Mechanism Alteration Reveals Patterns of Cellular Information Processing

Saporin Actinomycin Dcycles/day TST - norm control TLT- norm control TST - norm controlCOL 0.6856 0.9156 0.5805FB 0.6117 1.0849 2.4495FN 2.9583 1.3536 1.4846FGF -0.8073 0.3482 1.3648UTF 0.9206 1.055 2.5341LIN 0.696 0.1118 4.0091GDF/H19 -1.0265 0.3732 1.5774GAPDH 2.506 1.1262 1.4478

SAP - TST AD - TST MMC - TST COL 0.6856 0.5805 -4.2397FB 0.6117 2.4495 -0.2433FN 2.9583 1.4846 0.6917FGF -0.8073 1.3648 -3.2789UTF 0.9206 2.5341 0.5542LIN 0.696 4.0091 0.4021GDF/H19 -1.0265 1.5774 -0.5909GAPDH 2.506 1.4478 -4.6508

Mitomycin CTLT- norm control TST - norm control TLT- norm control

-0.2526 -4.2397 -0.09213.3065 -0.2433 1.9327

-1.1475 0.6917 -0.0593-1.4274 -3.2789 -1.32440.5175 0.5542 -0.6232

-0.3266 0.4021 -0.2807-1.2925 -0.5909 0.45271.5881 -4.6508 2.0768

SAP - TLT AD - TLT MMC - TLTCOL 0.9156 -0.2526 -0.0921FB 1.0849 3.3065 1.9327FN 1.3536 -1.1475 -0.0593FGF 0.3482 -1.4274 -1.3244UTF 1.055 0.5175 -0.6232LIN 0.1118 -0.3266 -0.2807GDF/H19 0.3732 -1.2925 0.4527GAPDH 1.1262 1.5881 2.0768

Saporincycles/day TST - norm control + GADPHCOL -1.8205FB -1.8943FN 0.4522FGF -3.3133UTF -1.5855LIN -1.8101GDF -3.5325

COVARIANCE X-Correlation0.48 0.400.78 0.760.67 0.70

-0.02 -0.010.22 0.37

-0.17 -0.52-0.90 -0.98-1.14 -0.93

TST - norm control + GADPH

Actinomycin D, TLTCOL FB FGF FN GAPDH H19

CONTROL 28.4165333 25.27113 26.7536 24.87367 25.3902 35.1961d 31.2348667 27.34467 37.7151 30.2511 31.31807 36.547532d 27.8972667 25.62433 21.99833 23.49003 24.34077 35.641753d 30.2104333 26.72317 30.1051 26.57243 33.44477 34.4083

U CONTROL 1d 2d 3dCONTROL -0.4817 0.3216 0.3385 0.74161d -0.5436 -0.6309 0.4692 -0.29372d -0.4607 0.6665 -0.0045 -0.58623d -0.5101 -0.2332 -0.8156 0.1421

SV1 SV2 SV3 SV4 SV5 SV6 SV7167.281 0 0 0 0 0 0

0 10.1592 0 0 0 0 00 0 4.8721 0 0 0 00 0 0 1.5164 0 0 0

V COL FB FGF FN GAPDH H19COL -0.3523 0.0967 -0.1006 -0.1054 -0.8394 -0.3257FB -0.3137 0.1696 -0.1079 -0.3384 0.432 -0.4031FGF -0.352 -0.743 0.4311 0.0969 -0.0269 0.1902FN -0.3157 -0.16 0.1716 -0.2847 0.2557 -0.4372GAPDH -0.3439 -0.3119 -0.841 0.0763 0.0977 0.2176H19 -0.4232 0.3931 0.1722 -0.4191 0.0015 0.6689LIN -0.3647 0.1246 0.1379 0.2526 -0.0239 -0.0893UTF -0.3516 0.3421 0.0837 0.7339 0.1803 -0.0372

AD-TLT-SV1 AD-TLT-SVAD-TLT-SVAD-TLT-SVAD-TLT-SVAD-TLT-SVCOL -0.3523 0.0967 -0.1006 -0.1054 -0.8394 -0.3257FB -0.3137 0.1696 -0.1079 -0.3384 0.432 -0.4031FGF -0.352 -0.743 0.4311 0.0969 -0.0269 0.1902FN -0.3157 -0.16 0.1716 -0.2847 0.2557 -0.4372GAPDH -0.3439 -0.3119 -0.841 0.0763 0.0977 0.2176H19 -0.4232 0.3931 0.1722 -0.4191 0.0015 0.6689LIN -0.3647 0.1246 0.1379 0.2526 -0.0239 -0.0893UTF -0.3516 0.3421 0.0837 0.7339 0.1803 -0.0372

Actinomycin D, TSTLIN UTF TST FB FGF30.30073 30.4093 CONTROL 20.0104 22.2466 24.1307332.56727 29.6454 1d 21.25073 22.03347 23.769928.7163 28.75433 2d 24.06173 23.69737 23.3497330.3296 29.01743 3d 26.46307 18.5853 25.7185

U CONTROL 1d 2dCONTROL -0.4728 -0.3744 0.51561d -0.4794 -0.2756 0.28462d -0.49 -0.3073 -0.80773d -0.5537 0.8303 0.028

SV8 SV1 SV2 SV3 SV40 144.5281 0 0 00 0 7.8773 0 00 0 0 3.5615 00 0 0 0 0.5115

LIN UTF V COL FB FGF-0.1856 -0.0143 COL -0.3189 0.1561 -0.6532-0.2681 -0.5707 FB -0.2974 -0.7937 -0.2463-0.2023 -0.226 FGF -0.3355 -0.1786 0.30020.1411 0.6984 FN -0.256 0.1957 -0.30540.0717 0.0968 GAPDH -0.2606 0.2122 -0.2958-0.0365 0.1112 H19 -0.4592 -0.2062 0.33980.8253 -0.2811 LIN -0.4072 0.3996 0.3427-0.3812 0.1858 UTF -0.4327 0.1682 0.0937

AD-TLT-SVAD-TLT-SVAD-TST-SVAD-TST-SV2 AD-TST-SVAD-TST-SVAD-TST-SV-0.1856 -0.0143 -0.3189 0.1561 -0.6532 0.3892 -0.2454-0.2681 -0.5707 -0.2974 -0.7937 -0.2463 -0.1147 0.0075-0.2023 -0.226 -0.3355 -0.1786 0.3002 -0.414 0.01020.1411 0.6984 -0.256 0.1957 -0.3054 -0.6101 -0.41730.0717 0.0968 -0.2606 0.2122 -0.2958 -0.1943 0.8665-0.0365 0.1112 -0.4592 -0.2062 0.3398 0.3477 0.02730.8253 -0.2811 -0.4072 0.3996 0.3427 -0.1274 -0.1145-0.3812 0.1858 -0.4327 0.1682 0.0937 0.3418 -0.0284

Saporin, TLTFN GAPDH H19 LIN UTF COL16.54367 16.69983 32.5028 27.31673 29.13453 CONTROL 34.5423716.75703 17.21873 32.74803 27.64333 29.8443 1d 30.868518.5676 18.80417 32.02 26.89153 29.94253 2d 32.2696821.7501 22.2186 35.4201 35.23627 35.72047 3d 32.69973

3d U CONTROL-0.6086 CONTROL -0.54540.7831 1d -0.4747-0.1146 2d -0.4758-0.0569 3d -0.5009

SV5 SV6 SV7 SV8 SV1 SV20 0 0 0 167.6492 00 0 0 0 0 9.74990 0 0 0 0 00 0 0 0 0 0

FN GAPDH H19 LIN UTF V COL0.3892 -0.2454 -0.2246 -0.0912 -0.4203 COL -0.389-0.1147 0.0075 -0.1044 0.4098 0.1699 FB -0.2655-0.414 0.0102 -0.4806 -0.5242 -0.297 FGF -0.3402-0.6101 -0.4173 0.4415 -0.129 0.2122 FN -0.308-0.1943 0.8665 0.1045 0.0029 -0.0061 GAPDH -0.36040.3477 0.0273 0.6452 -0.1592 -0.2606 H19 -0.3743-0.1274 -0.1145 -0.1741 0.6816 -0.1813 LIN -0.36320.3418 -0.0284 -0.235 -0.206 0.7486 UTF -0.407

AD-TST-SVAD-TST-SVAD-TST-SV8-0.2246 -0.0912 -0.4203-0.1044 0.4098 0.1699-0.4806 -0.5242 -0.2970.4415 -0.129 0.21220.1045 0.0029 -0.00610.6452 -0.1592 -0.2606-0.1741 0.6816 -0.1813-0.235 -0.206 0.7486

FB FGF FN GAPDH GDF3 LIN UTF29.47498 28.94709 29.53512 34.77905 36.88221 31.54602 32.9799519.02594 27.8989 23.53582 27.70005 28.53029 29.98016 34.9681718.46028 28.76208 23.54935 27.97517 30.31945 30.10277 31.7031521.19565 28.59528 26.24309 29.95253 29.27662 30.20385 37.0782

1d 2d 3d0.8317 0.0464 -0.0931-0.4041 0.1105 -0.7741-0.2341 -0.7927 0.3008-0.3003 0.5977 0.5492

SV3 SV4 SV5 SV6 SV7 SV80 0 0 0 0 00 0 0 0 0 0

3.9793 0 0 0 0 00 1.0549 0 0 0 0

FB FGF FN GAPDH H19 LIN UTF-0.1144 -0.2569 0.528 -0.3276 -0.2657 -0.3241 -0.45590.6299 0.3781 -0.2625 -0.2957 -0.4636 -0.0924 0.0997-0.2581 -0.3223 0.0636 0.0466 -0.3098 -0.0335 0.78130.1705 0.2484 0.5021 -0.2072 0.3779 0.5892 0.17130.2248 0.1007 0.1771 0.8658 -0.0786 -0.0511 -0.14050.3343 -0.4202 -0.3012 -0.0875 0.6193 -0.2972 0.0366-0.2043 -0.2597 -0.4731 -0.0102 -0.2036 0.6102 -0.3481-0.5389 0.6093 -0.2242 -0.0533 0.2111 -0.2737 -0.0105

Saporin, TSTCOL FB FGF FN GADPH GDF3 LIN

CONTROL 18.61341 19.31066 26.74731 20.65628 21.12369 29.08792 24.271311d 20.69792 21.40111 27.42938 23.6705 22.74588 29.62936 27.966612d 19.84636 21.33172 23.86297 23.04995 21.68374 25.47403 24.115473d 20.55972 22.19875 26.15959 20.14764 18.29384 28.06838 26.41879

U CONTROL 1d 2d 3dCONTROL -0.49 0.2596 -0.7052 0.44181d -0.5289 -0.1097 -0.187 -0.82052d -0.4851 -0.7513 0.2794 0.34953d -0.4948 0.5967 0.6243 0.0969

SV1 SV2 SV3 SV4 SV5 SV6 SV7 SV8138.2617 0 0 0 0 0 0 0

0 4.3861 0 0 0 0 0 00 0 3.6493 0 0 0 0 00 0 0 1.4871 0 0 0 0

V COL FB FGF FN GAPDH H19 LINCOL -0.2884 -0.0185 0.3795 0.114 -0.195 -0.4605 0.3482FB -0.3046 -0.0263 0.6028 0.3891 0.3856 0.3991 -0.2895FGF -0.3771 0.3683 -0.2717 0.1255 0.0446 -0.4784 -0.6338FN -0.3167 -0.5768 0.0072 -0.1932 -0.5902 0.1946 -0.3769GAPDH -0.3034 -0.5442 -0.4575 0.014 0.5875 -0.053 0.1426H19 -0.4063 0.4356 -0.3868 0.1101 -0.1994 0.5641 0.24LIN -0.3722 0.2004 0.2429 -0.8304 0.2243 0.0109 0.0782UTF -0.4312 -0.0678 0.0294 0.2842 -0.1667 -0.2021 0.4088

Mitomycin C, TLTUTF COL FB FGF FN GAPDH29.25005 CONTROL 27.33607 23.68657 33.24857 25.7127 28.9309731.20142 1d 27.87527 24.1558 35.6877 26.12007 28.5562329.32261 2d 28.36717 24.05053 35.5412 26.28237 33.070829.43281 3d 27.6911 28.0212 33.039 26.00137 32.70983

U CONTROL 1d 2d 3dCONTROL -0.4904 -0.2811 0.3026 -0.76741d -0.4959 -0.4639 0.3713 0.63332d -0.5113 -0.0997 -0.8532 0.02693d -0.5021 0.8342 0.2065 0.0968

SV1 SV2 SV3 SV4 SV5 SV6174.0083 0 0 0 0 0

0 4.8571 0 0 0 00 0 2.8611 0 0 00 0 0 1.665 0 0

UTF V COL FB FGF FN GAPDH-0.6231 COL -0.3197 -0.0706 0.0492 0.0699 -0.45930.0027 FB -0.2871 0.6411 0.4915 0.2868 0.00460.0065 FGF -0.3952 -0.3876 -0.0647 0.7427 -0.0984-0.037 FN -0.2992 -0.0564 0.1494 0.0187 0.8428-0.1844 GAPDH -0.3545 0.5375 -0.7341 -0.0387 0.0117-0.2608 H19 -0.3959 0.0419 0.3582 -0.4264 -0.25520.1277 LIN -0.3189 -0.1795 0.1174 -0.3136 0.01090.7015 UTF -0.4308 -0.3281 -0.2205 -0.2815 0.0597

Mitomycin C, TSTH19 LIN UTF COL FB34.5861 27.95747 37.37687 CONTROL 30.26357 26.77273

34.00137 27.7117 37.37777 1d 35.47733 27.5976334.31543 28.15673 39.01187 2d 35.72393 28.0523734.90667 27.1503 36.13137 3d 26.99787 27.11113

U CONTROL 1dCONTROL -0.4926 0.04641d -0.5182 -0.35832d -0.5165 -0.43663d -0.4713 0.8239

SV7 SV8 SV1 SV2 SV30 0 175.6593 0 00 0 0 9.9455 00 0 0 0 3.55510 0 0 0 0

H19 LIN UTF V COL FB-0.6147 -0.3842 -0.386 COL -0.367 -0.4687-0.1626 0.1093 0.3799 FB -0.3117 0.1450.3258 0.1463 -0.023 FGF -0.3669 -0.3306-0.0953 -0.2566 -0.3153 FN -0.344 0.33870.1143 0.0653 -0.1662 GAPDH -0.3519 -0.51980.6214 -0.2188 -0.1794 H19 -0.3818 0.3722-0.2376 0.8134 -0.1891 LIN -0.321 0.2818-0.1574 -0.1985 0.715 UTF -0.3776 0.217

FGF FN GAPDH H19 LIN UTF31.03073 28.73303 31.59757 33.2038 27.7752 34.6841334.4503 30.3085 33.6638 33.5385 28.13427 33.5015335.1896 30.26823 33.5441 32.90697 28.05097 32.23727

27.89245 31.69197 24.36227 34.64693 28.93843 32.31973

2d 3d-0.8446 0.20460.0958 -0.77070.4233 0.60290.3136 -0.0272

SV4 SV5 SV6 SV7 SV80 0 0 0 00 0 0 0 00 0 0 0 0

0.6448 0 0 0 0

FGF FN GAPDH H19 LIN UTF0.401 -0.5373 -0.3187 -0.2056 0.0428 -0.2245

0.1146 0.595 -0.2624 -0.2825 -0.3968 -0.45670.2064 0.3962 -0.1736 0.3349 -0.0416 0.64220.3898 -0.1446 0.6235 -0.3124 -0.1997 0.2603-0.4568 0.1267 0.5525 0.0382 0.0589 -0.2667-0.0104 -0.244 -0.0162 0.7488 -0.137 -0.27640.0519 0.1932 -0.0628 -0.1108 0.8691 -0.0771-0.6481 -0.2579 -0.318 -0.3063 -0.1467 0.3276

SaporinTST-sink-0 TST-sink-1 TST-sink-2 TST-sink-3

COL 0 2.08 0.85 0.71FB 0 2.09 0.07 0.87FGF 0 0.68 3.57 2.3FN 0 3.01 2.59 2.9GAPDH 0 1.62 1.06 3.39GDF 0 0.54 4.16 2.59LIN 0 3.7 3.85 2.3UTF 0 1.95 1.88 0.11

FF-0 FF-1 FF-2 FF-3COL 0 0 0 0FB 0 2.38 2.87 1FGF 0 0 0 0FN 0 0.13 0 0GAPDH 0 0 0 0GDF 0 1.1 0 0LIN 0 0 0 0UTF 0 0 0 0

TLT-sink-0 TLT-sink-1 TLT-sink-2 TLT-sink-3COL 0 3.67 1.4 0.43FB 0 10.45 0.57 2.74FGF 0 1.05 0.86 0.17FN 0 6 1.04 2.69GAPDH 0 7.08 0.28 1.98GDF 0 8.35 1.79 1.04LIN 0 1.57 0.12 0.1UTF 0 1.99 3.27 5.38

FB-0 FB-1 FB-2 FB-3COL 0 10.17 12.42 12.14FB 0 0 0 0FGF 0 0.47 11.66 2.44FN 0 0 4.9 6.1GAPDH 0 4.95 6.29 11.66GDF 0 0 4.85 1.21LIN 0 2.01 5.99 3.79UTF 0 3.77 2.38 7.65

Actinomycin DTST-sink-0 TST-sink-1 TST-sink-2

COL 0 1.24 2.81FB 0 0.21 1.66FGF 0 0.36 0.42FN 0 0.21 3.4GAPDH 0 0.52 1.59H19 0 0.25 0.73LIN 0 0.33 0.75UTF 0 0.71 0.1

FF-0 FF-1 FF-2COL 0 0 0FB 0 0 0FGF 0 0 1.35FN 0 0 1.01GAPDH 0 0 0H19 0 0 0LIN 0 0 0UTF 0 0.2 1.19

TLT-sink-0 TLT-sink-1 TLT-sink-2COL 0 2.82 3.34FB 0 2.07 1.72FGF 0 10.96 17.07FN 0 5.38 2.25GAPDH 0 5.93 6.98H19 0 1.35 0.91LIN 0 2.27 3.85UTF 0 0.96 2.08

FB-0 FB-1 FB-2COL 0 9.98 3.84FB 0 5.31 1.93FGF 0 13.95 11.23FN 0 13.49 0GAPDH 0 14.1 5.54H19 0 3.8 3.62LIN 0 4.92 1.82UTF 0 0 0

Mitomycin CTST-sink-3 TST-sink-0 TST-sink-1 TST-sink-2

2.4 COL 0 5.21 0.255.11 FB 0 0.82 0.452.37 FGF 0 3.42 0.743.18 FN 0 1.58 1.743.41 GAPDH 0 2.07 0.123.4 H19 0 0.33 0.63

8.34 LIN 0 0.36 0.085.78 UTF 0 1.18 1.26

FF-3 FF-0 FF-1 FF-20 COL 0 7.6 7.360 FB 0 3.44 40 FGF 0 0 00 FN 0 4.19 00 GAPDH 0 5.11 0.47

1.01 H19 0 0 04.91 LIN 0 0.42 06.7 UTF 0 0 0

TLT-sink-3 TLT-sink-0 TLT-sink-1 TLT-sink-22.31 COL 0 8.14 7.851.1 FB 0 3.91 4.11

8.11 FGF 0 2.44 0.153.08 FN 0 4.6 0.599.1 GAPDH 0 5.48 4.99

2.25 H19 0 0.58 0.316.52 LIN 0 0.67 0.456.97 UTF 0 0 1.63

FB-3 FB-0 FB-1 FB-23.75 COL 0 0 08.14 FB 0 0 04.39 FGF 0 1.24 8.354.82 FN 0 0 0.3511.23 GAPDH 0 0 0

0 H19 0 0.46 1.410 LIN 0 0 0.110 UTF 0 3.88 6.77

TST-sink-38.730.947.3

1.429.181.740.890.08

FF-3000

5.6900

1.790

TLT-sink-30.683.972.5

5.970.360.592.792.88

FB-30.690.915.15

08.350.26

03.81

SaporinTIME (days) 0.041237 0.082474 0.123711 0.164948 0.206185 0.247422COL-TST-sink 0 0.0429 0.0854 0.1275 0.1691 0.2103FB-TST-sink 0 0.0417 0.0832 0.1244 0.1654 0.206FGF-TST-sink 0 0.0489 0.0964 0.1425 0.1873 0.2308FN-TST-sink 0 0.0732 0.1436 0.2113 0.2762 0.3384GAPDH-TST-sink 0 0.0493 0.0975 0.1444 0.1901 0.2346GDF-TST-sink 0 0.0488 0.0961 0.1417 0.1859 0.2285LIN-TST-sink 0 0.0809 0.1585 0.2328 0.304 0.372UTF-TST-sink 0 0.0419 0.0834 0.1245 0.1651 0.2051

TIME (days) 0.041237 0.082474 0.123711 0.164948 0.206185 0.247422COL-TLT-sink 0 0.0442 0.0876 0.1302 0.172 0.213FB-TLT-sink 0 0.0497 0.0976 0.144 0.1887 0.2317FGF-TLT-sink 0 0.0417 0.0833 0.1247 0.1659 0.2067FN-TLT-sink 0 0.0589 0.1156 0.1701 0.2223 0.2724GAPDH-TLT-sink 0 0.0449 0.0884 0.1306 0.1715 0.2111GDF-TLT-sink 0 0.0534 0.1051 0.1551 0.2034 0.25LIN-TLT-sink 0 0.0417 0.0832 0.1247 0.1659 0.2069UTF-TLT-sink 0 0.0769 0.1507 0.2213 0.289 0.3536

TIME (days) 0.041237 0.082474 0.123711 0.164948 0.206185 0.247422COL-TLT-FB 0 0.1336 0.2651 0.3944 0.5217 0.647FB-TLT-FB 0 0.0497 0.0976 0.144 0.1887 0.2317FGF-TLT-FB 0 0.0477 0.0939 0.1386 0.1818 0.2236FN-TLT-FB 0 0.043 0.084 0.123 0.1602 0.1954GAPDH-TLT-FB 0 -0.0688 -0.1362 -0.2021 -0.2667 -0.3298GDF-TLT-FB 0 0.0421 0.0835 0.1242 0.1643 0.2037LIN-TLT-FB 0 0.0772 0.1513 0.2223 0.2902 0.3551UTF-TLT-FB 0 0.0705 0.1383 0.2035 0.266 0.326

Actinomycin DTIME (days) 0.041237 0.082474 0.123711 0.164948 0.206185 0.247422COL-TST-sink 0 0.0533 0.1051 0.1554 0.2041 0.2514FB-TST-sink 0 0.0434 0.0857 0.1271 0.1675 0.2069FGF-TST-sink 0 0.0419 0.0836 0.1251 0.1663 0.2072FN-TST-sink 0 0.0441 0.0868 0.1282 0.1682 0.2069GAPDH-TST-sink 0 0.045 0.0892 0.1324 0.1748 0.2163GDF-TST-sink 0 0.0422 0.0841 0.1255 0.1666 0.2072LIN-TST-sink 0 0.0431 0.0855 0.1273 0.1685 0.2091UTF-TST-sink 0 0.0419 0.0834 0.1244 0.165 0.2051

TIME (days) 0.041237 0.082474 0.123711 0.164948 0.206185 0.247422COL-TLT-sink 0 0.0719 0.141 0.2074 0.2711 0.3322FB-TLT-sink 0 0.0466 0.0923 0.1372 0.1812 0.2244

FGF-TLT-sink 0 0.0623 0.1238 0.1844 0.2443 0.3032FN-TLT-sink 0 0.0791 0.1551 0.2278 0.2975 0.364GAPDH-TLT-sink 0 -0.1288 -0.2547 -0.3778 -0.4981 -0.6155GDF-TLT-sink 0 0.0449 0.0891 0.1327 0.1756 0.2177LIN-TLT-sink 0 0.0768 0.1506 0.2214 0.2891 0.354UTF-TLT-sink 0 0.0545 0.1072 0.1579 0.2069 0.254

TIME (days) 0.041237 0.082474 0.123711 0.164948 0.206185 0.247422COL-TLT-FB 0 0.0369 0.0725 0.1068 0.1397 0.1713FB-TLT-FB 0 0.0542 0.1067 0.1573 0.2062 0.2534FGF-TLT-FB 0 -0.0042 -0.0086 -0.0131 -0.0177 -0.0225FN-TLT-FB 0 0.0425 0.0837 0.1237 0.1624 0.2GAPDH-TLT-FB 0 0.008 0.0158 0.0232 0.0303 0.0372GDF-TLT-FB 0 0.0427 0.0838 0.1234 0.1615 0.198LIN-TLT-FB 0 0.0423 0.0836 0.1239 0.1632 0.2016UTF-TLT-FB 0 0.0545 0.1072 0.1579 0.2069 0.254

