Nanomaterial Drug Delivery Group 5: Daniel Ehlers Daniel Barnes Ann-Marie Scarborough Nguyen Lam Featuring: Nanomaterials For Drug Delivery https://encrypted- tbn1.gstatic.com/images? q=tbn:ANd9GcSh0iVqg8Z7WUm1a_XO7uTQ QpHl67Lz1El1kl2YHlNy4qkCEz2KBQ http:// research.mdhs.unimelb.e du.au/event/nano- medicine-bio21-cluster- symposium
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Nanomaterial Drug Delivery Group 5: Daniel Ehlers Daniel Barnes Ann-Marie Scarborough Nguyen Lam Featuring: Nanomaterials For Drug Delivery
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• Another problem: Overcome defenses in cytoplasm of cancer cell
• Nanomaterial overcomes defenses and rapidly delivers siRNA drug into cell
• siRNA modifies the cancer cell DNA and causes it to die http://www.sciencemag.org/content/337/6092/303/F1.large.jpg
Specific Cancer Drug Design: Carbon
Nanotubes• Antibodies are
designed that will fight cancer cells
• Carbon Nanotube carriers have molecular strands that contain the antibodies and a link system to cancer cells
• Recognize cancer cells by pH, biological markers
http://www.ncbi.nlm.nih.gov/pubmed/23143677
Specific Cancer Drug Design: Carbon
Nanotubes• Carbon Nanotubes can
be PEGed and attached with antibodies to bring it specifically to a cancer cell
• The drugs inside the nanotube can be released in the presence RF frequencies
• Metal nanotubes also heat in presence of RF waves, and “burn up” cancer cells
http://www.ncbi.nlm.nih.gov/pubmed/23143677
Specific Cancer Drug Design:
Nanodiamonds• Drug can be placed in
nanodiamonds• Nanodiamonds contain
receptors that allow them only to bind and react with tumor cells
• Nanodiamonds release drug into tumor cell and result in highly effective treatment http://www.sciencedaily.com/releases/2013/04/130415172308.htm
Assessment of Work• The use of Nano-Diamonds and their effects on the PH increase
solubility in the solution for several types of deliveries by making the pH closer to that of the natural body levels
• Table 1• Plotted n value of the release of RB from carbon nanomaterials at
pH 7.4 and pH 4.5.• n value at pH 7.4 n value at pH 4.5 Drug release mode• CB–RB 0.39 0.32 Fickian diffusion• CNT–RB 0.42 0.64 Fickian diffusion at pH 7.4,• anomalous transport at pH 4.5• f-CNT–RB 0.5 0.64 Anomalous transport• GO–RB 1 0.63 Case II transport at pH7.4,• anomalous transport at pH 4.5• Zhang and Olin Pg. 1251
Assessment of Work• In addition, they allow for a controlled time
release of the drug for consistant delivery
• Zhang and Olin pgl. 1250Time (min)
Assessment of Work• Allows better ability to
Penetrate the Plasma wall of the cells
• Can release on correct rNA code recognition for needed antigen.
Conclusions• The use of Nano-
Diamonds allows the Pharmicutical Industry to be much more presice in drug delivery due too pH Controlo Time Release Controlo rNA Release Control
Conclusion• It also allows a larger range of effective drugs to
References1. Nanomaterials for Drug Delivery. Jeffrey A. Hubbell and Ashutosh Chilkoti. Science 20 July 2012: 337 (6092), 303-305.
[DOI:10.1126/science.1219657]2. Nanodiamonds as novel nanomaterials for biomedical applications: drug delivery and imaging systems.
Badea, Ildiko and Kaur, Randeep. International Journal of Nanomedice. 8. Jan 2013. Web. 2 April 20133. Computational design of a CNT carrier for a high affinity bispecific anti-HER2 antibody based on trastuzumab
and pertuzumab Fabs. Salazar-Salinas Karim, Kubli-Garfias, Carlos, and Seminario, Jorge M. Springer-Verlag.