n t e rfoRepro ducti C e ve a n M i c ed er ic m in A e Ce 1 9 9 ......About Cleveland Clinic The American Center for Reproductive Medicine Cleveland Clinic’s American Center for

Ranked One of America’s Top 5 Hospitals

Hands on Training in Assisted Reproductive Technology

ART Training Alumni 2004 - 2015American Center for Reproductive Medicine

Abu Dhabi

Austria

Bahrain

Brazil

Canada

Chile

China

Colombia

Croatia

Czech Republic

Egypt

Greece

Guyana

Hong Kong

India

Iraq

Israel

Italy

Jamaica

Japan

Jordan

Kazakhstan

Korea

Kosovo

Kuwait

Lebanon

Malaysia

Mexico

Nigeria

Pakistan

Peru

Philippines

Romania

Saudi Arabia

Serbia

Slovak Republic

South Africa

Spain

Syria

Turkey

UAE

USA

Venezuela

Amer

ican

Center for Reproductive Medicine

Centrum Excellentiae Est.

1993

Training program in Assisted Reproductive Technology (ART)We offer a unique opportunity to learn the latest techniques in this rapidly changing subspecialty at one of the world’s premier ART centers:

• World-class faculty• State-of-the-art training facilities• Personalized hands-on training• Multiple comprehensive training modules• Tremendous satisfaction rates• Trained over 160 alumni from 43 countries since 2003• Certificate of Training awarded at the end of training

This intensive, 320-hour course is available exclusively to scientists and physicians with specific interest in gynecology, andrology or embryology as well as other health professionals such as embryologists, reproductive biologists and technologists.• In vitro fertilization (IVF)• Intracytoplasmic sperm injection (ICSI)• Gamete cryopreservation• Routine and advanced tests in andrology

2 | Cleveland Clinic American Center for Reproductive Medicine

Referral to a Human IVF Clinic may be available to select candidates looking for clinical observation.

• Logistics of running an IVF Lab • Observe IVF/ICSI procedures • Oocyte retrieval • Oocyte assessment • Fertilization check • Embryo assessment • Intrauterine insemination

Cleveland Clinic is ranked as one of America’s Top 5 Hospitals by U.S.News & World Report. Located in Cleveland, Ohio, Cleveland Clinic is a nonprofit, multispecialty academic medical center that integrates clinical and hospital care with research and education. Founded in 1921 by four renowned physicians with a vision of providing outstanding patient care based upon the principles of cooperation, compassion and innovation, it is the second largest group practice in the world with 3,262 physicians and scientists practicing and researching in more than 130 medical specialities and more than 1,400 beds.

In addition to the main hospital located near Cleveland’s historic University Circle, the Cleveland Clinic operates nine regional hospitals, a children’s hospital, and 18 full-service family health centers in Ohio, as well as hospitals in Florida, Las Vegas, Canada, and Abu Dhabi, employing more than 43,000 individuals and providing global world class medical care. Last year alone, 5.9 million patients from 147 countries and all 50 states received their care at the Cleveland Clinic.

The main hospital campus, located near downtown Cleveland, occupies 167 acres and 44 buildings. It includes a hospital, an outpatient clinic, a children’s hospital, cancer institute, eye institute, research institute, a medical school and supporting labs and facilities. To learn more, visit www.clevelandclinic.org.

About Cleveland ClinicLearn from the LeadersThe American Center for Reproductive MedicineCleveland Clinic’s American Center for Reproductive Medicine was established 23 years ago in 1993 with a three-fold mission to: conduct cutting-edge research into the causes of human reproductive pathologies, develop new fertility biomarkers and treatment modalities, and train physicians and scientists with a commitment to advancing the understanding of human reproduction, infertility and fertility preservation.

Learn more about our ART Training Program

Course ContentHands on Assisted Reproduction (IVF/ICSI) - Module 5A - 5C (160 hours)Learn basic and advanced techniques in:

IVF Techniques

• Module 5A • ICSI: Intracytoplasmic sperm injection • Classical IVF • Oocyte handling and scoring • Embryo handling and scoring • Catheter loading for embryo transfer

• Module 5B • Preparation of ICSI dishes • ICSI: injection of the spermatozoon into the oocyte • Oocyte handling (using fresh mouse oocytes)

Laboratory Training

• Equipments • Micromanipulators: components and mechanics • Installing and aligning the ICSI instruments

• Supplies & Culture Medium • Preparation of culture medium and dishes for IVF/ IVF-ICSI cases • Embryo culture • Extended embryo culture

Advanced ART Techniques• Assisted hatching (laser and chemical [acidified Tyrode’s] method)• Embryo biopsy (laser and chemical methods)

Pre-Implantation Genetic Diagnosis• Blastomere biopsy:• Learn the setting up of the micromanipulator• Biopsy of mouse/hamster 8-cell stage embryos• Use of laser and acid Tyrode’s solution for zona drilling• Blastomere and polar body aspiration and fixation techniques• Cell spreading• Fixation techniques

Cryopreservation• Embryo cryopreservation (mouse embryos)• Vitrification

Andrology• Sperm preparation for IVF/ICSI

Virtual Tour of Facilities

MODULE 5

Module 5A:IVF/ICSI/Micromanipulation (80 hours)Module 5B:ICSI/Micromanipulation (40 hours)Module 5C:Advanced ART Techniques (40 hours)Module 5D*:Customizable ART Training (40 - 320 hours)

*How Module 5D Works:1) Candidates select a) the techniques they wish to learn (Modules 1-8); and b) the duration of their training (1- 8 weeks).

2) Candidates consult with the Course Director regarding their training needs and choices, and together, they will decide on the appropriate modules and duration required by the candidate

3) A personalized training schedule is created specifically for the candidate

4) Training is provided at a pace established by the candidate and is geared towards fulfilling the candidates personal needs.

ART Trainee

taking Module 5

will receive a

FREE copy of

an ART Book

and more...

