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MIGRANT STUDIES Ronald E. LaPorte, Ph.D. Director, Disease Monitoring and Telecommunications WHO Collaborating Center, Professor of Epidemiology
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MIGRANT STUDIES Ronald E. LaPorte, Ph.D. Director, Disease Monitoring and Telecommunications WHO Collaborating Center, Professor of Epidemiology.

Jan 18, 2018

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Page 1: MIGRANT STUDIES Ronald E. LaPorte, Ph.D. Director, Disease Monitoring and Telecommunications WHO Collaborating Center, Professor of Epidemiology.

MIGRANT STUDIES

Ronald E. LaPorte, Ph.D.Director, Disease Monitoring and

Telecommunications WHO Collaborating Center, Professor of

Epidemiology

Page 2: MIGRANT STUDIES Ronald E. LaPorte, Ph.D. Director, Disease Monitoring and Telecommunications WHO Collaborating Center, Professor of Epidemiology.

Questions

• What is a Migrant Study?• How do Migrant Studies differ from

Admixture Studies?• What is the future for Admixture and

Migrant Studies?

Page 3: MIGRANT STUDIES Ronald E. LaPorte, Ph.D. Director, Disease Monitoring and Telecommunications WHO Collaborating Center, Professor of Epidemiology.

Migrants

pilgrimrefugeeconquerorsdisplaced people

Page 4: MIGRANT STUDIES Ronald E. LaPorte, Ph.D. Director, Disease Monitoring and Telecommunications WHO Collaborating Center, Professor of Epidemiology.

Migrant Studies

Studies taking advantage of migration to one country by those from other countries with different physical and biological environments, cultural background and/or genetic makeup, and different morbidity or mortality experience.

Page 5: MIGRANT STUDIES Ronald E. LaPorte, Ph.D. Director, Disease Monitoring and Telecommunications WHO Collaborating Center, Professor of Epidemiology.

From (KOFF)1967 PITTSBURGH

Page 6: MIGRANT STUDIES Ronald E. LaPorte, Ph.D. Director, Disease Monitoring and Telecommunications WHO Collaborating Center, Professor of Epidemiology.

Growth of Racial/Ethnic Groups in U.S.A.

0

20

40

60

80

100

120

AsianHispanicOtherIndianBlackWhite

Percent

Page 7: MIGRANT STUDIES Ronald E. LaPorte, Ph.D. Director, Disease Monitoring and Telecommunications WHO Collaborating Center, Professor of Epidemiology.

The migration of human populationprovides a tool for the study of therespective roles of host and environmentalfactors in the development of disease.

Page 8: MIGRANT STUDIES Ronald E. LaPorte, Ph.D. Director, Disease Monitoring and Telecommunications WHO Collaborating Center, Professor of Epidemiology.

05

1015202530

Rise and Fall of Migrant Studies

Page 9: MIGRANT STUDIES Ronald E. LaPorte, Ph.D. Director, Disease Monitoring and Telecommunications WHO Collaborating Center, Professor of Epidemiology.

Migratory Patterns

Jan Dorman

Ireland,1817Germany,1920

Poland, 1900

Page 10: MIGRANT STUDIES Ronald E. LaPorte, Ph.D. Director, Disease Monitoring and Telecommunications WHO Collaborating Center, Professor of Epidemiology.

Migration Patterns

Trevor Orchard

England, 1979

Page 11: MIGRANT STUDIES Ronald E. LaPorte, Ph.D. Director, Disease Monitoring and Telecommunications WHO Collaborating Center, Professor of Epidemiology.

Migratory Pattern

Ron LaPorte

France, 1819

Germany, 1880

Quebec, 1820

Buffolo,NY Pittsburgh,PA

Page 12: MIGRANT STUDIES Ronald E. LaPorte, Ph.D. Director, Disease Monitoring and Telecommunications WHO Collaborating Center, Professor of Epidemiology.

1993 Refugees to U.S.

Former Soviet Union 52,000

East Asia52,000South East Asia 7,000

Africa7,800

Latin America 3,500

EasternEurope,1,500

Page 13: MIGRANT STUDIES Ronald E. LaPorte, Ph.D. Director, Disease Monitoring and Telecommunications WHO Collaborating Center, Professor of Epidemiology.

MIAMI

HAVANA

1970s1950s

Page 14: MIGRANT STUDIES Ronald E. LaPorte, Ph.D. Director, Disease Monitoring and Telecommunications WHO Collaborating Center, Professor of Epidemiology.

Migrant Studies

SourcePopulation

Migrant Pop

HostPopulation

Page 15: MIGRANT STUDIES Ronald E. LaPorte, Ph.D. Director, Disease Monitoring and Telecommunications WHO Collaborating Center, Professor of Epidemiology.

Incidence of Disease X in source, host, and migrant populations

Environmental etiology

Page 16: MIGRANT STUDIES Ronald E. LaPorte, Ph.D. Director, Disease Monitoring and Telecommunications WHO Collaborating Center, Professor of Epidemiology.

Incidence of Disease X in source, host, and migrant populations

Genetic etiology

Page 17: MIGRANT STUDIES Ronald E. LaPorte, Ph.D. Director, Disease Monitoring and Telecommunications WHO Collaborating Center, Professor of Epidemiology.

