Modeling of inter- and intra-particle coating uniformity in a Wurster fluidized bed by a coupled CFD-DEM-Monte Carlo approach Zhaochen Jiang a,b,⇑ , Christian Rieck b , Andreas Bück a , Evangelos Tsotsas b a Institute of Particle Technology (LFG), FAU Erlangen-Nuremberg, Cauerstr. 4, 91058 Erlangen, Germany b Thermal Process Engineering, Otto-von-Guericke University Magdeburg, Universitaetsplatz 2, 39106 Magdeburg, Germany highlights Modeling of Wurster coating by a coupled CFD-DEM-Monte Carlo approach. Prediction of intra- and inter-particle layer thickness and uniformity of porosity. Calculated residence time distributions are in accordance with PEPT measurement . Intra-particle layer thickness distribution agrees well with coating experiment. graphical abstract article info Article history: Received 21 June 2019 Received in revised form 18 September 2019 Accepted 12 October 2019 Available online 16 October 2019 Keywords: Coating Surface coverage Monte Carlo CFD-DEM Wurster fluidized bed abstract A coupled CFD-DEM and Monte Carlo approach was developed to investigate coating properties in a Wurster fluidized bed by considering gas flow, particle motion, droplet deposition, and the drying and solidifying of droplets on particle surfaces. Based on the spherical centroidal Voronoi tessellation (CVT), the Monte Carlo approach can model the deposition and splashing of spray droplets on the surface of individual particles. The capillary force induced by liquid bridges between particles was accounted in the DEM to investigate its influence on the coating and agglomeration behavior. The new model can pro- vide information about the cycle time distribution, residence time distribution, coating coverage, unifor- mity of porosity (influenced by splashing) and layer thickness distributions on each individual particle (intra-particle) and in the particle population (inter-particle). The simulation results are compared with experimental data on residence time and intra-particle layer thickness distributions. Good agreement is observed between the simulation and the measurements. Ó 2019 Elsevier Ltd. All rights reserved. 1. Introduction Coating of particulate materials is widely applied in the phar- maceutical, food, cosmetic, and fertilizer industries. In pharmaceu- tical applications, polymer-based film coating is critical to control https://doi.org/10.1016/j.ces.2019.115289 0009-2509/Ó 2019 Elsevier Ltd. All rights reserved. ⇑ Corresponding author at: Institute of Particle Technology (LFG), FAU Erlangen- Nuremberg, Cauerstr. 4, 91058 Erlangen, Germany. E-mail address: [email protected] (Z. Jiang). Chemical Engineering Science 211 (2020) 115289 Contents lists available at ScienceDirect Chemical Engineering Science journal homepage: www.elsevier.com/locate/ces
Modeling of inter- and intra-particle coating uniformity in a Wurster fluidized bed by a coupled CFD-DEM-Monte Carlo approach
Jun 15, 2023
Welcome message from author
This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
Related Documents