Mitomycin CTIME (days) 0.041237 0.082474 0.123711 0.164948 0.206185 0.247422COL-TST-sink 0 0.0449 0.0882 0.1302 0.1707 0.2097FB-TST-sink 0 0.0419 0.0836 0.1251 0.1663 0.2073FGF-TST-sink 0 0.055 0.1079 0.1586 0.2072 0.2536FN-TST-sink 0 0.0465 0.0923 0.1372 0.1813 0.2245GAPDH-TST-sink 0 0.0427 0.0842 0.1245 0.1636 0.2015GDF-TST-sink 0 0.0419 0.0836 0.1251 0.1663 0.2072LIN-TST-sink 0 0.0417 0.0832 0.1247 0.1659 0.2068UTF-TST-sink 0 0.0417 0.0832 0.1245 0.1656 0.2063

TIME (days) 0.041237 0.082474 0.123711 0.164948 0.206185 0.247422COL-TLT-sink 0 0.0437 0.0866 0.1289 0.1705 0.2115FB-TLT-sink 0 0.092 0.1801 0.2646 0.3454 0.4225FGF-TLT-sink 0 0.0425 0.0842 0.1252 0.1654 0.2048FN-TLT-sink 0 0.0538 0.1053 0.1544 0.2013 0.246GAPDH-TLT-sink 0 0.049 0.0957 0.1403 0.1827 0.223GDF-TLT-sink 0 0.0417 0.0833 0.1247 0.1659 0.2069LIN-TLT-sink 0 0.0424 0.0845 0.1263 0.1676 0.2085UTF-TLT-sink 0 0.042 0.0834 0.1243 0.1646 0.2042

TIME (days) 0.041237 0.082474 0.123711 0.164948 0.206185 0.247422COL-TLT-FB 0 0.0417 0.0832 0.1247 0.1659 0.2068FB-TLT-FB 0 0.092 0.1801 0.2646 0.3454 0.4225FGF-TLT-FB 0 0.0555 0.1092 0.1611 0.2112 0.2595FN-TLT-FB 0 0.0417 0.0832 0.1247 0.1659 0.2068GAPDH-TLT-FB 0 0.0417 0.0832 0.1247 0.1661 0.2074GDF-TLT-FB 0 0.0417 0.0834 0.1248 0.166 0.2069

LIN-TLT-FB 0 0.0417 0.0832 0.1247 0.1659 0.2068UTF-TLT-FB 0 0.0661 0.1295 0.1903 0.2485 0.3041

0.288659 0.329896 0.371133 0.41237 0.453607 0.494844 0.536081 0.577318 0.6185550.2509 0.291 0.3304 0.3692 0.4073 0.4446 0.4811 0.5168 0.55170.2462 0.2859 0.3252 0.3639 0.402 0.4394 0.4762 0.5122 0.54740.2728 0.3136 0.3529 0.391 0.4277 0.463 0.497 0.5297 0.56110.398 0.4549 0.5093 0.561 0.6103 0.657 0.7013 0.7432 0.7827

0.2779 0.32 0.3609 0.4005 0.4389 0.476 0.5119 0.5466 0.580.2695 0.3091 0.3471 0.3837 0.4188 0.4524 0.4846 0.5153 0.54460.4368 0.4987 0.5575 0.6133 0.6662 0.7162 0.7634 0.8078 0.84950.2446 0.2835 0.3217 0.3593 0.3961 0.4322 0.4676 0.5021 0.5357

0.288659 0.329896 0.371133 0.41237 0.453607 0.494844 0.536081 0.577318 0.6185550.2531 0.2925 0.3309 0.3686 0.4053 0.4411 0.4761 0.5101 0.54320.2732 0.3131 0.3514 0.3881 0.4233 0.4569 0.489 0.5197 0.54880.2472 0.2873 0.3268 0.3658 0.4041 0.4418 0.4788 0.5149 0.55020.3203 0.3661 0.4098 0.4515 0.4911 0.5288 0.5644 0.5982 0.630.2495 0.2866 0.3225 0.3571 0.3906 0.4229 0.4539 0.4838 0.51260.295 0.3384 0.3802 0.4204 0.459 0.4961 0.5317 0.5657 0.5983

0.2475 0.2877 0.3275 0.3668 0.4055 0.4435 0.4809 0.5174 0.55320.4152 0.474 0.5299 0.5829 0.6332 0.6807 0.7255 0.7677 0.8073

0.288659 0.329896 0.371133 0.41237 0.453607 0.494844 0.536081 0.577318 0.6185550.7702 0.8913 1.0104 1.1275 1.2426 1.3556 1.4667 1.5759 1.6830.2732 0.3131 0.3514 0.3881 0.4233 0.4569 0.489 0.5197 0.54880.2638 0.3027 0.3401 0.3761 0.4107 0.4438 0.4756 0.5061 0.53510.2288 0.2604 0.2901 0.3181 0.3444 0.3689 0.3917 0.4129 0.4324-0.3915 -0.4519 -0.5109 -0.5685 -0.6248 -0.6798 -0.7334 -0.7857 -0.83670.2425 0.2806 0.3179 0.3546 0.3907 0.426 0.4606 0.4945 0.52760.4171 0.4761 0.5323 0.5856 0.6361 0.6839 0.729 0.7714 0.81120.3834 0.4383 0.4907 0.5407 0.5883 0.6335 0.6763 0.7168 0.755

0.288659 0.329896 0.371133 0.41237 0.453607 0.494844 0.536081 0.577318 0.6185550.2971 0.3413 0.384 0.4252 0.4649 0.5031 0.5398 0.575 0.60870.2453 0.2828 0.3193 0.3548 0.3893 0.4229 0.4555 0.4872 0.51790.2476 0.2877 0.3272 0.3663 0.4047 0.4425 0.4797 0.5161 0.55180.2443 0.2804 0.3151 0.3485 0.3806 0.4115 0.441 0.4693 0.49620.2569 0.2966 0.3353 0.373 0.4098 0.4457 0.4805 0.5143 0.54720.2474 0.2871 0.3262 0.3648 0.4028 0.4402 0.4769 0.513 0.54840.249 0.2884 0.3271 0.3652 0.4028 0.4397 0.476 0.5117 0.5469

0.2448 0.2841 0.3229 0.3612 0.3991 0.4364 0.4733 0.5097 0.5457

0.288659 0.329896 0.371133 0.41237 0.453607 0.494844 0.536081 0.577318 0.6185550.3907 0.4466 0.5 0.5508 0.5992 0.6452 0.6887 0.7299 0.76870.2666 0.3079 0.3482 0.3876 0.4259 0.4633 0.4995 0.5347 0.5688

0.3614 0.4187 0.4753 0.531 0.5859 0.64 0.6933 0.7458 0.79750.4276 0.4881 0.5457 0.6004 0.6522 0.7012 0.7475 0.791 0.8318-0.7301 -0.842 -0.9512 -1.0576 -1.1614 -1.2625 -1.3609 -1.4567 -1.54990.2591 0.2996 0.3394 0.3783 0.4163 0.4534 0.4896 0.5248 0.5590.4159 0.475 0.5313 0.5848 0.6356 0.6837 0.7291 0.7719 0.81220.2993 0.3429 0.3847 0.4248 0.4632 0.5 0.535 0.5685 0.6003

0.288659 0.329896 0.371133 0.41237 0.453607 0.494844 0.536081 0.577318 0.6185550.2017 0.2307 0.2584 0.2849 0.3102 0.3342 0.3569 0.3785 0.39890.2988 0.3426 0.3847 0.4251 0.4639 0.501 0.5366 0.5706 0.603-0.0275 -0.0326 -0.0378 -0.0432 -0.0487 -0.0543 -0.0601 -0.066 -0.07210.2364 0.2715 0.3055 0.3383 0.3699 0.4004 0.4297 0.4579 0.48490.0437 0.0499 0.0559 0.0615 0.0669 0.072 0.0768 0.0813 0.08560.2331 0.2667 0.2988 0.3295 0.3587 0.3866 0.413 0.438 0.46170.239 0.2754 0.3109 0.3454 0.3789 0.4115 0.4431 0.4737 0.5035

0.2993 0.3429 0.3847 0.4248 0.4632 0.5 0.535 0.5685 0.6003

0.288659 0.329896 0.371133 0.41237 0.453607 0.494844 0.536081 0.577318 0.6185550.2474 0.2837 0.3186 0.3521 0.3843 0.4151 0.4446 0.4729 0.49980.2478 0.2879 0.3274 0.3664 0.4048 0.4424 0.4793 0.5154 0.55070.298 0.3404 0.3807 0.4191 0.4555 0.4899 0.5225 0.5531 0.582

0.2668 0.3083 0.3488 0.3883 0.4268 0.4644 0.5008 0.5363 0.57060.2383 0.2739 0.3084 0.3417 0.3739 0.4051 0.4351 0.464 0.49190.2477 0.2877 0.3272 0.3661 0.4045 0.4421 0.4791 0.5153 0.55060.2474 0.2875 0.3272 0.3663 0.4048 0.4426 0.4796 0.5158 0.55110.2465 0.2864 0.3257 0.3645 0.4027 0.4402 0.4769 0.5129 0.548

0.288659 0.329896 0.371133 0.41237 0.453607 0.494844 0.536081 0.577318 0.6185550.2517 0.2913 0.3302 0.3685 0.4061 0.443 0.4793 0.515 0.550.4961 0.5662 0.6328 0.696 0.7558 0.8123 0.8656 0.9158 0.96270.2434 0.2811 0.318 0.354 0.3891 0.4233 0.4566 0.4889 0.52020.2884 0.3287 0.3668 0.4028 0.4368 0.4686 0.4985 0.5264 0.55240.2612 0.2974 0.3315 0.3636 0.3938 0.422 0.4483 0.4728 0.49540.2474 0.2876 0.3272 0.3663 0.4047 0.4424 0.4794 0.5156 0.55080.2489 0.2888 0.3281 0.3668 0.405 0.4424 0.4791 0.5151 0.55040.2432 0.2815 0.3192 0.3561 0.3922 0.4276 0.4622 0.4959 0.5288

0.288659 0.329896 0.371133 0.41237 0.453607 0.494844 0.536081 0.577318 0.6185550.2474 0.2876 0.3273 0.3664 0.4048 0.4426 0.4796 0.5158 0.5510.4961 0.5662 0.6328 0.696 0.7558 0.8123 0.8656 0.9158 0.96270.306 0.3508 0.3939 0.4353 0.475 0.5131 0.5495 0.5843 0.6176

0.2474 0.2875 0.3272 0.3663 0.4047 0.4424 0.4793 0.5154 0.55050.2486 0.2896 0.3306 0.3715 0.4122 0.4528 0.4933 0.5336 0.57380.2474 0.2875 0.3271 0.3662 0.4047 0.4424 0.4795 0.5158 0.5512

0.2474 0.2875 0.3272 0.3662 0.4046 0.4423 0.4792 0.5152 0.55030.3573 0.4079 0.4562 0.502 0.5454 0.5865 0.6253 0.6618 0.6961

0.659792 0.701029 0.742266 0.783503 0.82474 0.865977 0.907214 0.948451 0.9896880.5856 0.6186 0.6506 0.6815 0.7114 0.7401 0.7677 0.794 0.81910.5818 0.6153 0.6478 0.6794 0.7099 0.7394 0.7677 0.7948 0.82060.5911 0.6199 0.6473 0.6734 0.6982 0.7217 0.7439 0.7648 0.78430.8198 0.8546 0.8871 0.9173 0.9453 0.9712 0.9949 1.0164 1.03590.6122 0.6431 0.6727 0.7011 0.7283 0.7541 0.7787 0.802 0.8240.5726 0.5991 0.6242 0.6479 0.6703 0.6914 0.7111 0.7295 0.74660.8884 0.9247 0.9584 0.9895 1.0181 1.0442 1.0679 1.0892 1.10820.5685 0.6003 0.6312 0.661 0.6898 0.7176 0.7442 0.7697 0.794

0.659792 0.701029 0.742266 0.783503 0.82474 0.865977 0.907214 0.948451 0.9896880.5754 0.6066 0.6368 0.666 0.6943 0.7215 0.7478 0.773 0.79710.5764 0.6026 0.6274 0.6507 0.6726 0.6932 0.7123 0.7301 0.74650.5845 0.6178 0.6501 0.6813 0.7113 0.7401 0.7676 0.7937 0.8184

0.66 0.6881 0.7144 0.7389 0.7616 0.7826 0.802 0.8196 0.83560.5403 0.5668 0.5922 0.6165 0.6398 0.662 0.6832 0.7033 0.72250.6293 0.659 0.6871 0.7139 0.7393 0.7632 0.7859 0.8071 0.82710.588 0.6219 0.6548 0.6866 0.7172 0.7467 0.7748 0.8017 0.8271

0.8443 0.8787 0.9107 0.9403 0.9674 0.9922 1.0147 1.0349 1.0529

0.659792 0.701029 0.742266 0.783503 0.82474 0.865977 0.907214 0.948451 0.9896881.7882 1.8915 1.9929 2.0923 2.1899 2.2855 2.3793 2.4713 2.56140.5764 0.6026 0.6274 0.6507 0.6726 0.6932 0.7123 0.7301 0.74650.5628 0.5892 0.6143 0.6381 0.6605 0.6817 0.7016 0.7202 0.73760.4504 0.4667 0.4815 0.4948 0.5066 0.517 0.5259 0.5334 0.5395-0.8864 -0.9348 -0.9819 -1.0277 -1.0724 -1.1157 -1.1578 -1.1987 -1.23840.5601 0.5918 0.6228 0.653 0.6825 0.7112 0.7392 0.7664 0.79280.8484 0.8831 0.9153 0.945 0.9724 0.9973 1.02 1.0404 1.05850.7909 0.8247 0.8562 0.8856 0.9128 0.938 0.9611 0.9822 1.0013

0.659792 0.701029 0.742266 0.783503 0.82474 0.865977 0.907214 0.948451 0.9896880.641 0.6717 0.701 0.7288 0.7551 0.7799 0.8033 0.8252 0.8457

0.5477 0.5766 0.6045 0.6315 0.6575 0.6826 0.7069 0.7301 0.75250.5867 0.6207 0.6538 0.6859 0.7171 0.7472 0.7762 0.804 0.83070.522 0.5464 0.5696 0.5916 0.6123 0.6318 0.6501 0.6671 0.68290.579 0.6098 0.6395 0.6681 0.6957 0.7222 0.7476 0.7719 0.79510.583 0.6169 0.65 0.6822 0.7137 0.7442 0.7739 0.8026 0.8303

0.5814 0.6154 0.6488 0.6816 0.7139 0.7456 0.7767 0.8073 0.83730.5811 0.616 0.6505 0.6844 0.7178 0.7507 0.783 0.8148 0.8461

0.659792 0.701029 0.742266 0.783503 0.82474 0.865977 0.907214 0.948451 0.9896880.8052 0.8395 0.8715 0.9012 0.9289 0.9543 0.9777 0.999 1.01820.6018 0.6336 0.6643 0.6937 0.722 0.749 0.7748 0.7993 0.8225

0.8484 0.8986 0.9479 0.9965 1.0443 1.0913 1.1376 1.1831 1.22780.8701 0.9057 0.9387 0.9693 0.9974 1.0231 1.0464 1.0674 1.0862-1.6406 -1.7287 -1.8143 -1.8973 -1.9779 -2.056 -2.1317 -2.205 -2.27590.5922 0.6244 0.6554 0.6854 0.7142 0.7418 0.7682 0.7934 0.81740.8499 0.8851 0.9179 0.9483 0.9763 1.002 1.0254 1.0465 1.06540.6306 0.6593 0.6865 0.7121 0.7363 0.759 0.7802 0.8 0.8185

0.659792 0.701029 0.742266 0.783503 0.82474 0.865977 0.907214 0.948451 0.9896880.4181 0.4361 0.453 0.4687 0.4833 0.4967 0.5091 0.5203 0.53050.6339 0.6633 0.6912 0.7176 0.7425 0.766 0.7881 0.8088 0.8281-0.0783 -0.0846 -0.091 -0.0975 -0.1042 -0.111 -0.118 -0.125 -0.13210.5108 0.5356 0.5594 0.582 0.6035 0.624 0.6434 0.6617 0.6790.0896 0.0933 0.0967 0.0999 0.1028 0.1054 0.1078 0.1099 0.11180.484 0.505 0.5247 0.5431 0.5601 0.5759 0.5904 0.6037 0.6158

0.5322 0.5601 0.587 0.6129 0.638 0.6621 0.6852 0.7075 0.72880.6306 0.6593 0.6865 0.7121 0.7363 0.759 0.7802 0.8 0.8185

0.659792 0.701029 0.742266 0.783503 0.82474 0.865977 0.907214 0.948451 0.9896880.5255 0.5499 0.5731 0.595 0.6158 0.6353 0.6537 0.6709 0.6870.5849 0.6182 0.6505 0.6816 0.7115 0.7402 0.7676 0.7936 0.81820.609 0.6342 0.6576 0.6793 0.6993 0.7176 0.7343 0.7493 0.7628

0.6038 0.6358 0.6667 0.6964 0.7249 0.7521 0.7781 0.8028 0.82610.5187 0.5444 0.5692 0.5928 0.6155 0.6372 0.6579 0.6776 0.69630.5851 0.6186 0.6511 0.6826 0.713 0.7422 0.7702 0.797 0.82240.5855 0.6188 0.651 0.6821 0.7119 0.7405 0.7676 0.7934 0.81760.5822 0.6155 0.6477 0.6789 0.709 0.7378 0.7654 0.7918 0.8168

0.659792 0.701029 0.742266 0.783503 0.82474 0.865977 0.907214 0.948451 0.9896880.5844 0.6181 0.6512 0.6838 0.7157 0.7469 0.7776 0.8077 0.83721.0066 1.0475 1.0853 1.1203 1.1524 1.1816 1.2081 1.2319 1.2530.5506 0.5799 0.6083 0.6355 0.6618 0.6869 0.711 0.7339 0.75570.5764 0.5986 0.6189 0.6374 0.6542 0.6691 0.6824 0.694 0.70390.5163 0.5353 0.5526 0.5683 0.5822 0.5945 0.6052 0.6143 0.62190.5851 0.6183 0.6505 0.6815 0.7112 0.7397 0.7668 0.7924 0.81650.5848 0.6183 0.651 0.6828 0.7136 0.7433 0.7721 0.7998 0.82640.5609 0.592 0.6222 0.6514 0.6796 0.7068 0.733 0.7582 0.7822

0.659792 0.701029 0.742266 0.783503 0.82474 0.865977 0.907214 0.948451 0.9896880.5852 0.6184 0.6505 0.6814 0.711 0.7392 0.7661 0.7915 0.81531.0066 1.0475 1.0853 1.1203 1.1524 1.1816 1.2081 1.2319 1.2530.6492 0.6793 0.7078 0.7348 0.7604 0.7844 0.807 0.8282 0.84790.5846 0.6177 0.6496 0.6802 0.7096 0.7376 0.7642 0.7893 0.81280.6139 0.6538 0.6935 0.7331 0.7726 0.8119 0.851 0.8899 0.92870.5857 0.6193 0.6518 0.6832 0.7135 0.7425 0.7703 0.7967 0.8218

0.5844 0.6174 0.6492 0.6798 0.7091 0.7371 0.7636 0.7885 0.81190.7282 0.7582 0.786 0.8117 0.8353 0.8569 0.8766 0.8943 0.91

1.030925 1.072162 1.113399 1.154636 1.195873 1.23711 1.278347 1.319584 1.3608210.843 0.8655 0.8866 0.9063 0.9245 0.9412 0.9564 0.97 0.982

0.8452 0.8685 0.8904 0.9108 0.9298 0.9472 0.963 0.9773 0.98980.8027 0.8197 0.8354 0.8499 0.8631 0.875 0.8856 0.895 0.90311.0533 1.0687 1.0821 1.0936 1.1031 1.1108 1.1166 1.1206 1.12280.8448 0.8642 0.8824 0.8992 0.9148 0.929 0.9419 0.9536 0.96390.7623 0.7768 0.7901 0.802 0.8128 0.8223 0.8305 0.8376 0.84351.1249 1.1393 1.1516 1.1616 1.1696 1.1755 1.1794 1.1813 1.18120.817 0.8388 0.8594 0.8785 0.8963 0.9127 0.9277 0.9412 0.9531

1.030925 1.072162 1.113399 1.154636 1.195873 1.23711 1.278347 1.319584 1.3608210.8202 0.8422 0.8632 0.883 0.9017 0.9193 0.9358 0.9511 0.96530.7615 0.7753 0.7877 0.7989 0.8087 0.8173 0.8247 0.8308 0.83570.8416 0.8633 0.8833 0.9017 0.9184 0.9333 0.9463 0.9574 0.9666

0.85 0.8629 0.8742 0.8839 0.8922 0.899 0.9044 0.9084 0.9110.7406 0.7578 0.774 0.7892 0.8035 0.8169 0.8294 0.841 0.85170.8457 0.8631 0.8791 0.894 0.9076 0.9199 0.9311 0.9411 0.950.8511 0.8736 0.8944 0.9137 0.9312 0.947 0.9609 0.9729 0.9831.0687 1.0824 1.094 1.1036 1.1111 1.1167 1.1204 1.1222 1.1221

1.030925 1.072162 1.113399 1.154636 1.195873 1.23711 1.278347 1.319584 1.3608212.6496 2.736 2.8206 2.9034 2.9845 3.0637 3.1412 3.2169 3.29090.7615 0.7753 0.7877 0.7989 0.8087 0.8173 0.8247 0.8308 0.83570.7538 0.7687 0.7824 0.7949 0.8063 0.8164 0.8254 0.8333 0.840.5443 0.5477 0.5499 0.5508 0.5504 0.5489 0.5461 0.5423 0.5373-1.2769 -1.3142 -1.3503 -1.3852 -1.419 -1.4516 -1.483 -1.5134 -1.54260.8184 0.8433 0.8674 0.8906 0.9131 0.9348 0.9556 0.9756 0.99481.0745 1.0882 1.0999 1.1096 1.1172 1.1228 1.1265 1.1283 1.12831.0184 1.0335 1.0468 1.0582 1.0678 1.0756 1.0816 1.0859 1.0885

1.030925 1.072162 1.113399 1.154636 1.195873 1.23711 1.278347 1.319584 1.3608210.8647 0.8822 0.8983 0.9129 0.9261 0.9378 0.9481 0.957 0.96440.774 0.7946 0.8142 0.833 0.8509 0.8678 0.8839 0.8992 0.9135

0.8562 0.8803 0.9031 0.9246 0.9446 0.9631 0.9801 0.9956 1.00940.6976 0.711 0.7233 0.7343 0.7442 0.7529 0.7605 0.7669 0.77220.8171 0.838 0.8577 0.8762 0.8936 0.9097 0.9247 0.9384 0.95090.8571 0.8828 0.9075 0.9311 0.9536 0.975 0.9951 1.0141 1.03190.8668 0.8957 0.924 0.9519 0.9792 1.0059 1.0322 1.0579 1.08310.8769 0.9071 0.9367 0.9658 0.9944 1.0224 1.0498 1.0766 1.1028

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1.030925 1.072162 1.113399 1.154636 1.195873 1.23711 1.278347 1.319584 1.3608210.8375 0.8581 0.8769 0.8938 0.9089 0.9219 0.933 0.9419 0.94871.2716 1.2875 1.301 1.3121 1.3207 1.327 1.3311 1.3329 1.33250.8663 0.8832 0.8989 0.9131 0.9261 0.9378 0.9482 0.9573 0.96520.8347 0.8549 0.8732 0.8897 0.9042 0.9168 0.9273 0.9356 0.94170.9673 1.0057 1.0439 1.0819 1.1197 1.1573 1.1947 1.2319 1.26880.8454 0.8674 0.8879 0.9068 0.924 0.9394 0.953 0.9647 0.9744

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1.1203 1.1167 1.1114 1.1045 1.0959 1.0858 1.0742 1.061 1.0465

