MIGRA MIGRA Ç Ç ÕES, DOEN ÕES, DOEN Ç Ç AS EMERGENTES E DOEN AS EMERGENTES E DOEN Ç Ç AS AS TROPICAIS TROPICAIS Luís Távora Tavira
MIGRAMIGRAÇÇÕES, DOENÕES, DOENÇÇAS EMERGENTES E DOENAS EMERGENTES E DOENÇÇAS AS TROPICAISTROPICAISLuís Távora Tavira
BASIC CONCEPTS
EMERGING DISEASES & GEOGRAPHICAL DISTRIBUTION
CAN TROPICAL DISEASES EMERGE IN THE NORTH?
STUDY CASE 1: MALARIA
STUDY CASE 2: DENGUE
STUDY CASE 3: LEISHMANIASIS
CONCLUSIONS & QUESTIONS
DISCUSSION
3
3
5
3
3
3
5
60
TIM
EL
INE
EBOLATIMELINE
1973 Rotavirus Enteritis/Diarrhea
1976 Cryptosporidium Enteritis/Diarrhea
1977 Ebola virus VHF
1977 Legionella Legionnaire’s dz
1977 Hantaan virus VHF w/ renal flr
1977 Campylobacter Enteritis/Diarrhea
1980 HTLV-1 Lymphoma
1981 Toxin prod. S.aureus Toxic Shock Synd.
1982 E.coli 0157:H7 HUS
1982 HTLV-II Leukemia
1982 Borrelia burgdorferi Lyme disease
1983 HIV AIDS
1983 Helicobacter pylori Peptic ulcer dz
1988 Hepatitis E Hepatitis
1989 Hepatitis C Hepatitis
1990 Guanarito virus VHF
1991 Encephalitozoon Disseminated dz
1992 Vibrio cholerae O139 Cholera
1992 Bartonella henselae Cat scratch dz
1993 Sin Nombre virus Hanta Pulm. Synd.
1994 Sabia virus VHF
1994 Hendra virus Respiratory dz
1995 Hepatitis G Hepatitis
1995 H Herpesvirus-8 Kaposi sarcoma
1996 vCJD prion Variant CJD
1997 Avian influenza (H5N1) Influenza
1999 Nipah virus Encephalitis
1999 West Nile virus Encephalitis
2001 BT Bacillus anthracis Anthrax
2003 Monkeypox Pox
2003 SARS-CoV SARS
CHOLERA
AIDS
BA
SIC
CO
NC
EP
TS
EMERGING DISEASE REMARKS
Class Diseases
New Disease AIDS ;
Ebola;
Legionnaires; Nipah virus infection
Old Disease, New Place
Smallpox, the New World, 16th
Century,
Black death (plague), Europe, 14th
Century
Hepatitis E, Haiti ;
West Nile fever, NY, 1999 Reintroduced
Plague, India;
Dengue fever, Texas ;
Measles, United States;
Malaria, Korea; Adenovirus, US Military training camps
New Population
Malaria, US soldiers in Somalia ; Marburg virus, lab workers in Germany
;
Cholera, PeruIncreased Virulence
Influenza, 1918 worldwide pandemic;
H5N1 influenza, Hong Kong ;
E. coli O157:H7, United States
Drug Resistance
Campylobacter;
Malaria;
Strep
BA
SIC
CO
NC
EP
TS
TROPICAL DISEASES
TDR
disease
category
Disease burden
DALYs* (thousands)
Deaths
(thousands)
Total Male Female Total Male Female
African trypanosomiasis 1 1,525 996 559 48 31 17
Dengue 1 616 279 337 19 8 10
Leishmaniasis 1 2,090 1,249 840 51 30 21
Malaria 2 46,486 22,243 22,242 1,272 607 665
Schistosomiasis 2 1,702 1,020 681 15 10 5
Tuberculosis 2 34,736 21,905 12,831 1,566 1,030 536
Chagas disease 3 667 343 324 14 8 7
Leprosy 3 199 117 82 6 4 2
Lymphatic filariasis 3 5,777 4,413 1,364 0 0 0
Onchocerciasis 3 484 280 204 0 0 0
GE
OG
RA
PH
ICA
LGLOBAL
GE
OG
RA
PH
ICA
LCHOLERA
MALARIA
EM
ER
GIN
G D
ISE
AS
ES
& G
EO
GR
AP
HIC
AL
DIS
TR
IBU
TIO
NMALARIA
ANOPHELES
LEISHMANIASIS
SLEEPING SICKNESS
CH
AN
GIN
G P
AT
TE
RN
SSOUTH TO NORTH
REMARKS
NORTH TO SOUTH
REMARKS
ST
UD
Y C
AS
E 1
: MA
LA
RIA
STATUS
MYTHS
RISKS
FACTS
ST
UD
Y C
AS
E 2
: DE
NG
UE
STATUS
MYTHS
RISKS
FACTS
ST
UD
Y C
AS
E 3
: LE
ISM
AN
IAS
ISSTATUS
MYTHS
RISKS
FACTS
CO
NC
LU
SIO
NS
CONCERNING TROPICAL DISEASES AS EMERGENT
1973 Rotavirus Enteritis/Diarrhea
1976 Cryptosporidium Enteritis/Diarrhea
1977 Ebola virus VHF
1977 Legionella Legionnaire’s dz
1977 Hantaan virus VHF w/ renal flr
1977 Campylobacter Enteritis/Diarrhea
1980 HTLV-1 Lymphoma
1981 Toxin prod. S.aureus Toxic Shock Synd.
1982 E.coli 0157:H7 HUS
1982 HTLV-II Leukemia
1982 Borrelia burgdorferi Lyme disease
1983 HIV AIDS
1983 Helicobacter pylori Peptic ulcer dz
1988 Hepatitis E Hepatitis
1989 Hepatitis C Hepatitis
1990 Guanarito virus VHF
1991 Encephalitozoon Disseminated dz
1992 Vibrio cholerae O139 Cholera
1992 Bartonella henselae Cat scratch dz
1993 Sin Nombre virus Hanta Pulm. Synd.
1994 Sabia virus VHF
1994 Hendra virus Respiratory dz
1995 Hepatitis G Hepatitis
1995 H Herpesvirus-8 Kaposi sarcoma
1996 vCJD prion Variant CJD
1997 Avian influenza (H5N1) Influenza
1999 Nipah virus Encephalitis
1999 West Nile virus Encephalitis
2001 BT Bacillus anthracis Anthrax
2003 Monkeypox Pox
2003 SARS-CoV SARS
ABOUT CHANGING PATTERNS
QU
ES
TIO
NS
LINGUAGENS E IDIOMAS
PRODUÇÃO E REGULAÇÃO DA EVIDÊNCIA
MEDIAEPIDEMICS
GLOBALIZAÇÃO E TRANSFERÊNCIA DE TECNOLOGIA