Mike P. Holzer, MD Annett Mannsfeld, MSc Angela Ehmer, MSc Gerd U. Auffarth, MD [email protected] International Vision Correction.

Mike P. Holzer, MDAnnett Mannsfeld, MSc

Angela Ehmer, MSc

Gerd U. Auffarth, MD

[email protected] www.lasik-hd.de

International Vision Correction Research Centre

Dept. of Ophthalmology, University of Heidelberg, GermanyActing chairman: G.U. Auffarth, MD

Corneal changes following INTRACOR

femtosecond laser treatment

Study and research has

been supported by

Technolas Perfect Vision GmbH, Heidelberg, Germany

Femtosecond Laser: Femtec

Mike P. Holzer, MD

Femtec (Technolas Perfect Vision GmbH, Heidelberg, Germany) CE mark FDA 510k clearance 40 kHz

FEMTEC fixation of eye:

Curved patient interface

less stress on cornea

less suction pressure

INTRACOR

• Purely intrastromal refractive

treatment with Femtec Laser

• No cut of epithelium,

Bowman‘s or Descemet

• No incision, pockets etc.

• Cut design and stromal depth

algorithm depending on

refractive error

• Duration approx. 20 seconds

Mike P. Holzer, MD

Patients & Methods

• Ongoing prospective, multicenter study

• Approval of Ethics Committee (Univ. of Heidelberg)

• Intrastromal correction of presbyopia

• 25 patients treated between July & Sept. 2008

• Age 56.2 ± 5.79 years (range 47 – 67 years)

• Up to 6 months postoperative follow up

• Minimum near add +2.0 D

• Non dominant eye treatedMike P. Holzer, MD

4 days preop

INTRACOR Presbyopia

Mike P. Holzer, MD

4 days preop 1 hour postop 1 week postop

1 hour postop

Cavitation gas in ring cuts

1 day postop

Gas escaped from cornea

Development near UCVA

Mike P. Holzer, MD

0.7 = 20/100 0.26 = 20/30

n=25 n=25 n=25 n=25 n=24

* p < 0.01Friedman-Test

*

DCNVA:0.23 ± 0.08 logMAR

Development near UCVA

Mike P. Holzer, MD

preop

3M postop

Near and distance visual acuity

Distance correction

preop 3M postop

Sphere +0.75 D ± 0.23 D +0.15 ± 0.31 D

Cylinder -0.33 D ± 0.17 D -0.42 ± 0.23 D

preop D1 W1 M1 M3

UCDVA 0.11 ± 0.11 0.09 ± 0.10 0.06 ± 0.08 0.06 ± 0.09 0.05 ± 0.10

BCDVA -0.06 ± 0.06 na na -0.02 ± 0.06 0.00 ± 0.07

UCNVA 0.70 ± 0.16 0.39 ± 0.25 0.39 ± 0.22 0.36 ± 0.18 0.26 ± 0.21

DCNVA 0.59 ± 0.12 na na 0.33 ± 0.17 0.23 ± 0.18

BCNVA -0.04 ± 0.08 na na 0.01 ± 0.10 -0.03 ± 0.07

Mike P. Holzer, MD

Pentacam pre- / 3M postop: Exp. 1

Mike P. Holzer, MD Preop 3M postop central steepening

Pentacam pre- / 3M postop: Exp. 2

Mike P. Holzer, MD Preop 3M postop central steepening

Corneal asphericity

Mike P. Holzer, MD

pre anterior

preposterior

1M anterior

1M posterior

3M anterior

3M posterior

Mean value

-0.20 -0.34 -0.25 -0.43 -0.26 -0.41

Std. Dev. 0.16 0.16 0.16 0.18 0.18 0.18

Q-value (6.0 mm)

Q-value more negative following INTRACOR treatment

Summary: INTRACOR

• High potential for correction of presbyopia

• Non invasive very low risk for infections

• Stable refractive outcome during follow up period

• Significant gain in uncorrected near visual acuity

• Slight central steepening and negative q-value

• No weakening of cornea

• Future treatments: low myopia / hyperopia / astigmatism,

retreatments of remaining refractive errors following

IOL- or Excimer Laser Surgery

Mike P. Holzer, MD