Microbubble Super - Localisation in Human Lower Limb Microvasculature with Motion Correction Sevan Harput, Kirsten Christensen-Jeffries, Yuanwei Li, Jemma Brown, Paul Aljabar, Robert J. Eckersley, Christopher Dunsby and Meng-Xing Tang Rotterdam 19-20 January 2017
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Microbubble Super-Localisation in Human Lower Limb … · Microbubble Super-Localisation in Human Lower Limb Microvasculature with Motion Correction Sevan Harput, Kirsten Christensen-Jeffries,
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Peripheral Artery Disease and Intermittent Claudication
Patient Group Hypothesis
1 - Healthy VolunteersLarge difference in microvascular flow
before and after exercise
2 - ClaudicationSmall difference in microvascular flow
before and after exercise
3 - DiabetesAlmost no difference in microvascular flow
before and after exercise
Figure: http://www.adameducation.com
CEUS imaging of human lower limb
Motion Estimation1
(non-rigid registration)
Transformation Matrix
Spatio-temporal Filtering
B-mode
Contrast
Motion Correction(non-rigid)
Noise Threshold(depth-dependant)
MB detection2,3 Super-Localization2,3
Motion Estimation &Correction (rigid)
Motion Correction(rigid)
Transformation Matrix
1 Rueckert et al. "Nonrigid Registration Using Free-Form Deformations: Application to Breast MR Images", IEEE Trans Med Imag, 1999.2 Viessmann et. al. “Acoustic super-resolution with ultrasound and microbubbles.,” Phys. Med. Biol., 2013.3 Christensen-Jeffries et. al. “In Vivo Acoustic Super-Resolution and Super-Resolved Velocity Mapping Using MBs”, IEEE Trans Med Imag, 2015.
Rigid Motion Estimation & Correction
Figure: Christensen-Jeffries “Super-Resolution Ultrasound Imaging with Microbubbles”, PhD Thesis, 2016.