Migrants are almost neverrepresentative of their nativepopulations

Page 18: MIGRANT STUDIES Ronald E. LaPorte, Ph.D. Director, Disease Monitoring and Telecommunications WHO Collaborating Center, Professor of Epidemiology.

Existing Migrant Data

Page 19: MIGRANT STUDIES Ronald E. LaPorte, Ph.D. Director, Disease Monitoring and Telecommunications WHO Collaborating Center, Professor of Epidemiology.

Some example of IDDM incidence per 100000

Nationality

Russian 5 (Siberia) 9 (Estonia)

Norwegian 22 (Norway) 8 (Iceland)

French 8 (4 areas) 8 (Quebec)

Chinese 7(Shanhai) 3(Hawaia)

Japanese 2 (some areas) 3 (Hawaia)

Jewish 6 (Israel) 15 (Canada)Mexican 1(Some areas) 10 (Colorado)

Source Migrant

Page 20: MIGRANT STUDIES Ronald E. LaPorte, Ph.D. Director, Disease Monitoring and Telecommunications WHO Collaborating Center, Professor of Epidemiology.

Differences in Incidence, Migration vs Geographic

Variation Ratios Absolute

Differences

Migration 3-6 16

Geographic Differences

50 34

Page 21: MIGRANT STUDIES Ronald E. LaPorte, Ph.D. Director, Disease Monitoring and Telecommunications WHO Collaborating Center, Professor of Epidemiology.

Questions

• What is a Migrant Study?• How do Migrant Studies differ from

Admixture Studies?• What is the future for Admixture and

Migrant Studies?

Page 22: MIGRANT STUDIES Ronald E. LaPorte, Ph.D. Director, Disease Monitoring and Telecommunications WHO Collaborating Center, Professor of Epidemiology.

Admixture studiesHybrid populations

Parent population

1

H1

H2

H3

Parent population

2

Page 23: MIGRANT STUDIES Ronald E. LaPorte, Ph.D. Director, Disease Monitoring and Telecommunications WHO Collaborating Center, Professor of Epidemiology.

Incidence of Diseases X in source and hybrid populations

Page 24: MIGRANT STUDIES Ronald E. LaPorte, Ph.D. Director, Disease Monitoring and Telecommunications WHO Collaborating Center, Professor of Epidemiology.

Correlation of Incidence of Disease X and admixture proportion

Admixture proportion

Incidence

AB C

DE

FG H

I

Page 25: MIGRANT STUDIES Ronald E. LaPorte, Ph.D. Director, Disease Monitoring and Telecommunications WHO Collaborating Center, Professor of Epidemiology.

Migration Time Line

1st Generation

Environmental“Shower”

Genetic Change

3rd Generation2nd Generation

Cultural Change

ClimateViruses

ShowersCulture Genetics

Full Assimilation

Page 26: MIGRANT STUDIES Ronald E. LaPorte, Ph.D. Director, Disease Monitoring and Telecommunications WHO Collaborating Center, Professor of Epidemiology.

Migration Time Line

1st Generation

Environmental“Shower”

Genetic Change

3rd Generation2nd Generation

Cultural Change

Beginning Loss of Language Changes in Diet

Page 27: MIGRANT STUDIES Ronald E. LaPorte, Ph.D. Director, Disease Monitoring and Telecommunications WHO Collaborating Center, Professor of Epidemiology.

IDDM in Asian Populations

01234567

JPN

TAIW

ATa

iland

Kor

ea

Haw

aii(j

apan

ese)

CA

(Kor

eian

s)

per 100000

Ten fold Difference

Page 28: MIGRANT STUDIES Ronald E. LaPorte, Ph.D. Director, Disease Monitoring and Telecommunications WHO Collaborating Center, Professor of Epidemiology.

Questions

• What is a Migrant Study?• How do Migrant Studies differ from

Admixture Studies?• What is the future for Admixture and

Migrant Studies?

Page 29: MIGRANT STUDIES Ronald E. LaPorte, Ph.D. Director, Disease Monitoring and Telecommunications WHO Collaborating Center, Professor of Epidemiology.

Heritage Research: The Next Generationof Migrant Studies

Page 30: MIGRANT STUDIES Ronald E. LaPorte, Ph.D. Director, Disease Monitoring and Telecommunications WHO Collaborating Center, Professor of Epidemiology.

Heritage studies

Genetic factors

Parent population

1

H1

H2

H3

Environmental Factors

Page 31: MIGRANT STUDIES Ronald E. LaPorte, Ph.D. Director, Disease Monitoring and Telecommunications WHO Collaborating Center, Professor of Epidemiology.

IDDM Incidence in Latin America

02468

1012

Spai

n

Bra

zil

Cub

a

Chi

li

Peru

Incidence per 100 000

Page 32: MIGRANT STUDIES Ronald E. LaPorte, Ph.D. Director, Disease Monitoring and Telecommunications WHO Collaborating Center, Professor of Epidemiology.

SPAIN

NORTHandSOUTHAMERICA

Iberian - heritage collaboration