Cleveland Clinic American Center for Reproductive Medicine | 3Learn more about our ART Training Program

Edmund Sabanegh, MDChairman, Department of UrologyHead, Section of Male InfertilityProfessor, Lerner College of Medicine

Sajal Gupta, MS, MD, TS (ABB) (MS in Clinical Embryology, Jones Institute)Reproductive SpecialistSupervisor, Andrology CenterAssistant Professor, Lerner College of Medicine

Rakesh Sharma, PhDResearch Coordinator,American Center for Reproductive MedicineAssociate Professor, Lerner College of Medicine

Ashok Agarwal, PhD, HCLDDirector, Andrology CenterDirector, American Center forReproductive MedicineProfessor, Lerner College of Medicine

Christina Anagnostopoulou, MSClinical EmbryologistIVF Clinic “Embryo ART”Athens, GreeceTestimonial

Israel Maldonado Rosas, MScIVF Lab DirectorMexican Institute for Advanced Reproductive Technology (Inmater)Mexico City, MexicoTestimonial

Semenology - Modules 1A (8 hours) and 1B (16 hours)Gain proficiency in:

Module 1A: • Collection and delivery of semen sample • Routine semen analysis • Computer assisted semen analysis (CASA) • Review quality control method for semen analysis • Proficiency survey for semen analysis

Module 1B: • Name and perform sperm morphology assessments by WHO and Kruger’s strict criteria (WHO 4th and 5th Ed.) • Distinguish the differences between the two morphology classification systems • Observe semen smear preparation and practice staining techniques • Review quality control measures

ART Sperm Preparation - Module 3 (16 hours)Develop skills in sperm preparation for ART: • Preparation of ejaculated sperm for ART: Sperm wash Double density gradient technique Swim-up protocol • Method of retrieval of sperm from retrograde ejaculate (demonstration only) • Sperm retrieval and preparation of testicular biopsy specimens (using rat or mouse specimens)

Advanced Andrology Techniques - Module 2A (40 hours) and 2B (80 Hours)Gain proficiency in these advanced techniques:

Module 2A (40 hours) • Measurement of sperm DNA fragmentation by TUNEL assay using FACS* Flow Cytometry • Measurement of Oxidation Reduction Potential (ORP) in semen samples • Measurement of Reactive Oxygen Species (ROS) levels in semen samples • Measurement of lipid peroxidation in semen samples • Measurement of Total Antioxidant Capacity (TAC) in seminal plasma • Selection of non-apoptotic spermatozoa using MACS** technique

Module 2B (80 hours) • Measurement of sperm DNA fragmentation by TUNEL assay using FACS* BD Accuri C6 Benchtop Flow Cytometer • Measurement of Oxidation Reduction Potential (ORP) in semen samples • Measurement of Reactive Oxygen Species (ROS) levels in semen samples • Measurement of lipid peroxidation in semen samples • Measurement of Total Antioxidant Capacity (TAC) in seminal plasma • Selection of non-apoptotic spermatozoa using MACS** technique

*Fluorescence-activated cell sorting**Magnetic-activated cell sorting

Cryopreservation - Module 4 (8 hours)Learn the proper procedures for freezing human spermatozoa: • Procedure for freezing of ejaculated human spermatozoa • Cryopreservation of epididymal and vas deferens aspirates* • Isolation and cryopreservation of sperm from testicular biopsy specimens* • Protocol for cryopreservation of ovarian tissue from cancer patients**demonstration only

Management of IVF and Andrology Laboratories - Module 7 (16 hours)Gain proficiency in: • Implementing a Total Quality Management Program • Regulation, licensing and accreditation • Quality Control and Quality Assurance • Proficiency Testing • Quality management tools • Troubleshooting

Vitrification - Module 6 (8 hours)Acquire competency and knowledge of vitrification: • The fundamentals of vitrification • Setting up vitrification for routine use in an embryology laboratory • Hands on training in vitrification of oocytes and embryos using techniques such as: open and closed vitrification system, warming of cryopreserved oocytes and embryos, oocyte and blastocyst vitrification, cleavage stage embryo vitrification

Preparing for CAP Accreditation and FDA Inspection - Module 8 (16 hours)Learn how to prepare your laboratory or tissue bank for accreditation by the Collegeof American Pathologists (CAP) Reproductive Laboratory Inspection Program • How to prepare for your laboratory accreditation by the College of American Pathologists (CAP) Reproductive Laboratory Inspection Program or your tissue banks by the United States Food and Drug Administration (FDA) inspection (Client Depositor only). • What to do: Pre-inspection, during inspection and post inspection • Inspection Techniques • Quality Management (pre-analytic, analytic and post-analytic processes) • Critical indicators for all three processes • Laboratory General Checklist • Reproductive Laboratory Checklist (Embryology and Andrology) • Team Leader assessment • FDA Compliance

Training Faculty

AccreditationAccredited for 320 AMA PRA Category 1 CreditsTM

Participants claiming CME credit from this activity may submit the credit hours to the American Osteopathic Association Council on Continuing Medical Education for Category 2 credit.Accredited by the American College of Embryology

Learn More For complete information, application instructions and course fees, visit www.clevelandclinic/org/reproductiveresearchcenter/arttraining.html

Virtual tour of the American Center for Reproductive Medicine

Training Methodology:1. Training provided by 2 certified, practicing Clinical Embryologists

2. Trainers include Andrologists, Reproductive Endocrinologists and other experts in ART

3. Fully hands-on, one-on-one laboratory training sessions under the direct guidance of Clinical Embryologists • Training is done using animal models (frozen hamster oocyte and mouse embryos) (Module 5)

4. Each training session is customized to the trainee’s • Professional background • Level of skill and competence • Specific training needs • Desired outcomes from attending the ART training course

5. Interactive discussion and teaching sessions

6. Live lectures and multimedia presentations in small group sessions

7. Four state-of-the-art micromanipulators dedicated solely for training purposes (IVF/ICSI)

Note:• Training is offered in a dedicated ART training suite inside a non-clinical research laboratory• There is no patient contact

Trainee Evaluations:Each Trainee is tested at the end of their training for:

1. Knowledge/Theoretical Component (30%): Multiple choice questions on lab techniques linked to each course module

2. Practical Skills (50%): Tested on specific lab techniques taught during the training

3. Verbal Communication & Comprehension Skills/Integrative Component (20%):

• The performance of the candidate throughout the course will be reflected in a Grading Report.

