Microfluidics Mixing Chamber. 1.Where? / With Whom? 2.Intro to Project 3.Proposal 4.How?

Microfluidics Mixing Chamber

1. Where? / With Whom?

2. Intro to Project

3. Proposal

4. How?

Micro-Fabrication Facility (MFF)

• Dr. Michael Khbeis• Kristopher Lawler• Andy Lingley

Class 10000 cleanroom -> Class 10011,500 sq ft of wet & dry lab space• Photolithography• Nanolithography• Dry Etch• PVD• CVD• Thermal processing• Metrology

Turbulent

Laminar

How is microfluidic mixing different?

[5]

Reynolds Number[2]

Re = (ρ * V * L) / mu• Dimensionless measure of the ratio of inertia force to viscous force• Inertial forces = density (ρ) * velocity (V) * gradient of the velocity

(dV/dx)• Viscous forces = dynamic viscosity coefficient (μ) * second gradient of

the velocity (d2V/dx2)

• High Reynolds numbers - turbulent mixing• Low Reynolds numbers - mixing relies on diffusion

0.1 = (1000kg/m3 * 0.0001m * 0.001m/s) [1] 0.001Ns/m2

Passive Microfluidic Mixers[1]

• Lamination• Intersecting Channels • Zigzag Channels • Three-Dimensional Serpentine Structures• Embedded Barriers • Slanted Wells • Surface-Chemistry Technology in Microchannels

Laminar mixing

• Diffusion limited• Takes time and distance

[1]

Intersecting and Zigzag Channels

[1]

[1]

Three-Dimensional Serpentine Structures and Grooves

[1]

[4]

Embedded Barriers

Hong Chamber

[6]

Questions?

[7]

1. Lee CY, Chang CL, Wang YN, Fu LM (2011) Microfluidic mixing: a review. Int J Mol Sci 12: 3263–3287.

2. Benson, Tom. "Reynolds Number." Reynolds Number. NASA.gov, 22 May 2009. Web. 18 Apr. 2013. <http://www.grc.nasa.gov/WWW/K-12/airplane/reynolds.html>.

3. De Buryn Kops, Steve, and Jim Riley. "Turbulent Mixing." EFluids Gallery Image and Description. EFluids.com, n.d. Web. 18 Apr. 2013. <http://www.efluids.com/efluids/gallery/gallery_pages/mixing_page.htm>.

4. "Injection Molding Static Mixing Nozzle (Type SMN)." - StaMixCo Polymer Melt Viscous Processing Static Mixer Products & Technology. Stamixco-usa.com, n.d. Web. 18 Apr. 2013. <http://www.stamixco-usa.com/products/injection-molding-mixing-nozzle-and-filter/default.html>.

5. "Mass Transport · Teaching Notes." Department of Chemical Engineering and Biotechnology. University of Cambridge, 2013. Web. 18 Apr. 2013. <http://www.ceb.cam.ac.uk/pages/mass-transport.html>.

6. "Microfluidic CFD Applications: Multiphase Mixing and Bubble Dynamics." Microfluidics Applications: Simulating Multiphase Mixing. Flow Science, n.d. Web. 19 Apr. 2013. <http://www.flow3d.com/apps/microfluidics/multiphase-mixing.html>.

7. Applied Physical Sciences - Chemistry: Andres W. Martinez, Scott T. Phillips, and George M. Whitesides Three-dimensional microfluidic devices fabricated in layered paper and tape PNAS 2008 105 (50) 19606-19611; published ahead of print December 8, 2008, doi:10.1073/pnas.0810903105

Works Cited