Members of Dr. Mandal Laboratory - University of … Lab members...Members of Dr. Mandal Laboratory Current Lab members Research: Understating roles of histone methyl-transferases

Members of Dr. Mandal Laboratory

Current Lab members

Research: Understating roles of histone methyl-transferases in gene regulation, hormone signaling and cancer in

human. Publications 1. Ansari KI, Shrestha B., Hussain I, Kasiri S, and Mandal SS*, Histone Methylases MLL1 and MLL3 Coordinate

with Estrogen Receptors in Estrogen-Mediated HOXB9 Expression, Biochemistry 2011, in press. 2. Ansari KI, Kasiri S, Grant JD, and Mandal SS* Iron (III)-salen and salphen complexes induce apoptosis in

tumor cells, J Biomol Screen 2011, 16, 26-35. 3. Ansari KI and Mandal SS.*, Mixed Lineage Leukemia: roles in gene expression, hormone signaling and mRNA

processing, FEBS J 2010, 277, 1790-1804. Review. 4. Ansari KI, Hussain I, Kasiri S, and Mandal SS.*, MLL histone methylases in estrogen-mediated regulation of

HOXC13, FEBS J 2009, 276: 7400-11. 5. Ansari KI, Kasiri S, Grant JD, and Mandal SS.*, Apoptosis and antitumor activities of Mn(III)-salen and

salphen complexes, Dalton Trans 2009, 40, 8525-8531. 6. Ansari KI., Hussain I., Das HK., and Mandal SS.*, MLL1 histone methylase is upregulated upon exposure a

common food contaminant mycotoxin, deoxynivalenol, FEBS J 2009, 276, 3299-307. 7. Ansari KI., Grant, JD., Kasiri S., Woldemariam GA., Shrestha B. and Mandal SS.*, Mn(III)-salen induce tumor

selective apoptosis in MCF7 cells, J Inorg Biochem 2009, 103, 818-826. 8. Mishra BP., Ansari KI. and Mandal SS.*, Dynamic association of MLL1, H3K4 trimethylation with chromatin

and Hox gene expression during cell cycle, FEBS J 2009, 276, 1629-40. Featured on journal cover. 9. Ansari KI, Mishra BM, and Mandal SS*, MLL histone methylases in gene expression, hormone signaling and

cell cycle, Front Biosci 2009, 14, 3483-95, Review. 10. Ansari KI., Grant JD., Woldemariam GA. Kasiri S., and Mandal SS.*, Iron(III)-salen complexes with less DNA

cleavage activity exhibit more efficient apoptosis in MCF7 cells, Org Biomol Chem 2009, 7, 926-932. 11. Ansari KI., Mishra BM., and Mandal SS.*, Human CpG Binding Protein Interacts with MLL1, MLL2 and

hSet1 and Regulates Hox gene expression, Biochim Biophys Acta 2008, 1779(1), 66-73.

Khairul I Ansari, PhD

Postdoctoral fellow

PhD and MSc: National University of Ireland, Ireland MSc (Biotech) and BSc (Agri): Assam Agricultural University, India Interests: Music, Movie, Violin, Photography, Traveling, soccer Email: [email protected]

Subhrangsu S. Mandal, PhD Assistant Professor PhD: Indian Institute of Science, Bangalore, India Postdoctoral: HHMI/University of Medicine and Dentistry of New Jersey, USA; University of Alberta, Canada Interest: Trekking and exploring nature Email:[email protected]; http://www.uta.edu/chemistry/html/mandal.html

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Imran Hussain

PhD Student (2008 –present) M Tech. Indian Institute of Technology-Kharagpur, India M Sc. Allahabad University, India B.Sc. Gorakhpur University, India Interests: Music and Cricket Email: [email protected]

Research: I am interested in understanding the roles of estrogen and progesterone in breast cancer. Publications 1. Ansari KI, Shrestha B., Hussain I, Kasiri S, and Mandal SS*, Histone Methylases MLL1 and MLL3 Coordinate

with Estrogen Receptors in Estrogen-Mediated HOXB9 Expression, Biochemistry 2011, in press. 2. Ansari KI., Hussain I., Das HK., and Mandal SS.*, MLL1 histone methylase is upregulated upon exposure a

common food contaminant mycotoxin, deoxynivalenol, FEBS J 2009, 276, 3299-307. 3. Ansari KI, Kasiri S, Hussain I and Mandal SS.*, MLL histone methylases in estrogen-mediated regulation of

HOXC13, FEBS J 2009, 276:7400-11.