• Candidates who meet the training requirements and successfully complete the course work will be awarded a Training Certificate

Registered Trainees Will Receive…1. Course Syllabus with Reading Material and Lab Protocols

2. Free Access to the Cleveland Clinic Alumni Library

3. Free Text Book on “Practical Manual of In Vitro Fertilization: Advanced Methods and Novel Devices” edited by Dr. Peter Nagy et al, Springer (only for Modules 5A-5D)

4. WHO Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction. Fifth Edition (CD)

5. Certificate of Training (issued upon successful assessment by the instructor)

6. Daily Meal Tickets

ASHOK AGARWAL, Ph.D. Professor, Department of Urology Director, American Center for Reproductive Medicine Director, Andrology Center

RAKESH SHARMA, Ph.D.Associate Professor, Department of Urology Coordinator of Research,American Center for Reproductive Medicine

SAJAL GUPTA, M.D.Assistant Professor, Department of Urology Assistant Research CoordinatorAmerican Center for Reproductive Medicine

American Center for Reproductive Medicine

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Cleveland ClinicThe Cleveland Clinic

Let it be known that

Abdullah Ahmed Al Najmi, M.D.Jazan, Saudi Arabia

has receivedHands on Training in Human Assisted Reproduction

(Module 1: Semenology; Module 2: Advanced Sperm Function Tests; Module 3: Sperm Preperation; Module 4: Crypreservation; Module 5D: Assisted Reproduction (IVF/ICSI); Module 6: Vitrification)

for 360 hours offered by the American Center for Reproductive Medicine, Cleveland Clinic

September 1 - October 28, 2015

Scholarship in Teaching AwardTraining Program in Advanced Reproductive Techniques

The Case Western Reserve School of Medicine Scholarship in Teaching Awards is an annual program designed to recognize faculty contribution to education from the preceding year and promote undergraduate, graduate, and continuing medical education teaching as a scholarly activity.

Teaching approaches considered scholarly are characterized by 1) purposeful planning 2) systematic implementation and 3) reflection and assessment for improvement. The result should be an academic product that is actively shared and that will support the development of a community of teaching scholars.

This award was given out at the Case Medical School Education Retreat on March 12, 2015. ACRM’s hands-on ART training program has previously been twice-recognized with this prestigious Scholarship in Teaching Award, in 2013 and again in 2014. Besides the ART Training Program, ACRM’s Summer Internship program has also been thrice-recognized with this prestigious Scholarship in Teaching Award, in 2011, 2013 and 2014 respectively.

Certificate of Training Awarded Upon the Successful Completion

of the Hands on ART Training

01.2016

ASHOK AGARWAL, Ph.D. Professor, Department of Urology Director, American Center for Reproductive Medicine Director, Andrology Center

RAKESH SHARMA, Ph.D.Associate Professor, Department of Urology Coordinator of Research,American Center for Reproductive Medicine

SAJAL GUPTA, M.D.Assistant Professor, Department of Urology Assistant Research CoordinatorAmerican Center for Reproductive Medicine


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Cleveland ClinicThe Cleveland Clinic

Let it be known that

Shazia Magray, M.D, MRCOGDubai, UAE

has receivedHands on Training in Human Assisted Reproduction

Module 3: Sperm Prepration, Module 4: Cryopreservation, Module 6: Vitrification and Module 5A: IVF/ICSI, Micromanipulation, for 160 hrs offered by the

American Center for Reproductive Medicine, Cleveland Clinic

October 5, 2015 - October 30, 2015

Center for Reproductive Medicine ART Training

This document reflects the performance of the candidate during the 2015 ART Training Session: Module 5A (IVF/ICSI/Micromanipulation)

This is to attest that the trainee,

“Bindu Garg”

has successfully completed the course work prescribed by the Cleveland Clinic’s Center for Reproductive Medicine and is therefore recommended for the award of the

ART Training Certificate

Grading Report

Grading Scale: A+ (>96%), A (91-95%), A- (86-90%), B+ (81-85%), B (76-80%), B- (71-75%), C (<70% is Fail)

Theoretical Component (30%)

Total Marks Marks Obtained Contribution (30%)

30 24 (80%) 24

Practical component (50%)

40 29 (76%) 38

Integrative Component (20%)Presentation and viva voce

100 100 (20%) 20

FINAL GRADE 82%

Christina Anagnostopoulou, MSc Trainer, ART Training

Israel Maldonado, MSc Trainer, ART Training

October 12th, 2015 Date Dr. Ashok Agarwal, Program Director

ART Training Certificate Presentation Ceremony, ACRM, September 2013

ACRM Staff and Fellows with Dr. Joanna Ellington, Andrology Center, March 2015

Meet Our 2015 ART Trainees

Amer

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1993

“We experienced a homely environment and received unrivaled hospitality from the Senior Staff. The course is run very

well and it meets the demands and expectations of the candidates.”

Bindu Garg, MD, DGO, FICMCHGurgaon, India

“The hands-on training and small teacher to student ratio

was good. I am the type of learner that needs to do the task

to learn - the time for practice, repetition, and asking questions

helped me learn the material.”Aimee Parker, MTPoughkeepsie, USA

“I found the in-depth coverage of topics, customized personal training by the outstanding teaching faculty and extensive

quality control, as the most effective aspects of this course.”Shubhadeep Roychoudhury, PhDSilchar, India

“The hands-on part of the training and the expert Trainers - it’s the

best training in the world and I encourage everyone to have it”.Osama Abdalmageed, MDAssiut, Egypt

“For me as a beginner, the whole course was very effective. Techniques such as ICSI, vitrification and embryo transfer

were practiced so many times that at the end, you feel as if you have been performing them for a long time. The

training is an amazing opportunity for those involved in the field of reproductive medicine - A MUST DO”.

