molecular biology

ANA MILENA SÁNCHEZ HENAOMEDICINE STUDENT

III SEMESTER

TEACHER:LINA MARÍA MARTÍNEZ

SÁNCHEZMOLECULAR BIOLOGY

AUGUST 27

The place where the assembly is made of proteins is the ribosome, which in order to provide ideal structures and genetically altered not to remain in perfect condition and have been properly synthesized without bad replication of RNAs requiring programmed control part of the cells to destroy it if necessary and so prevent a number of malformations and diseases of

this origin that cause mortality or decreased quality of life for the population

To find out whether medicines are effective, you need to understand how the receptors in the cell wall work. An important means of achieving this is to crystallize the protein, so that it can be examined with x-rays.

“Since then, a handful of structures of other receptors have appeared in the scientific literature, but at such a low resolution that in some cases it was even difficult to determine how medicines bind to such receptors” “With our new structure, we have achieved the highest resolution ever for any protein in the human cell wall”

Degree of detail of the new high-resolution

crystal structure makes it

possible to see

This gives an insight into the

way natrium ions affect the working of hormones and

neurotransmitters in the body

Previously, they had used the protein lysozyme for this process

But this time they used proteins that crystallize even

more easily and that are a better match for the

receptor

By binding the receptor protein, that is oily and therefore does not easily crystallize, to another protein that crystallizes readily, the researchers were able to produce minuscule crystals of the fusion product.

Research indicates that coffee drinkers are less susceptible to developing Parkinson's disease.

Caffeine has been shown to inhibit the effect of the receptor,

adenosine A2A, associated with this disorder.

I believe the future that this research will therefore have a clear objective and the results obtained have been very important and contributors. It seems very interesting , since it is a breakthrough that supports and strengthens the scientific studies about the intervention and modification of proteins that serves as a molecular target for pharmaceutical treatment of pathologies related, in addition, these studies can understand the origins of many diseases and be defined accuracy from molecular biology.

"The existing knowledge about relatives from the so-called rhomboid protease family did not help us in our quest for the molecules processed by the enzyme we discovered," says Dr. Lemberg. Unlike all rhomboid proteases that had been studied so far, the new rhomboid localizes to the Endoplasmic Reticulum (ER), the site in the cell where new membrane proteins are produced.

"WE NOW HAVE REVEALED THAT THE ER RHOMBOID PROTEASE CLEAVES ABERRANT MEMBRANE PROTEINS WITHIN THEIR MEMBRANE ANCHOR”, SAYS DR. LEMBERG

The scientists demonstrated The scientists demonstrated that this protease cooperates that this protease cooperates directly with components of the directly with components of the so-called ER-associated so-called ER-associated degradation (ERAD) pathway to degradation (ERAD) pathway to dispose of the faulty protein.dispose of the faulty protein.

These new insights now provide the basis for a molecular understanding of how membrane proteins that the make up a large fraction of cellular proteins are extracted from these membranes for degradation without getting into each other’s way

These new insights now provide the basis for a molecular understanding of how membrane proteins that the make up a large fraction of cellular proteins are extracted from these membranes for degradation without getting into each other’s way

Recognize and detect each protein forms a structure that contributes to better management of it and thus to better techniques to modify, create or transform, this being a good target for treating deadly diseases

Recognize and detect each protein forms a structure that contributes to better management of it and thus to better techniques to modify, create or transform, this being a good target for treating deadly diseases may, in this notice are working with a receiver A2A adenosine receptor that is a caffeine from the body, work and handling of the 2A2 receiver released an important preventive method on Parkinson's disease since it was discovered that A2A receptor inhibition by caffeine drinkers in people coffee the risk of suffering from the disease diminishes what excellent advances patents on knowledge and control of diseases that are becoming increasingly more common in our society.

This new is very important because discovering how to degrade defective proteins believed to cause metabolic disorders, cellular and systemic reduces mortality in human population and the qualityof life improves and some way to prolong life

Recognize that the accumulation of misfolded proteins can seriously damage cells causing Alzheimer's and Parkinson causes the genetic material can be manipulated to reduce the risk of such diseases or proteins that are targets of destruction or treatment, which decreases the incidence of these diseases if detected early.

 Martinez Sánchez, Lina Maria. “Biología Molecular” 7ª edition UPB medical faculty

 “Highest Resolution Ever for Human Protein” .Science daily , July 11 /2012  “How Cells Degrade Aberrant membrane”. Science daily, July 13 /2012