Iron/Caffeine as a Catalytic System for Microwave-Promoted Benzamide Formation Chemistry of Amide; nature, application, synthetic method アアアののの ののの ののの のののの ;、、 Microwave Chemistry; principle, feature アアアアアのの ; ののののの Application of microwave to chemical reactions のののののののののののののの Eur. J. Org. Chem. 2015, 417 2015/05/22 Isamu Katsuyam
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Iron/Caffeine as a Catalytic System for Microwave-Promoted Benzamide Formation
Chemistry of Amide; nature, application, synthetic method
アミドの化学;性質、応用、合成方法Microwave Chemistry; principle, feature マイクロ波化学 ; 原理や特徴 Application of microwave to chemical reactions マイクロ波の化学反応への応用
Eur. J. Org. Chem. 2015, 417
2015/05/22 Isamu Katsuyama
アミドの化学
自然界では、タンパク質、生理活性天然物などに存在
R1 N
O
R2
R3R1 N
O
R3
R2
• 化学的に安定• ほとんどのアミドは平面構造• アミド基は極性が高い(水素結合、静電相互作用)
性質
生理活性化合物の活性発現に関与していることが多い。
合成医薬品への応用例
アミドの主な合成法
“One-pot” oxidative amidation from alcohols with amines
Coupling reaction from calboxylic acids with amines