MIGRANT STUDIES Ronald E. LaPorte, Ph.D. Director, Disease Monitoring and Telecommunications WHO Collaborating Center, Professor of Epidemiology
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MIGRANT STUDIES
Ronald E. LaPorte, Ph.D.Director, Disease Monitoring and
Telecommunications WHO Collaborating Center, Professor of
Epidemiology
Questions
• What is a Migrant Study?• How do Migrant Studies differ from
Admixture Studies?• What is the future for Admixture and
Migrant Studies?
Migrants
pilgrimrefugeeconquerorsdisplaced people
Migrant Studies
Studies taking advantage of migration to one country by those from other countries with different physical and biological environments, cultural background and/or genetic makeup, and different morbidity or mortality experience.
From (KOFF)1967 PITTSBURGH
Growth of Racial/Ethnic Groups in U.S.A.
0
20
40
60
80
100
120
AsianHispanicOtherIndianBlackWhite
Percent
The migration of human populationprovides a tool for the study of therespective roles of host and environmentalfactors in the development of disease.
05
1015202530
Rise and Fall of Migrant Studies
Migratory Patterns
Jan Dorman
Ireland,1817Germany,1920
Poland, 1900
Migration Patterns
Trevor Orchard
England, 1979
Migratory Pattern
Ron LaPorte
France, 1819
Germany, 1880
Quebec, 1820
Buffolo,NY Pittsburgh,PA
1993 Refugees to U.S.
Former Soviet Union 52,000
East Asia52,000South East Asia 7,000
Africa7,800
Latin America 3,500
EasternEurope,1,500
MIAMI
HAVANA
1970s1950s
Migrant Studies
SourcePopulation
Migrant Pop
HostPopulation
Incidence of Disease X in source, host, and migrant populations
Environmental etiology
Incidence of Disease X in source, host, and migrant populations
Genetic etiology
Migrants are almost neverrepresentative of their nativepopulations
Existing Migrant Data
Some example of IDDM incidence per 100000
Nationality
Russian 5 (Siberia) 9 (Estonia)
Norwegian 22 (Norway) 8 (Iceland)
French 8 (4 areas) 8 (Quebec)
Chinese 7(Shanhai) 3(Hawaia)
Japanese 2 (some areas) 3 (Hawaia)
Jewish 6 (Israel) 15 (Canada)Mexican 1(Some areas) 10 (Colorado)
Source Migrant
Differences in Incidence, Migration vs Geographic
Variation Ratios Absolute
Differences
Migration 3-6 16
Geographic Differences
50 34
Questions
• What is a Migrant Study?• How do Migrant Studies differ from
Admixture Studies?• What is the future for Admixture and
Migrant Studies?
Admixture studiesHybrid populations
Parent population
1
H1
H2
H3
Parent population
2
Incidence of Diseases X in source and hybrid populations
Correlation of Incidence of Disease X and admixture proportion
Admixture proportion
Incidence
AB C
DE
FG H
I
Migration Time Line
1st Generation
Environmental“Shower”
Genetic Change
3rd Generation2nd Generation
Cultural Change
ClimateViruses
ShowersCulture Genetics
Full Assimilation
Migration Time Line
1st Generation
Environmental“Shower”
Genetic Change
3rd Generation2nd Generation
Cultural Change
Beginning Loss of Language Changes in Diet
IDDM in Asian Populations
01234567
JPN
TAIW
ATa
iland
Kor
ea
Haw
aii(j
apan
ese)
CA
(Kor
eian
s)
per 100000
Ten fold Difference
Questions
• What is a Migrant Study?• How do Migrant Studies differ from
Admixture Studies?• What is the future for Admixture and
Migrant Studies?
Heritage Research: The Next Generationof Migrant Studies
Heritage studies
Genetic factors
Parent population
1
H1
H2
H3
Environmental Factors
IDDM Incidence in Latin America
02468
1012
Spai
n
Bra
zil
Cub
a
Chi
li
Peru
Incidence per 100 000
SPAIN
NORTHandSOUTHAMERICA
Iberian - heritage collaboration
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