Microneedle patch array for point-of-care medicine 1 We have developed a novel open-channel microneedle patch to address the clinical need for unskilled, painless collection of blood or transcutaneous delivery of pharmaceuticals. Skin is penetrated by ultra-sharp grooved microneedles that introduce microfluidic channels across the skin. The patch has a microfluidic network connected to microneedle channels for molecular analysis or drug delivery. The microneedle patch is passively filled by capillary action. This technology will allow soldiers to perform blood diagnostics and administer drugs rapidly across the skin in combat or disaster relief situations. www.derm101.com/inflammatory/embryol ogic-histologic-and-anatomic- aspects/blood-vessels/ http://www.wisegeek.org/why -do-mosquito-bites-itch.htm The field has focused on manufacture of microneedles that penetrate the superficial capillary plexus estimated to be at a depth of at least 600 microns. • Optimal microneedle designs for painless blood collection and drug delivery • Scale-out manufacture of microneedle arrays 2 • Integration of microneedle with microfluidics for molecular analysis or drug delivery 3D laser lithography Nanoscribe GmbH Prototype mould Elastomeric negative mould Thermoplastic replicas . Background Research Goals Manufacturing Process 1. Nordon, R.E., Davies, G.J., Anthony, C., Prewett, P., Faraji Rad, Z Microfluidic devices and fabrication. International PCT Application No. PCT/AU2015/05 2. Romar Engineering Pty Ltd
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Microneedle patch array for point-of-care medicine1
We have developed a novel open-channel microneedle patch to address the clinical need for unskilled, painless collection of blood or transcutaneous delivery of pharmaceuticals. Skin is penetrated by ultra-sharp grooved microneedles that introduce microfluidic channels across the skin. The patch has a microfluidic network connected to microneedle channels for molecular analysis or drug delivery. The microneedle patch is passively filled by capillary action. This technology will allow soldiers to perform blood diagnostics and administer drugs rapidly across the skin in combat or disaster relief situations.
www.derm101.com/inflammatory/embryol
ogic-histologic-and-anatomic-
aspects/blood-vessels/ http://www.wisegeek.org/why
-do-mosquito-bites-itch.htm
The field has focused on manufacture of microneedles that penetrate the superficial capillary plexus estimated to be at a depth of at least 600 microns.
• Optimal microneedle designs for painless blood collection and drug delivery
• Scale-out manufacture of microneedle arrays2
• Integration of microneedle with microfluidics for molecular analysis or drug delivery
3D laser lithography Nanoscribe GmbH
Prototype mould Elastomeric negative mould
Thermoplastic replicas.
Background
Research Goals
Manufacturing Process
1. Nordon, R.E., Davies, G.J., Anthony, C., Prewett, P., Faraji Rad, Z Microfluidic devices and fabrication. International PCT Application No. PCT/AU2015/05
2. Romar Engineering Pty Ltd
Microneedle patch array for point-of-care medicine
Submicron resolution 3D printing directly from CAD drawings (SEM*)
High fidelity replication of thermoplastic microneedles (SEM)
* SEM Scanning Electron Micrographs
Drug delivery
1
2sin
wR
2w
2 sinleakP
w
12cos
wR
2w
2 cosCP
w
Passive filling by capillary tension
Delivery of fluorescein into skin
Penetration of skin (confocal microscopy)
Microneedle array after skin penetration
Disposal (no sharps)
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