Shazia Magray, MD, MRCOGDubai, UAE

“The module has the scope to give more time in areas which the trainee finds tough, so the course is flexible according to one’s

needs. The complete hands on experience is like no place else.”

Priya Mehta, MBBS, DGOFaridabad, India

“The working environment was very comfortable and the

hands-on training coupled with the didactic lectures were very effective.”

Jason Krumholtz, MDPoughkeepsie, USA

“The most effective aspect is having the one-on-one attention of the ART Trainer.”Gulfam Ahmad, PhD, MCELahore, Pakistan

“This is the most wholesome course on embryology that I have ever come across.

The difficult aspects like trouble-shooting of ICSI or recent advances like vitrification were made very clear to us. Overall, the

techniques taught here are tremendously useful in day-to-day practice.”Shweta Pati, MBBSKolhapur, India

“I’m planning to take another course in future to develop my skills even more.”Ibrahim Alogaili, BScAmman, Jordan

“The highlight of my experience would have to be receiving my hands on andrology technique certificate - it was a lot of

work but I am proud that I was able to complete the training requirements. I am taking away a lot from the experience.”Rian Salasin

Pennsylvania, USA

Read Additional Evaluations

“I gained so much theoretical and technical know-how from the comprehensive teaching in all the 6 modules that I was training in. Over the 2 months, the trainers personalized my teaching for maximum benefit and were ever willing to patiently explain and answer my queries. ”Abdullah Al Najmi, MD

Jazan, Saudi Arabia


ACRM Staff, Fellows and Students, Lerner Research Institute, July 2013


Sezgin Gunes, PhDSamsun, Turkey“The ART training was very valuable and helpful in learning the basics and the latest developments in IVF technologies and to transmit my genetic knowledge into reproductive medicine.”

Stefan du Plessis, MBA, PhDTygerberg, South Africa“Experienced embryologists provided individual training. The ART Course was tailored to specific needs.”

David Guerra, MD, OBGynFlorida, USA“Great training lab and patient teachers. Excellent learning material and friendly staff.”

Efiok Eyo Efiok, MBBCh, FWACSCross River State, Nigeria“Excellent hands-on training.”

Godwin Akhabhoa, FMCOG, FWACSLagos, Nigeria“The Director and other Departmental Personnel showed personal interest. Excellent teachers in a beautiful learning environment.”

Avraham Harlev, MDBeer-Sheba, Israel“The experience the Trainers have from previous years are reflected by their patient teaching.”

Abdullahi Abdulwahab-Ahmed, MDSokoto State, Nigeria“The hands-on nature of the course made it a standout way of learning the techniques of ART from

experienced and seasoned Trainers and Organizers.”

Ashlie Sadler, MAFlorida, USA“Hands on experience and knowledgeable teachers - everything is wonderful”

Arun Muthuvel, MDChennai, India“Each Trainee gets an individual Trainer. The Course was completely custom-made, I could

choose the areas where I needed more help. Trainers were very patient and were willing to teach us all the time. This is the only program that gives real hands-on training. This program is the best I could think of in any part of the world. Real spoon feeding!”

Oziga Dada Vincent, MBBS, FWACSDelta State, Nigeria“Excellent relationship between Trainers and Trainees. Good practical demonstration sessions.”

Zainab Shilbayeh, MDTexas, USA“The way the Trainers taught was very efficient. It was such an excellent experience here that I think I can’t find it anywhere else.”

Ini Jackson Etukudo, FWACSAkwa Ibom State, Nigeria“A theoretical background to all the hands-on activities are provided in lectures. The hands-on experience is excellent.”

Heidi Price, RMAFlorida, USA“This was a very helpful hands on training course.”

Zahraa Alyahaei, DPhilAl Ain, UAE“There was plenty of time to practise the techniques and discuss different topics related to the IVF lab with the Course Instructors. Excellent knowledge sharing and transfer.”

Mai Jawad Abdullah Al-Qattan, MBAKuwait City, Kuwait“Learning the most recent techniques and sharing of different knowledge with different co-workers was aneffective aspect of this course.”

Dharmaraj Palanisamy, MS, DNBTamil Nadu, India“Step by step procedure in ICSI and hands-on training that can never be forgotten. All teaching staff had the patience to teach head to toe within the stipulated period.”


Beatriz Jimenez Vanegas, MScTexas, USA“For me to switch from animal to human ICSI was an important step. Also the use of vitrification, as animal IVF uses more slow freezing. This course is a plus for me in this learning process and will help me in the future for my PhD.”

2014

2013

Twelve Years of ART Training (2004 - 2015): Feedback by our ART Training Alumni

6 | Cleveland Clinic American Center for Reproductive Medicine Learn more about our ART Training Program

Satya Baalasundaram, MVSc India, 2013“I liked the one to one, hands on experience and having been given more time to learn better. Also the lectures/presentations prior to training were very helpful.”

Johnkennedy Anyanwu, PhDTexas, USA, 2013“The one-on-one training was excellent and knowledgeable – I never felt hurried.”

Krishnan Kanniah, BSc Malaysia, 2013“There is a systematic training program for each day. The review process every morning about what we learnt the day before – brings about good explanation and discussion. Trainers were willing to answer questions and provide excellent explanation.”

Rizwan Malik, MDIndiana, USA, 2013“Lectures are excellentand informative. Great course, superb experience. Faculty and staff are very caring. Course was verywell organized.”

Sridevi Kammela, MDIndia, 2013“Trainers gave personalized commitment that benefited each candidate. Attention was also given to every detail.”

Sreedhar Kammela, MDIndia, 2013“There was strict punctuality throughout the course. I received a thorough update of scientific knowledge and an orientation to research.”

Saranda Murtezaj, BScKosovo, 2013“I enjoyed the many different ways of learning techniques from the trainers - this is different from what I am used to.”

