MOLECULAR DIAGNOSTICS CORE HOUSTON METHODIST RESEARCH INSTITUTE Molecular Diagnostics Core Core Director: Randall J. Olsen, MD, PhD 713.441.6802 Email: [email protected]Core Staff: Dilzi Mody 713.441.1771 Email: [email protected]houstonmethodist.org/molecular-diagnostics Houston Methodist Research Institute 6670 Bertner Avenue Houston, TX 77030 houstonmethodist.org/research HMRI Communications & External Relations | RICORE-018 | MM | DH | 250 | 08.2014 M.D. ANDERSON BLVD. MOURSUND ST. M.D. Anderson Cancer Center BERTNER AVE. BATES ST. McGovern Commons & Trevisio UNIVERSITY BLVD. DRYDEN RD. JOHN FREEMAN BLVD. St. Luke’s Hospital Texas Children’s Hospital Texas Heart Institute WILKINS ST. E. CULLEN ST. ROSS STERLING AVE. Garage 1 Baylor College of Medicine Marriot Garage 7 University of Texas Health & Science P P P P Jones Tower Outpatient Center P P FANNIN ST. RICE UNIVERSITY SOUTH MAIN ST. N R Smith Tower Scurlock Fondren Building Tower Rice Bioscience Research Collaborative Texas Children’s Neurological Research Institute A Mary Gibb Jones Building Research Institute Houston Methodist METRORAIL DRYDEN/TMC METRORAIL STATION P PARKING MAP LEGEND FONDREN BUILDING ACCOMODATIONS R A
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MOLECULAR DIAGNOSTICS CORE
HOUSTON METHODISTRESEARCH INSTITUTE
Molecular Diagnostics Core
Core Director: Randall J. Olsen, MD, PhD713.441.6802Email: [email protected]
The Houston Methodist Research Institute Molecular Diagnostics Core facility provides Houston Methodist investigators and the Texas Medical Center community with access to advanced molecular tools for research studies.
All equipment is conveniently located in the Molecular Diagnostics Core Laboratory in Fondren 554. User training and instrument reservations can be scheduled using iLab.
FACILITY
The Molecular Diagnostics Core provides investigators access to cutting-edge instrumentation for expression analysis, SNP genotyping, and other molecular assays. Some of the available technologies include:
Capillary Electrophoresis – The Agilent 2100 is a microfluidics-based platform offering solutions for the analysis of DNA, RNA, proteins and cells. Typical applications include: • RNA sample QC prior to microarray or
qPCR experiments • DNA Analysis of PCR/mPCR and RT-PCR
products • Protein expression analysis • Protein purity during purification • Cell-based analysis in gene silencing or
apoptosis
Spectrophotometry – The NanoDrop® ND-1000 UV-Vis Spectrophotometer enables highly accurate analyses with remarkable reproducibility, eliminates the need for cuvettes and capillaries, and need for most dilutions. This technology is used for: • Nucleic Acid Measurement • Microarray labeling QC • Protein Measurement • Cell Culture
Microarray Instrumentation – The Affymetrix GeneChip® Instrument System is one of the most advanced microarray analysis platforms available to generate reliable, Gene Expression Analysis and DNA Analysis data. The Dell Precision 490 workstation accompanies the GeneChip System.
Software • Affymetrix Software • Partek Genomics Suite
The core offers training for the use of instrumentation, assistance in the design of experimental protocols, and ongoing consultation and support. Core instrumentation is available for self-use by trained investigators.