Michael Chang (CEO) Ashok Ilankovan (CTO) Stephanie Pan (CMO) Patric Prado (COO) Alyssa Rios (CFO)

Michael Chang (CEO)Ashok Ilankovan (CTO)

Stephanie Pan (CMO)Patric Prado (COO)Alyssa Rios (CFO)

Patric Prado (COO/CRO)

Ashok Ilankovan (CTO)

Stephanie Pan (CMO)

Alyssa Rios (CFO)

Michael Chang (CEO)

What is Spinal Muscular Atrophy (SMA)?

• Genetic disease• Attacks motor neurons in

spinal cord• Leads to muscle

weakness and atrophy

DS2 (Intro) → DS1→ DS1 → DS3 → DS2 (Devices) → DS4 → Summary → DS3 → DS2 (Devices) → DS4 → Summary

• #1 genetic killer of children < age 2 (95% mortality)

• SMA type II ~ age 20 = 77%

Why design for SMA?

• Recent breakthroughs in research– SMN1 and SMN2 genes– NIH and NINDS massive

funding– Research (JHU, Columbia,

MIT, Stanford)• Lots of new therapy

treatments

BUT….• Current evaluations are

subjective, inaccurate, and insensitive.

Clinicians Need:• Robust and quantitative

motion capture and analysis system

DS2 (Intro)DS2 (Intro) → → DS1 → DS3 → DS2 (Devices) → DS4 → Summary → DS3 → DS2 (Devices) → DS4 → Summary

Constraints and Specifications

ROBUSTNESSROBUSTNESS

ERGONOMICSERGONOMICS

SAFETYSAFETY

RELIABILITYRELIABILITY

EASE OF USE / CONVENIENCEEASE OF USE / CONVENIENCE

COSTCOST

Variety of Patients

Variety of Patients

Intentional MovementsIntentional Movements

Limited WeightLimited Weight Natural Movements

Natural Movements

Constant arm support

Constant arm support

RepeatabilityRepeatability Not overly sensitive

Not overly sensitive CalibrationCalibration

Minimal External Cables

Minimal External Cables PortablePortable Minimal

TrainingMinimal Training

Balance Cost and NecessityBalance Cost and Necessity

Max Cost: Gaming Console

Max Cost: Gaming Console

DS2 (Intro)DS2 (Intro) → DS1→ DS1 → → DS3 → DS2 (Devices) → DS4 → Summary → DS2 (Devices) → DS4 → Summary

Reduce FrictionReduce Friction

Available Products

SMArtViewInertial sensor

Accelerometerbased system

Measures accelerations in 2D

Price: > $2000

VisualeyezActive LED markers

Optical based system

Tracks motion of markers

ShapeSensorOptical Sensor

Fiber optic based system

Measures bends & twists

Price: >$5000 Price: varies

DS2 (Intro)DS2 (Intro) → DS1→ DS1 → DS3 → → DS3 → DS2 (Devices) → DS4 → Summary → DS4 → Summary

Related Products

Air Hockey Table

Air nozzles

Floats objects on air

Requires air compressor

Price: $200 - $1000

Ball Transfer Plate

Ball bearing rollers

Provides a low friction platform

Requires Lubrication

Price: $100 – 300

DS2 (Intro)DS2 (Intro) → DS1→ DS1 → DS3 → → DS3 → DS2 (Devices) → DS4 → Summary → DS4 → Summary

Sling

Strap

Supports an injured arm

Provides support by loading on another object

Price: ~ $10 - 30

Related Products

Optical Mouse

CMOS sensor

Based on camera technology

Tracks 2D motion on a surface

Price: < $10

Laser Gun

Laser Transmitter/ Detector

Based on transmit/receive time

Measures velocity

Price: ~ $500

Security Sensor

IR Sensor

Based on detecting IR emitted from humans

Triggers an alarm

Price: ~ $30

DS2 (Intro)DS2 (Intro) → DS1→ DS1 → DS3 → → DS3 → DS2 (Devices) → DS4 → Summary → DS4 → Summary

Idea 1

DS2 (Intro)DS2 (Intro) → DS1→ DS1 → DS3 → DS2 (Devices) → → DS3 → DS2 (Devices) → DS4 → Summary → Summary

DS2 (Intro)DS2 (Intro) → DS1→ DS1 → DS3 → DS2 (Devices) → → DS3 → DS2 (Devices) → DS4 → Summary → Summary

Idea 2

DS2 (Intro)DS2 (Intro) → DS1→ DS1 → DS3 → DS2 (Devices) → → DS3 → DS2 (Devices) → DS4 → Summary → Summary

Idea 2

DS2 (Intro)DS2 (Intro) → DS1→ DS1 → DS3 → DS2 (Devices) → → DS3 → DS2 (Devices) → DS4 → Summary → Summary

Idea 3

DS2 (Intro)DS2 (Intro) → DS1→ DS1 → DS3 → DS2 (Devices) → → DS3 → DS2 (Devices) → DS4 → Summary → Summary

DS2 (Intro)DS2 (Intro) → DS1→ DS1 → DS3 → DS2 (Devices) → → DS3 → DS2 (Devices) → DS4 → Summary → Summary

In a Nutshell…

• SMA is a deadly genetic disease

• Many new therapies coming out

• Need for a robust, quantitative motion capture and analysis system

• Current devices are either very advanced or too simple

• We propose:– a device to capture &

evaluate 2D movements on frictionless, horizontal plane

DS2 (Intro)DS2 (Intro) → DS1→ DS1 → DS3 → DS2 (Devices) → DS4 → → DS3 → DS2 (Devices) → DS4 → Summary

Acknowledgements

Elisa Konofagou, PhDAssistant Professor of Biomed. Eng.Columbia University

Petra Kaufmann, MDAssistant Professor of NeurologyAssociate Director, Pediatric MDA

Neuromuscular Clinic

Elizabeth Hillman, PhDElizabeth Hillman, PhDAssistant Professor of Biomed. Eng.Assistant Professor of Biomed. Eng.Columbia UniversityColumbia University

Keith YeagerKeith YeagerSenior Staff Associate, Lab ManagerSenior Staff Associate, Lab ManagerColumbia UniversityColumbia University

Jacqueline MontesClinical Coordinator, Physical TherapistPediatric MDA Neuromuscular Clinic

Viktor GamarnikColumbia University Alumnus

Benjamin KooColumbia University Alumnus

Barclay Morrison, PhDBarclay Morrison, PhDAssociate Professor of Biomed. Eng.Associate Professor of Biomed. Eng.Columbia UniversityColumbia University

Questions?