Mouse Nomenclature - Washington University Department of ...genetics.wustl.edu/.../2018/03/0301-TA-PPT-v.5-Mouse-Nomenclature.pdf · Genes & Loci •First letter capitalized •Italicized

Mouse NomenclatureMarch 1st, 2018

Wild-type…

• Not exactly wild…

• Inbred is 20 consecutive generations of sib mating

• C57BL/6J

• C57Bl = parent strain

• 6 = line

• J = Jackson Lab code

• Lab codes are where cross was carried out

• J – Jackson

• Mcw – Medical College of Wisconsin

• Kyo – Kyoto University

• Mit: MIT

Crossing Strains

• Progeny of hybrids, designated by F1

• Intercrossing two F1s -> F2

• D2B6F1

• DBA/2 mother & C57BL6/J father

• D2B6F2

• offspring of a D2B6F1 cross

Genes & Loci

• First letter capitalized

• Italicized

• Example

• Apc = adenomatosis polyposis coli

• Mutant allele name may be placeholder for unknown gene

• Leprdb used to be Dbdb

• Loci: D8Mit17 = 17th locus to mouse chromosome 8 by MIT

Alleles

• Named by phenotype

• Superscripted

• Italicized

• Dominant = first letter uppercase

• Recessive = all lowercase

• Examples:

• ApcMin = dominant, multiple intestinal neoplasia allele of the adenomatosis polyposis coli gene.

• Leprdb = recessive, diabetes allele of the leptin receptor gene.

Genotypes

• Includes genetic background - geneallele/lab designation

• Example

• MRL/MpJ-Faslpr/J

Induced mutation

• Includes lab code after allele

Transgenic Strains

Proteins

• All capital letters

• No italics

• Examples

• LEPR

• APC

Comparison of All

Resources

• http://www.informatics.jax.org/mgihome/nomen/

• https://www.jax.org/news-and-insights/jax-blog/2013/august/top-seven-tips-for-understanding-mouse-nomenclature

• http://www.informatics.jax.org/mgihome/nomen/strains.shtml