Nanomedicine: An Innovative Approach Towards Treating ... · Nanomedicine: An Innovative Approach Towards Treating Tuberculosis. H. SWAI. 1, L. KALOMBO, B. SEMETE and L. KATATA ...
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• In vitro assays • In vitro efficacy• In vitro stability and slow release profile• Particle uptake
• In vivo assays• Macrophage uptake• No abnormalities in tissues• No inflammatory response• Sustained release profile over 6 days
• Generic technology• Anti-retrovirals, antibiotics etc. • In search of collaborators in Malaria and traditional actives
www.csir.co.za
www.csir.co.za
Active targeted drug delivery
• Inherent macrophage mechanisms being manipulated- Phagocytosis and endocytosis- Over expression of protein in TB infected macrophages
• Direct mannose receptor mediated particle uptake• Novel technology• Aptamers against target protein• Preferential localization of particles
• Macrophage over expressing protein
• Mycolic acid• Cell wall of M.tb• Directing nanoparticles to M.tb in cells
Single stranded RNA
Folding
Incubation with target protein
Molecular complex
www.csir.co.za
Overview of drug delivery platform relationships & agreements
www.csir.co.za
Progress on HR Capacity Building• Recruitment progress
• 4 Post docs - Boitumelo Semete, Paul Chelule and Malebogo Legodi, Lebogang Katata
• 4 PhD students –Yolandy Benadie, Lonji Kalombo, Lindiwe Nkabinde and Laetitia Booysen
• 3 MSc students – Phumzile Hadebe, Saloshnee Naidoo and Trudy Maluleke• 4 Technikon students - Sonia Mathopo, Batabile Ramalapa and Koketso
Rapatla and Mofahloshi Chuene• Training completed (2006-2008)
• University of London, UK• EPFL, Switzerland • PGIMER, Chandigarh, India. • University of Nottingham, UK • University of Cardiff, UK• University of Liverpool, UK
• Training arranged for 2009 onwards• National Jewish Medical and Research Centre, USA • University of Nottingham, UK• University of London, UK• University of Colorado, USA