Midbrain dopamine controls anxiety-like behavior by ... Dopamine controls anxiety-like behavior.pdf61 Anxiety is a complex, multi-circuit behavioral phenomenon characterized by a prolonged
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Midbrain dopamine controls anxiety-like behavior by engaging unique interpeduncularnucleus microcircuitry
Steven R. DeGroot, Rubing Zhao-Shea, Leeyup Chung, Paul M. Klenowski,Fangmiao Sun, Susanna Molas, Paul D. Gardner, Yulong Li, Andrew R. Tapper
Please cite this article as: DeGroot S.R., Zhao-Shea R., Chung L., Klenowski P.M., Sun F., MolasS., Gardner P.D., Li Y. & Tapper A.R., Midbrain dopamine controls anxiety-like behavior by engagingunique interpeduncular nucleus microcircuitry, Biological Psychiatry (2020), doi: https://doi.org/10.1016/j.biopsych.2020.06.018.
This is a PDF file of an article that has undergone enhancements after acceptance, such as the additionof a cover page and metadata, and formatting for readability, but it is not yet the definitive version ofrecord. This version will undergo additional copyediting, typesetting and review before it is publishedin its final form, but we are providing this version to give early visibility of the article. Please note that,during the production process, errors may be discovered which could affect the content, and all legaldisclaimers that apply to the journal pertain.
10.5 ng), or saline control (n=15). (One-way ANOVA with repeated measures: F(2, 35)= 523
25
11.43, p = 0.0002). *p≤0.05, ***p≤0.001. Data presented as mean ± SEM. (C) Total arm 524
entries in the EPM after drug infusion. (One-way ANOVA with repeated measures: F(2, 525
35) = 0.6541, p=0.5261). Data presented as mean ± SEM. (D) Representative heat map 526
of mouse position in the OFT after infusion of drug into the IPN (left). Quantification of 527
center time in the OFT (right). (n=10, 9, 8 for saline, agonist, antagonist, respectively, 528
One-way ANOVA with repeated measures: *p≤0.05, **p≤0.01, F(2, 24) = 8.558. Mean ± 529
SEM.) (E) Quantification of total distance moved in the OFT. There was no significant 530
difference between groups. (One-way ANOVA with repeated measures: F (2, 24) = 1.437, 531
p=0.2574). Data are presented as mean ± SEM. 532
Figure 8. Circuit model for DA signal amplification in the IPN. Circles represent 533
neurons, the lines originating from the circles represent axons and the triangles 534
represent terminals. The terminals are set so that the side of the triangle opposite the 535
axon faces its presumed target. Each color represents a unique population of neurons. 536
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References 550
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Figure 2
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Figure 4.
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***Baseline 10 µM DA Wash
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VTA DAergic neurons
Glutamatergic neuronsNet release activated by GABA(MHb dominant)
Glutamatergic neuronsNet release inhibited by GABA(MHb sparse)