1.402058 1.443295 1.484532 1.525769 1.567006 1.608243 1.64948 1.690717 1.7319543.3631 3.4337 3.5025 3.5697 3.6352 3.699 3.7611 3.8216 3.88050.8394 0.8419 0.8432 0.8434 0.8424 0.8403 0.8371 0.8328 0.82740.8456 0.8501 0.8535 0.8557 0.857 0.8571 0.8562 0.8543 0.85130.5312 0.524 0.5158 0.5066 0.4964 0.4853 0.4732 0.4602 0.4464-1.5707 -1.5977 -1.6236 -1.6484 -1.6722 -1.6949 -1.7165 -1.7372 -1.75671.0132 1.0307 1.0474 1.0632 1.0782 1.0923 1.1055 1.1179 1.12931.1264 1.1228 1.1174 1.1104 1.1018 1.0915 1.0798 1.0665 1.05171.0894 1.0886 1.0863 1.0823 1.0769 1.0699 1.0614 1.0516 1.0402

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1.0216 1.0321 1.0408 1.0477 1.0527 1.0559 1.0571 1.0563 1.05350.7763 0.7793 0.7811 0.7819 0.7815 0.78 0.7774 0.7738 0.7690.9621 0.9721 0.9808 0.9882 0.9944 0.9992 1.0027 1.0048 1.00561.0484 1.0636 1.0775 1.0901 1.1013 1.1111 1.1195 1.1264 1.13181.1077 1.1319 1.1555 1.1787 1.2013 1.2235 1.2451 1.2662 1.28691.1285 1.1536 1.178 1.2019 1.2252 1.2479 1.2699 1.2913 1.3121

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1.6344 1.671 1.707 1.7422 1.7768 1.8106 1.8437 1.8761 1.90791.1578 1.1544 1.1492 1.1423 1.1338 1.1236 1.1119 1.0987 1.084-2.8586 -2.9047 -2.9488 -2.9907 -3.0306 -3.0685 -3.1043 -3.1382 -3.17010.9814 0.9896 0.9962 1.0012 1.0045 1.0061 1.006 1.0042 1.00051.1424 1.1398 1.1354 1.1294 1.1217 1.1124 1.1016 1.0892 1.07540.931 0.9356 0.9391 0.9414 0.9427 0.943 0.9422 0.9404 0.9376

1.402058 1.443295 1.484532 1.525769 1.567006 1.608243 1.64948 1.690717 1.7319540.5758 0.5749 0.5731 0.5704 0.5668 0.5624 0.557 0.5508 0.5437

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0.8922 0.9036 0.9142 0.9238 0.9326 0.9405 0.9476 0.9538 0.95910.931 0.9356 0.9391 0.9414 0.9427 0.943 0.9422 0.9404 0.9376

1.402058 1.443295 1.484532 1.525769 1.567006 1.608243 1.64948 1.690717 1.7319540.788 0.7925 0.796 0.7986 0.8003 0.801 0.8008 0.7998 0.7979

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0.72 0.714 0.7067 0.6982 0.6886 0.6778 0.6658 0.6528 0.63870.6196 0.6123 0.6039 0.5943 0.5836 0.5718 0.559 0.5452 0.53040.9607 0.9639 0.9648 0.9633 0.9594 0.953 0.944 0.9323 0.9181.0233 1.0353 1.0457 1.0546 1.0618 1.0674 1.0712 1.0734 1.07370.9572 0.9676 0.9765 0.9841 0.9902 0.9948 0.998 0.9996 0.9996

1.402058 1.443295 1.484532 1.525769 1.567006 1.608243 1.64948 1.690717 1.7319540.9532 0.9554 0.9552 0.9525 0.9473 0.9395 0.9291 0.9159 0.89991.3301 1.3255 1.319 1.3104 1.3 1.2877 1.2737 1.2578 1.24030.9719 0.9774 0.9817 0.9848 0.9868 0.9877 0.9875 0.9863 0.98390.9455 0.9469 0.9459 0.9424 0.9363 0.9276 0.9161 0.9019 0.88471.3056 1.3421 1.3784 1.4145 1.4503 1.4859 1.5212 1.5563 1.59110.9822 0.9879 0.9914 0.9928 0.992 0.9888 0.9833 0.9753 0.9649

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1.773191 1.814428 1.855665 1.896902 1.938139 1.979376 2.020613 2.06185 2.1030871.04 1.0405 1.0396 1.0375 1.034 1.0292 1.0229 1.0153 1.0064

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1.939 1.9693 1.999 2.0281 2.0564 2.0841 2.1112 2.1375 2.16321.0678 1.0503 1.0314 1.0112 0.9897 0.967 0.9432 0.9182 0.8922

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1.773191 1.814428 1.855665 1.896902 1.938139 1.979376 2.020613 2.06185 2.1030870.7951 0.7915 0.787 0.7818 0.7758 0.769 0.7614 0.7531 0.74410.9346 0.918 0.8987 0.8766 0.8518 0.824 0.7933 0.7596 0.72280.7514 0.7387 0.725 0.7103 0.6946 0.678 0.6606 0.6422 0.6230.984 0.9754 0.965 0.9528 0.9386 0.9225 0.9044 0.8843 0.8622

0.8829 0.8847 0.8856 0.8859 0.8855 0.8843 0.8825 0.88 0.87690.9831 0.9708 0.9561 0.9388 0.9189 0.8965 0.8713 0.8435 0.81280.903 0.883 0.8601 0.8342 0.8053 0.7732 0.738 0.6995 0.6576

0.9594 0.9454 0.929 0.9099 0.8882 0.8638 0.8366 0.8067 0.7738

1.773191 1.814428 1.855665 1.896902 1.938139 1.979376 2.020613 2.06185 2.1030871.29 1.3085 1.3265 1.344 1.361 1.3776 1.3936 1.4092 1.4243

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1.773191 1.814428 1.855665 1.896902 1.938139 1.979376 2.020613 2.06185 2.1030870.881 0.8591 0.8343 0.8063 0.7752 0.7409 0.7032 0.6622 0.6177

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3.628856 3.670093 3.71133 3.752567 3.793804 3.835041 3.876278 3.917515 3.958752-4.0889 -4.3162 -4.5496 -4.7894 -5.0354 -5.2878 -5.5467 -5.8121 -6.0842-0.4649 -0.5014 -0.537 -0.5716 -0.6053 -0.6379 -0.6694 -0.6997 -0.72890.0814 0.052 0.0226 -0.007 -0.0366 -0.0663 -0.0959 -0.1256 -0.1552-4.2405 -4.4732 -4.7122 -4.9575 -5.2093 -5.4676 -5.7325 -6.004 -6.28232.8414 2.8593 2.8768 2.8937 2.9102 2.9262 2.9418 2.9568 2.9714-3.2521 -3.4478 -3.6489 -3.8555 -4.0675 -4.2852 -4.5085 -4.7375 -4.9722

-4.2961 -4.5307 -4.7716 -5.019 -5.2729 -5.5334 -5.8005 -6.0743 -6.3549-0.4721 -0.5061 -0.5397 -0.5728 -0.6055 -0.6376 -0.6693 -0.7004 -0.7309

3.999989-3.5651-3.9469-1.038-0.8854-1.2914-0.6791-0.7603-3.1107

3.999989-1.1411-0.6994-5.371-0.40240.4121-0.0504-5.3113-0.7069

3.9999894.9652-0.6994-0.5285-0.82

-1.55290.2274-0.76

-0.8074

3.999989-1.40540.1882-3.6282-0.9569-1.3903-1.71671.77951.3448

3.999989-0.8673-2.5624

2.7051-0.7054-2.5716-2.7897-0.7711-0.0512

3.999989-0.7719-0.1293-0.8479-0.261-0.274-0.78360.0146-0.0512

3.999989-0.1913-5.3293-0.6947-2.7790.2136-4.5412-6.0299-4.8231

3.9999891.6851-0.7568-1.9514-0.7926-0.8342-6.0038-2.7061-2.1472

3.999989-6.3628-0.7568-0.1848-6.56742.9854-5.2128

-6.6423-0.7607

Saporin0 0.0417 0.0833 0.125 0.1667 0.2083

COL-TST-sink 0 0.0429 0.0854 0.1275 0.1691 0.2103FB-TST-sink 0 0.0417 0.0832 0.1244 0.1654 0.206FGF-TST-sink 0 0.0489 0.0964 0.1425 0.1873 0.2308FN-TST-sink 0 0.0732 0.1436 0.2113 0.2762 0.3384GAPDH-TST-sink 0 0.0493 0.0975 0.1444 0.1901 0.2346GDF-TST-sink 0 0.0488 0.0961 0.1417 0.1859 0.2285LIN-TST-sink 0 0.0809 0.1585 0.2328 0.304 0.372UTF-TST-sink 0 0.0419 0.0834 0.1245 0.1651 0.2051

0 0.0417 0.0833 0.125 0.1667 0.2083COL-TLT-sink 0 0.0442 0.0876 0.1302 0.172 0.213FB-TLT-sink 0 0.0497 0.0976 0.144 0.1887 0.2317FGF-TLT-sink 0 0.0417 0.0833 0.1247 0.1659 0.2067FN-TLT-sink 0 0.0589 0.1156 0.1701 0.2223 0.2724GAPDH-TLT-sink 0 0.0449 0.0884 0.1306 0.1715 0.2111GDF-TLT-sink 0 0.0534 0.1051 0.1551 0.2034 0.25LIN-TLT-sink 0 0.0417 0.0832 0.1247 0.1659 0.2069UTF-TLT-sink 0 0.0769 0.1507 0.2213 0.289 0.3536

0 0.0417 0.0833 0.125 0.1667 0.2083COL-TLT-FB 0 0.1336 0.2651 0.3944 0.5217 0.647FB-TLT-FB 0 0.0497 0.0976 0.144 0.1887 0.2317FGF-TLT-FB 0 0.0477 0.0939 0.1386 0.1818 0.2236FN-TLT-FB 0 0.043 0.084 0.123 0.1602 0.1954GAPDH-TLT-FB 0 -0.0688 -0.1362 -0.2021 -0.2667 -0.3298GDF-TLT-FB 0 0.0421 0.0835 0.1242 0.1643 0.2037LIN-TLT-FB 0 0.0772 0.1513 0.2223 0.2902 0.3551UTF-TLT-FB 0 0.0705 0.1383 0.2035 0.266 0.326

Actinomycin D0 0.0417 0.0833 0.125 0.1667 0.2083

COL-TST-sink 0 0.0533 0.1051 0.1554 0.2041 0.2514FB-TST-sink 0 0.0434 0.0857 0.1271 0.1675 0.2069FGF-TST-sink 0 0.0419 0.0836 0.1251 0.1663 0.2072FN-TST-sink 0 0.0441 0.0868 0.1282 0.1682 0.2069GAPDH-TST-sink 0 0.045 0.0892 0.1324 0.1748 0.2163GDF-TST-sink 0 0.0422 0.0841 0.1255 0.1666 0.2072LIN-TST-sink 0 0.0431 0.0855 0.1273 0.1685 0.2091UTF-TST-sink 0 0.0419 0.0834 0.1244 0.165 0.2051

0 0.0417 0.0833 0.125 0.1667 0.2083COL-TLT-sink 0 0.0719 0.141 0.2074 0.2711 0.3322

0

0.2917

0.58330.875

1.1666

1.45831.75

2.0416

2.33332.625

2.9166

3.2083

3.4999

3.7916

-5

-4

-3

-2

-1

0

1

2

COL-TST-sinkFB-TST-sinkFGF-TST-sinkFN-TST-sinkGAPDH-TST-sinkGDF-TST-sinkLIN-TST-sinkUTF-TST-sink

0

0.3333

0.6667 1

1.3333

1.6666 2

2.3333

2.6666 3

3.3333

3.6666 4

-4

-3

-2

-1

0

1

2

3

COL-TST-sinkFB-TST-sinkFGF-TST-sinkFN-TST-sinkGAPDH-TST-sinkGDF-TST-sinkLIN-TST-sinkUTF-TST-sink

FB-TLT-sink 0 0.0466 0.0923 0.1372 0.1812 0.2244FGF-TLT-sink 0 0.0623 0.1238 0.1844 0.2443 0.3032FN-TLT-sink 0 0.0791 0.1551 0.2278 0.2975 0.364GAPDH-TLT-sink 0 -0.1288 -0.2547 -0.3778 -0.4981 -0.6155GDF-TLT-sink 0 0.0449 0.0891 0.1327 0.1756 0.2177LIN-TLT-sink 0 0.0768 0.1506 0.2214 0.2891 0.354UTF-TLT-sink 0 0.0545 0.1072 0.1579 0.2069 0.254

0 0.0417 0.0833 0.125 0.1667 0.2083COL-TLT-FB 0 0.0369 0.0725 0.1068 0.1397 0.1713FB-TLT-FB 0 0.0542 0.1067 0.1573 0.2062 0.2534FGF-TLT-FB 0 -0.0042 -0.0086 -0.0131 -0.0177 -0.0225FN-TLT-FB 0 0.0425 0.0837 0.1237 0.1624 0.2GAPDH-TLT-FB 0 0.008 0.0158 0.0232 0.0303 0.0372GDF-TLT-FB 0 0.0427 0.0838 0.1234 0.1615 0.198LIN-TLT-FB 0 0.0423 0.0836 0.1239 0.1632 0.2016UTF-TLT-FB 0 0.0545 0.1072 0.1579 0.2069 0.254

Mitomycin C0 0.0417 0.0833 0.125 0.1667 0.2083

COL-TST-sink 0 0.0449 0.0882 0.1302 0.1707 0.2097FB-TST-sink 0 0.0419 0.0836 0.1251 0.1663 0.2073FGF-TST-sink 0 0.055 0.1079 0.1586 0.2072 0.2536FN-TST-sink 0 0.0465 0.0923 0.1372 0.1813 0.2245GAPDH-TST-sink 0 0.0427 0.0842 0.1245 0.1636 0.2015GDF-TST-sink 0 0.0419 0.0836 0.1251 0.1663 0.2072LIN-TST-sink 0 0.0417 0.0832 0.1247 0.1659 0.2068UTF-TST-sink 0 0.0417 0.0832 0.1245 0.1656 0.2063

0 0.0417 0.0833 0.125 0.1667 0.2083COL-TLT-sink 0 0.0437 0.0866 0.1289 0.1705 0.2115FB-TLT-sink 0 0.092 0.1801 0.2646 0.3454 0.4225FGF-TLT-sink 0 0.0425 0.0842 0.1252 0.1654 0.2048FN-TLT-sink 0 0.0538 0.1053 0.1544 0.2013 0.246GAPDH-TLT-sink 0 0.049 0.0957 0.1403 0.1827 0.223GDF-TLT-sink 0 0.0417 0.0833 0.1247 0.1659 0.2069LIN-TLT-sink 0 0.0424 0.0845 0.1263 0.1676 0.2085UTF-TLT-sink 0 0.042 0.0834 0.1243 0.1646 0.2042

0 0.0417 0.0833 0.125 0.1667 0.2083COL-TLT-FB 0 0.0417 0.0832 0.1247 0.1659 0.2068FB-TLT-FB 0 0.092 0.1801 0.2646 0.3454 0.4225FGF-TLT-FB 0 0.0555 0.1092 0.1611 0.2112 0.2595FN-TLT-FB 0 0.0417 0.0832 0.1247 0.1659 0.2068

0

0.3333

0.6667 1

1.3333

1.6666 2

2.3333

2.6666 3

3.3333

3.6666 4

-4

-3

-2

-1

0

1

2

3

COL-TST-sinkFB-TST-sinkFGF-TST-sinkFN-TST-sinkGAPDH-TST-sinkGDF-TST-sinkLIN-TST-sinkUTF-TST-sink

0

0.2083

0.41670.625

0.8333

1.0416

1.25

1.4583

1.66661.875

2.0833

2.2916 2.

5

2.7083

2.91663.125

3.3333

3.5416

3.7499

3.9583

-7

-6

-5

-4

-3

-2

-1

0

1

2

COL-TST-sinkFB-TST-sinkFGF-TST-sinkFN-TST-sinkGAPDH-TST-sinkGDF-TST-sinkLIN-TST-sinkUTF-TST-sink

GAPDH-TLT-FB 0 0.0417 0.0832 0.1247 0.1661 0.2074GDF-TLT-FB 0 0.0417 0.0834 0.1248 0.166 0.2069LIN-TLT-FB 0 0.0417 0.0832 0.1247 0.1659 0.2068UTF-TLT-FB 0 0.0661 0.1295 0.1903 0.2485 0.3041

0.25 0.2917 0.3333 0.375 0.4167 0.4583 0.5 0.5417 0.58330.2509 0.291 0.3304 0.3692 0.4073 0.4446 0.4811 0.5168 0.55170.2462 0.2859 0.3252 0.3639 0.402 0.4394 0.4762 0.5122 0.54740.2728 0.3136 0.3529 0.391 0.4277 0.463 0.497 0.5297 0.56110.398 0.4549 0.5093 0.561 0.6103 0.657 0.7013 0.7432 0.7827

0.2779 0.32 0.3609 0.4005 0.4389 0.476 0.5119 0.5466 0.580.2695 0.3091 0.3471 0.3837 0.4188 0.4524 0.4846 0.5153 0.54460.4368 0.4987 0.5575 0.6133 0.6662 0.7162 0.7634 0.8078 0.84950.2446 0.2835 0.3217 0.3593 0.3961 0.4322 0.4676 0.5021 0.5357

0.25 0.2917 0.3333 0.375 0.4167 0.4583 0.5 0.5417 0.58330.2531 0.2925 0.3309 0.3686 0.4053 0.4411 0.4761 0.5101 0.54320.2732 0.3131 0.3514 0.3881 0.4233 0.4569 0.489 0.5197 0.54880.2472 0.2873 0.3268 0.3658 0.4041 0.4418 0.4788 0.5149 0.55020.3203 0.3661 0.4098 0.4515 0.4911 0.5288 0.5644 0.5982 0.630.2495 0.2866 0.3225 0.3571 0.3906 0.4229 0.4539 0.4838 0.51260.295 0.3384 0.3802 0.4204 0.459 0.4961 0.5317 0.5657 0.5983

0.2475 0.2877 0.3275 0.3668 0.4055 0.4435 0.4809 0.5174 0.55320.4152 0.474 0.5299 0.5829 0.6332 0.6807 0.7255 0.7677 0.8073

0.25 0.2917 0.3333 0.375 0.4167 0.4583 0.5 0.5417 0.58330.7702 0.8913 1.0104 1.1275 1.2426 1.3556 1.4667 1.5759 1.6830.2732 0.3131 0.3514 0.3881 0.4233 0.4569 0.489 0.5197 0.54880.2638 0.3027 0.3401 0.3761 0.4107 0.4438 0.4756 0.5061 0.53510.2288 0.2604 0.2901 0.3181 0.3444 0.3689 0.3917 0.4129 0.4324-0.3915 -0.4519 -0.5109 -0.5685 -0.6248 -0.6798 -0.7334 -0.7857 -0.83670.2425 0.2806 0.3179 0.3546 0.3907 0.426 0.4606 0.4945 0.52760.4171 0.4761 0.5323 0.5856 0.6361 0.6839 0.729 0.7714 0.81120.3834 0.4383 0.4907 0.5407 0.5883 0.6335 0.6763 0.7168 0.755

0.25 0.2917 0.3333 0.375 0.4167 0.4583 0.5 0.5417 0.58330.2971 0.3413 0.384 0.4252 0.4649 0.5031 0.5398 0.575 0.60870.2453 0.2828 0.3193 0.3548 0.3893 0.4229 0.4555 0.4872 0.51790.2476 0.2877 0.3272 0.3663 0.4047 0.4425 0.4797 0.5161 0.55180.2443 0.2804 0.3151 0.3485 0.3806 0.4115 0.441 0.4693 0.49620.2569 0.2966 0.3353 0.373 0.4098 0.4457 0.4805 0.5143 0.54720.2474 0.2871 0.3262 0.3648 0.4028 0.4402 0.4769 0.513 0.54840.249 0.2884 0.3271 0.3652 0.4028 0.4397 0.476 0.5117 0.5469

0.2448 0.2841 0.3229 0.3612 0.3991 0.4364 0.4733 0.5097 0.5457

0.25 0.2917 0.3333 0.375 0.4167 0.4583 0.5 0.5417 0.58330.3907 0.4466 0.5 0.5508 0.5992 0.6452 0.6887 0.7299 0.7687

0

0.2917

0.58330.875

1.1666

1.45831.75

2.0416

2.33332.625

2.9166

3.2083

3.4999

3.7916

-5

-4

-3

-2

-1

0

1

2

COL-TST-sinkFB-TST-sinkFGF-TST-sinkFN-TST-sinkGAPDH-TST-sinkGDF-TST-sinkLIN-TST-sinkUTF-TST-sink

0

0.2917

0.58330.875

1.1666

1.45831.75

2.0416

2.33332.625

2.9166

3.2083

3.4999

3.7916

-6

-5

-4

-3

-2

-1

0

1

2

COL-TLT-sinkFB-TLT-sinkFGF-TLT-sinkFN-TLT-sinkGAPDH-TLT-sinkGDF-TLT-sinkLIN-TLT-sinkUTF-TLT-sink

0

0.3333

0.6667 1

1.3333

1.6666 2

2.3333

2.6666 3

3.3333

3.6666 4

-4

-3

-2

-1

0

1

2

3

COL-TST-sinkFB-TST-sinkFGF-TST-sinkFN-TST-sinkGAPDH-TST-sinkGDF-TST-sinkLIN-TST-sinkUTF-TST-sink

0.2666 0.3079 0.3482 0.3876 0.4259 0.4633 0.4995 0.5347 0.56880.3614 0.4187 0.4753 0.531 0.5859 0.64 0.6933 0.7458 0.79750.4276 0.4881 0.5457 0.6004 0.6522 0.7012 0.7475 0.791 0.8318-0.7301 -0.842 -0.9512 -1.0576 -1.1614 -1.2625 -1.3609 -1.4567 -1.54990.2591 0.2996 0.3394 0.3783 0.4163 0.4534 0.4896 0.5248 0.5590.4159 0.475 0.5313 0.5848 0.6356 0.6837 0.7291 0.7719 0.81220.2993 0.3429 0.3847 0.4248 0.4632 0.5 0.535 0.5685 0.6003

0.25 0.2917 0.3333 0.375 0.4167 0.4583 0.5 0.5417 0.58330.2017 0.2307 0.2584 0.2849 0.3102 0.3342 0.3569 0.3785 0.39890.2988 0.3426 0.3847 0.4251 0.4639 0.501 0.5366 0.5706 0.603-0.0275 -0.0326 -0.0378 -0.0432 -0.0487 -0.0543 -0.0601 -0.066 -0.07210.2364 0.2715 0.3055 0.3383 0.3699 0.4004 0.4297 0.4579 0.48490.0437 0.0499 0.0559 0.0615 0.0669 0.072 0.0768 0.0813 0.08560.2331 0.2667 0.2988 0.3295 0.3587 0.3866 0.413 0.438 0.46170.239 0.2754 0.3109 0.3454 0.3789 0.4115 0.4431 0.4737 0.5035

0.2993 0.3429 0.3847 0.4248 0.4632 0.5 0.535 0.5685 0.6003

0.25 0.2917 0.3333 0.375 0.4167 0.4583 0.5 0.5417 0.58330.2474 0.2837 0.3186 0.3521 0.3843 0.4151 0.4446 0.4729 0.49980.2478 0.2879 0.3274 0.3664 0.4048 0.4424 0.4793 0.5154 0.55070.298 0.3404 0.3807 0.4191 0.4555 0.4899 0.5225 0.5531 0.582

0.2668 0.3083 0.3488 0.3883 0.4268 0.4644 0.5008 0.5363 0.57060.2383 0.2739 0.3084 0.3417 0.3739 0.4051 0.4351 0.464 0.49190.2477 0.2877 0.3272 0.3661 0.4045 0.4421 0.4791 0.5153 0.55060.2474 0.2875 0.3272 0.3663 0.4048 0.4426 0.4796 0.5158 0.55110.2465 0.2864 0.3257 0.3645 0.4027 0.4402 0.4769 0.5129 0.548

0.25 0.2917 0.3333 0.375 0.4167 0.4583 0.5 0.5417 0.58330.2517 0.2913 0.3302 0.3685 0.4061 0.443 0.4793 0.515 0.550.4961 0.5662 0.6328 0.696 0.7558 0.8123 0.8656 0.9158 0.96270.2434 0.2811 0.318 0.354 0.3891 0.4233 0.4566 0.4889 0.52020.2884 0.3287 0.3668 0.4028 0.4368 0.4686 0.4985 0.5264 0.55240.2612 0.2974 0.3315 0.3636 0.3938 0.422 0.4483 0.4728 0.49540.2474 0.2876 0.3272 0.3663 0.4047 0.4424 0.4794 0.5156 0.55080.2489 0.2888 0.3281 0.3668 0.405 0.4424 0.4791 0.5151 0.55040.2432 0.2815 0.3192 0.3561 0.3922 0.4276 0.4622 0.4959 0.5288

0.25 0.2917 0.3333 0.375 0.4167 0.4583 0.5 0.5417 0.58330.2474 0.2876 0.3273 0.3664 0.4048 0.4426 0.4796 0.5158 0.5510.4961 0.5662 0.6328 0.696 0.7558 0.8123 0.8656 0.9158 0.96270.306 0.3508 0.3939 0.4353 0.475 0.5131 0.5495 0.5843 0.6176

0.2474 0.2875 0.3272 0.3663 0.4047 0.4424 0.4793 0.5154 0.5505

0

0.3333

0.6667 1

1.3333

1.6666 2

2.3333

2.6666 3

3.3333

3.6666 4

-4

-3

-2

-1

0

1

2

3

COL-TST-sinkFB-TST-sinkFGF-TST-sinkFN-TST-sinkGAPDH-TST-sinkGDF-TST-sinkLIN-TST-sinkUTF-TST-sink

0

0.2083

0.41670.625

0.8333

1.0416

1.25

1.4583

1.66661.875

2.0833

2.2916 2.