Rifat Morina, PhDKosovo, 2013“The equipment and the possibility to learn new techniques were good. The possibility to get answers for every question regarding the course was perfect.”

Lillian Parzianello, BScBrazil, 2013“I had exclusive attention from the trainers; they were able to explain the procedures because they have many years of experience in their own labs. Training is provided by experts in IVF/Andrology that have published in the best journals. It was great to receive the best and complete textbook on ART, i.e. the ART-Practical Manual of IVF.”

Kannappan Palaniappan, MDMalaysia, 2013“Personalized guidance in teaching and in lab preparation. A well-structured course; very comprehensive.”

Kristina Staab, BScPennsylvania, USA, 2013“I was able to ask questions at any time and get immediate feedback.”

Jeanne Ricci, MScPennsylvania, USA, 2013“We were taught by different trainers and used different types of media.”

Gözde Köksal, MScTurkey, 2012“Excellent training with lots of opportunity for hands on work.”

Swetha Thumula, MDIndia, 2013“The hands on and one-to-one training is unique. The course is well organized and caters to what you want to learn. The feedback session everyday is excellent and gives you more confidence.”

Mahipal Singh, PhDAtlanta, USA, 2013“I commend the personal commitment of the staff and I enjoyed the home-like environment in the lab.”

Malathy Shanmugam, MBBS, DGOIndia, 2013“I was taught all about the basics of handling a microscope, micromanipulators, laser optical system etc. I also learnt to do ICSI confidently.”


Reem Taha, BScJordan, 2012“The hands on experience for me was the most effective because it provided me with practice and taught new techniques that I had never seen before.”

Sweta Tiwari, MDIndia, 2012“The one on one training for ART was excellent. The trainer taught the steps patiently and provided me with completeunderstanding of the protocols.”

Liliana-Aura Chitu, PhDRomania, 2012“As a result of the training provided at Cleveland Clinic, I was able to masterthe skills and achievedexterity in ART techniques.”

2013

2012

2011Raffaele DinardoItaly, 2011“Everything was amazing, especially the skills and patience of the trainers.”

Marisabel Hernandez, BScVenezuela, 2011“The most effective part for me was the hands on training. The equipment was in perfect condition, the lectures are in tune with the practices and the staff are very helpful. I think I improved exponentially and was able to see my own this progress.”

Bianca Kreuscher, MSBrazil, 2011“The course was extremely important, because Ilearned new things that I can use immediately. The best of all was having the opportunity to relate to important people and make new contacts. It was more than I expected.”


Helena Malvezzi, MSBrazil, 2011“I learned many new things and had the chance to meet and work with interesting people from all over the world.”

ACRM Staff and Fellows with the ART Trainer and Trainees, ACRM, Sept 2012

Kelly J Porter, HTL (ASCP)New Jersey, USA, 2010“Overall this was a great course with a tremendous amount of material. After spending a week at Cleveland Clinic, I have a much greater understanding of semen analysis and feel confident I will be able to introduce this testing to my facility. This week has also given me a greater sense of appreciation for Andrology in general.”

Canan Aslan, MScTurkey, 2010“Adequate hands on practice helped me master the techniques.”

2010

Christopher Danga, BSNigeria, 2009“Hands on training - I was given the opportunity to participate in cell biopsy and fixation, and advanced sperm function tests - everything was NEW!”

Carolina Sellito, PhDItaly, 2010“I would recommend the ART Training at the Cleveland Clinic to anyone who is looking to receive world class, hands on training in ART. The knowledge and friendships that I have brought back to Italy will be of immense significance to me for many years to come.”

2009

Romil Stanislavov, PhDBulgaria, 2009“The presentation and demonstration of the methods (are) in detail. Appropriate time (given) for discussion and questions.”

Gulnara Utepova, MDKazakhstan, 2009“Friendly staff. New information. Excellent overall course management and facility (is) conducive to learning.”


Mary Robert, MBBS, MD, DGOUnited Arab Emirates, 2004“The impossible being made possible! I benefited immensely from the precise manner by which the techniques were made simple. I am now able to perform the technique independently and with confidence.”

Troy Anhalt, BSWisconsin, USA, 2005“I enjoyed my time here. The staff were wonderful and I am exited to take this information back to my lab.”

Andrea Mustata, MDRomania, 2007“Hands-on-training techniques were very well organized. Very dedicated trainers who were patient and helpful. Excellent ART training.”

Lina Garcia, MTCPPuerto Rico, 2008“The experience was great. Everybody was very professional and willing to help me at all moments. I felt very happy about choosing this program and I will come back if I decide to expand.”

Pratima Sekhar, MDIndia, 2006 “It was a great experience being in such a huge IVF lab with the best of the infrastructure and technical personnel.”

Desta Gelagay, BS (ASCP)California, USA, 2008“The course has met every expectation that I had made for the class. The class was a ton of fun, but very intellectually challenging at the same time. I was able to learn a great deal of information that will help in my current job. The experience has motivated me to work harder.”

Luis A Murrain Jr, DONew York, USA, 2008“The one to one interaction with the instructors allowed the trainee to focus on the areas they feel they need to work on the most while meeting the course objectives. Helpful critique of technique and common pitfalls to avoid. This is an excellent training course for those seeking to learn new skills or refine their technique. The strong emphasis on research ensures the trainee will be up to date on current literature and treatment protocol.”

Amanda Setti, BSBrazil, 2007“I have learned everything I wanted to mainly because of the trainer’s knowledge and patience in teaching.”

Harry Beauvais, MDHaiti, 2007“The accessibility of the trainers to provide assistance and share their great experience was very valuable.”

Karuna Sharma, MDSaudi Arabia, 2006“The faculty members are very encouraging and they were boosting your morale all the time.”

Samina Naeem Khalid, MDPakistan, 2006“I liked the collaboration of researchers from all over the world – it gave me the opportunity to learn more.”

Chris Agboghoroma, MDNigeria, 2007“Very conducive atmosphere to learning.”

Pamela Herbst, MTFlorida, USA, 2005“This was a refresher course for me, so the hands on time was very valuable.”


