Innovation: A Vital Ingredient for the Advancement of Medicine, Society Medical Devices and mHealth mHEALTH Israel 2014 Marvin J. Slepian, M.D. Professor of Medicine and Biomedical Engineering McGuire Scholar, Eller College of Management Director, Arizona Center for Accelerated Biomedical Innovation Director, Interventional Cardiology Sarver Heart Center University of Arizona Tucson, Arizona
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mHealth Israel_Dr. Marvin Slepian_ Innovation: A Vital Ingredient for the Advancement of Medicine, Society Medical Devices and mHealth
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Innovation: A Vital Ingredient for the
Advancement of Medicine, Society Medical Devices and mHealth
mHEALTH Israel 2014
Marvin J. Slepian, M.D.Professor of Medicine and Biomedical Engineering
McGuire Scholar, Eller College of Management
Director, Arizona Center for Accelerated Biomedical Innovation
Director, Interventional Cardiology
Sarver Heart Center
University of Arizona
Tucson, Arizona
If we look back over time we see that Medicine has continued to evolve at a progressively accelerating pace
Anatomy
Physiology
Pathology
Pharmacy/
Pharmacognosy
ECG
Endoscopy
Antibiotics
Chemistries
Imaging
Biomarkers
Mechanistic/Designer Biomolecules
Telemetry
Robotics
> 100 > 50
University of Chicago 2012Norman Rockwell 1945
Fildes
“The Doctor”
1891
Lisinopril
To advance, Medicine has relied on Innovation
Innovation is all around us
Innovation is an opportunity
Operative Hypotheses
To remain as an effective leading force in the US, world-wide and
society in general, Medicine has to actively adopt Innovation in its
teaching and culture, rather than letting it occur passively.
Innovation Thinking and Science is a valuable skill set.
Innovation is needed to overcome the many stresses that exist
on Medicine today - increased prevention, better Dxics and Txics
cost-effectiveness, increased access to care
Medicine is a tremendous arena, laboratory or workshop in which
to be Innovative, i.e. alternative career = biomedical innovator.
Medical Innovations, new diagnostic, Pharma or devices
remains an important economic engine for the US and Israel.
Arizona Center for AcceleratedBioMedical Innovation (ACABI)
Center specifically dedicated to:
1. Addressing unmet needs – broadly in the BioMedicalScience arena
2. Maximizing the therapeutic and commercial value of University discoveries and technology, often unrealized
ACABI as a center is “creativity engine” - a mechanism,
to facilitate the rapid transformation of novel scientific
discoveries and new technologies into therapeutic
solutions (products), that may be rapidly brought forth
as clinical therapeutic realities.
NY Times June 3, 2013
Now
$>6 TT
WSJ 1/8/14
Infant Mortality
United States 78.2 83.1 42nd!
World Population Growth
Every second4 babies born, 2 people die = growth by 2
200,000 people/d75MM people/yr1.2% annual growth rateWorld population doubles every 60 yrs
9 BB World population in 2050
Improvement Dx/Tx < Population Growth
VBWG
*
Center for Medicare & Medicaid Services (CMS)
Focused on Readmissions (any admission to the same
hospital occurring within 30d of discharge)
Marker of poor quality care, wasted revenue and
inefficient use of resources
17.6% of all admissions = readmission < 30d (MedPAC report 2007)
An Illustrative Example: Lyticas Data Platform (Apurba Technologies)
RichXML
RichXML
LytAP
Content Processing and Normalization
Control
FilesDB
LytAP API
File BasedAPI
Programmatic API(SOAP web Service)
WebAgents
RDBMSBased API
Categorizer
Semantic Tagging
Language ID
Headline Generation
Classifier
Extraction Modules
Language Classifier
Templates
Categorization Manager
LytAPDeveloper/Modeler
Languages Configuration
Key ConceptsConfiguration
LytAP Studio
RichXML
External Feed
Configuration & Monitoring
Console
Cloud Manager
Inference Modules Generate Inference
Global Mapping Modules LytAP Knowledge Base
Domain Experts
NLP Stack
Structured DataDB
Unstructured Data XML DB
Open Source Proprietary
XML
ControlAPI (Application
Programming Interface)
Integrated Electronic Biomaterial Systems
Skin patch
Catheter
Sheet/Array
PPM
ICD
Smart Stent
VAD/TAH
Big Data
Summary
Despite dramatic advances in Dx/Tx Medicine remains under increasing pressure – multiple stresses
Innovation as a science & methodology is a key adaptive mechanism yielding new solutions for emerging challenges
Despite varying economic climates medical device approaches have been a steady means of rapidly developing translational Txics which address unmet needs
The combination of new advances in biomaterials, polymerchemistry, microelectronics, robotics, fluid mechanics, Rx delivery will yield many novel, cost-effective Dxics/Txicin the years to come.
Novel innovations may help not only the patient, but medicine, the economy and society as a whole