MULTI-MODAL FLUORESCENCE IMAGING OF CONTRACTING INTACT HEARTS 2 nd BE-OPTICAL School: 2-5 May 2017, Torun Vineesh Kappadan Research Group Biomedical Physics Max Planck Institute for Dynamics and Self-Organization Project Supervisors Prof. Ulrich Parlitz & Dr. Jan Christoph Research Group Biomedical Physics Max Planck Institute for Dynamics and Self-Organization
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MULTI-MODAL FLUORESCENCE IMAGING OF
CONTRACTING INTACT HEARTS2nd BE-OPTICAL School: 2-5 May 2017, Torun
Vineesh Kappadan
Research Group Biomedical Physics
Max Planck Institute for Dynamics and Self-Organization
Project Supervisors
Prof. Ulrich Parlitz & Dr. Jan Christoph
Research Group Biomedical Physics
Max Planck Institute for Dynamics and Self-Organization
Introduction
Heart and Diseases
Sudden Cardiac Arrest (SCA) is a leading cause of death in Europe affecting0.35-0.7 million people every year.
About 25-30 % SCA victims have ventricular fibrillation (VF), a heartrhythm disorder [1].
1. European Resuscitation Council Guidelines for Resuscitation 2010, Rudolph W. Koster, Michael A Baubin
Heart Rhythm Disorders (Cardiac Arrhythmias)
Occurs due to malfunctioning of electrical activity of heart
Sinus Rhythm TachycardiaVentricular
Fibrillation[Numerical simulation by P. Bittihn,
Biomedical Physics Group, 2012]
ECG of heart
Cardiac Arrhythmias
Presence of spiral waves
Electrical Conduction System of Heart
Electrical impulses are responsible for mechanical contraction
Electrical Signal: SA Node AV node Bundle branches Purkinje Fibres