Bishakha Shrestha

PhD Student (2007 –present) BSc: Minnesota State University, Marshall, Minnesota. Interests: Tennis, Hiking Drawing, Painting, and Traveling Email: [email protected]

Research: Investigating roles of MLL histone methylases in steroid hormone signaling. Publications 1. Shrestha B., Hussain I, Ansari KI, and Mandal SS*, Function of HOXB9 in transcriptional regulation of Renin,

Manuscript under preparation 2011. 2. Ansari KI, Shrestha B., Hussain I, Kasiri S, and Mandal SS*, Histone Methylases MLL1 and MLL3 Coordinate

with Estrogen Receptors in Estrogen-Mediated HOXB9 Expression, Biochemistry 2011, in press. 3. Ansari KI., Grant, JD., Kasiri S., Woldemariam GA., Shrestha B. and Mandal SS.*, Mn(III)-salen induce tumor

Sahba Kasiri

PhD Student (2008 – present) Pharmacy Tech, CVS Pharmacy, Arlington TX. BSc. Bahai Institute of higher Education, Iran Interests: Music, movies, traveling and watching soccer Email: [email protected]

Research: Investigating functions of estrogen in epigenetic and cancer. I am also studying biochemical activities for various small molecules towards developing novel drugs.

Publications 1. Kasiri S., Bashyal A., Ansari KI, and Mandal SS.*, Iron(III)-salphen complexes induce cytochrome c release,

caspase activation and apoptosis in cancer cells, 2011, Submitted. 2. Ansari KI, Shrestha B., Hussain I, Kasiri S, and Mandal SS*, Histone Methylases MLL1 and MLL3

Coordinate with Estrogen Receptors in Estrogen-Mediated HOXB9 Expression, Biochemistry 2011, in press. 3. Ansari KI, Kasiri S, Grant JD, and Mandal SS* Iron (III)-salen and salphen complexes induce apoptosis in

tumor cells, J Biomol Screen 2011, 16, 26-35. 4. Ansari KI., Grant JD., Woldemariam GA. Kasiri S. and Mandal SS.*, Iron(III)-salen complexes with less DNA

cleavage activity exhibit more efficient apoptosis in MCF7 cells, Org Biomol Chem 2009, 7, 926-32. 5. Ansari KI, Kasiri S, Grant JD, and Mandal SS.*, Apoptosis and antitumor activities of Mn(III)-salen and

salphen complexes, Dalton Trans 2009, 8525-8531. 6. Ansari KI., Grant, JD., Kasiri S., Woldemariam GA., Shrestha B. and Mandal SS.*, Mn(III)-salen induce

tumor selective apoptosis in MCF7 cells, J Inorg Biochem 2009, 103, 818-826. 7. Ansari KI, Hussain I, Kasiri S, and Mandal SS.*, MLL histone methylases in estrogen-mediated regulation of

HOXC13, FEBS J 2009, 276, 7400-11

Aarti Bashyal

Undergraduate research Student (2009 –present) Interests: Swimming, traveling and reading Email: [email protected] “Undergraduate research award” from UTA 2010

Research: Mechanism of apoptosis and antitumor activities of Metallo salen; Roles of steroid hormones in placental function Publications 1. Kasiri S., Bashyal A., Ansari KI, and Mandal SS.*, Iron(III)-salphen complexes induce cytochrome c release,

caspase activation and apoptosis in cancer cells, 2011, Submitted. 2. Kasiri S., Bashyal A., Ansari KI, and Mandal SS.*, Antitumor activities of Manganese (III)-salphen complexes,

2011, under preparation.

Arunoday Bhan

PhD Student (2010 –present) M Sc. Maharaja Sayajirao University, India B.Sc. Maharaja Sayajirao University, India Interests: Football, cricket and computer games Email: [email protected]

Research: I am interested in understanding the roles of steroid hormones in cardiovascular disease and cancer. Publications 1. Bhan A. and Mandal S.S.*, Roles of histone methylases in gene regulation and diseases, Review in progress.

Jennifer Rodriguez

Undergraduate research Student Interests: Swimming, traveling and reading Research project: Transcriptional regulation of human genes and cell signaling

Mahmuda N Farha

Undergraduate research Student Interests: Swimming, traveling and reading Research project: Transcriptional regulation of human genes, immune response and cell signaling

PAST LAB MEMBERS

Getachew A Woldemariam (Graduate Student 2005 –08)

PhD Thesis: Cytotoxicity studies on metallo-salens and their applications in gene delivery. BSc and MSc: Addis Ababa University, Ethiopia Current position: Postdoctoral fellow (University of Southern California)

Publications 1. Woldemariam GA. and Mandal SS.*, Iron(III)-salen Damages DNA and Induces Apoptosis in Human Cell via

Mitochondrial Pathway, J. Inorg. Biochem. 2008, 102(4):740-7. 2. Osugi ME., Zanoni MVB., Chenthamarakshan CR., Tacconi NR., Woldemariam GA., Mandal SS. and Rajeshwar

K. Toxicity assessment and degradation of disperse azo dyes by photoelectrocatalytic oxidation on Ti/TiO2 nano-tubular array electrodes, J. Adv. Oxid. Technol 2008, 11, 425-434.

3. Ansari KI., Grant JD., Woldemariam GA. Kasiri S., & Mandal SS.*, Iron(III)-salen complexes with less DNA cleavage activity exhibit more efficient apoptosis in MCF7 cells, Org Biomol Chem 2009, 7, 926-932

4. Ansari KI., Grant, JD., Kasiri S., Woldemariam GA., Shrestha B. and Mandal SS.*, Mn(III)-salen induce tumor selective apoptosis in MCF7 cells, J Inorg Biochem 2009, 103, 818-826.