5

2.7083

2.91663.125

3.3333

3.5416

3.7499

3.9583

-7

-6

-5

-4

-3

-2

-1

0

1

2

COL-TST-sinkFB-TST-sinkFGF-TST-sinkFN-TST-sinkGAPDH-TST-sinkGDF-TST-sinkLIN-TST-sinkUTF-TST-sink

0

0.2083

0.41670.625

0.8333

1.0416

1.25

1.4583

1.66661.875

2.0833

2.2916 2.

5

2.7083

2.91663.125

3.3333

3.5416

3.7499

3.9583

-7

-6

-5

-4

-3

-2

-1

0

1

2

3

COL-TLT-sinkFB-TLT-sinkFGF-TLT-sinkFN-TLT-sinkGAPDH-TLT-sinkGDF-TLT-sinkLIN-TLT-sinkUTF-TLT-sink

0.2486 0.2896 0.3306 0.3715 0.4122 0.4528 0.4933 0.5336 0.57380.2474 0.2875 0.3271 0.3662 0.4047 0.4424 0.4795 0.5158 0.55120.2474 0.2875 0.3272 0.3662 0.4046 0.4423 0.4792 0.5152 0.55030.3573 0.4079 0.4562 0.502 0.5454 0.5865 0.6253 0.6618 0.6961

0.625 0.6667 0.7083 0.75 0.7917 0.8333 0.875 0.9167 0.95830.5856 0.6186 0.6506 0.6815 0.7114 0.7401 0.7677 0.794 0.81910.5818 0.6153 0.6478 0.6794 0.7099 0.7394 0.7677 0.7948 0.82060.5911 0.6199 0.6473 0.6734 0.6982 0.7217 0.7439 0.7648 0.78430.8198 0.8546 0.8871 0.9173 0.9453 0.9712 0.9949 1.0164 1.03590.6122 0.6431 0.6727 0.7011 0.7283 0.7541 0.7787 0.802 0.8240.5726 0.5991 0.6242 0.6479 0.6703 0.6914 0.7111 0.7295 0.74660.8884 0.9247 0.9584 0.9895 1.0181 1.0442 1.0679 1.0892 1.10820.5685 0.6003 0.6312 0.661 0.6898 0.7176 0.7442 0.7697 0.794

0.625 0.6667 0.7083 0.75 0.7917 0.8333 0.875 0.9167 0.95830.5754 0.6066 0.6368 0.666 0.6943 0.7215 0.7478 0.773 0.79710.5764 0.6026 0.6274 0.6507 0.6726 0.6932 0.7123 0.7301 0.74650.5845 0.6178 0.6501 0.6813 0.7113 0.7401 0.7676 0.7937 0.8184

0.66 0.6881 0.7144 0.7389 0.7616 0.7826 0.802 0.8196 0.83560.5403 0.5668 0.5922 0.6165 0.6398 0.662 0.6832 0.7033 0.72250.6293 0.659 0.6871 0.7139 0.7393 0.7632 0.7859 0.8071 0.82710.588 0.6219 0.6548 0.6866 0.7172 0.7467 0.7748 0.8017 0.8271

0.8443 0.8787 0.9107 0.9403 0.9674 0.9922 1.0147 1.0349 1.0529

0.625 0.6667 0.7083 0.75 0.7917 0.8333 0.875 0.9167 0.95831.7882 1.8915 1.9929 2.0923 2.1899 2.2855 2.3793 2.4713 2.56140.5764 0.6026 0.6274 0.6507 0.6726 0.6932 0.7123 0.7301 0.74650.5628 0.5892 0.6143 0.6381 0.6605 0.6817 0.7016 0.7202 0.73760.4504 0.4667 0.4815 0.4948 0.5066 0.517 0.5259 0.5334 0.5395-0.8864 -0.9348 -0.9819 -1.0277 -1.0724 -1.1157 -1.1578 -1.1987 -1.23840.5601 0.5918 0.6228 0.653 0.6825 0.7112 0.7392 0.7664 0.79280.8484 0.8831 0.9153 0.945 0.9724 0.9973 1.02 1.0404 1.05850.7909 0.8247 0.8562 0.8856 0.9128 0.938 0.9611 0.9822 1.0013

0.625 0.6667 0.7083 0.75 0.7917 0.8333 0.875 0.9167 0.95830.641 0.6717 0.701 0.7288 0.7551 0.7799 0.8033 0.8252 0.8457

0.5477 0.5766 0.6045 0.6315 0.6575 0.6826 0.7069 0.7301 0.75250.5867 0.6207 0.6538 0.6859 0.7171 0.7472 0.7762 0.804 0.83070.522 0.5464 0.5696 0.5916 0.6123 0.6318 0.6501 0.6671 0.68290.579 0.6098 0.6395 0.6681 0.6957 0.7222 0.7476 0.7719 0.79510.583 0.6169 0.65 0.6822 0.7137 0.7442 0.7739 0.8026 0.8303

0.5814 0.6154 0.6488 0.6816 0.7139 0.7456 0.7767 0.8073 0.83730.5811 0.616 0.6505 0.6844 0.7178 0.7507 0.783 0.8148 0.8461

0.625 0.6667 0.7083 0.75 0.7917 0.8333 0.875 0.9167 0.95830.8052 0.8395 0.8715 0.9012 0.9289 0.9543 0.9777 0.999 1.0182

0

0.2917

0.58330.875

1.1666

1.45831.75

2.0416

2.33332.625

2.9166

3.2083

3.4999

3.7916

-6

-5

-4

-3

-2

-1

0

1

2

COL-TLT-sinkFB-TLT-sinkFGF-TLT-sinkFN-TLT-sinkGAPDH-TLT-sinkGDF-TLT-sinkLIN-TLT-sinkUTF-TLT-sink

00.25 0.

50.75 1

1.25 1.

51.75 2

2.25 2.

52.75 3

3.2499

3.4999

3.7499 4

-3

-2

-1

0

1

2

3

4

5

6

00.25 0.

50.75 1

1.25 1.

51.75 2

2.25 2.

52.75 3

3.2499

3.4999

3.7499 4

-4

-3

-2

-1

0

1

2

3

4

0.6018 0.6336 0.6643 0.6937 0.722 0.749 0.7748 0.7993 0.82250.8484 0.8986 0.9479 0.9965 1.0443 1.0913 1.1376 1.1831 1.22780.8701 0.9057 0.9387 0.9693 0.9974 1.0231 1.0464 1.0674 1.0862-1.6406 -1.7287 -1.8143 -1.8973 -1.9779 -2.056 -2.1317 -2.205 -2.27590.5922 0.6244 0.6554 0.6854 0.7142 0.7418 0.7682 0.7934 0.81740.8499 0.8851 0.9179 0.9483 0.9763 1.002 1.0254 1.0465 1.06540.6306 0.6593 0.6865 0.7121 0.7363 0.759 0.7802 0.8 0.8185

0.625 0.6667 0.7083 0.75 0.7917 0.8333 0.875 0.9167 0.95830.4181 0.4361 0.453 0.4687 0.4833 0.4967 0.5091 0.5203 0.53050.6339 0.6633 0.6912 0.7176 0.7425 0.766 0.7881 0.8088 0.8281-0.0783 -0.0846 -0.091 -0.0975 -0.1042 -0.111 -0.118 -0.125 -0.13210.5108 0.5356 0.5594 0.582 0.6035 0.624 0.6434 0.6617 0.6790.0896 0.0933 0.0967 0.0999 0.1028 0.1054 0.1078 0.1099 0.11180.484 0.505 0.5247 0.5431 0.5601 0.5759 0.5904 0.6037 0.6158

0.5322 0.5601 0.587 0.6129 0.638 0.6621 0.6852 0.7075 0.72880.6306 0.6593 0.6865 0.7121 0.7363 0.759 0.7802 0.8 0.8185

0.625 0.6667 0.7083 0.75 0.7917 0.8333 0.875 0.9167 0.95830.5255 0.5499 0.5731 0.595 0.6158 0.6353 0.6537 0.6709 0.6870.5849 0.6182 0.6505 0.6816 0.7115 0.7402 0.7676 0.7936 0.81820.609 0.6342 0.6576 0.6793 0.6993 0.7176 0.7343 0.7493 0.7628

0.6038 0.6358 0.6667 0.6964 0.7249 0.7521 0.7781 0.8028 0.82610.5187 0.5444 0.5692 0.5928 0.6155 0.6372 0.6579 0.6776 0.69630.5851 0.6186 0.6511 0.6826 0.713 0.7422 0.7702 0.797 0.82240.5855 0.6188 0.651 0.6821 0.7119 0.7405 0.7676 0.7934 0.81760.5822 0.6155 0.6477 0.6789 0.709 0.7378 0.7654 0.7918 0.8168

0.625 0.6667 0.7083 0.75 0.7917 0.8333 0.875 0.9167 0.95830.5844 0.6181 0.6512 0.6838 0.7157 0.7469 0.7776 0.8077 0.83721.0066 1.0475 1.0853 1.1203 1.1524 1.1816 1.2081 1.2319 1.2530.5506 0.5799 0.6083 0.6355 0.6618 0.6869 0.711 0.7339 0.75570.5764 0.5986 0.6189 0.6374 0.6542 0.6691 0.6824 0.694 0.70390.5163 0.5353 0.5526 0.5683 0.5822 0.5945 0.6052 0.6143 0.62190.5851 0.6183 0.6505 0.6815 0.7112 0.7397 0.7668 0.7924 0.81650.5848 0.6183 0.651 0.6828 0.7136 0.7433 0.7721 0.7998 0.82640.5609 0.592 0.6222 0.6514 0.6796 0.7068 0.733 0.7582 0.7822

0.625 0.6667 0.7083 0.75 0.7917 0.8333 0.875 0.9167 0.95830.5852 0.6184 0.6505 0.6814 0.711 0.7392 0.7661 0.7915 0.81531.0066 1.0475 1.0853 1.1203 1.1524 1.1816 1.2081 1.2319 1.2530.6492 0.6793 0.7078 0.7348 0.7604 0.7844 0.807 0.8282 0.84790.5846 0.6177 0.6496 0.6802 0.7096 0.7376 0.7642 0.7893 0.8128

0

0.2083

0.41670.625

0.8333

1.0416

1.25

1.4583

1.66661.875

2.0833

2.2916 2.

5

2.7083

2.91663.125

3.3333

3.5416

3.7499

3.9583

-7

-6

-5

-4

-3

-2

-1

0

1

2

3

COL-TLT-sinkFB-TLT-sinkFGF-TLT-sinkFN-TLT-sinkGAPDH-TLT-sinkGDF-TLT-sinkLIN-TLT-sinkUTF-TLT-sink

0

0.1667

0.3333 0.

5

0.6667

0.8333 1

1.1666

1.3333 1.

5

1.6666

1.8333 2

2.1666

2.3333 2.

5

2.6666

2.8333 3

3.1666

3.3333

3.4999

3.6666

3.8333 4

-8

-6

-4

-2

0

2

4

COL-TLT-FBFB-TLT-FBFGF-TLT-FBFN-TLT-FBGAPDH-TLT-FBGDF-TLT-FBLIN-TLT-FBUTF-TLT-FB

0.6139 0.6538 0.6935 0.7331 0.7726 0.8119 0.851 0.8899 0.92870.5857 0.6193 0.6518 0.6832 0.7135 0.7425 0.7703 0.7967 0.82180.5844 0.6174 0.6492 0.6798 0.7091 0.7371 0.7636 0.7885 0.81190.7282 0.7582 0.786 0.8117 0.8353 0.8569 0.8766 0.8943 0.91

1 1.0416 1.0833 1.125 1.1666 1.2083 1.25 1.2916 1.33330.843 0.8655 0.8866 0.9063 0.9245 0.9412 0.9564 0.97 0.982

0.8452 0.8685 0.8904 0.9108 0.9298 0.9472 0.963 0.9773 0.98980.8027 0.8197 0.8354 0.8499 0.8631 0.875 0.8856 0.895 0.90311.0533 1.0687 1.0821 1.0936 1.1031 1.1108 1.1166 1.1206 1.12280.8448 0.8642 0.8824 0.8992 0.9148 0.929 0.9419 0.9536 0.96390.7623 0.7768 0.7901 0.802 0.8128 0.8223 0.8305 0.8376 0.84351.1249 1.1393 1.1516 1.1616 1.1696 1.1755 1.1794 1.1813 1.18120.817 0.8388 0.8594 0.8785 0.8963 0.9127 0.9277 0.9412 0.9531

1 1.0416 1.0833 1.125 1.1666 1.2083 1.25 1.2916 1.33330.8202 0.8422 0.8632 0.883 0.9017 0.9193 0.9358 0.9511 0.96530.7615 0.7753 0.7877 0.7989 0.8087 0.8173 0.8247 0.8308 0.83570.8416 0.8633 0.8833 0.9017 0.9184 0.9333 0.9463 0.9574 0.9666

0.85 0.8629 0.8742 0.8839 0.8922 0.899 0.9044 0.9084 0.9110.7406 0.7578 0.774 0.7892 0.8035 0.8169 0.8294 0.841 0.85170.8457 0.8631 0.8791 0.894 0.9076 0.9199 0.9311 0.9411 0.950.8511 0.8736 0.8944 0.9137 0.9312 0.947 0.9609 0.9729 0.9831.0687 1.0824 1.094 1.1036 1.1111 1.1167 1.1204 1.1222 1.1221

1 1.0416 1.0833 1.125 1.1666 1.2083 1.25 1.2916 1.33332.6496 2.736 2.8206 2.9034 2.9845 3.0637 3.1412 3.2169 3.29090.7615 0.7753 0.7877 0.7989 0.8087 0.8173 0.8247 0.8308 0.83570.7538 0.7687 0.7824 0.7949 0.8063 0.8164 0.8254 0.8333 0.840.5443 0.5477 0.5499 0.5508 0.5504 0.5489 0.5461 0.5423 0.5373-1.2769 -1.3142 -1.3503 -1.3852 -1.419 -1.4516 -1.483 -1.5134 -1.54260.8184 0.8433 0.8674 0.8906 0.9131 0.9348 0.9556 0.9756 0.99481.0745 1.0882 1.0999 1.1096 1.1172 1.1228 1.1265 1.1283 1.12831.0184 1.0335 1.0468 1.0582 1.0678 1.0756 1.0816 1.0859 1.0885

1 1.0416 1.0833 1.125 1.1666 1.2083 1.25 1.2916 1.33330.8647 0.8822 0.8983 0.9129 0.9261 0.9378 0.9481 0.957 0.96440.774 0.7946 0.8142 0.833 0.8509 0.8678 0.8839 0.8992 0.9135

0.8562 0.8803 0.9031 0.9246 0.9446 0.9631 0.9801 0.9956 1.00940.6976 0.711 0.7233 0.7343 0.7442 0.7529 0.7605 0.7669 0.77220.8171 0.838 0.8577 0.8762 0.8936 0.9097 0.9247 0.9384 0.95090.8571 0.8828 0.9075 0.9311 0.9536 0.975 0.9951 1.0141 1.03190.8668 0.8957 0.924 0.9519 0.9792 1.0059 1.0322 1.0579 1.08310.8769 0.9071 0.9367 0.9658 0.9944 1.0224 1.0498 1.0766 1.1028

1 1.0416 1.0833 1.125 1.1666 1.2083 1.25 1.2916 1.33331.0354 1.0506 1.0639 1.0753 1.0848 1.0925 1.0983 1.1024 1.1047

00.25 0.

50.75 1

1.25 1.

51.75 2

2.25 2.

52.75 3

3.2499

3.4999

3.7499 4

-3

-2

-1

0

1

2

3

4

5

6

00.25 0.

50.75 1

1.25 1.

51.75 2

2.25 2.

52.75 3

3.2499

3.4999

3.7499 4

-4

-3

-2

-1

0

1

2

3

4

00.25 0.

50.75 1

1.25 1.

51.75 2

2.25 2.

52.75 3

3.2499

3.4999

3.7499 4

-1

-0.5

0

0.5

1

1.5

0.8443 0.8648 0.8839 0.9017 0.918 0.9329 0.9463 0.9582 0.96861.2718 1.3151 1.3575 1.3993 1.4403 1.4806 1.5201 1.5589 1.5971.1027 1.117 1.1291 1.1392 1.1471 1.1531 1.1571 1.1592 1.1594-2.3444 -2.4106 -2.4745 -2.536 -2.5953 -2.6524 -2.7072 -2.7598 -2.81030.8401 0.8614 0.8814 0.9001 0.9173 0.9331 0.9474 0.9603 0.97161.0822 1.0969 1.1094 1.1199 1.1285 1.135 1.1397 1.1424 1.14330.8355 0.8512 0.8656 0.8787 0.8905 0.901 0.9103 0.9184 0.9253

1 1.0416 1.0833 1.125 1.1666 1.2083 1.25 1.2916 1.33330.5396 0.5477 0.5547 0.5607 0.5657 0.5696 0.5726 0.5746 0.57570.8461 0.8627 0.878 0.8921 0.9048 0.9163 0.9265 0.9356 0.9434-0.1394 -0.1468 -0.1543 -0.1619 -0.1696 -0.1774 -0.1853 -0.1933 -0.20140.6952 0.7105 0.7247 0.7379 0.7501 0.7613 0.7715 0.7807 0.7890.1134 0.1147 0.1158 0.1167 0.1173 0.1177 0.1179 0.1178 0.11750.6266 0.6362 0.6447 0.652 0.6581 0.6631 0.667 0.6698 0.67140.7492 0.7687 0.7873 0.805 0.8218 0.8377 0.8526 0.8667 0.87990.8355 0.8512 0.8656 0.8787 0.8905 0.901 0.9103 0.9184 0.9253

1 1.0416 1.0833 1.125 1.1666 1.2083 1.25 1.2916 1.33330.7019 0.7157 0.7285 0.7401 0.7507 0.7602 0.7687 0.7761 0.78260.8413 0.8629 0.8829 0.9012 0.9177 0.9325 0.9455 0.9565 0.96560.7746 0.785 0.7938 0.8011 0.807 0.8114 0.8144 0.8161 0.81640.8481 0.8687 0.8879 0.9057 0.9221 0.9369 0.9503 0.9621 0.97240.7141 0.7309 0.7468 0.7617 0.7758 0.7889 0.8012 0.8125 0.8230.8465 0.8691 0.8902 0.9099 0.9279 0.9443 0.959 0.9719 0.9830.8403 0.8613 0.8806 0.8982 0.9139 0.9277 0.9395 0.9493 0.9570.8403 0.8624 0.883 0.902 0.9194 0.9351 0.949 0.9611 0.9714

1 1.0416 1.0833 1.125 1.1666 1.2083 1.25 1.2916 1.33330.8661 0.8944 0.9221 0.9492 0.9758 1.0018 1.0272 1.0521 1.07641.2716 1.2875 1.301 1.3121 1.3207 1.327 1.3311 1.3329 1.33250.7764 0.7959 0.8142 0.8313 0.8471 0.8618 0.8751 0.8872 0.8980.7123 0.719 0.7242 0.7279 0.7301 0.7308 0.7302 0.7281 0.72470.6279 0.6325 0.6356 0.6374 0.6377 0.6367 0.6343 0.6307 0.62580.8391 0.8601 0.8793 0.8968 0.9124 0.9261 0.9379 0.9476 0.95520.8518 0.8761 0.8991 0.9209 0.9414 0.9606 0.9784 0.9948 1.00980.8051 0.8269 0.8476 0.867 0.8852 0.9022 0.9179 0.9323 0.9454

1 1.0416 1.0833 1.125 1.1666 1.2083 1.25 1.2916 1.33330.8375 0.8581 0.8769 0.8938 0.9089 0.9219 0.933 0.9419 0.94871.2716 1.2875 1.301 1.3121 1.3207 1.327 1.3311 1.3329 1.33250.8663 0.8832 0.8989 0.9131 0.9261 0.9378 0.9482 0.9573 0.96520.8347 0.8549 0.8732 0.8897 0.9042 0.9168 0.9273 0.9356 0.9417

0

0.1667

0.3333 0.

5

0.6667

0.8333 1

1.1666

1.3333 1.

5

1.6666

1.8333 2

2.1666

2.3333 2.

5

2.6666

2.8333 3

3.1666

3.3333

3.4999

3.6666

3.8333 4

-8

-6

-4

-2

0

2

4

COL-TLT-FBFB-TLT-FBFGF-TLT-FBFN-TLT-FBGAPDH-TLT-FBGDF-TLT-FBLIN-TLT-FBUTF-TLT-FB

0.9673 1.0057 1.0439 1.0819 1.1197 1.1573 1.1947 1.2319 1.26880.8454 0.8674 0.8879 0.9068 0.924 0.9394 0.953 0.9647 0.97440.8337 0.8537 0.8719 0.8882 0.9026 0.9149 0.9252 0.9333 0.93910.9239 0.9359 0.9462 0.9546 0.9613 0.9663 0.9696 0.9713 0.9713

1.375 1.4166 1.4583 1.5 1.5416 1.5833 1.625 1.6666 1.70830.9923 1.0009 1.0077 1.0128 1.016 1.0173 1.0167 1.0141 1.00951.0006 1.0097 1.0169 1.0222 1.0256 1.0271 1.0265 1.0239 1.0191

0.91 0.9156 0.9199 0.923 0.9249 0.9255 0.9249 0.9231 0.921.1233 1.1221 1.1192 1.1146 1.1084 1.1007 1.0914 1.0806 1.06830.9729 0.9805 0.9869 0.9919 0.9955 0.9979 0.9988 0.9985 0.99680.8482 0.8517 0.8541 0.8553 0.8554 0.8544 0.8523 0.849 0.84471.1793 1.1756 1.17 1.1627 1.1537 1.1431 1.1308 1.117 1.10160.9636 0.9724 0.9796 0.9851 0.9889 0.991 0.9914 0.9899 0.9866

1.375 1.4166 1.4583 1.5 1.5416 1.5833 1.625 1.6666 1.70830.9782 0.99 1.0006 1.01 1.0181 1.025 1.0307 1.035 1.03810.8394 0.8419 0.8432 0.8434 0.8424 0.8403 0.8371 0.8328 0.82740.9737 0.9787 0.9816 0.9822 0.9805 0.9765 0.9701 0.9613 0.94990.9123 0.9123 0.911 0.9084 0.9047 0.8997 0.8936 0.8863 0.8780.8616 0.8706 0.8788 0.8862 0.8928 0.8986 0.9036 0.9079 0.91140.9577 0.9642 0.9697 0.9741 0.9774 0.9797 0.9809 0.9812 0.98040.991 0.997 1.0008 1.0024 1.0018 0.9988 0.9934 0.9855 0.9752

1.1203 1.1167 1.1114 1.1045 1.0959 1.0858 1.0742 1.061 1.0465

1.375 1.4166 1.4583 1.5 1.5416 1.5833 1.625 1.6666 1.70833.3631 3.4337 3.5025 3.5697 3.6352 3.699 3.7611 3.8216 3.88050.8394 0.8419 0.8432 0.8434 0.8424 0.8403 0.8371 0.8328 0.82740.8456 0.8501 0.8535 0.8557 0.857 0.8571 0.8562 0.8543 0.85130.5312 0.524 0.5158 0.5066 0.4964 0.4853 0.4732 0.4602 0.4464-1.5707 -1.5977 -1.6236 -1.6484 -1.6722 -1.6949 -1.7165 -1.7372 -1.75671.0132 1.0307 1.0474 1.0632 1.0782 1.0923 1.1055 1.1179 1.12931.1264 1.1228 1.1174 1.1104 1.1018 1.0915 1.0798 1.0665 1.05171.0894 1.0886 1.0863 1.0823 1.0769 1.0699 1.0614 1.0516 1.0402

1.375 1.4166 1.4583 1.5 1.5416 1.5833 1.625 1.6666 1.70830.9704 0.975 0.9781 0.9798 0.9801 0.979 0.9765 0.9725 0.96720.927 0.9396 0.9513 0.9622 0.9722 0.9814 0.9897 0.9972 1.0038

1.0216 1.0321 1.0408 1.0477 1.0527 1.0559 1.0571 1.0563 1.05350.7763 0.7793 0.7811 0.7819 0.7815 0.78 0.7774 0.7738 0.7690.9621 0.9721 0.9808 0.9882 0.9944 0.9992 1.0027 1.0048 1.00561.0484 1.0636 1.0775 1.0901 1.1013 1.1111 1.1195 1.1264 1.13181.1077 1.1319 1.1555 1.1787 1.2013 1.2235 1.2451 1.2662 1.28691.1285 1.1536 1.178 1.2019 1.2252 1.2479 1.2699 1.2913 1.3121

1.375 1.4166 1.4583 1.5 1.5416 1.5833 1.625 1.6666 1.70831.1053 1.1043 1.1015 1.0972 1.0913 1.0838 1.0748 1.0644 1.0524

00.25 0.