2008 2006

2005

2004

2007

Cleveland Clinic’s American Center for Reproductive MedicineHands on Training in Assisted Reproductive TechnologyFor more info, contact Dr. Ashok AgarwalDirector of ART [email protected], +1.216.444.9485http://www.clevelandclinic.org/reproductiveresearchcenter/artmain.html

ACRM Staff and Fellows with ART Trainer and Trainees, Andrology Clinical Laboratory, Sept 2011


Training in Scientific Writing - Module 9 (120 hours)

Develop fundamental skills set necessary for you to write high quality scientific articles from start to completion:

• Conduct a systematic literature search and scientific review of identified articles

• Select the relevant articles and present significant findings from these reviewed articles

• Develop an outline of the proposed article

• Develop a strategy for scientific writing

• Edit, revise and finalize the manuscript for submission to a journal

Training in Bench Research - Module 10 (160 hours)

Develop fundamental skills necessary to conduct high quality scientific experiments in your laboratory:

• Design and develop a bench research project

• Conduct research by application of the relevant experimental techniques

• Acquire skills necessary for data analysis

• Develop the ability to present and write the research data in a methodical, scientifically and statistically sound manner

• Acquire skills to write a scientific report based on the outcomes of the research conducted

For more information, please contact

The Cleveland Clinic’s American Center Center for Reproductive Medicine gives you a unique opportunity to:• Receive mentoring by world-renowned faculty in medicine and health sciences• Participate in meaningful, real-time bench research experience• Engage in intensive training in scientific writing• Publish research articles in prestigious medical journals• Listen to captivating lectures delivered by a team of reputed scientists and physicians

To learn more about our Summer Internship Course, including program faculty, internship syllabus daily schedule, complete project listing, internship awards, pictures of interns’ presentations, reception banquet, multimedia feedback, and accommodation options, please visit our 2015 Summer Mentorship webpage.

Gain priceless research experience underthe guidance of world-renowned experts in

reproductive medicine, male fertility, and women’s health

at the Cleveland Clinic

Faculty

Program Director Coordinators Consultants

Ashok Agarwal, PhDProfessor, Lerner College of MedicineDirector, American Center for Reproductive MedicineDirector, Andrology CenterDepartment of UrologyCleveland Clinic

Rakesh Sharma, PhDAssociate Professor,Department of UrologyResearch Coordinator, American Center for Reproductive MedicineCleveland Clinic

Sajal Gupta, MDAssistant Professor,Department of UrologyAssistant Research Coordinator, American Center for Reproductive MedicineCleveland Clinic

Sijo Parekattil, MDCo-Director of Personalized Urology and Robotics ClinicSouth Lake Hospital and Orlando HealthClermont, Florida

Botros Rizk, MDProfessor of Ob-Gyn Reprod Endocrinol & InfertilityUniversity of South AlabamaMobile, Alabama

The American Center for Reproductive MedicineThe American Center for Reproductive Medicine (ACRM) is a part of the Glickman Urological and Kidney Institute of the Cleveland Clinic. The Department of Urology is ranked as the No. 2 Urology program in the nation by U.S.News & World Report.

The American Center for Reproductive Medicine enjoys an international reputation for excellence and innovation in human infertility research and is dedicated to disseminating its results. Research papers from the Center staff are selected regularly for publication in distinguished medical journals. The Center’s website has been ranked No. 1 for research in reproductive medicine and andrology since 2001 by all top five international search engines, including Google, Bing, Yahoo! and Ask.com. It has attracted over 930,000 visitors from all over the world.

More than 515 physicians and scientists from more than 50 countries have received their training at the American Center for Reproductive Medicine during the past 22 years. Nearly 140 students in majors ranging from biology to English to the musical arts have participated in summer internships at our Center.

2016

For additional information on internship staff, please visit our faculty page.

For more information, please contact

Make this a summer to remember!

· Ce

nter

for R

eproductive Medicine ·

Cleveland Clinic

Be part of theCleveland Clinic American Center

for Reproductive Medicine2016 Summer Internship

June 13 to July 29, 2016The 9th Annual Summer Mentorship Course in

“Reproductive Medicine and Research”

Josh Disbrow, MBACEO, Aytu BioScience Inc.

Suresh Sikka, PhDProfessor of Urology,

Tulane University, New Orleans

Hassan Sallam, MD, PhDProfessor of Ob-Gyn,

Alexandria University, Egypt

Cleveland ClinicAmerican Center for Reproductive MedicineMail Code X-1110681 Carnegie AvenueCleveland, OH 44195, USPhone: 216.444.9485Fax: 216.445.6049Email: [email protected]

Amer

ican



1993

Amer

ican



1993

Amer

ican



1993

Research Fellowship in

Human Reproduction and Male Infertility

Our Research Fellowship and training opportunities represent one of the most active, state-of-the-art and comprehensive programs in human reproduction and infertility in the United States.

Our Fellows gain priceless research experience under the strong mentorship of world-renowned experts in reproductive medicine and biology at our Center in the Cleveland Clinic.


Scientific Presentation Day, Summer Internship 2014, Lerner Research Institute

For more information, please contact:

Center for Reproductive Medicine and the Andrology CenterCleveland Clinic, X-1110681 Carnegie AvenueCleveland OH 44195, United StatesTel: +1.216.444.9485Toll-Free: 1.800.CCF.CARE (ext. 4-9485)Fax: +1.216.445.6049Email: [email protected]://www.ClevelandClinic.org/ReproductiveResearchCenter

Table of ContentsOur Mission 2Testimonials 2-3Application 3Who We Are 4Books Published 4Research Collaborators 5, 8, 9Research Overview 6 – 14Publications 8 – 14Recent Research Alumni 15 – 16Fulbright Research Scholars 17About Our Center 18 – 19Reproductive Research Alumni 20 – 22About Cleveland 23