5. Woldemariam GA. and Mandal SS.*, Metallo-salen mediated DNA delivery in human cells, Under preparation.

James (Dave) D Grant (Undergraduate Research Student, 2007 –08) BS (Chemistry) University of Texas at Arlington “Undergraduate research award” from UTA, 2008.

Publications 1. Mandal SS.*, Ansari KI., and Grant JD., Anti-tumor and Apoptosis Activities of Metallo-salens, Pending US

patent, 2008, Application No. 61/075378 2. Ansari KI., Grant JD., Woldemariam GA. Kasiri S. and Mandal SS.*, Iron(III)-salen complexes with less

DNA cleavage activity exhibit more efficient apoptosis in MCF7 cells, Org Biomol Chem 2009, 7, 926-32. 3. Ansari KI, Kasiri S, Grant JD, and Mandal SS.*, Apoptosis and antitumor activities of Mn(III)-salen and

salphen complexes, Dalton Trans 2009, 8525-8531. 4. Ansari KI., Grant, JD., Kasiri S., Woldemariam GA., Shrestha B. and Mandal SS.*, Mn(III)-salen induce

tumor selective apoptosis in MCF7 cells, J Inorg Biochem 2009, 103, 818-826. 5. Ansari KI., Kasiri S., Grant JD., and Mandal SS* Iron (III)-salen and salphen complexes induce apoptosis in

tumor cells, J Biomol Screen 2011, 16, 26-35.

Publications 1. Ansari KI., Mishra BP. and Mandal SS.*, Human CpG Binding Protein Interacts with MLL1, MLL2 and hSet1

and Regulates Hox gene expression, Biochim Biophys Acta, 2008, 1779(1), 66-73. 2. Ansari KI., Mishra BP. and Mandal S.S*, MLL histone methylases in gene expression, hormone signaling and

cell cycle, Review Front Biosci 2009, 14, 3483-95. 3. Mishra BP., Ansari KI. and Mandal SS.*, Dynamic association of MLL1, H3K4 trimethylation with chromatin

and Hox gene expression during cell cycle, FEBS J 2009, 276, 1629-40. Featured on journal cover.

Bibhu P Mishra (Graduate student 2005 – 09),

PhD Thesis: Mixed lineage leukemia histone methylase in HOX gene expression and cell cycle

Graduate Research Award 2009 MSc (Botany): Utkal University, India Current position: Postdoctoral fellow

Undergraduates, Research Associates and Visitors

Undergraduates Research Scholars 2005: Anish Bhandari 2006: Hua Zhou, Miranda Newberry, Linda Rosema, Anjenique Anderson, Isaac Trevino, Kreshnik Ahmeti 2007: Mai Nguyen, Leslie Morgan, Vinh Phan, James D. Grant, Sahba Kasiri, 2008: James D. Grant, Bhawana Uprety, Thao Nguyen, Katrina Campbel, Annie Acharya 2009: Bhawana Uprety, Amna Sayed, Nhan Tran, Aarti Bashyal, Mahmuda Farha 2010: Aarti Bashyal, Mahmuda Farha, Hem Thapa, Amanda Beckwith, Diego Lopez; Rebecca Denny. 2011: Aarti Bashyal; Amanda Beckwith, Jennifer Rodriguez

Welch summer scholar

Anish Borakar (2006), Richard Hong (2007), Annie Scavone (2009) Visiting Scholars and Research Associates

Saoni Mandal (2005-present), Kirti Jain (2006), Vasudha M (2007), Priyanka Prasar (2008), Rajshree Shrivastava (2008)

PICTURES AND EVENTS

Saoni and Ion Frequent visitor to the lab

Bogala M Reddy (2007-09)

Vinh Phan (Undergraduate Research 2006-07)

Bhawana Uprety (Undergraduate Research 08-09)

Spring 2006: Celebration of “Texas-ARP” grant in Tandoor

Spring 2007: American Heart Association” grant celebration in Mayuri  

August 2009:   Bihbu Mishra graduated (PhD) 

Research group 2007: G Woldemariam, B Reddy, P Prasar, S Mandal, K Ansari, B Mishra, R Srivastava, B. Uprety, B Shrestha, S Kasiri, I Hussain, J Grant

Little princes “Subarnarekha” Bibhu with his journal

cover

Research group 2008

Drs. Bhattacharya and Mandal in New Orleans 2008

“Our place” 2010: Celebration of NIH grants

Sahba and Dr. Mandal in El Paso ACS meeting 2009

Mandal and Schug exploring the “Great Wall” in China 2010

Group 2010: River Legacy Park Sahba, Imran, Hem, Subhra, Aarti, Bishakha

and Diego

Dr. Mandal visiting NEU China

ACS meeting 2010, NO

Dr. Mandal visiting Univ. of Suzhou