50.75 1

1.25 1.

51.75 2

2.25 2.

52.75 3

3.2499

3.4999

3.7499 4

-1

-0.5

0

0.5

1

1.5

0.9774 0.9848 0.9905 0.9946 0.9971 0.998 0.9971 0.9946 0.99041.6344 1.671 1.707 1.7422 1.7768 1.8106 1.8437 1.8761 1.90791.1578 1.1544 1.1492 1.1423 1.1338 1.1236 1.1119 1.0987 1.084-2.8586 -2.9047 -2.9488 -2.9907 -3.0306 -3.0685 -3.1043 -3.1382 -3.17010.9814 0.9896 0.9962 1.0012 1.0045 1.0061 1.006 1.0042 1.00051.1424 1.1398 1.1354 1.1294 1.1217 1.1124 1.1016 1.0892 1.07540.931 0.9356 0.9391 0.9414 0.9427 0.943 0.9422 0.9404 0.9376

1.375 1.4166 1.4583 1.5 1.5416 1.5833 1.625 1.6666 1.70830.5758 0.5749 0.5731 0.5704 0.5668 0.5624 0.557 0.5508 0.5437

0.95 0.9555 0.9599 0.9631 0.9653 0.9664 0.9664 0.9653 0.9633-0.2097 -0.218 -0.2264 -0.2349 -0.2435 -0.2521 -0.2609 -0.2698 -0.27870.7964 0.8028 0.8082 0.8127 0.8163 0.819 0.8208 0.8217 0.82180.1169 0.1162 0.1152 0.1139 0.1125 0.1108 0.109 0.1069 0.10460.672 0.6716 0.6701 0.6675 0.664 0.6594 0.6539 0.6474 0.64

0.8922 0.9036 0.9142 0.9238 0.9326 0.9405 0.9476 0.9538 0.95910.931 0.9356 0.9391 0.9414 0.9427 0.943 0.9422 0.9404 0.9376

1.375 1.4166 1.4583 1.5 1.5416 1.5833 1.625 1.6666 1.70830.788 0.7925 0.796 0.7986 0.8003 0.801 0.8008 0.7998 0.7979

0.9726 0.9776 0.9804 0.981 0.9793 0.9752 0.9688 0.96 0.94860.8153 0.813 0.8095 0.8046 0.7986 0.7914 0.7831 0.7736 0.7630.9811 0.9882 0.9936 0.9974 0.9995 0.9999 0.9986 0.9955 0.99060.8327 0.8415 0.8495 0.8566 0.863 0.8685 0.8733 0.8773 0.88050.9923 0.9997 1.0051 1.0084 1.0097 1.0089 1.0059 1.0006 0.9930.9625 0.9658 0.9667 0.9653 0.9614 0.955 0.9461 0.9344 0.92010.9798 0.9861 0.9905 0.9927 0.9929 0.9908 0.9865 0.9798 0.9708

1.375 1.4166 1.4583 1.5 1.5416 1.5833 1.625 1.6666 1.70831.1002 1.1234 1.1461 1.1682 1.1898 1.2109 1.2315 1.2515 1.2711.3301 1.3255 1.319 1.3104 1.3 1.2877 1.2737 1.2578 1.24030.9075 0.9156 0.9224 0.9278 0.9318 0.9344 0.9356 0.9354 0.9336

0.72 0.714 0.7067 0.6982 0.6886 0.6778 0.6658 0.6528 0.63870.6196 0.6123 0.6039 0.5943 0.5836 0.5718 0.559 0.5452 0.53040.9607 0.9639 0.9648 0.9633 0.9594 0.953 0.944 0.9323 0.9181.0233 1.0353 1.0457 1.0546 1.0618 1.0674 1.0712 1.0734 1.07370.9572 0.9676 0.9765 0.9841 0.9902 0.9948 0.998 0.9996 0.9996

1.375 1.4166 1.4583 1.5 1.5416 1.5833 1.625 1.6666 1.70830.9532 0.9554 0.9552 0.9525 0.9473 0.9395 0.9291 0.9159 0.89991.3301 1.3255 1.319 1.3104 1.3 1.2877 1.2737 1.2578 1.24030.9719 0.9774 0.9817 0.9848 0.9868 0.9877 0.9875 0.9863 0.98390.9455 0.9469 0.9459 0.9424 0.9363 0.9276 0.9161 0.9019 0.8847

0

0.1667

0.3333 0.

5

0.6667

0.8333 1

1.1666

1.3333 1.

5

1.6666

1.8333 2

2.1666

2.3333 2.

5

2.6666

2.8333 3

3.1666

3.3333

3.4999

3.6666

3.8333 4

-8

-6

-4

-2

0

2

4

COL-TLT-FBFB-TLT-FBFGF-TLT-FBFN-TLT-FBGAPDH-TLT-FBGDF-TLT-FBLIN-TLT-FBUTF-TLT-FB

1.3056 1.3421 1.3784 1.4145 1.4503 1.4859 1.5212 1.5563 1.59110.9822 0.9879 0.9914 0.9928 0.992 0.9888 0.9833 0.9753 0.96490.9427 0.9438 0.9425 0.9387 0.9323 0.9232 0.9114 0.8967 0.87920.9698 0.9668 0.9622 0.9562 0.9488 0.94 0.9298 0.9183 0.9055

1.75 1.7916 1.8333 1.875 1.9166 1.9583 2 2.0416 2.08331.0029 0.9942 0.9834 0.9703 0.9551 0.9376 0.9178 0.8956 0.87111.0122 1.003 0.9916 0.9778 0.9617 0.9432 0.9222 0.8987 0.87260.9157 0.9102 0.9034 0.8955 0.8863 0.8759 0.8643 0.8516 0.83761.0546 1.0395 1.023 1.0051 0.986 0.9656 0.9439 0.9211 0.8970.9937 0.9893 0.9835 0.9763 0.9678 0.9579 0.9466 0.9339 0.91990.8394 0.833 0.8255 0.817 0.8075 0.797 0.7856 0.7731 0.75971.0848 1.0665 1.0469 1.0259 1.0036 0.9801 0.9553 0.9294 0.90240.9813 0.9742 0.9651 0.9541 0.9409 0.9258 0.9085 0.8891 0.8675

1.75 1.7916 1.8333 1.875 1.9166 1.9583 2 2.0416 2.08331.04 1.0405 1.0396 1.0375 1.034 1.0292 1.0229 1.0153 1.0064

0.821 0.8134 0.8049 0.7953 0.7847 0.7731 0.7606 0.7471 0.73260.9359 0.9193 0.8999 0.8778 0.8528 0.825 0.7942 0.7603 0.72340.8686 0.8581 0.8466 0.8342 0.8208 0.8064 0.7912 0.7751 0.75820.9142 0.9163 0.9177 0.9185 0.9186 0.918 0.9168 0.915 0.91250.9786 0.9759 0.9723 0.9678 0.9623 0.956 0.9488 0.9407 0.93180.9622 0.9466 0.9283 0.9072 0.8833 0.8565 0.8267 0.7939 0.7581.0305 1.0132 0.9945 0.9746 0.9535 0.9312 0.9077 0.8832 0.8576

1.75 1.7916 1.8333 1.875 1.9166 1.9583 2 2.0416 2.08333.9378 3.9934 4.0475 4.1 4.1509 4.2002 4.248 4.2943 4.33910.821 0.8134 0.8049 0.7953 0.7847 0.7731 0.7606 0.7471 0.7326

0.8474 0.8424 0.8364 0.8295 0.8216 0.8128 0.803 0.7922 0.78060.4317 0.4163 0.4 0.383 0.3653 0.3468 0.3277 0.308 0.2876-1.7753 -1.7929 -1.8094 -1.825 -1.8396 -1.8532 -1.8659 -1.8776 -1.88841.1399 1.1496 1.1584 1.1663 1.1733 1.1794 1.1845 1.1887 1.1921.0355 1.018 0.9991 0.9789 0.9574 0.9348 0.911 0.8861 0.86011.0276 1.0135 0.9982 0.9815 0.9636 0.9445 0.9243 0.9028 0.8803

1.75 1.7916 1.8333 1.875 1.9166 1.9583 2 2.0416 2.08330.9604 0.9522 0.9427 0.9317 0.9194 0.9057 0.8905 0.874 0.85621.0096 1.0145 1.0187 1.022 1.0244 1.0261 1.027 1.027 1.02621.0486 1.0415 1.0323 1.0208 1.0071 0.991 0.9726 0.9517 0.92840.7632 0.7563 0.7483 0.7393 0.7292 0.7181 0.706 0.6928 0.67861.0051 1.0031 0.9998 0.9951 0.989 0.9814 0.9724 0.962 0.95011.1357 1.138 1.1388 1.138 1.1355 1.1314 1.1256 1.118 1.10871.3071 1.3268 1.346 1.3647 1.383 1.4008 1.4182 1.4351 1.45151.3323 1.3518 1.3707 1.3889 1.4065 1.4235 1.4398 1.4554 1.4703

1.75 1.7916 1.8333 1.875 1.9166 1.9583 2 2.0416 2.08331.0391 1.0244 1.0083 0.991 0.9723 0.9524 0.9312 0.9089 0.8855

0.9844 0.9767 0.9671 0.9558 0.9426 0.9276 0.9107 0.8919 0.87111.939 1.9693 1.999 2.0281 2.0564 2.0841 2.1112 2.1375 2.1632

1.0678 1.0503 1.0314 1.0112 0.9897 0.967 0.9432 0.9182 0.8922-3.2 -3.228 -3.2541 -3.2784 -3.3007 -3.3213 -3.34 -3.357 -3.3722

0.9951 0.9878 0.9786 0.9676 0.9546 0.9397 0.9228 0.9039 0.88291.0601 1.0435 1.0255 1.0061 0.9855 0.9637 0.9407 0.9165 0.89120.9339 0.9292 0.9236 0.9172 0.9098 0.9016 0.8926 0.8828 0.8723

1.75 1.7916 1.8333 1.875 1.9166 1.9583 2 2.0416 2.08330.5358 0.5271 0.5176 0.5073 0.4962 0.4843 0.4717 0.4583 0.44420.9603 0.9563 0.9513 0.9454 0.9386 0.9308 0.9222 0.9128 0.9025-0.2877 -0.2968 -0.306 -0.3152 -0.3246 -0.334 -0.3434 -0.353 -0.36260.8209 0.8192 0.8167 0.8133 0.809 0.804 0.7981 0.7914 0.7840.1021 0.0993 0.0964 0.0933 0.09 0.0865 0.0828 0.0789 0.07480.6316 0.6223 0.6121 0.601 0.589 0.5761 0.5625 0.548 0.53260.9635 0.9671 0.9699 0.9718 0.9728 0.973 0.9724 0.9709 0.96860.9339 0.9292 0.9236 0.9172 0.9098 0.9016 0.8926 0.8828 0.8723

1.75 1.7916 1.8333 1.875 1.9166 1.9583 2 2.0416 2.08330.7951 0.7915 0.787 0.7818 0.7758 0.769 0.7614 0.7531 0.74410.9346 0.918 0.8987 0.8766 0.8518 0.824 0.7933 0.7596 0.72280.7514 0.7387 0.725 0.7103 0.6946 0.678 0.6606 0.6422 0.6230.984 0.9754 0.965 0.9528 0.9386 0.9225 0.9044 0.8843 0.8622

0.8829 0.8847 0.8856 0.8859 0.8855 0.8843 0.8825 0.88 0.87690.9831 0.9708 0.9561 0.9388 0.9189 0.8965 0.8713 0.8435 0.81280.903 0.883 0.8601 0.8342 0.8053 0.7732 0.738 0.6995 0.6576

0.9594 0.9454 0.929 0.9099 0.8882 0.8638 0.8366 0.8067 0.7738

1.75 1.7916 1.8333 1.875 1.9166 1.9583 2 2.0416 2.08331.29 1.3085 1.3265 1.344 1.361 1.3776 1.3936 1.4092 1.4243

1.2212 1.2005 1.1782 1.1545 1.1293 1.1028 1.0749 1.0458 1.01550.9304 0.9257 0.9195 0.9118 0.9024 0.8916 0.8791 0.865 0.84930.6236 0.6076 0.5905 0.5726 0.5537 0.534 0.5135 0.4922 0.47010.5147 0.4981 0.4807 0.4623 0.4432 0.4233 0.4027 0.3813 0.35930.9009 0.8809 0.858 0.8322 0.8033 0.7713 0.7361 0.6977 0.65591.0723 1.069 1.0639 1.0568 1.0478 1.0368 1.0237 1.0086 0.99140.9981 0.995 0.9902 0.9838 0.9757 0.9659 0.9543 0.941 0.9259

1.75 1.7916 1.8333 1.875 1.9166 1.9583 2 2.0416 2.08330.881 0.8591 0.8343 0.8063 0.7752 0.7409 0.7032 0.6622 0.6177

1.2212 1.2005 1.1782 1.1545 1.1293 1.1028 1.0749 1.0458 1.01550.9806 0.9762 0.9708 0.9645 0.9572 0.9489 0.9398 0.9297 0.91880.8647 0.8416 0.8155 0.7862 0.7536 0.7178 0.6786 0.636 0.5898

1.6257 1.66 1.694 1.7278 1.7613 1.7945 1.8274 1.86 1.89230.9519 0.9363 0.9181 0.8971 0.8733 0.8467 0.8171 0.7846 0.74910.8587 0.8352 0.8086 0.7788 0.7457 0.7094 0.6696 0.6264 0.57960.8915 0.8762 0.8597 0.8421 0.8234 0.8036 0.7828 0.7609 0.7381

2.125 2.1666 2.2083 2.25 2.2916 2.3333 2.375 2.4166 2.45830.8441 0.8147 0.7828 0.7483 0.7112 0.6714 0.629 0.5839 0.5360.844 0.8126 0.7786 0.7418 0.7022 0.6597 0.6143 0.566 0.5146

0.8224 0.806 0.7885 0.7698 0.7498 0.7288 0.7065 0.6831 0.65850.8719 0.8456 0.8183 0.7899 0.7605 0.7302 0.6989 0.6668 0.63370.9044 0.8876 0.8694 0.8497 0.8287 0.8062 0.7824 0.7571 0.73040.7453 0.73 0.7137 0.6966 0.6785 0.6596 0.6397 0.6191 0.59750.8743 0.8452 0.8151 0.7841 0.7522 0.7195 0.6859 0.6516 0.61660.8437 0.8176 0.7893 0.7586 0.7256 0.6902 0.6524 0.6121 0.5693

2.125 2.1666 2.2083 2.25 2.2916 2.3333 2.375 2.4166 2.45830.9959 0.9841 0.9709 0.9561 0.94 0.9223 0.9032 0.8826 0.86040.7172 0.7009 0.6836 0.6655 0.6465 0.6267 0.606 0.5844 0.56210.6833 0.6401 0.5936 0.5437 0.4904 0.4337 0.3735 0.3097 0.24230.7405 0.722 0.7028 0.6828 0.6622 0.6409 0.619 0.5966 0.57350.9095 0.9059 0.9018 0.8971 0.8919 0.8862 0.88 0.8733 0.86610.9222 0.9117 0.9004 0.8884 0.8757 0.8623 0.8481 0.8333 0.81780.719 0.6767 0.6312 0.5824 0.5301 0.4744 0.4152 0.3523 0.2859

0.8309 0.8034 0.7749 0.7455 0.7153 0.6843 0.6526 0.6201 0.587

2.125 2.1666 2.2083 2.25 2.2916 2.3333 2.375 2.4166 2.45834.3823 4.4241 4.4643 4.5031 4.5405 4.5764 4.6108 4.6438 4.67550.7172 0.7009 0.6836 0.6655 0.6465 0.6267 0.606 0.5844 0.56210.7681 0.7547 0.7404 0.7252 0.7092 0.6923 0.6747 0.6562 0.63690.2667 0.2452 0.2232 0.2006 0.1776 0.1542 0.1304 0.1061 0.0815-1.8983 -1.9072 -1.9153 -1.9224 -1.9287 -1.9341 -1.9387 -1.9423 -1.94521.1943 1.1957 1.1961 1.1956 1.1941 1.1917 1.1882 1.1838 1.17840.833 0.805 0.776 0.7461 0.7154 0.6838 0.6515 0.6184 0.5846

0.8566 0.8319 0.8062 0.7795 0.7518 0.7232 0.6937 0.6633 0.6322

2.125 2.1666 2.2083 2.25 2.2916 2.3333 2.375 2.4166 2.45830.8369 0.8163 0.7943 0.7709 0.7462 0.7201 0.6926 0.6638 0.63361.0247 1.0223 1.0191 1.0152 1.0105 1.0049 0.9986 0.9916 0.98370.9026 0.8742 0.8432 0.8095 0.7732 0.734 0.6921 0.6474 0.59970.6634 0.6472 0.63 0.6118 0.5926 0.5724 0.5512 0.5291 0.50610.9368 0.9219 0.9056 0.8877 0.8684 0.8474 0.825 0.801 0.77541.0976 1.0848 1.07 1.0534 1.0349 1.0145 0.9922 0.9678 0.94141.4675 1.483 1.4981 1.5127 1.527 1.5407 1.5541 1.567 1.57951.4846 1.4981 1.511 1.5232 1.5348 1.5456 1.5557 1.5651 1.5737

2.125 2.1666 2.2083 2.25 2.2916 2.3333 2.375 2.4166 2.45830.8609 0.8352 0.8085 0.7807 0.752 0.7223 0.6917 0.6602 0.6278

0.8484 0.8238 0.7971 0.7685 0.7377 0.705 0.6701 0.6331 0.5942.1883 2.2127 2.2365 2.2597 2.2822 2.304 2.3253 2.3459 2.36590.8651 0.837 0.808 0.7781 0.7473 0.7157 0.6834 0.6503 0.6165-3.3857 -3.3974 -3.4075 -3.4159 -3.4227 -3.4278 -3.4313 -3.4333 -3.43370.8599 0.8348 0.8075 0.7781 0.7465 0.7127 0.6766 0.6383 0.59770.8649 0.8375 0.8091 0.7798 0.7496 0.7185 0.6865 0.6538 0.62040.8609 0.8489 0.8361 0.8227 0.8086 0.7939 0.7785 0.7626 0.7461

2.125 2.1666 2.2083 2.25 2.2916 2.3333 2.375 2.4166 2.45830.4294 0.4138 0.3976 0.3807 0.3631 0.3449 0.326 0.3065 0.28640.8914 0.8795 0.8668 0.8534 0.8392 0.8243 0.8087 0.7925 0.7755-0.3723 -0.382 -0.3918 -0.4017 -0.4116 -0.4216 -0.4316 -0.4417 -0.45190.7757 0.7667 0.7569 0.7463 0.735 0.7229 0.7101 0.6966 0.68240.0705 0.0661 0.0614 0.0566 0.0516 0.0465 0.0411 0.0356 0.030.5165 0.4996 0.482 0.4635 0.4444 0.4245 0.4039 0.3827 0.36070.9655 0.9615 0.9567 0.9511 0.9447 0.9374 0.9294 0.9205 0.91080.8609 0.8489 0.8361 0.8227 0.8086 0.7939 0.7785 0.7626 0.7461

2.125 2.1666 2.2083 2.25 2.2916 2.3333 2.375 2.4166 2.45830.7344 0.7239 0.7128 0.701 0.6886 0.6755 0.6618 0.6475 0.63260.683 0.6399 0.5936 0.544 0.491 0.4346 0.3747 0.3112 0.24410.603 0.5822 0.5606 0.5383 0.5152 0.4915 0.4672 0.4422 0.41660.838 0.8118 0.7835 0.7531 0.7205 0.6858 0.6488 0.6097 0.5683

0.8731 0.8686 0.8636 0.8579 0.8516 0.8447 0.8372 0.8292 0.82060.7794 0.743 0.7037 0.6614 0.616 0.5675 0.5159 0.4611 0.4030.6124 0.5637 0.5115 0.4557 0.3962 0.333 0.266 0.1951 0.12030.738 0.6992 0.6574 0.6124 0.5643 0.513 0.4585 0.4005 0.3393

2.125 2.1666 2.2083 2.25 2.2916 2.3333 2.375 2.4166 2.45831.4389 1.4531 1.4667 1.48 1.4928 1.5051 1.517 1.5285 1.53950.9841 0.9515 0.9179 0.8833 0.8477 0.8113 0.774 0.736 0.69720.8319 0.8129 0.7922 0.7698 0.7456 0.7197 0.6921 0.6627 0.63150.4473 0.4238 0.3997 0.3749 0.3495 0.3236 0.2972 0.2702 0.24280.3366 0.3133 0.2894 0.265 0.2401 0.2146 0.1887 0.1624 0.13570.6108 0.5622 0.5102 0.4545 0.3952 0.3322 0.2654 0.1947 0.12020.9721 0.9506 0.9269 0.9009 0.8726 0.8421 0.8091 0.7738 0.7360.909 0.8903 0.8697 0.8472 0.8227 0.7964 0.7681 0.7378 0.7054

2.125 2.1666 2.2083 2.25 2.2916 2.3333 2.375 2.4166 2.45830.5698 0.5182 0.463 0.404 0.3413 0.2747 0.2042 0.1297 0.05110.9841 0.9515 0.9179 0.8833 0.8477 0.8113 0.774 0.736 0.69720.907 0.8944 0.8809 0.8667 0.8517 0.8359 0.8194 0.8022 0.7843

0.5401 0.4867 0.4296 0.3687 0.3039 0.2352 0.1625 0.0857 0.0047

1.9244 1.9561 1.9875 2.0186 2.0494 2.0799 2.11 2.1398 2.16930.7104 0.6686 0.6236 0.5753 0.5237 0.4687 0.4102 0.3482 0.28270.5293 0.4752 0.4174 0.3558 0.2903 0.2208 0.1472 0.0696 -0.01220.7143 0.6896 0.6641 0.6377 0.6105 0.5826 0.5539 0.5246 0.4945

2.5 2.5416 2.5833 2.625 2.6666 2.7083 2.75 2.7916 2.83330.4853 0.4317 0.3752 0.3159 0.2535 0.1881 0.1197 0.0481 -0.02660.4602 0.4027 0.3421 0.2782 0.2111 0.1407 0.067 -0.0102 -0.09080.6327 0.6058 0.5777 0.5485 0.5182 0.4866 0.454 0.4202 0.38530.5999 0.5652 0.5298 0.4937 0.4568 0.4193 0.3812 0.3425 0.30320.7023 0.6727 0.6417 0.6093 0.5755 0.5401 0.5034 0.4652 0.42550.5752 0.552 0.528 0.5032 0.4776 0.4512 0.4241 0.3963 0.36770.581 0.5447 0.5079 0.4705 0.4326 0.3944 0.3557 0.3167 0.2774

0.5239 0.476 0.4254 0.3722 0.3163 0.2577 0.1963 0.1321 0.0651

2.5 2.5416 2.5833 2.625 2.6666 2.7083 2.75 2.7916 2.83330.8367 0.8115 0.7848 0.7564 0.7265 0.695 0.6619 0.6272 0.59090.539 0.5151 0.4904 0.4649 0.4387 0.4118 0.3842 0.3559 0.3269

