Medical Applications of Synchrotron Radiation: Growth and Outlook for an Emerging Field of Science W. Thomlinson Frau Roentgen’s Hand Wilhelm Roentgen’s Laboratory University of Wurtzburg 1895 European Synchrotron Radiation Facility Grenoble France, 2010 3D monochromatic high-resolution dynamic digital imaging ANSTO Nov. 30, 2010 115 Years Later
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Medical Applications of Synchrotron Radiation: Growth … · Medical Applications of Synchrotron Radiation: Growth and Outlook for an Emerging Field of Science W. Thomlinson Frau
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Medical Applications of Synchrotron Radiation:Growth and Outlook for an Emerging Field of Science
W. Thomlinson
Frau Roentgen’s Hand
Wilhelm Roentgen’s LaboratoryUniversity of Wurtzburg 1895 European Synchrotron Radiation Facility
Grenoble France, 2010
3D monochromatic high-resolutiondynamic digital imaging ANSTO
Nov. 30, 2010
115 YearsLater
Synchrotron Radiation is Extremely Intense Light!
The Electromagnetic Spectrum
Synchrotron Radiation
Light is produced by the Acceleration of Charged Particles.
In Synchrotron Facilities, these Particles are Electrons
ELECTRON AT REST
ELECTROSTATIC FIELDNO MAGNETIC FIELD
ELECTRON MOVING AT CONSTANT VELOCITYSTATIC
MAGNETICFIELD
ACCELERATING ELECTRON (LINEAR)
SLOW FAST
ELECTROMAGNETIC RADIATION = LIGHT
FAST ELECTRON MOVING IN A CIRCLE(RELATIVISTIC HIGH ENERGY ELECTRON
S. Fiedler, A. Bravin, J. Keyriläinen, M. Fernández, P. Suortti, W. Thomlinson, M. Tenhunen, P. Virkkunen, M-L. Karjalainen-Lindsberg, Phys. Med. Biol. 49 (2004) 175 - 188.
Canadian Light SourceBioMedical Imaging and Therapy (BMIT)
D. Chapman and T. Wysokinski
Bill’s Car!
BioMedical Imaging and Therapy Beamline
HumanMedical Area
ID LineVeterinary
AreaBM Line
DEI Radiograph
Proof of principle08-09 during commissioning of BMITCadaveric specimen (soft tissue intact)
Cooper et al. Can Assoc Radiol J. 2010 Jun 29.
DEI of Trabecular Bone at the Human Wrist
Australian SynchrotronImaging and Medical Beamline (IMBL)
Daniel Hausermann and Chris Hall
Lung ImagingPhase ContrastRadiation Therapy
Australian Synchrotron
Satellite building with stations 3A and 3B – 150 m
IMBL in Experimental Hall
Imaging and Medical Beamline
Phase 3.1/3.2: 3A and 3B
Phase 2.1,2.2: 2A and 2B
Phase 1.1,1.21A and 1B
Australian Synchrotron
Case Study: Lung Aeration at BirthR. Lewis, A. Fouras, S. Dubsky, M. Kitchen, S. Hooper
■ During fetal life the future airways of the lungs are liquid-filled■ At birth lungs must rapidly transform from being liquid to air filled■ How this happens is poorly understood but the process
♦ Develops late in pregnancy♦ Is initiated by labour
■ Preterm and caesarean section infants often develop problems♦ Incidence is increasing♦ Require weeks of assisted ventilation (>$2,000/day)
■ We know that ventilating infants causes injury♦ ~30% develop chronic lung disease♦ Becomes apparent after 15 years
Australian Synchrotron
Phase Contrast X-ray imaging
Object Detector
Distance
Intensity
Australian Synchrotron
Phase Contrast Imaging
■ Air bubbles in water. Pixel Size = 2.8 μm, Energy=25 keV