Int.J.Curr.Microbiol.App.Sci (2017) 6(8): 1899-1911 1899 Original Research Article https://doi.org/10.20546/ijcmas.2017.608.224 Microbiological Profile of Childhood Pneumonias in Hyderabad, India Vipparti Haritha 1* and V.V. Shailaja 2 1 Department of Microbiology, Malla Reddy Institute of Medical Sciences, Hyderabad, Telangana state, India 2 Department of Microbiology, Gandhi Medical College, Hyderabad, Telangana state, India *Corresponding author ABSTRACT Introduction Lower respiratory tract infections are a persistent and pervasive public health problem, placing a considerable strain on the health budget and are generally more serious than upper respiratory tract infections. They cause a greater burden of disease worldwide than human immunodeficiency virus infection, malaria, cancer, or heart attacks (1). Pneumonia is a form of acute Lower Respiratory Tract Infection that affects the lungs and has being the single largest cause of death in children. Worldwide, 35-40% mortality among children aged less than 5 years is attributed to respiratory tract infections accounting for 2.04 million deaths/year. In India, more than 4 lakh deaths every year are due to pneumonia accounting for 13%-16% of all deaths in the pediatric hospital admissions (2, 3). Clinicians use a wide range of disease definitions, such as tracheitis, acute bronchitis, bronchiolitis and pneumonia, depending on the symptoms and signs and anatomic structure involved, aspiration pneumonia, obstruction pneumonia and ventilator-associated pneumonia based on International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 6 Number 8 (2017) pp. 1899-1911 Journal homepage: http://www.ijcmas.com The present study was undertaken from 30/6/11 – 14/8/12 to know the Bacterial, and Mycological profile profile and drug susceptibility patterns in children suffering from pneumonias. Sputa (expectorated and induced) and Pleural fluid were collected from 113 cases and processed by conventional methods. Antibiotic sensitivity testing of these isolates was done as per CLSI guidelines. Bacterial pathogens were isolated in 44.25% of cases from both Sputum and Pleural fluid. Klebsiella pneumoniae was the predominant isolate 28% followed by Pseudomonas aeruginosa 24% and Staphylococcus aureus 22%. 72% of Staphylococcus aureus strains were Methicillin Resistant. Candida albicans was the most common isolated fungi 6.2% followed by Non Albicans Candida from sputum samples. Pleural fluid cultures for fungi were negative. Respiratory tract infections are a significant public health problem in developing countries. Timely detection followed by expeditious identification of pathogens and determination of susceptibility to antimicrobial agents can have a great diagnostic and prognostic importance. Keywords Bacteria, Gram negative, ESBL, MRSA, Fungi, Pleural fluid. Accepted: 19 June 2017 Available Online: 10 August 2017 Article Info
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Original Research Article https://doi.org/10.20546/ijcmas.2017.608.224
Microbiological Profile of Childhood Pneumonias in Hyderabad, India
Vipparti Haritha1*
and V.V. Shailaja2
1Department of Microbiology, Malla Reddy Institute of Medical Sciences,
Hyderabad, Telangana state, India 2Department of Microbiology, Gandhi Medical College, Hyderabad, Telangana state, India
*Corresponding author
A B S T R A C T
Introduction
Lower respiratory tract infections are a
persistent and pervasive public health
problem, placing a considerable strain on the
health budget and are generally more serious
than upper respiratory tract infections. They
cause a greater burden of disease worldwide
than human immunodeficiency virus
infection, malaria, cancer, or heart attacks (1).
Pneumonia is a form of acute Lower
Respiratory Tract Infection that affects the
lungs and has being the single largest cause of
death in children. Worldwide, 35-40%
mortality among children aged less than 5
years is attributed to respiratory tract
infections accounting for 2.04 million
deaths/year. In India, more than 4 lakh deaths
every year are due to pneumonia accounting
for 13%-16% of all deaths in the pediatric
hospital admissions (2, 3).
Clinicians use a wide range of disease
definitions, such as tracheitis, acute
bronchitis, bronchiolitis and pneumonia,
depending on the symptoms and signs and
anatomic structure involved, aspiration
pneumonia, obstruction pneumonia and
ventilator-associated pneumonia based on
International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 6 Number 8 (2017) pp. 1899-1911 Journal homepage: http://www.ijcmas.com
The present study was undertaken from 30/6/11 – 14/8/12 to know the Bacterial,
and Mycological profile profile and drug susceptibility patterns in children
suffering from pneumonias. Sputa (expectorated and induced) and Pleural fluid
were collected from 113 cases and processed by conventional methods. Antibiotic
sensitivity testing of these isolates was done as per CLSI guidelines. Bacterial
pathogens were isolated in 44.25% of cases from both Sputum and Pleural fluid.
Klebsiella pneumoniae was the predominant isolate 28% followed by
Pseudomonas aeruginosa 24% and Staphylococcus aureus 22%. 72% of
Staphylococcus aureus strains were Methicillin Resistant. Candida albicans was
the most common isolated fungi 6.2% followed by Non Albicans Candida from
sputum samples. Pleural fluid cultures for fungi were negative. Respiratory tract
infections are a significant public health problem in developing countries. Timely
detection followed by expeditious identification of pathogens and determination of
susceptibility to antimicrobial agents can have a great diagnostic and prognostic