0.1712 0.0963 0.0176 -0.065 -0.1515 -0.242 -0.3366 -0.4354 -0.53830.5499 0.5258 0.5013 0.4763 0.4508 0.425 0.3989 0.3724 0.34560.8585 0.8505 0.842 0.8332 0.8239 0.8143 0.8043 0.7939 0.78330.8017 0.7849 0.7676 0.7496 0.7311 0.7121 0.6925 0.6724 0.65180.2157 0.1417 0.0639 -0.0178 -0.1034 -0.1931 -0.2869 -0.3848 -0.48690.5533 0.519 0.4841 0.4488 0.413 0.3769 0.3403 0.3035 0.2664

2.5 2.5416 2.5833 2.625 2.6666 2.7083 2.75 2.7916 2.83334.7057 4.7345 4.762 4.7881 4.8128 4.8363 4.8583 4.8791 4.89860.539 0.5151 0.4904 0.4649 0.4387 0.4118 0.3842 0.3559 0.3269

0.6168 0.5959 0.5743 0.5519 0.5288 0.5049 0.4803 0.4551 0.42910.0566 0.0314 0.0059 -0.0198 -0.0458 -0.0719 -0.0982 -0.1246 -0.1511-1.9472 -1.9484 -1.9488 -1.9483 -1.9471 -1.9451 -1.9424 -1.9388 -1.93461.172 1.1646 1.1561 1.1467 1.1362 1.1248 1.1123 1.0987 1.0841

0.5502 0.5151 0.4796 0.4434 0.4068 0.3698 0.3324 0.2946 0.25660.6002 0.5674 0.534 0.4998 0.465 0.4295 0.3934 0.3568 0.3196

2.5 2.5416 2.5833 2.625 2.6666 2.7083 2.75 2.7916 2.83330.6021 0.5693 0.5351 0.4995 0.4626 0.4244 0.3849 0.344 0.30180.9751 0.9658 0.9556 0.9447 0.9331 0.9207 0.9076 0.8938 0.87920.5492 0.4956 0.439 0.3793 0.3165 0.2505 0.1813 0.1088 0.0330.482 0.4571 0.4312 0.4043 0.3766 0.3479 0.3183 0.2878 0.2565

0.7482 0.7194 0.6891 0.6571 0.6234 0.5881 0.5512 0.5126 0.47230.913 0.8825 0.8499 0.8152 0.7783 0.7393 0.698 0.6545 0.6086

1.5916 1.6033 1.6145 1.6254 1.6358 1.6459 1.6555 1.6648 1.67371.5817 1.5889 1.5954 1.6011 1.6062 1.6104 1.6139 1.6167 1.6187

2.5 2.5416 2.5833 2.625 2.6666 2.7083 2.75 2.7916 2.83330.5947 0.5607 0.526 0.4906 0.4544 0.4177 0.3803 0.3423 0.3037

0.5528 0.5093 0.4637 0.4158 0.3657 0.3133 0.2586 0.2017 0.14232.3853 2.404 2.4222 2.4398 2.4567 2.4731 2.4888 2.504 2.51860.5821 0.5471 0.5116 0.4755 0.439 0.4021 0.3648 0.3272 0.2893-3.4326 -3.43 -3.4259 -3.4203 -3.4133 -3.4049 -3.3951 -3.384 -3.37150.5547 0.5094 0.4617 0.4115 0.3589 0.3039 0.2463 0.1862 0.12360.5862 0.5514 0.5159 0.4799 0.4433 0.4062 0.3687 0.3307 0.29240.7291 0.7115 0.6934 0.6749 0.6559 0.6365 0.6167 0.5965 0.576

2.5 2.5416 2.5833 2.625 2.6666 2.7083 2.75 2.7916 2.83330.2657 0.2444 0.2225 0.2001 0.1771 0.1536 0.1295 0.1049 0.07990.758 0.7398 0.721 0.7017 0.6818 0.6613 0.6404 0.6189 0.597

-0.4621 -0.4723 -0.4826 -0.493 -0.5033 -0.5138 -0.5242 -0.5347 -0.54530.6674 0.6518 0.6355 0.6185 0.6008 0.5825 0.5636 0.544 0.52370.0241 0.0181 0.012 0.0057 -0.0008 -0.0074 -0.0142 -0.0211 -0.02810.3381 0.3149 0.291 0.2665 0.2414 0.2158 0.1896 0.1628 0.13550.9003 0.889 0.877 0.8641 0.8504 0.836 0.8207 0.8047 0.78790.7291 0.7115 0.6934 0.6749 0.6559 0.6365 0.6167 0.5965 0.576

2.5 2.5416 2.5833 2.625 2.6666 2.7083 2.75 2.7916 2.83330.6171 0.6011 0.5845 0.5674 0.5498 0.5317 0.5131 0.4941 0.47460.1734 0.099 0.0207 -0.0614 -0.1474 -0.2374 -0.3314 -0.4295 -0.53180.3905 0.3638 0.3366 0.3089 0.2808 0.2522 0.2232 0.1939 0.16420.5246 0.4786 0.4303 0.3797 0.3266 0.2712 0.2133 0.153 0.09020.8115 0.8018 0.7916 0.7809 0.7696 0.7579 0.7457 0.7331 0.71990.3415 0.2767 0.2084 0.1367 0.0614 -0.0174 -0.1 -0.1862 -0.27620.0415 -0.0414 -0.1284 -0.2196 -0.3151 -0.4149 -0.5191 -0.6278 -0.74110.2745 0.2063 0.1345 0.0591 -0.0199 -0.1027 -0.1893 -0.2797 -0.3739

2.5 2.5416 2.5833 2.625 2.6666 2.7083 2.75 2.7916 2.83331.5501 1.5603 1.5701 1.5794 1.5883 1.5969 1.605 1.6127 1.62010.6578 0.6177 0.5771 0.536 0.4944 0.4524 0.4101 0.3674 0.32450.5985 0.5637 0.527 0.4884 0.448 0.4056 0.3614 0.3152 0.2670.215 0.1868 0.1582 0.1293 0.1001 0.0706 0.0409 0.011 -0.019

0.1086 0.0812 0.0536 0.0256 -0.0026 -0.031 -0.0595 -0.0882 -0.1170.0416 -0.041 -0.1277 -0.2186 -0.3137 -0.4132 -0.517 -0.6253 -0.73820.6958 0.6531 0.6078 0.56 0.5095 0.4564 0.4006 0.3421 0.28080.671 0.6346 0.596 0.5554 0.5125 0.4676 0.4204 0.3709 0.3193

2.5 2.5416 2.5833 2.625 2.6666 2.7083 2.75 2.7916 2.8333-0.0317 -0.1186 -0.2099 -0.3055 -0.4055 -0.51 -0.6191 -0.7328 -0.85130.6578 0.6177 0.5771 0.536 0.4944 0.4524 0.4101 0.3674 0.32450.7657 0.7464 0.7265 0.706 0.6849 0.6633 0.6411 0.6183 0.595-0.0805 -0.17 -0.2638 -0.3621 -0.465 -0.5724 -0.6844 -0.8012 -0.9228

2.1984 2.2272 2.2557 2.2838 2.3115 2.3389 2.3659 2.3926 2.41890.2135 0.1405 0.0639 -0.0166 -0.101 -0.1893 -0.2816 -0.378 -0.4785-0.0983 -0.1888 -0.2836 -0.3829 -0.4867 -0.5952 -0.7084 -0.8263 -0.9490.4639 0.4326 0.4008 0.3685 0.3357 0.3025 0.2688 0.2348 0.2004

2.875 2.9166 2.9583 3 3.0416 3.0833 3.125 3.1666 3.2083-0.1044 -0.1855 -0.2699 -0.3576 -0.4486 -0.543 -0.6409 -0.7423 -0.8471-0.1749 -0.2625 -0.3538 -0.4486 -0.5472 -0.6495 -0.7556 -0.8656 -0.97940.3492 0.3121 0.2738 0.2343 0.1938 0.1522 0.1094 0.0656 0.02060.2634 0.2231 0.1824 0.1412 0.0996 0.0577 0.0155 -0.027 -0.06980.3844 0.3418 0.2978 0.2523 0.2053 0.1568 0.1069 0.0554 0.00250.3384 0.3083 0.2776 0.2462 0.2141 0.1814 0.148 0.114 0.07940.2378 0.198 0.1581 0.118 0.0779 0.0378 -0.0024 -0.0424 -0.0824-0.0047 -0.0775 -0.1533 -0.232 -0.3137 -0.3985 -0.4864 -0.5774 -0.6716

2.875 2.9166 2.9583 3 3.0416 3.0833 3.125 3.1666 3.20830.5529 0.5132 0.4719 0.4289 0.3842 0.3379 0.2897 0.2399 0.18830.2973 0.267 0.236 0.2045 0.1723 0.1396 0.1063 0.0724 0.038-0.6455 -0.7569 -0.8728 -0.9931 -1.1179 -1.2472 -1.3812 -1.5199 -1.66330.3186 0.2913 0.2638 0.2362 0.2084 0.1804 0.1524 0.1244 0.09630.7723 0.761 0.7494 0.7376 0.7255 0.7132 0.7006 0.6879 0.67490.6307 0.6092 0.5872 0.5648 0.542 0.5189 0.4953 0.4714 0.4472-0.5933 -0.7041 -0.8192 -0.9388 -1.063 -1.1917 -1.3251 -1.4632 -1.6060.2291 0.1915 0.1539 0.1161 0.0783 0.0405 0.0027 -0.0351 -0.0727

2.875 2.9166 2.9583 3 3.0416 3.0833 3.125 3.1666 3.20834.9168 4.9337 4.9493 4.9637 4.9769 4.9888 4.9995 5.009 5.01730.2973 0.267 0.236 0.2045 0.1723 0.1396 0.1063 0.0724 0.0380.4024 0.3751 0.3472 0.3186 0.2893 0.2595 0.229 0.1979 0.1663-0.1777 -0.2044 -0.231 -0.2577 -0.2843 -0.3108 -0.3373 -0.3636 -0.3898-1.9296 -1.9238 -1.9174 -1.9102 -1.9023 -1.8938 -1.8846 -1.8747 -1.86411.0685 1.0518 1.034 1.0152 0.9953 0.9743 0.9523 0.9291 0.90480.2182 0.1797 0.1409 0.102 0.0631 0.0241 -0.015 -0.0539 -0.09280.2819 0.2438 0.2052 0.1662 0.1268 0.0871 0.0471 0.0068 -0.0338

2.875 2.9166 2.9583 3 3.0416 3.0833 3.125 3.1666 3.20830.2583 0.2134 0.1673 0.1198 0.071 0.0209 -0.0304 -0.0831 -0.13710.8638 0.8478 0.831 0.8135 0.7953 0.7764 0.7568 0.7364 0.7154-0.0462 -0.1287 -0.2148 -0.3043 -0.3974 -0.4941 -0.5945 -0.6985 -0.80630.2242 0.1911 0.157 0.1222 0.0864 0.0498 0.0124 -0.0259 -0.0650.4303 0.3866 0.3412 0.294 0.2451 0.1944 0.142 0.0878 0.03180.5605 0.5101 0.4573 0.4021 0.3444 0.2843 0.2218 0.1567 0.08911.6822 1.6903 1.698 1.7054 1.7124 1.719 1.7252 1.7311 1.73671.6199 1.6204 1.6201 1.619 1.6171 1.6144 1.6109 1.6066 1.6015

2.875 2.9166 2.9583 3 3.0416 3.0833 3.125 3.1666 3.20830.2647 0.2251 0.1851 0.1446 0.1038 0.0626 0.0211 -0.0207 -0.0628

0.0806 0.0165 -0.05 -0.1189 -0.1903 -0.2641 -0.3405 -0.4193 -0.50082.5326 2.546 2.5589 2.5712 2.5829 2.5941 2.6047 2.6147 2.62420.2512 0.2128 0.1744 0.1358 0.0972 0.0585 0.0199 -0.0187 -0.0571-3.3577 -3.3426 -3.3262 -3.3086 -3.2897 -3.2697 -3.2484 -3.226 -3.20250.0583 -0.0096 -0.0801 -0.1533 -0.2292 -0.3079 -0.3893 -0.4735 -0.56050.2537 0.2147 0.1755 0.136 0.0964 0.0566 0.0167 -0.0232 -0.06310.5551 0.5339 0.5124 0.4906 0.4686 0.4464 0.424 0.4014 0.3787

2.875 2.9166 2.9583 3 3.0416 3.0833 3.125 3.1666 3.20830.0543 0.0283 0.0018 -0.0251 -0.0525 -0.0803 -0.1084 -0.137 -0.1660.5746 0.5518 0.5286 0.5049 0.4809 0.4565 0.4318 0.4068 0.3815-0.5558 -0.5664 -0.5771 -0.5877 -0.5984 -0.6091 -0.6199 -0.6307 -0.64140.5029 0.4814 0.4593 0.4367 0.4134 0.3896 0.3652 0.3403 0.3148-0.0353 -0.0426 -0.0501 -0.0577 -0.0654 -0.0733 -0.0813 -0.0894 -0.09760.1076 0.0793 0.0505 0.0212 -0.0086 -0.0387 -0.0694 -0.1004 -0.13180.7704 0.752 0.7329 0.713 0.6924 0.671 0.6489 0.6259 0.60230.5551 0.5339 0.5124 0.4906 0.4686 0.4464 0.424 0.4014 0.3787

2.875 2.9166 2.9583 3 3.0416 3.0833 3.125 3.1666 3.20830.4547 0.4343 0.4135 0.3924 0.3709 0.349 0.3268 0.3042 0.2814-0.6383 -0.7491 -0.8642 -0.9837 -1.1076 -1.2361 -1.3692 -1.5069 -1.64930.1342 0.1039 0.0733 0.0425 0.0115 -0.0197 -0.051 -0.0825 -0.1140.0249 -0.0429 -0.1133 -0.1863 -0.2619 -0.3401 -0.421 -0.5045 -0.59080.7064 0.6924 0.678 0.6631 0.6479 0.6323 0.6163 0.5999 0.5832-0.37 -0.4676 -0.5692 -0.6747 -0.7843 -0.898 -1.0158 -1.1378 -1.264

-0.8589 -0.9814 -1.1087 -1.2408 -1.3778 -1.5197 -1.6666 -1.8186 -1.9757-0.4722 -0.5744 -0.6807 -0.7911 -0.9057 -1.0245 -1.1477 -1.2751 -1.407

2.875 2.9166 2.9583 3 3.0416 3.0833 3.125 3.1666 3.20831.627 1.6336 1.6398 1.6456 1.6511 1.6562 1.6609 1.6653 1.6693

0.2815 0.2383 0.195 0.1517 0.1084 0.0652 0.0221 -0.0208 -0.06340.2168 0.1647 0.1106 0.0544 -0.0039 -0.0642 -0.1266 -0.1911 -0.2577-0.0492 -0.0795 -0.1098 -0.1402 -0.1706 -0.2009 -0.2312 -0.2613 -0.2914-0.1458 -0.1747 -0.2036 -0.2325 -0.2613 -0.29 -0.3186 -0.3471 -0.3753-0.8556 -0.9776 -1.1044 -1.2359 -1.3724 -1.5137 -1.66 -1.8114 -1.96790.2167 0.1498 0.08 0.0073 -0.0684 -0.147 -0.2287 -0.3134 -0.40120.2653 0.2091 0.1505 0.0895 0.0262 -0.0395 -0.1077 -0.1783 -0.2514

2.875 2.9166 2.9583 3 3.0416 3.0833 3.125 3.1666 3.2083-0.9745 -1.1025 -1.2355 -1.3734 -1.5165 -1.6646 -1.8179 -1.9765 -2.14050.2815 0.2383 0.195 0.1517 0.1084 0.0652 0.0221 -0.0208 -0.06340.5712 0.547 0.5223 0.4972 0.4716 0.4457 0.4193 0.3926 0.3656-1.0493 -1.1807 -1.3171 -1.4586 -1.6053 -1.7572 -1.9144 -2.077 -2.245

2.4448 2.4703 2.4954 2.5202 2.5445 2.5685 2.592 2.6151 2.6379-0.5831 -0.6921 -0.8053 -0.9229 -1.0449 -1.1715 -1.3025 -1.4382 -1.5785-1.0767 -1.2093 -1.347 -1.4898 -1.6379 -1.7911 -1.9498 -2.1138 -2.28330.1657 0.1307 0.0955 0.06 0.0245 -0.0113 -0.0471 -0.083 -0.1189

3.2499 3.2916 3.3333 3.3749 3.4166 3.4583 3.4999 3.5416 3.5833-0.9556 -1.0676 -1.1833 -1.3027 -1.4258 -1.5527 -1.6835 -1.818 -1.9565-1.0972 -1.219 -1.3448 -1.4747 -1.6087 -1.7469 -1.8894 -2.0361 -2.1872-0.0255 -0.0726 -0.1208 -0.1702 -0.2206 -0.2721 -0.3246 -0.3783 -0.433-0.1128 -0.156 -0.1993 -0.2428 -0.2863 -0.3299 -0.3735 -0.417 -0.4606-0.0519 -0.1079 -0.1653 -0.2242 -0.2846 -0.3466 -0.41 -0.475 -0.54150.0442 0.0083 -0.0281 -0.065 -0.1026 -0.1406 -0.1792 -0.2184 -0.258-0.1222 -0.1618 -0.2011 -0.2402 -0.2789 -0.3173 -0.3552 -0.3926 -0.4295-0.7689 -0.8695 -0.9734 -1.0806 -1.1912 -1.3051 -1.4224 -1.5432 -1.6675

3.2499 3.2916 3.3333 3.3749 3.4166 3.4583 3.4999 3.5416 3.58330.1349 0.0798 0.0229 -0.0358 -0.0963 -0.1587 -0.2229 -0.2889 -0.35680.003 -0.0324 -0.0684 -0.1048 -0.1418 -0.1791 -0.2169 -0.2552 -0.2938

-1.8115 -1.9645 -2.1225 -2.2855 -2.4536 -2.6267 -2.805 -2.9886 -3.17750.0682 0.0402 0.0122 -0.0157 -0.0435 -0.0711 -0.0985 -0.1257 -0.15270.6618 0.6485 0.635 0.6214 0.6077 0.5939 0.5801 0.5661 0.55210.4227 0.3979 0.3728 0.3475 0.3219 0.2961 0.2701 0.244 0.2176-1.7537 -1.9063 -2.0639 -2.2265 -2.3942 -2.567 -2.7451 -2.9284 -3.1171-0.1101 -0.1473 -0.1843 -0.221 -0.2574 -0.2934 -0.3289 -0.364 -0.3986

3.2499 3.2916 3.3333 3.3749 3.4166 3.4583 3.4999 3.5416 3.58335.0245 5.0304 5.0353 5.0389 5.0415 5.0429 5.0432 5.0424 5.04060.003 -0.0324 -0.0684 -0.1048 -0.1418 -0.1791 -0.2169 -0.2552 -0.2938

0.1341 0.1014 0.0681 0.0342 -0.0001 -0.035 -0.0703 -0.1062 -0.1425-0.4157 -0.4415 -0.4671 -0.4923 -0.5173 -0.5419 -0.5662 -0.5902 -0.6137-1.8529 -1.8411 -1.8286 -1.8156 -1.8019 -1.7876 -1.7728 -1.7574 -1.74140.8795 0.853 0.8254 0.7967 0.7669 0.7359 0.7038 0.6706 0.6362-0.1316 -0.1702 -0.2087 -0.2468 -0.2847 -0.3222 -0.3594 -0.3961 -0.4323-0.0745 -0.1155 -0.1565 -0.1977 -0.239 -0.2803 -0.3217 -0.363 -0.4043

3.2499 3.2916 3.3333 3.3749 3.4166 3.4583 3.4999 3.5416 3.5833-0.1924 -0.249 -0.3069 -0.366 -0.4264 -0.4881 -0.5511 -0.6154 -0.68090.6937 0.6712 0.6481 0.6244 0.5999 0.5747 0.5489 0.5224 0.4953-0.9179 -1.0333 -1.1526 -1.2758 -1.403 -1.5342 -1.6696 -1.809 -1.9526-0.105 -0.1457 -0.1873 -0.2297 -0.2728 -0.3168 -0.3615 -0.4071 -0.4534-0.026 -0.0857 -0.1472 -0.2105 -0.2757 -0.3427 -0.4117 -0.4825 -0.55520.0189 -0.0539 -0.1293 -0.2073 -0.2881 -0.3715 -0.4577 -0.5467 -0.63851.7419 1.7467 1.7512 1.7554 1.7592 1.7627 1.7659 1.7687 1.77121.5956 1.5889 1.5814 1.573 1.5638 1.5538 1.5429 1.5312 1.5186

3.2499 3.2916 3.3333 3.3749 3.4166 3.4583 3.4999 3.5416 3.5833-0.1051 -0.1476 -0.1902 -0.233 -0.2759 -0.3188 -0.3617 -0.4047 -0.4476

-0.5848 -0.6714 -0.7606 -0.8524 -0.9469 -1.0441 -1.144 -1.2466 -1.3522.6332 2.6416 2.6494 2.6568 2.6636 2.6698 2.6756 2.6808 2.6855-0.0953 -0.1334 -0.1712 -0.2087 -0.2458 -0.2826 -0.319 -0.3548 -0.3902-3.1779 -3.1522 -3.1254 -3.0976 -3.0688 -3.039 -3.0082 -2.9764 -2.9438-0.6504 -0.7432 -0.8389 -0.9375 -1.0392 -1.1438 -1.2514 -1.3621 -1.4758-0.1031 -0.1429 -0.1827 -0.2223 -0.2617 -0.3009 -0.3398 -0.3784 -0.41670.3558 0.3328 0.3098 0.2867 0.2635 0.2404 0.2172 0.1941 0.1711

3.2499 3.2916 3.3333 3.3749 3.4166 3.4583 3.4999 3.5416 3.5833-0.1953 -0.225 -0.2551 -0.2854 -0.3161 -0.3471 -0.3784 -0.41 -0.44180.3559 0.3301 0.304 0.2777 0.2512 0.2245 0.1976 0.1707 0.1436-0.6522 -0.6631 -0.6739 -0.6848 -0.6956 -0.7065 -0.7174 -0.7283 -0.73910.2888 0.2622 0.2352 0.2076 0.1795 0.1509 0.1219 0.0923 0.0624-0.106 -0.1145 -0.1231 -0.1318 -0.1406 -0.1495 -0.1585 -0.1676 -0.1768-0.1636 -0.1958 -0.2283 -0.2612 -0.2944 -0.3278 -0.3616 -0.3956 -0.42990.5779 0.5527 0.5269 0.5002 0.4729 0.4448 0.416 0.3864 0.35620.3558 0.3328 0.3098 0.2867 0.2635 0.2404 0.2172 0.1941 0.1711

3.2499 3.2916 3.3333 3.3749 3.4166 3.4583 3.4999 3.5416 3.58330.2582 0.2348 0.2111 0.1872 0.163 0.1386 0.114 0.0892 0.0643-1.7965 -1.9485 -2.1054 -2.2672 -2.434 -2.6059 -2.783 -2.9652 -3.1526-0.1456 -0.1773 -0.209 -0.2406 -0.2723 -0.3038 -0.3352 -0.3666 -0.3977-0.6798 -0.7715 -0.8661 -0.9635 -1.0637 -1.1667 -1.2727 -1.3816 -1.49340.5662 0.5488 0.5311 0.5131 0.4947 0.4761 0.4573 0.4381 0.4188-1.3945 -1.5294 -1.6687 -1.8125 -1.9608 -2.1136 -2.2711 -2.4332 -2.6001-2.1381 -2.3058 -2.4788 -2.6572 -2.8411 -3.0306 -3.2257 -3.4265 -3.633-1.5433 -1.6841 -1.8295 -1.9795 -2.1342 -2.2936 -2.4578 -2.6269 -2.8009

3.2499 3.2916 3.3333 3.3749 3.4166 3.4583 3.4999 3.5416 3.58331.673 1.6763 1.6793 1.6819 1.6843 1.6863 1.688 1.6894 1.6904

-0.1058 -0.1478 -0.1894 -0.2306 -0.2712 -0.3113 -0.3507 -0.3895 -0.4276-0.3264 -0.3974 -0.4705 -0.5458 -0.6233 -0.703 -0.785 -0.8693 -0.9559-0.3212 -0.3509 -0.3803 -0.4095 -0.4384 -0.4669 -0.4951 -0.5228 -0.5502-0.4034 -0.4311 -0.4587 -0.4858 -0.5127 -0.5392 -0.5652 -0.5908 -0.616-2.1296 -2.2966 -2.4688 -2.6465 -2.8296 -3.0182 -3.2125 -3.4124 -3.618-0.4921 -0.5862 -0.6835 -0.7841 -0.8879 -0.995 -1.1055 -1.2194 -1.3367-0.3271 -0.4052 -0.4859 -0.5692 -0.6552 -0.7437 -0.835 -0.9289 -1.0255

