Multifactorial d1

HEALTH.2012.2.1.2-2: SYSTEMS MEDICINE: APPLYING SYSTEMS BIOLOGY APPROACHES FOR

UNDERSTANDING MULTIFACTORIAL HUMAN DISEASES AND THEIR CO-MORBIDITIES

Partners:- Donetsk national medical university

Departments of Histology, Cytology and Embryology, Propaedeutics of Internal Medicine, Department of Dermatology, Medical Biophysics, Medical Equipment and Clinical Informatics

-Laboratory of fundamental research (Institute of Urgent and Recovery Surgery)

MULTIFACTORIAL HUMAN DISEASES AND THEIR CO-MORBIDITIES

Embryonic development

Genotype

Diet, nutrients Environmental factors

Life Style

INTRINSIC AND EXTRINSIC FACTORS INTERACTION

Various clinical manifestation Co-morbidities???

DiabetesDiabetes

AtherosclerosisAtherosclerosis

ObesityObesity

Coronary diseases

Coronary diseases

Digestive system pathology

Digestive system pathology

Endocrinological disturbance

Endocrinological disturbance

Autonomic system dysregulacation

Autonomic system dysregulacation

Metabolical disturbance Metabolical disturbance

ImmunopatholgyImmunopatholgy

Co-morbidities of multifactorial diseases

Proposition

Gene polymorphism

Cells response and resistance to different stimuli

Investigation of Cross-interactions in regulatory axis and metabolic ways of affected organs and their dependence on

individual reactivity of organism

PATIENTS WITH:

PROPOSED DESIGN OF INVESTIGATION

ClinicalInstrumentalLaboratoryBiochemicalImmunoenzymological

METHODS:

ATHEROSCLEROSIS

ANGINA. INFARCTION OF MYOCARDIUM

ISCHEMIC STROKE

PEPTIC ULCERS OF STOMACH AND DUODENUM

MorphologicalImmunocytochemicalMoleculo-geneticBiostatistics, Neurocybernetics

PROPOSED DESIGN OF INVESTIGATION

Regulatory axis in affected organ, system

Interlinks / co-morbities

Organ specific regulators

Regenerative potential

Metabolic peculiarities

State of innate and adaptive immunity

Network analysis

PLATELETS

Participate in:

- atherothrombosis- inflammation- vessels remodeling- reparation

PROPOSED MODEL FOR ANALYSIS

In vitro analysis of: AggregationSensitivity to systemic and organospecific regulators

PLATELETS AS SENSORS OF CARDIOVACULAR SYSTEM AND MIRROW OF REACTIVITY

Intracellular signaling systemsGranules and hyaloplasm content Enzymes activity

PLATELETS

Are targets for:

- Hormones- Neurotransmitters- cytokines- chemokines

1. Establish the role and key determinants of reactivity of organism in organospecific pattern of multifactorial diseases.

2. Detect the key regulatory factors in development, progression and risk of co-morbid pathology associated with AS.

3. Develop the system of prognostic criteria of organospecific manifestation of atherosclerosis.

EXPEXTED RESULTS

DEVELOPMENT OF INDIVIDUALIZED STRATEGY OF THERAPY