NEW in 2016Other Training Modules at ACRM

ART Training Alumni 2004 - 2015Alumni

AlumniAm

eric

an Center for Reproductive Medicine


1993

Ranked One of America’s Top 5 Hospitals

Hands on Training in Assisted Reproductive Technology


Abu Dhabi

Austria

Bahrain

Brazil

Canada

Chile

China

Colombia

Croatia

Czech Republic

Egypt

Greece

Guyana

Hong Kong

India

Iraq

Israel

Italy

Jamaica

Japan

Jordan

Kazakhstan

Korea

Kosovo

Kuwait

Lebanon

Malaysia

Mexico

Nigeria

Pakistan

Peru

Philippines

Romania

Saudi Arabia

Serbia

Slovak Republic

South Africa

Spain

Syria

Turkey

UAE

USA

Venezuela

20042005

2008

2009

2006

2007

Eman Geneidi

Amanda SettiAline Souza

Anwar Al Harban

Gita Khanna

Carmen MirzanBetty John

Lina Garcia

Asifa Ehsani

Fu Nan Wang

Lidia de Oliveira

Anna Frusch

Mary Roberts

Xueyu Xiang

Harry Beauvais

Daniel de Matos Darlaine Dorval

Gabriela Parise

Madhuma ShilaharLuis Murrain Jr. Rizwan Malik

Christopher Danga

Harjot Kaur Chahlal

Andreea Mustata

Luciana Lopes

Desta Gelagay

Nilofer Poonawala

Gulnara Utepova

Pamela Herbst

Angelica Zuccolotto

Nirmala Agarwal

Franciele Lunardi

Nitin Lad

Leila Chalova

Arozia Moazzam

Ayodele Benson

Preethi Abraham

Heloisa Lavorato

Shital Punjabi

Karuna Sharma

Barbara Scheetz

Vaishali Kale

Israel Maldonado

SunithaSoundarapandian

Madhu Singh

Bruna Barros

Wirla Munhoz

Jaime Mendiola-Olivares

Surveen Sindhu

Pratima Sekhar

Carla Silva

Pallavi KhannaHullamani Puttapa

Jessica Torres

Wirla Munhoz

Sameera Madan

Chris Agoboghoroma

Amit Gupta

Kiran Bijlani

Samina Khalid

ChristinaAnagnostopoulou

Ana Paula Porto

Lakshmi Prasuna

Amanda Alvarez Eva Hernandez Mohamed Hajjo

2010

2011

2012

2013

2014

2015

Canan Aslan

Bruna Selbach

Caroline Lapa

Krishnan Kanniah

Arun Muthuvel

David Guerra

Vincent Oziga

Aijaz Anjum

Bianca Kreuscher

Amani Shaman

Kannappan Palaniappan

Zahraa Alyahaei

Sezgin Gunes

Carolina Sellitto

Janis Roman

Debora Rangel Helena Malvezzi

DamayanthiDurairajanayagam Gozde Koksal

Mariana De Mello

Kristina Staab Lilian Parzianello Rifat Morina

Abdullahi Ahmed

Zainab Shilbayeh Avraham Harlev

Kelly Porter

Laura Vellez

Julian Trejos

Mahipal Singh

Ashlie Sadler

Simon du Plessis

Priya Mehta

Lisa Fradl

MarisabelHernandez

Liliana-Aura Chitu

MalathyShanmugam

Beatriz Vanegas

Rian Salasin

Jason Krumholtz Aimee Parker

NataliyaSavateyeva

Midna Torres

Raffaele Dinardo

Reem Taha

Rizwan Malik

Dharmaraj Palanisamy

Abdullah Najmi

Osama Abdalmageed

Shubhadeep Roychoudhury

Rajul Tyagi

Shilla Chakrabarty

Saad Al-Dujaily

Rogerio de Souza

Saranda Murtezaj

Efiok Efiok

Bindu Garg

Romil Stanislavov

Susana Cordoba

Sarat Sajja

Saad Alshahrani

SatyaBaalasundaram

Godwin Akhabhoa

Gulfam Ahmad

Sarita Oberoi

Marilia Pieretti

Stella Antinori

Sreedhar Kammela

Heidi Price

Shweta Patki

Vessela Nikolova

Ana Nogueira

Moisa Pedrosa

Jeanne Ricci

Sridevi Kammela

Ini Etukudo

Ibrahim Alogaili

Ashish Kale

Addeli Angulski

Johnkennedy Anyanwu

Swetha Thumula

Mai Al-Qattan

Shazia Magray

ART

TRAI

NIN

G A

LUM

NI

2004 - 2015

ART TRAINING ALUMNI

2004 - 2015

Sweta Tiwari


” ” ”

”The spermatozoa and oocyte represent the personalized,

hands-on ART training course offered annually since

2003. Candidates from more than 41 countries

have participated in this course.

The open book and beaker represent the

Summer Internship program, offered annually

since 2008. Nearly 170 interns have experienced

bench research and scientific writing under the

personalized mentorship of scientists/physicians and

reproductive biologists worldwide.

The DNA strand represents the essence of the research

fellowship in human reproduction, andrology and male

infertility, offered at the ACRM since 1993. More than 500

scientists/physicians from over 50 countries have

trained at the ACRM. The Center is currently focusing

on the use of proteomics and bioinformatics to

elucidate biomarkers of male infertility.

The microscope and a hand holding the test tube represent the routine and advanced

diagnostic testing offered to infertility patients

at the Andrology Center and Reproductive Tissue

Bank, one of the largest state-of-the-art facilities in

the country. Our staff has more than 3 decades of experience

in assisting patients with male infertility.

American Center for Reproductive Medicine (ACRM)

Our Story

our vision our mission our values

“

“

“ “Am

eric

an Center for Reproductive Medicine


1993

To be a premier center for researchers interested in human reproduction, providing them individualized mentoring and high quality training opportunities that lead to technical, analytical, and intellectual expertise in the field.

We believe in integrity, excellence, innovation, accountability, commitment, perseverance, teamwork and collaboration.

To conduct cutting-edge research in human reproduction and into the causes of infertility, and to train physicians and scientists to advance the understanding of reproductive sciences.