3.2499 3.2916 3.3333 3.3749 3.4166 3.4583 3.4999 3.5416 3.5833-2.3098 -2.4846 -2.665 -2.851 -3.0427 -3.2401 -3.4434 -3.6526 -3.8677-0.1058 -0.1478 -0.1894 -0.2306 -0.2712 -0.3113 -0.3507 -0.3895 -0.42760.3383 0.3107 0.2828 0.2546 0.2262 0.1976 0.1688 0.1398 0.1107-2.4186 -2.5977 -2.7825 -2.973 -3.1693 -3.3716 -3.5797 -3.7939 -4.0141

2.6602 2.682 2.7035 2.7245 2.7451 2.7653 2.785 2.8043 2.8231-1.7236 -1.8735 -2.0282 -2.1878 -2.3524 -2.522 -2.6967 -2.8766 -3.0617-2.4584 -2.6391 -2.8255 -3.0177 -3.2157 -3.4197 -3.6296 -3.8456 -4.0677-0.1548 -0.1907 -0.2265 -0.2622 -0.2978 -0.3331 -0.3683 -0.4032 -0.4378

3.6249 3.6666 3.7083 3.7499 3.7916 3.8333 3.8749 3.9166 3.9583-2.0989 -2.2453 -2.3958 -2.5503 -2.7089 -2.8717 -3.0386 -3.2098 -3.3853-2.3426 -2.5025 -2.6668 -2.8357 -3.0092 -3.1873 -3.3701 -3.5576 -3.7498-0.4887 -0.5456 -0.6035 -0.6624 -0.7224 -0.7834 -0.8455 -0.9087 -0.9728-0.504 -0.5473 -0.5905 -0.6335 -0.6762 -0.7187 -0.7609 -0.8028 -0.8443-0.6096 -0.6792 -0.7503 -0.8229 -0.8971 -0.9728 -1.0501 -1.129 -1.2094-0.2981 -0.3387 -0.3797 -0.4213 -0.4632 -0.5056 -0.5484 -0.5916 -0.6352-0.4659 -0.5017 -0.5368 -0.5711 -0.6048 -0.6377 -0.6697 -0.7008 -0.7311-1.7954 -1.9268 -2.0617 -2.2004 -2.3427 -2.4887 -2.6385 -2.7921 -2.9495

3.6249 3.6666 3.7083 3.7499 3.7916 3.8333 3.8749 3.9166 3.9583-0.4266 -0.4982 -0.5718 -0.6473 -0.7247 -0.804 -0.8853 -0.9686 -1.0539-0.3328 -0.3723 -0.412 -0.4522 -0.4926 -0.5334 -0.5745 -0.6159 -0.6575-3.3717 -3.5713 -3.7764 -3.9871 -4.2034 -4.4253 -4.653 -4.8864 -5.1257-0.1794 -0.2058 -0.2318 -0.2575 -0.2828 -0.3077 -0.3322 -0.3561 -0.37950.538 0.5239 0.5098 0.4958 0.4817 0.4676 0.4536 0.4397 0.4259

0.1912 0.1646 0.1379 0.1111 0.0842 0.0573 0.0304 0.0034 -0.0235-3.3112 -3.5107 -3.7158 -3.9264 -4.1427 -4.3648 -4.5926 -4.8262 -5.0657-0.4326 -0.466 -0.4988 -0.5309 -0.5623 -0.593 -0.6228 -0.6517 -0.6798

3.6249 3.6666 3.7083 3.7499 3.7916 3.8333 3.8749 3.9166 3.95835.0376 5.0337 5.0286 5.0226 5.0155 5.0074 4.9983 4.9882 4.9772-0.3328 -0.3723 -0.412 -0.4522 -0.4926 -0.5334 -0.5745 -0.6159 -0.6575-0.1792 -0.2164 -0.254 -0.2921 -0.3306 -0.3694 -0.4086 -0.4482 -0.4882-0.6367 -0.6593 -0.6814 -0.703 -0.7241 -0.7445 -0.7644 -0.7836 -0.8022-1.7249 -1.7078 -1.6902 -1.6721 -1.6534 -1.6343 -1.6146 -1.5945 -1.5740.6006 0.5639 0.526 0.4869 0.4467 0.4052 0.3626 0.3187 0.2737-0.4681 -0.5033 -0.5379 -0.5719 -0.6052 -0.6378 -0.6696 -0.7006 -0.7307-0.4455 -0.4866 -0.5275 -0.5683 -0.6089 -0.6492 -0.6892 -0.7289 -0.7683

3.6249 3.6666 3.7083 3.7499 3.7916 3.8333 3.8749 3.9166 3.9583-0.7477 -0.8158 -0.8851 -0.9557 -1.0275 -1.1006 -1.175 -1.2505 -1.32740.4675 0.439 0.4099 0.3802 0.3498 0.3187 0.287 0.2547 0.2218-2.1004 -2.2525 -2.4089 -2.5696 -2.7347 -2.9044 -3.0785 -3.2571 -3.4403-0.5004 -0.5482 -0.5968 -0.646 -0.6961 -0.7468 -0.7983 -0.8505 -0.9034-0.6299 -0.7065 -0.785 -0.8655 -0.948 -1.0324 -1.1189 -1.2073 -1.2978-0.7331 -0.8305 -0.9309 -1.0342 -1.1404 -1.2496 -1.3618 -1.477 -1.59531.7734 1.7753 1.7769 1.7781 1.7791 1.7798 1.7801 1.7802 1.781.5052 1.4909 1.4757 1.4597 1.4427 1.4249 1.4063 1.3867 1.3662

3.6249 3.6666 3.7083 3.7499 3.7916 3.8333 3.8749 3.9166 3.9583-0.4904 -0.5332 -0.5758 -0.6182 -0.6604 -0.7024 -0.7441 -0.7855 -0.8266

-1.4602 -1.5711 -1.6849 -1.8016 -1.9211 -2.0434 -2.1687 -2.297 -2.42822.6897 2.6934 2.6966 2.6993 2.7015 2.7032 2.7044 2.7051 2.7053-0.425 -0.4592 -0.4927 -0.5255 -0.5576 -0.5889 -0.6194 -0.649 -0.6777-2.9102 -2.8758 -2.8405 -2.8044 -2.7675 -2.7298 -2.6913 -2.6521 -2.6122-1.5927 -1.7128 -1.836 -1.9624 -2.092 -2.2249 -2.3611 -2.5006 -2.6435-0.4545 -0.492 -0.5289 -0.5654 -0.6013 -0.6366 -0.6713 -0.7053 -0.73860.1481 0.1252 0.1025 0.0799 0.0575 0.0352 0.0132 -0.0085 -0.03

3.6249 3.6666 3.7083 3.7499 3.7916 3.8333 3.8749 3.9166 3.9583-0.4739 -0.5062 -0.5388 -0.5715 -0.6045 -0.6376 -0.671 -0.7044 -0.73810.1164 0.0891 0.0618 0.0345 0.0071 -0.0203 -0.0476 -0.0749 -0.1021-0.75 -0.7609 -0.7718 -0.7827 -0.7936 -0.8045 -0.8154 -0.8262 -0.8371

0.0319 0.001 -0.0303 -0.062 -0.0942 -0.1268 -0.1598 -0.1931 -0.2269-0.1862 -0.1956 -0.2051 -0.2147 -0.2243 -0.2341 -0.244 -0.2539 -0.2639-0.4645 -0.4992 -0.5342 -0.5694 -0.6047 -0.6402 -0.6759 -0.7117 -0.74760.3252 0.2935 0.2611 0.228 0.1942 0.1596 0.1244 0.0885 0.05190.1481 0.1252 0.1025 0.0799 0.0575 0.0352 0.0132 -0.0085 -0.03

3.6249 3.6666 3.7083 3.7499 3.7916 3.8333 3.8749 3.9166 3.95830.0392 0.0139 -0.0115 -0.037 -0.0625 -0.0882 -0.1139 -0.1397 -0.1655-3.3454 -3.5436 -3.7471 -3.9562 -4.1708 -4.3911 -4.617 -4.8486 -5.086-0.4287 -0.4595 -0.49 -0.5203 -0.5502 -0.5799 -0.6092 -0.6381 -0.6666-1.6082 -1.7259 -1.8467 -1.9706 -2.0975 -2.2275 -2.3606 -2.4969 -2.63630.3991 0.3793 0.3592 0.3389 0.3185 0.2978 0.277 0.256 0.2349-2.7718 -2.9483 -3.1297 -3.3161 -3.5074 -3.7039 -3.9054 -4.1121 -4.324-3.8454 -4.0636 -4.2878 -4.5181 -4.7544 -4.9969 -5.2456 -5.5007 -5.762-2.9799 -3.1638 -3.3529 -3.5471 -3.7464 -3.951 -4.161 -4.3762 -4.5969

3.6249 3.6666 3.7083 3.7499 3.7916 3.8333 3.8749 3.9166 3.95831.6912 1.6917 1.6918 1.6917 1.6913 1.6906 1.6896 1.6884 1.6869-0.4649 -0.5014 -0.537 -0.5716 -0.6053 -0.6379 -0.6694 -0.6997 -0.7289-1.0447 -1.1359 -1.2295 -1.3254 -1.4236 -1.5243 -1.6274 -1.7329 -1.8409-0.5771 -0.6034 -0.6293 -0.6546 -0.6793 -0.7033 -0.7267 -0.7494 -0.7714-0.6406 -0.6647 -0.6882 -0.7111 -0.7334 -0.755 -0.776 -0.7961 -0.8156-3.8294 -4.0467 -4.2699 -4.4991 -4.7343 -4.9757 -5.2233 -5.4771 -5.7373-1.4574 -1.5817 -1.7095 -1.8408 -1.9758 -2.1144 -2.2567 -2.4027 -2.5525-1.1249 -1.2271 -1.332 -1.4398 -1.5504 -1.6639 -1.7803 -1.8997 -2.0219

3.6249 3.6666 3.7083 3.7499 3.7916 3.8333 3.8749 3.9166 3.9583-4.0889 -4.3162 -4.5496 -4.7894 -5.0354 -5.2878 -5.5467 -5.8121 -6.0842-0.4649 -0.5014 -0.537 -0.5716 -0.6053 -0.6379 -0.6694 -0.6997 -0.72890.0814 0.052 0.0226 -0.007 -0.0366 -0.0663 -0.0959 -0.1256 -0.1552-4.2405 -4.4732 -4.7122 -4.9575 -5.2093 -5.4676 -5.7325 -6.004 -6.2823

2.8414 2.8593 2.8768 2.8937 2.9102 2.9262 2.9418 2.9568 2.9714-3.2521 -3.4478 -3.6489 -3.8555 -4.0675 -4.2852 -4.5085 -4.7375 -4.9722-4.2961 -4.5307 -4.7716 -5.019 -5.2729 -5.5334 -5.8005 -6.0743 -6.3549-0.4721 -0.5061 -0.5397 -0.5728 -0.6055 -0.6376 -0.6693 -0.7004 -0.7309

4-3.5651-3.9469-1.038-0.8854-1.2914-0.6791-0.7603-3.1107

4-1.1411-0.6994-5.371-0.40240.4121-0.0504-5.3113-0.7069

44.9652-0.6994-0.5285-0.82

-1.55290.2274-0.76

-0.8074

4-1.40540.1882-3.6282-0.9569-1.3903-1.71671.77951.3448

4-0.8673

-2.56242.7051-0.7054-2.5716-2.7897-0.7711-0.0512

4-0.7719-0.1293-0.8479-0.261-0.274-0.78360.0146-0.0512

4-0.1913-5.3293-0.6947-2.7790.2136-4.5412-6.0299-4.8231

41.6851-0.7568-1.9514-0.7926-0.8342-6.0038-2.7061-2.1472

4-6.3628-0.7568-0.1848-6.5674

2.9854-5.2128-6.6423-0.7607

SaporinTIME (days) 0.041237 0.082474 0.123711 0.164948 0.206185 0.247422COL-TST-sink 0 0.0429 0.0854 0.1275 0.1691 0.2103FB-TST-sink 0 0.0417 0.0832 0.1244 0.1654 0.206FGF-TST-sink 0 0.0489 0.0964 0.1425 0.1873 0.2308FN-TST-sink 0 0.0732 0.1436 0.2113 0.2762 0.3384GAPDH-TST-sink 0 0.0493 0.0975 0.1444 0.1901 0.2346GDF-TST-sink 0 0.0488 0.0961 0.1417 0.1859 0.2285LIN-TST-sink 0 0.0809 0.1585 0.2328 0.304 0.372UTF-TST-sink 0 0.0419 0.0834 0.1245 0.1651 0.2051

TIME (days) 0.041237 0.082474 0.123711 0.164948 0.206185 0.247422COL-TST-sink 0 189.3585896 101.5719 72.67596 58.54589 50.39342FB-TST-sink 0 171.5252763 92.04917 65.80111 53.03142 45.59607FGF-TST-sink 0 162.7648944 120.7696 86.82862 68.29707 57.31994FN-TST-sink 0 1.42997E-05 9.77E-05 0.000281 0.000568 0.000943GAPDH-TST-sink 0 6.34206E-06 4.36E-05 0.000127 0.000258 0.000431GDF-TST-sink 0 5.57084E-06 3E-05 8.63E-05 0.000179 0.000305LIN-TST-sink 0 9.23398E-06 4.95E-05 0.000142 0.000292 0.000495UTF-TST-sink 0 4.78139E-06 2.6E-05 7.56E-05 0.000158 0.000272

TIME (days) 0.041237 0.082474 0.123711 0.164948 0.206185 0.247422COL-TLT-sink 0 0.0442 0.0876 0.1302 0.172 0.213FB-TLT-sink 0 0.0497 0.0976 0.144 0.1887 0.2317FGF-TLT-sink 0 0.0417 0.0833 0.1247 0.1659 0.2067FN-TLT-sink 0 0.0589 0.1156 0.1701 0.2223 0.2724GAPDH-TLT-sink 0 0.0449 0.0884 0.1306 0.1715 0.2111GDF-TLT-sink 0 0.0534 0.1051 0.1551 0.2034 0.25LIN-TLT-sink 0 0.0417 0.0832 0.1247 0.1659 0.2069UTF-TLT-sink 0 0.0769 0.1507 0.2213 0.289 0.3536

TIME (days) 0.041237 0.082474 0.123711 0.164948 0.206185 0.247422COL-TLT-sink 0 310.7502097 166.6966 119.949 96.91936 83.70914FB-TLT-sink 0 318.5907161 169.2628 120.9032 96.86032 82.89275FGF-TLT-sink 0 149.2876481 133.6199 104.6686 86.38814 75.22485FN-TLT-sink 0 4.27127E-06 2.92E-05 8.3E-05 0.000166 0.000274GAPDH-TLT-sink 0 1.90482E-06 1.32E-05 3.79E-05 7.71E-05 0.000129GDF-TLT-sink 0 2.39664E-06 1.48E-05 4.07E-05 8.16E-05 0.000135LIN-TLT-sink 0 1.87137E-06 1.17E-05 3.27E-05 6.65E-05 0.000112UTF-TLT-sink 0 3.4508E-06 2.11E-05 5.81E-05 0.000116 0.00019

TIME (days) 0.041237 0.082474 0.123711 0.164948 0.206185 0.247422COL-TLT-FB 0 0.1336 0.2651 0.3944 0.5217 0.647FB-TLT-FB 0 0.0497 0.0976 0.144 0.1887 0.2317FGF-TLT-FB 0 0.0477 0.0939 0.1386 0.1818 0.2236

FN-TLT-FB 0 0.043 0.084 0.123 0.1602 0.1954GAPDH-TLT-FB 0 -0.0688 -0.1362 -0.2021 -0.2667 -0.3298GDF-TLT-FB 0 0.0421 0.0835 0.1242 0.1643 0.2037LIN-TLT-FB 0 0.0772 0.1513 0.2223 0.2902 0.3551UTF-TLT-FB 0 0.0705 0.1383 0.2035 0.266 0.326

TIME (days) 0.041237 0.082474 0.123711 0.164948 0.206185 0.247422COL-TLT-FB 0 41.79449061 21.17051 14.30343 10.86844 8.810537FB-TLT-FB 0 20.89860183 10.56419 7.136623 5.418379 4.387932FGF-TLT-FB 0 17.88798035 9.833977 6.7629 5.172166 4.206896FN-TLT-FB 0 0.000172655 0.001321 0.004269 0.009716 0.018215GAPDH-TLT-FB 0 -0.00025506 -0.00198 -0.00649 -0.01499 -0.02855GDF-TLT-FB 0 0.000160929 0.001241 0.004096 0.009583 0.018569LIN-TLT-FB 0 0.000294919 0.002243 0.007293 0.01677 0.031916UTF-TLT-FB 0 0.000269018 0.002041 0.00661 0.015104 0.028504

Actinomycin DTIME (days) 0.041237 0.082474 0.123711 0.164948 0.206185 0.247422COL-TST-sink 0 0.0533 0.1051 0.1554 0.2041 0.2514FB-TST-sink 0 0.0434 0.0857 0.1271 0.1675 0.2069FGF-TST-sink 0 0.0419 0.0836 0.1251 0.1663 0.2072FN-TST-sink 0 0.0441 0.0868 0.1282 0.1682 0.2069GAPDH-TST-sink 0 0.045 0.0892 0.1324 0.1748 0.2163GDF-TST-sink 0 0.0422 0.0841 0.1255 0.1666 0.2072LIN-TST-sink 0 0.0431 0.0855 0.1273 0.1685 0.2091UTF-TST-sink 0 0.0419 0.0834 0.1244 0.165 0.2051

TIME (days) 0.041237 0.082474 0.123711 0.164948 0.206185 0.247422COL-TST-sink 0 3743.024466 2029.433 1466.364 1197.855 1035.104FB-TST-sink 0 31042.23433 20248.65 17662.12 16607.65 15294.1FGF-TST-sink 0 187.3859892 391.5074 592.0654 770.7275 908.628FN-TST-sink 0 2.20345E-08 1.48E-07 4.17E-07 8.21E-07 1.35E-06GAPDH-TST-sink 0 3.355E-10 1.56E-09 3.03E-09 4.52E-09 6.59E-09GDF-TST-sink 0 3.15342E-10 1.48E-09 2.91E-09 4.37E-09 6.43E-09LIN-TST-sink 0 3.22067E-10 1.51E-09 2.95E-09 4.42E-09 6.49E-09UTF-TST-sink 0 3.131E-10 1.47E-09 2.88E-09 4.33E-09 6.36E-09

TIME (days) 0.041237 0.082474 0.123711 0.164948 0.206185 0.247422COL-TLT-sink 0 0.0719 0.141 0.2074 0.2711 0.3322FB-TLT-sink 0 0.0466 0.0923 0.1372 0.1812 0.2244FGF-TLT-sink 0 0.0623 0.1238 0.1844 0.2443 0.3032FN-TLT-sink 0 0.0791 0.1551 0.2278 0.2975 0.364GAPDH-TLT-sink 0 -0.1288 -0.2547 -0.3778 -0.4981 -0.6155GDF-TLT-sink 0 0.0449 0.0891 0.1327 0.1756 0.2177LIN-TLT-sink 0 0.0768 0.1506 0.2214 0.2891 0.354

UTF-TLT-sink 0 0.0545 0.1072 0.1579 0.2069 0.254

TIME (days) 0.041237 0.082474 0.123711 0.164948 0.206185 0.247422COL-TLT-sink 0 15.18293945 7.645034 5.133805 3.877355 3.124868FB-TLT-sink 0 8.773847229 4.458659 3.023646 2.305678 1.876715FGF-TLT-sink 0 11.02615736 5.862986 4.021685 3.087705 2.523292FN-TLT-sink 0 0.002412594 0.018833 0.06187 0.14159 0.261569GAPDH-TLT-sink 0 -0.00343994 -0.02692 -0.08874 -0.20407 -0.38046GDF-TLT-sink 0 0.001070444 0.008328 0.028254 0.068547 0.139083LIN-TLT-sink 0 0.001827869 0.013997 0.046733 0.112213 0.228277UTF-TLT-sink 0 0.001293016 0.009825 0.032111 0.073864 0.13779

TIME (days) 0.041237 0.082474 0.123711 0.164948 0.206185 0.247422COL-TLT-FB 0 0.0369 0.0725 0.1068 0.1397 0.1713FB-TLT-FB 0 0.0542 0.1067 0.1573 0.2062 0.2534FGF-TLT-FB 0 -0.0042 -0.0086 -0.0131 -0.0177 -0.0225FN-TLT-FB 0 0.0425 0.0837 0.1237 0.1624 0.2GAPDH-TLT-FB 0 0.008 0.0158 0.0232 0.0303 0.0372GDF-TLT-FB 0 0.0427 0.0838 0.1234 0.1615 0.198LIN-TLT-FB 0 0.0423 0.0836 0.1239 0.1632 0.2016UTF-TLT-FB 0 0.0545 0.1072 0.1579 0.2069 0.254

TIME (days) 0.041237 0.082474 0.123711 0.164948 0.206185 0.247422COL-TLT-FB 0 81.07933132 40.97233 27.63664 20.94263 16.93004FB-TLT-FB 0 102.2709506 51.7787 34.95031 26.53879 21.49893FGF-TLT-FB 0 -5.04896904 -3.69964 -2.8133 -2.27817 -1.93863FN-TLT-FB 0 4.53057E-05 0.00035 0.001144 0.002631 0.004995GAPDH-TLT-FB 0 3.92841E-06 3.04E-05 9.84E-05 0.000224 0.000423GDF-TLT-FB 0 2.04865E-05 0.000156 0.000503 0.001144 0.002148LIN-TLT-FB 0 2.02911E-05 0.000155 0.000504 0.001154 0.002179UTF-TLT-FB 0 2.61389E-05 0.000199 0.000641 0.001459 0.002735

Mitomycin CTIME (days) 0.041237 0.082474 0.123711 0.164948 0.206185 0.247422COL-TST-sink 0 0.0449 0.0882 0.1302 0.1707 0.2097FB-TST-sink 0 0.0419 0.0836 0.1251 0.1663 0.2073FGF-TST-sink 0 0.055 0.1079 0.1586 0.2072 0.2536FN-TST-sink 0 0.0465 0.0923 0.1372 0.1813 0.2245GAPDH-TST-sink 0 0.0427 0.0842 0.1245 0.1636 0.2015GDF-TST-sink 0 0.0419 0.0836 0.1251 0.1663 0.2072LIN-TST-sink 0 0.0417 0.0832 0.1247 0.1659 0.2068UTF-TST-sink 0 0.0417 0.0832 0.1245 0.1656 0.2063

TIME (days) 0.041237 0.082474 0.123711 0.164948 0.206185 0.247422COL-TST-sink 0 2140.443173 1203.098 916.7181 782.9871 715.2084

FB-TST-sink 0 1713.834947 977.4566 755.9152 657.3222 614.2742FGF-TST-sink 0 244.8191069 426.9542 513.5324 543.4007 550.9975FN-TST-sink 0 7.10499E-08 4.46E-07 1.14E-06 2.07E-06 3.07E-06GAPDH-TST-sink 0 4.74775E-08 2.93E-07 7.38E-07 1.31E-06 1.9E-06GDF-TST-sink 0 4.85511E-08 3.11E-07 7.56E-07 1.28E-06 1.81E-06LIN-TST-sink 0 4.83189E-08 3.09E-07 7.54E-07 1.28E-06 1.81E-06UTF-TST-sink 0 4.83184E-08 3.09E-07 7.53E-07 1.28E-06 1.8E-06

TIME (days) 0.041237 0.082474 0.123711 0.164948 0.206185 0.247422COL-TLT-sink 0 0.0437 0.0866 0.1289 0.1705 0.2115FB-TLT-sink 0 0.092 0.1801 0.2646 0.3454 0.4225FGF-TLT-sink 0 0.0425 0.0842 0.1252 0.1654 0.2048FN-TLT-sink 0 0.0538 0.1053 0.1544 0.2013 0.246GAPDH-TLT-sink 0 0.049 0.0957 0.1403 0.1827 0.223GDF-TLT-sink 0 0.0417 0.0833 0.1247 0.1659 0.2069LIN-TLT-sink 0 0.0424 0.0845 0.1263 0.1676 0.2085UTF-TLT-sink 0 0.042 0.0834 0.1243 0.1646 0.2042

