Mycotoxins contamination of animal feed

Mycotoxins contamination of animal feed

Francois StepmanNovember 18th- 20th 2015 Berlin

16th annual meeting of the Inter-Agency Donor Group (IADG) on pro-poor livestock research and development

courtesy of Prof. dr. Siska CROUBELSDepartment of Pharmacology, Toxicology and Biochemistry

Faculty of Veterinary Medicine – Ghent University

www.mytox.be

• Introduction• AflaNet to be funded by German BLE• Influencing EC funded research

Outline of the presentation

01-02 October 2014. Berlin, Germany. Federal Ministry for Economic Development and Cooperation (BMZ). Expert meeting on Food Safety for Nutrition Security discussing aflatoxin.

4

Mycotoxins:

• Introduction• Effects in animals• Effects on intestinal barrier function• Consequences of impaired barrier function• Transfer of residues to animal food products

Effects on animal health

Pig reduced performancereduced feed utilization and efficiencyimpaired fertilityskin lesions

Poultry reduced performance“fatty liver” syndromedecreased egg productionpoor carcass quality

Cattle reduced milk yieldimpaired fertilitymastitisketonuria

Horse neurotoxic syndrome

Subclinical doses: immunosuppressive effects

CLINICAL EFFECTS IN ANIMALS

dr. J. Leus

www.mycotoxins.infowww.thepoultrysite.com

Dependent on

- type and dose

- duration of exposure

- species, gender, age, health status

- synergistic effects (single vs. multiple toxins)

www.efsa.eu.intwww.knowmycotoxins.com

www.thepoultrysite.comwww.mycotoxins.info

CLINICAL EFFECTS IN ANIMALS

EFFECTS OF MYCOTOXINS

www.mycotoxins.info

EFFECTS OF MYCOTOXINS

www.mycotoxins.info

EFFECTS OF MYCOTOXINS

www.mycotoxins.info

Small intestine:• Absorption of water and nutrients• Dynamic barrier

GASTROINTESTINAL TRACT: FIRST TARGET FOR MYCOTOXINS

MYCOTOXINS IMPAIR INTESTINAL BARRIER

Altered intestinal functions:CONSEQUENCES?

Enhanced susceptibility to enteric infections?

Altered digestion and absorption of nutrients?

Altered absorption of veterinary drugs and feed additives?

Toxins, 2014

TRANSFER OF MYCOTOXINS TO ANIMAL FOOD PRODUCTS

•Feed contamination: 1 mycotoxin << multimycotoxin (1+1 = sometimes 3)

•Effect of high contamination levels of the feed (rare) on animal health is mostly known, however the effects of low to moderate contamination levels (frequently occurring) is less well-known

•Even low contamination levels (< max. EU guidance levels) can have a negative effect on poultry, pigs, …

•Economic impact of mycotoxins ≠ animals with clinical mycotoxicosis

TAKE-HOME MESSAGES

•Negative impact on the intestinal morphology and function: -enhanced susceptibility for infectious diseases-altered digestion and absorption of nutrients-altered absorption of veterinary drugs

•Modulate the immune response

•(Partial) hydrolysis of masked DON and release of native DON in poultry and pigs

•Limited transfer of residues to animal food products, except e.g. for aflatoxin B1 (M1) to milk and ochratoxin A to kidney tissue

TAKE-HOME MESSAGES

AflaNETNetworking on aflatoxin reduction in the food value chain

Application at BLE German Federal Office for Agriculture and Food

Joint cooperation in the area of combating Aflatoxin contamination

Department of Safety and Quality of Cereals

16th annual meeting of the Inter-Agency Donor Group (IADG) on pro-poor livestock research and development

01.05.23 17

Associated partners

• JKI Federal Research Centre for Cultivated Plants • FLI Federal Research Institute for Animal Health• PAEPARD Platform for African – European Partnership• EAFF Eastern Africa Farmers Federation• KALRO Kenya Agricultural and Livestock Research Organization • ILRI International Livestock Research Institute• AflaStop Project funded by the ACDI/VOCA organization • GIZ GmbH Deutsche Gesellschaft für Internationale Zusammenarbeit

MRI – Federal Research Institute of Nutrition and Food

The goal is to initiate a long-lasting scientific network between African and German

partners by working out the possibilities to reduce aflatoxins in the food value chain

via close contacts.

Project leader MRI Federal Research Institute of Nutrition and FoodDr. Christine Schwake-Anduschus

Budget 173.312 – Duration 12/2015 – 12/2016

16th annual meeting of the Inter-Agency Donor Group (IADG) on pro-poor livestock research and development

Workpackages

01.05.23 18MRI – Federal Research Institute of Nutrition and Food

WP 2 Applicability of rapid test kits for aflatoxin detection

WP 3Aflatoxin M1 development:Knowledge about the ratio B1 feed/M1milk

WP 4Aflatoxin B1 inactivation ofbiosynthesis at the molecular level

WP 6 dissemination of project results, Networking East-Africa and Kenya-Germany

Prospects of Minimization of Aflatoxin in Feed and Food in KenyaLong lasting Cooperation of

German Federal Institutes and Kenyan/ East-African Key Actors

Installation of sustainable relationships

WP 1Liasion officer in KenyaExcursion andExperts survey on siteConference and exchangewith scientists and active groups in Kenya, e.g. EAFF, KALRO, ILRI, PACA, MRI, JKI, FLI

Germany Kenya

WP 5 Capacity building: visits of Kenyan scientists at MRI

16th annual meeting of the Inter-Agency Donor Group (IADG) on pro-poor livestock research and development

Please contact the project leader

Dr. Christine Schwake-AnduschusMax Rubner-Institut

Department of Safety and Quality of CerealsSchuetzenberg 12

32756 Detmold, GermanyTel 0049 (0) 5231 741 132

[email protected]

www.mri.bund.de

Advisory participation is appreciated !

01.05.23 19MRI – Federal Research Institute of Nutrition and Food

1. mobile phone apps on awareness creation and moisture control;

2. the use of binders in feed to reduce waste and give an incentive to farmers for contaminated crops which should be destroyed;

3. biological control measures: in particular the use of antagonistic bio control agents in addition to the bio control agent ‘aflasafe™’. The use of Trichoderma strains or extracts as bio-fertilizer or bioagents also out-competes Aspergius flavius in the soil.

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