome these limitations
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Advantages Better physical stability.
Ease of preparation and scale-up.
Increased dispersability in an aqueous medium.
High entrapment of lipophilic drugs and hydrophilic drugs.
Controlled particle size.
An advanced and efficient carrier system in particular for
substances.
Increase of skin occlusion.
Extended release of the drug.
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Types of NLC Type 1: Imperfect type NLC Solid and liquid lipids are blended.
Small amount of liquid lipid.
The difference in the structures of the lipids and special
requirements in the crystallization process lead to a highly
disordered, imperfect lipid matrix structure offering space for drug
molecules and clusters of drugs.
Drug
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Type 2: Multiple type NLC The multiple oil/fat/water, drug can be accomodated in the solid,
but at increased solubility in the oily parts of the lipid matrix.
At high oil concentrations a miscibility gap of two lipids occurs
during the cooling phase, leading to phase separation, that means
precipitation of tiny oily nano compartments.
Drug
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Type 3: Amorphous type NLC Lipids are mixed in a way that prevents them from crystallizing.
The lipid matrix is solid but, in a amorphous state.