Molecular and Rheological Characterization of Hyaluronic Acid and Equine Synovial Fluid for the Treatment of Lameness in Horses Sara Tracy Advisors: Dr. Skip Rochefort PhD and *Dr. Jill Parker VMD DACVS Department of Chemical Engineering and *College of Veterinary Medicine Oregon State University Corvallis, Oregon
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Molecular and Rheological Characterization of Hyaluronic Acid and Equine Synovial Fluid for the Treatment of Lameness in Horses Sara Tracy Advisors: Dr.
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Molecular and Rheological Characterization of Hyaluronic Acid and Equine Synovial Fluid
for the Treatment of Lameness in Horses
Sara TracyAdvisors: Dr. Skip Rochefort PhD and *Dr. Jill Parker VMD DACVS
Department of Chemical Engineering and *College of Veterinary MedicineOregon State University
Corvallis, Oregon
Objective
• Establish baselines for the properties of healthy joints• Correlate concentration and molecular weight of HA to
viscoelastic properties• Study the difference between healthy and diseased
synovial fluid
Motivation
• The equine industry looses up to one billion each year due to lameness
• Up to 14% of the horse population has problems with lameness
• Hyaluronic acid is used to treat lameness and joint pain in both horses and humans
Motivation
Hyaluronic Acid (HA)
Sodium Hyaluronate, HyaluronanSodium Hyaluronate, Hyaluronan• Made up of repeating glucuronic acid and N-Made up of repeating glucuronic acid and N-
acetylglucosamine subunitsacetylglucosamine subunits• High molecular weight: 0.2 to 10 million DaltonHigh molecular weight: 0.2 to 10 million Dalton• Major component of synovial fluidMajor component of synovial fluid• Exhibits viscoelastic propertiesExhibits viscoelastic properties
Synovial FluidMultipurpose fluid surrounding all Multipurpose fluid surrounding all articular jointsarticular joints
Has both viscous and elastic Has both viscous and elastic properties properties