Founded in 1993, the ACRM offers research fellowships, hands-on training in human assisted reproduction, and summer mentorship opportunities. We also offer diagnostic services for male infertility and cancer patients. In the past 23 years, more than 1,000 scientists, physicians, researchers, reproductive medicine professionals and students from all over the world have trained at our Center.


Cleveland Clinic’s Glickman Urological and Kidney Institute is recognized worldwide for excellence inpatient care, teaching and research. It merges Cleveland Clinic’s urology and nephrology programs. Urologyand nephrology physicians and scientists at Cleveland Clinic are recognized worldwide for excellence inpatient care, teaching and research. This year, U.S. News & World Report ranked our urology program No.2 and our kidney disease program No. 2 in the nation.Please visit us at: clevelandclinic.org/services/urology-kidney/about-urology-nephrology

About Cleveland ClinicNinety-five years ago, four physicians founded a new medical center in Cleveland. It was a nonprofit grouppractice where doctors from many specialties could collaborate for efficiency and better patient care. Theirmission was “to care for the sick, investigate their problems and educate those who serve.” Located inCleveland, Ohio, Cleveland Clinic is a nonprofit, multispecialty academic medical center that integratesclinical and hospital care with research and education. Today, with more than 1,400 beds on ClevelandClinic main campus and 4,450 beds system-wide, Cleveland Clinic is one of the largest and mostrespected hospitals in the country.

Today, Cleveland Clinic is a main campus, eight community hospitals and more than 75 outpatientlocations (including 16 family health centers) in northern Ohio, and facilities in Florida, Nevada, Torontoand Abu Dhabi. Our locations are linked by health information technology and critical care transport,getting patients to the right facility, at the right time, for the right care. Cleveland Clinic is organized intopatient-centered institutes based on single diseases or organ systems. Each institute combines medical andsurgical services at the same location under the same leadership to improve patient care and experience.Each institute is required to establish benchmarks and measure and improve quality. Institutes are alsorequired to publish annual outcomes books showing volumes, results, innovations, publications and otherinformation relevant to patients and referring physicians. Cleveland Clinic integrates its far-flung systemwith an extensive electronic medical records system. This system includes participating communityphysicians and patients, who are able to access test results and portions of their medical record remotelyvia the Internet. Cleveland Clinic’s model of medicine has made it possible for us to achieve cost savingson a vast scale over the past several years. Our mantra is “Patients First.” Our motto is “To Act as a Unit.”Our goal is to give every patient the best outcome and experience. That’s the Cleveland Clinic way.Visit: clevelandclinic.org

9500 Euclid Avenue, Cleveland, OH 44195

The Cleveland Clinic Foundation is an independent,not-for-profit, multispecialty academic medicalcenter. It is dedicated to providing quality specializedcare and includes an outpatient clinic, a hospitalwith more than 1,000 available beds, an educationdivision and a research institute.


For more information about Cleveland, visit these resources:About Cleveland, Cleveland.com, Cleveland, The New American City, Positively Cleveland, Travel Cleveland, and Discover Ohio.

Cleveland is the second largest city in the state of Ohio, after Cincinnati. Located on the southern shores of Lake Erie, Cleveland lies at the outflow of the Cuyahoga River into Lake Erie. The main campus of Cleveland Clinic is situated 5 miles east of downtown Cleveland. Case Western Reserve University and University Hospitals are within one mile of Cleveland Clinic. Cleveland State University and John Carroll University are also within a short distance of the Cleveland Clinic main campus. Nearby the Cleveland Clinic is University Circle, which serves as the cultural, medical and education center of Cleveland and Northeast Ohio. Medical research in the University Circle institutions places Cleveland as one of the major medical research environments in the country.

University Circle is also the home to the Cleveland Museum of Art, the Cleveland Institute of Music, the Cleveland Institute of Art, and the Museum of Natural History. The Cleveland Museum of Art houses one of the country’s most highly acclaimed art collections. The world-famous Cleveland Orchestra, performs regularly in the elegant Severance Hall. Playhouse Square is the home to several large theaters that host traveling Broadway plays and various other performances.

The University Circle area is walking distance from Cleveland’s historic Little Italy with its brick streets, a quaint and charming area of intimate Italian restaurants, antique and craft shops, and art galleries. The Coventry Village area is close to the Clinic’s main campus and popular with its shops and restaurants.

Cleveland hosts the Rock and Roll Hall of Fame and Museum, and the Great Lakes Science Center. Outdoor enthusiasts of all ages enjoy the ‘Emerald Necklace’, the Cleveland Metroparks network of parks that encircles the city, which offer a variety of recreational opportunities. When it comes to professional sports, Cleveland is the proud home to the Browns football, Cavaliers basketball, Indians baseball and Lake Erie Monsters hockey teams respectively. As the Great Lakes city on America’s North Coast, Cleveland offers abundant lakeshore for different activities.

Cleveland and its surrounding suburbs are home to nearly 3 million residents. A vibrant and versatile metropolitan area, Cleveland has nearly 80 residential communities. Fine residential areas are located within minutes of the Cleveland Clinic campus. Recognized as one of the best places to live and visit, Cleveland and North-East Ohio is bustling with exciting things to do for people of all ages.

Art Museum Duck Pond in Spring Cleveland skyline in Summer Autumn in the Park Lake Erie in Winter

Cleveland — a great place to call HOME!

Rock and Roll Hall of Fame

State Theater Playhouse Square Beachwood Place Mall

Cuyahoga Valley National Park Edgewater Park

Browns Stadium

CopyrightAmerican Center for Reproductive Medicine, Cleveland Clinic Foundation, United States of America

Editor: Ashok Agarwal l Consultant: Damayanthi Durairajanayagam l Graphic Design: Bernastine BuchananFirst Edition: Jan 15, 2016


n t e rfoRepro ducti C e ve a n M i c ed er ic m in A e Ce 1 9 9 ......About Cleveland Clinic The American Center for Reproductive Medicine Cleveland Clinic’s American Center for

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