TIME (days) 0.041237 0.082474 0.123711 0.164948 0.206185 0.247422COL-TLT-sink 0 148.5147013 78.87797 55.85901 44.52057 37.9176FB-TLT-sink 0 275.9050098 144.6967 101.0554 79.40891 66.61293FGF-TLT-sink 0 193.9522356 354.3207 452.2951 510.5392 553.1623FN-TLT-sink 0 1.70862E-05 0.000119 0.000348 0.000717 0.001212GAPDH-TLT-sink 0 4.05989E-06 2.87E-05 8.6E-05 0.000181 0.000313GDF-TLT-sink 0 3.08377E-06 4.76E-06 4.54E-06 4.71E-06 4.97E-06LIN-TLT-sink 0 3.13525E-06 4.83E-06 4.6E-06 4.76E-06 5.01E-06UTF-TLT-sink 0 3.10538E-06 4.77E-06 4.52E-06 4.67E-06 4.9E-06

TIME (days) 0.041237 0.082474 0.123711 0.164948 0.206185 0.247422COL-TLT-FB 0 0.0417 0.0832 0.1247 0.1659 0.2068FB-TLT-FB 0 0.092 0.1801 0.2646 0.3454 0.4225FGF-TLT-FB 0 0.0555 0.1092 0.1611 0.2112 0.2595FN-TLT-FB 0 0.0417 0.0832 0.1247 0.1659 0.2068GAPDH-TLT-FB 0 0.0417 0.0832 0.1247 0.1661 0.2074GDF-TLT-FB 0 0.0417 0.0834 0.1248 0.166 0.2069LIN-TLT-FB 0 0.0417 0.0832 0.1247 0.1659 0.2068UTF-TLT-FB 0 0.0661 0.1295 0.1903 0.2485 0.3041

TIME (days) 0.041237 0.082474 0.123711 0.164948 0.206185 0.247422COL-TLT-FB 0 124.9112725 67.54582 48.82035 39.68867 34.47461FB-TLT-FB 0 251.2520336 133.2452 94.30883 75.16992 64.02644FGF-TLT-FB 0 213.8269072 248.5232 222.027 196.6948 179.6689FN-TLT-FB 0 1.87239E-05 0.000128 0.000368 0.000744 0.001234GAPDH-TLT-FB 0 4.27788E-06 3.02E-05 8.99E-05 0.000188 0.000322GDF-TLT-FB 0 3.35001E-06 9.07E-06 1.81E-05 3.11E-05 4.7E-05

LIN-TLT-FB 0 3.3497E-06 9.04E-06 1.8E-05 3.11E-05 4.69E-05UTF-TLT-FB 0 5.30921E-06 1.41E-05 2.75E-05 4.66E-05 6.89E-05

0.288659 0.329896 0.371133 0.41237 0.453607 0.494844 0.536081 0.577318 0.6185550.2509 0.291 0.3304 0.3692 0.4073 0.4446 0.4811 0.5168 0.55170.2462 0.2859 0.3252 0.3639 0.402 0.4394 0.4762 0.5122 0.54740.2728 0.3136 0.3529 0.391 0.4277 0.463 0.497 0.5297 0.56110.398 0.4549 0.5093 0.561 0.6103 0.657 0.7013 0.7432 0.7827

0.2779 0.32 0.3609 0.4005 0.4389 0.476 0.5119 0.5466 0.580.2695 0.3091 0.3471 0.3837 0.4188 0.4524 0.4846 0.5153 0.54460.4368 0.4987 0.5575 0.6133 0.6662 0.7162 0.7634 0.8078 0.84950.2446 0.2835 0.3217 0.3593 0.3961 0.4322 0.4676 0.5021 0.5357

0.288659 0.329896 0.371133 0.41237 0.453607 0.494844 0.536081 0.577318 0.61855545.20745 41.74936 39.37329 37.80644 36.75694 36.13607 35.85836 35.86173 36.1156840.87361 37.69338 35.52019 34.06192 33.06751 32.45945 32.16882 32.11866 32.2817850.26763 45.52537 42.17732 39.87179 38.20239 37.05045 36.29312 35.83717 35.621820.001383 0.001859 0.002348 0.002815 0.003249 0.003629 0.003944 0.004187 0.0043560.000637 0.000864 0.0011 0.00133 0.001548 0.001744 0.001912 0.002049 0.0021510.000457 0.000628 0.000807 0.000984 0.001154 0.001308 0.001442 0.001552 0.0016380.000739 0.001009 0.001291 0.001565 0.001825 0.002057 0.002255 0.002415 0.0025350.000412 0.00057 0.00074 0.000909 0.001075 0.001229 0.001366 0.001484 0.001579

0.288659 0.329896 0.371133 0.41237 0.453607 0.494844 0.536081 0.577318 0.6185550.2531 0.2925 0.3309 0.3686 0.4053 0.4411 0.4761 0.5101 0.54320.2732 0.3131 0.3514 0.3881 0.4233 0.4569 0.489 0.5197 0.54880.2472 0.2873 0.3268 0.3658 0.4041 0.4418 0.4788 0.5149 0.55020.3203 0.3661 0.4098 0.4515 0.4911 0.5288 0.5644 0.5982 0.630.2495 0.2866 0.3225 0.3571 0.3906 0.4229 0.4539 0.4838 0.51260.295 0.3384 0.3802 0.4204 0.459 0.4961 0.5317 0.5657 0.5983

0.2475 0.2877 0.3275 0.3668 0.4055 0.4435 0.4809 0.5174 0.55320.4152 0.474 0.5299 0.5829 0.6332 0.6807 0.7255 0.7677 0.8073

0.288659 0.329896 0.371133 0.41237 0.453607 0.494844 0.536081 0.577318 0.61855575.40691 69.89555 66.15264 63.73933 62.16183 61.29374 61.01705 61.1426 61.6919474.06157 68.00383 63.79703 60.85791 58.79185 57.40429 56.55124 56.09347 55.9936868.22669 63.62834 60.66702 58.88813 57.89822 57.57984 57.76741 58.27891 59.133310.000397 0.00053 0.000663 0.000789 0.000903 0.001002 0.00108 0.001142 0.0011820.000189 0.000256 0.000325 0.000392 0.000455 0.000512 0.000561 0.000602 0.0006330.000197 0.000265 0.000333 0.000398 0.000459 0.000511 0.000555 0.000589 0.0006140.000165 0.000224 0.000286 0.000346 0.000404 0.000455 0.000499 0.000536 0.0005650.000276 0.000369 0.000462 0.000549 0.000628 0.000696 0.00075 0.000792 0.000821

0.288659 0.329896 0.371133 0.41237 0.453607 0.494844 0.536081 0.577318 0.6185550.7702 0.8913 1.0104 1.1275 1.2426 1.3556 1.4667 1.5759 1.6830.2732 0.3131 0.3514 0.3881 0.4233 0.4569 0.489 0.5197 0.54880.2638 0.3027 0.3401 0.3761 0.4107 0.4438 0.4756 0.5061 0.5351

0.2288 0.2604 0.2901 0.3181 0.3444 0.3689 0.3917 0.4129 0.4324-0.3915 -0.4519 -0.5109 -0.5685 -0.6248 -0.6798 -0.7334 -0.7857 -0.83670.2425 0.2806 0.3179 0.3546 0.3907 0.426 0.4606 0.4945 0.52760.4171 0.4761 0.5323 0.5856 0.6361 0.6839 0.729 0.7714 0.81120.3834 0.4383 0.4907 0.5407 0.5883 0.6335 0.6763 0.7168 0.755

0.288659 0.329896 0.371133 0.41237 0.453607 0.494844 0.536081 0.577318 0.6185557.439614 6.460556 5.727128 5.157764 4.702634 4.330606 4.021414 3.760212 3.536743.703052 3.213453 2.846593 2.561509 2.333697 2.147154 1.992231 1.8616 1.7494783.556427 3.090913 2.740299 2.467348 2.248394 2.068399 1.91879 1.792187 1.6830390.030218 0.046035 0.065771 0.089391 0.116654 0.147039 0.17985 0.214298 0.249357-0.04812 -0.07454 -0.1084 -0.15005 -0.19954 -0.25659 -0.32035 -0.38979 -0.463510.032006 0.050935 0.076493 0.11003 0.153106 0.207412 0.274884 0.357823 0.4587590.053973 0.084198 0.123944 0.174597 0.237792 0.315358 0.409106 0.521188 0.6539490.047659 0.073307 0.105997 0.146072 0.193617 0.248324 0.30929 0.37526 0.444458

0.288659 0.329896 0.371133 0.41237 0.453607 0.494844 0.536081 0.577318 0.6185550.2971 0.3413 0.384 0.4252 0.4649 0.5031 0.5398 0.575 0.60870.2453 0.2828 0.3193 0.3548 0.3893 0.4229 0.4555 0.4872 0.51790.2476 0.2877 0.3272 0.3663 0.4047 0.4425 0.4797 0.5161 0.55180.2443 0.2804 0.3151 0.3485 0.3806 0.4115 0.441 0.4693 0.49620.2569 0.2966 0.3353 0.373 0.4098 0.4457 0.4805 0.5143 0.54720.2474 0.2871 0.3262 0.3648 0.4028 0.4402 0.4769 0.513 0.54840.249 0.2884 0.3271 0.3652 0.4028 0.4397 0.476 0.5117 0.5469

0.2448 0.2841 0.3229 0.3612 0.3991 0.4364 0.4733 0.5097 0.5457

0.288659 0.329896 0.371133 0.41237 0.453607 0.494844 0.536081 0.577318 0.618555932.626 862.6467 808.3873 765.0598 727.5463 693.5757 659.3588 625.408 588.579

13155.17 10364.4 7627.373 5426.538 3838.638 2772.587 2035.165 1534.329 1171.384991.8254 1018.5 985.9048 912.9318 815.5936 710.6461 607.8323 515.1711 433.76311.97E-06 2.64E-06 3.38E-06 4.17E-06 5.04E-06 6E-06 7.11E-06 8.41E-06 1E-051.06E-08 1.97E-08 4.13E-08 9.12E-08 2E-07 4.15E-07 8.15E-07 1.49E-06 2.58E-061.04E-08 1.96E-08 4.15E-08 9.25E-08 2.05E-07 4.27E-07 8.45E-07 1.55E-06 2.7E-061.05E-08 1.97E-08 4.17E-08 9.26E-08 2.05E-07 4.27E-07 8.43E-07 1.54E-06 2.69E-061.03E-08 1.94E-08 4.11E-08 9.16E-08 2.03E-07 4.24E-07 8.38E-07 1.54E-06 2.69E-06

0.288659 0.329896 0.371133 0.41237 0.453607 0.494844 0.536081 0.577318 0.6185550.3907 0.4466 0.5 0.5508 0.5992 0.6452 0.6887 0.7299 0.76870.2666 0.3079 0.3482 0.3876 0.4259 0.4633 0.4995 0.5347 0.56880.3614 0.4187 0.4753 0.531 0.5859 0.64 0.6933 0.7458 0.79750.4276 0.4881 0.5457 0.6004 0.6522 0.7012 0.7475 0.791 0.8318-0.7301 -0.842 -0.9512 -1.0576 -1.1614 -1.2625 -1.3609 -1.4567 -1.54990.2591 0.2996 0.3394 0.3783 0.4163 0.4534 0.4896 0.5248 0.5590.4159 0.475 0.5313 0.5848 0.6356 0.6837 0.7291 0.7719 0.8122

0.2993 0.3429 0.3847 0.4248 0.4632 0.5 0.535 0.5685 0.6003

0.288659 0.329896 0.371133 0.41237 0.453607 0.494844 0.536081 0.577318 0.6185552.622947 2.263992 1.994608 1.784942 1.617117 1.479792 1.365157 1.26812 1.1847311.59021 1.385854 1.232456 1.113691 1.018435 0.94087 0.876093 0.821439 0.7746282.14716 1.87809 1.67693 1.520887 1.396424 1.295136 1.211295 1.140797 1.080816

0.415526 0.58522 0.746334 0.878026 0.969896 1.022667 1.043558 1.041019 1.023118-0.6138 -0.88472 -1.16239 -1.41444 -1.61852 -1.76556 -1.85895 -1.90773 -1.923090.25361 0.431647 0.702166 1.108037 1.715692 2.628075 4.009193 6.117931 9.357701

0.423581 0.742892 1.245697 2.002081 3.099637 4.672266 6.951276 10.33283 15.453740.218141 0.296022 0.351043 0.381643 0.400387 0.418917 0.442616 0.473455 0.511044

0.288659 0.329896 0.371133 0.41237 0.453607 0.494844 0.536081 0.577318 0.6185550.2017 0.2307 0.2584 0.2849 0.3102 0.3342 0.3569 0.3785 0.39890.2988 0.3426 0.3847 0.4251 0.4639 0.501 0.5366 0.5706 0.603-0.0275 -0.0326 -0.0378 -0.0432 -0.0487 -0.0543 -0.0601 -0.066 -0.07210.2364 0.2715 0.3055 0.3383 0.3699 0.4004 0.4297 0.4579 0.48490.0437 0.0499 0.0559 0.0615 0.0669 0.072 0.0768 0.0813 0.08560.2331 0.2667 0.2988 0.3295 0.3587 0.3866 0.413 0.438 0.46170.239 0.2754 0.3109 0.3454 0.3789 0.4115 0.4431 0.4737 0.5035

0.2993 0.3429 0.3847 0.4248 0.4632 0.5 0.535 0.5685 0.6003

0.288659 0.329896 0.371133 0.41237 0.453607 0.494844 0.536081 0.577318 0.61855514.25589 12.33954 10.90665 9.79072 8.902297 8.173152 7.563593 7.049367 6.60849318.12776 15.72778 13.93481 12.5358 11.42314 10.51184 9.755461 9.11579 8.568359-1.70527 -1.53248 -1.40033 -1.29844 -1.21628 -1.14829 -1.0933 -1.04643 -1.007530.008402 0.01301 0.018951 0.026364 0.03533 0.046011 0.058514 0.072894 0.0892440.000705 0.001081 0.001559 0.002146 0.002847 0.003668 0.004609 0.005672 0.0068640.003576 0.005474 0.007875 0.010822 0.014317 0.018401 0.023065 0.028315 0.0341540.003648 0.005615 0.008127 0.011231 0.014947 0.019323 0.024371 0.030108 0.0365630.004544 0.006943 0.009966 0.013662 0.018032 0.023114 0.028894 0.035387 0.042573

0.288659 0.329896 0.371133 0.41237 0.453607 0.494844 0.536081 0.577318 0.6185550.2474 0.2837 0.3186 0.3521 0.3843 0.4151 0.4446 0.4729 0.49980.2478 0.2879 0.3274 0.3664 0.4048 0.4424 0.4793 0.5154 0.55070.298 0.3404 0.3807 0.4191 0.4555 0.4899 0.5225 0.5531 0.582

0.2668 0.3083 0.3488 0.3883 0.4268 0.4644 0.5008 0.5363 0.57060.2383 0.2739 0.3084 0.3417 0.3739 0.4051 0.4351 0.464 0.49190.2477 0.2877 0.3272 0.3661 0.4045 0.4421 0.4791 0.5153 0.55060.2474 0.2875 0.3272 0.3663 0.4048 0.4426 0.4796 0.5158 0.55110.2465 0.2864 0.3257 0.3645 0.4027 0.4402 0.4769 0.5129 0.548

0.288659 0.329896 0.371133 0.41237 0.453607 0.494844 0.536081 0.577318 0.618555676.4768 652.6866 639.1393 626.102 612.863 595.3138 570.2006 539.4049 502.1091

596.0948 593.6147 603.9853 619.7879 640.5005 662.1442 678.1428 686.7561 684.6218550.2768 546.075 541.0222 531.271 517.18 496.6683 467.2871 430.9533 389.43974.08E-06 5.07E-06 5.98E-06 6.94E-06 7.96E-06 9.19E-06 1.08E-05 1.29E-05 1.59E-052.46E-06 2.96E-06 3.35E-06 3.7E-06 4E-06 4.29E-06 4.65E-06 5.09E-06 5.69E-062.32E-06 2.8E-06 3.22E-06 3.62E-06 4.01E-06 4.43E-06 4.94E-06 5.57E-06 6.4E-062.32E-06 2.8E-06 3.21E-06 3.62E-06 4.02E-06 4.43E-06 4.94E-06 5.57E-06 6.4E-062.31E-06 2.78E-06 3.2E-06 3.6E-06 3.99E-06 4.41E-06 4.91E-06 5.54E-06 6.36E-06

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SaporinTIME (days) 0.041237 0.082474 0.123711 0.164948 0.206185 0.247422COL-TST-sink 0 189.3585896 101.5719 72.67596 58.54589 50.39342FB-TST-sink 0 171.5252763 92.04917 65.80111 53.03142 45.59607FGF-TST-sink 0 162.7648944 120.7696 86.82862 68.29707 57.31994FN-TST-sink 0 1.43E-05 9.77E-05 0.000281 0.000568 0.000943GAPDH-TST-sink 0 6.34E-06 4.36E-05 0.000127 0.000258 0.000431GDF-TST-sink 0 5.57E-06 3.00E-05 8.63E-05 0.000179 0.000305LIN-TST-sink 0 9.23E-06 4.95E-05 0.000142 0.000292 0.000495UTF-TST-sink 0 4.78E-06 2.60E-05 7.56E-05 0.000158 0.000272

TIME (days) 0.5 1.0 1.5 2.0 2.5 3.0COL-FB 59.13127 39.96570961 70.98456 169.7593 301.6524 17.50722COL-FGF 53.47326 35.45350673 61.59908 147.8528 267.1413 16.26123COL-FN 62.42292 36.61755769 30.99476 10.76284 2.735461 0.645338COL-GAPDH 0.001432 0.004074424 0.001793 0.000336 9.43E-05 0.089336COL-GDF 0.000674 0.002077974 0.001017 0.000211 6.63E-05 0.082653COL-LIN 0.000495 0.001626811 0.000918 0.000186 5.45E-05 0.071169COL-UTF 0.000789 0.002468955 0.001307 0.000245 5.94E-05 0.0549FB-FGF 0.000456 0.001616179 0.000996 0.000215 5.61E-05 0.017447FB-FN 0 0 0 0 0 0FB-GAPDH 1.625 1.375 0 0 0 0FB-GDF 62.59416 46.07799234 0 0 0 0FB-LIN 55.14382 40.32269589 0 0 0 0FB-UTF 20.25263 3.745886049 0 0 0 0FGF-FN -0.0062 -0.00711689 0 0 0 0FGF-GAPDH -0.00719 -0.00764391 0 0 0 0FGF-GDF -0.00032 -0.00067233 0 0 0 0FGF-LIN -0.00526 -0.00579918 0 0 0 0FGF-UTF -0.04224 -0.04258638 0 0 0 0FN-GAPDH 0 0 0 0 0 0FN-GDF 0.375 0 0 0 0 0FN-LIN 13.58402 0 0 0 0 0FN-UTF 11.93331 0 0 0 0 0GAPDH-GDF 2.999815 0 0 0 0 0GAPDH-LIN -0.00166 0 0 0 0 0GAPDH-UTF -0.00185 0 0 0 0 0GDF-LIN -0.00012 0 0 0 0 0GDF-UTF -0.00138 0 0 0 0 0LIN-UTF -0.0106 0 0 0 0 0

TIME (days) 0.041237 0.082474 0.123711 0.164948 0.206185 0.247422COL-TLT-sink 0 310.7502097 166.6966 119.949 96.91936 83.70914FB-TLT-sink 0 318.5907161 169.2628 120.9032 96.86032 82.89275FGF-TLT-sink 0 149.2876481 133.6199 104.6686 86.38814 75.22485

FN-TLT-sink 0 4.27E-06 2.92E-05 8.30E-05 0.000166 0.000274GAPDH-TLT-sink 0 1.90E-06 1.32E-05 3.79E-05 7.71E-05 0.000129GDF-TLT-sink 0 2.40E-06 1.48E-05 4.07E-05 8.16E-05 0.000135LIN-TLT-sink 0 1.87E-06 1.17E-05 3.27E-05 6.65E-05 0.000112UTF-TLT-sink 0 3.45E-06 2.11E-05 5.81E-05 0.000116 0.00019

TIME (days) 0.5 1.0 1.5 2.0 2.5 3.0COL-FB 98.0562 67.95878715 109.7287 165.9655 54.28538 4.937322COL-FGF 97.61885 59.04304524 83.67334 153.4364 54.24941 2.964204COL-FN 76.33978 62.23073985 42.79223 11.01765 1.889916 -0.22006COL-GAPDH 0.000403 0.001113787 0.00057 0.000228 0.005516 0.152285COL-GDF 0.000199 0.00063065 0.000387 0.000154 0.006143 0.343676COL-LIN 0.000203 0.000616449 0.000446 0.00017 0.005859 0.240898COL-UTF 0.000175 0.000585923 0.000455 0.000167 0.002652 -0.16295FB-FGF 0.000281 0.00080495 0.000537 0.00018 0.004326 0.114097FB-FN 0 0 0 0 0 0FB-GAPDH 1.5 #REF! #REF! #REF! #REF! #REF!FB-GDF 55.58566 27.91649232 0 0 0 0FB-LIN 50.63284 24.52251974 0 0 0 0FB-UTF 27.6184 4.52331415 0 0 0 0FGF-FN 0.013429 0.013175914 0 0 0 0FGF-GAPDH 0.066157 0.066019005 0 0 0 0FGF-GDF 0.040144 0.040006943 0 0 0 0FGF-LIN -0.14399 -0.14411844 0 0 0 0FGF-UTF -0.01397 -0.01414737 0 0 0 0FN-GAPDH 0 0 0 0 0 0FN-GDF #REF! #REF! 0 0 0 0FN-LIN 10.43777 0 0 0 0 0FN-UTF 9.39442 0 0 0 0 0GAPDH-GDF 4.017714 0 0 0 0 0GAPDH-LIN 0.003326 0 0 0 0 0GAPDH-UTF 0.016522 0 0 0 0 0GDF-LIN 0.010019 0 0 0 0 0GDF-UTF -0.03601 0 0 0 0 0LIN-UTF -0.00351 0 0 0 0 0

TIME (days) 0.041237 0.082474 0.123711 0.164948 0.206185 0.247422COL-TLT-FB 0 41.79449061 21.17051 14.30343 10.86844 8.810537FB-TLT-FB 0 20.89860183 10.56419 7.136623 5.418379 4.387932FGF-TLT-FB 0 17.88798035 9.833977 6.7629 5.172166 4.206896FN-TLT-FB 0 0.000172655 0.001321 0.004269 0.009716 0.018215GAPDH-TLT-FB 0 -0.00025506 -0.00198 -0.00649 -0.01499 -0.02855GDF-TLT-FB 0 0.000160929 0.001241 0.004096 0.009583 0.018569LIN-TLT-FB 0 0.000294919 0.002243 0.007293 0.01677 0.031916UTF-TLT-FB 0 0.000269018 0.002041 0.00661 0.015104 0.028504

TIME (days) 0.5 1.0 1.5 2.0 2.5 3.0COL-FB 10.89714 3.057079567 2.054649 1.668253 1.466069 1.341582COL-FGF 5.434265 1.508096217 0.997804 0.78092 0.62106 0.415315COL-FN 5.002975 1.444823314 0.923523 0.665595 0.456121 0.25258COL-GAPDH 0.044067 0.346463285 0.450657 0.306282 0.123966 -0.03905COL-GDF -0.07412 -0.71413819 -1.22037 -1.24823 -1.13876 -0.97029COL-LIN 0.055303 1.198008527 5.964652 6.551318 3.196464 1.432568COL-UTF 0.087365 1.472218744 4.67835 3.80741 1.55707 0.405611FB-FGF 0.072292 0.654353798 1.03964 1.002532 0.700326 0.304161FB-FN 0 0 0 0 0 0FB-GAPDH 1.5 #REF! #REF! #REF! #REF! #REF!FB-GDF 3.082289 0.756585621 0 0 0 0FB-LIN 1.279165 0.122104868 0 0 0 0FB-UTF 1.263023 0.188390155 0 0 0 0FGF-FN 0.102566 0.037477547 0 0 0 0FGF-GAPDH -0.62059 -0.48921219 0 0 0 0FGF-GDF 1.706336 1.497451213 0 0 0 0FGF-LIN 1.108165 0.848234019 0 0 0 0FGF-UTF 0.355579 0.234471261 0 0 0 0FN-GAPDH 0 0 0 0 0 0FN-GDF #REF! #REF! 0 0 0 0FN-LIN 0.479859 0 0 0 0 0FN-UTF 0.175159 0 0 0 0 0GAPDH-GDF 0.181427 0 0 0 0 0GAPDH-LIN 0.017505 0 0 0 0 0GAPDH-UTF -0.13873 0 0 0 0 0GDF-LIN 0.400473 0 0 0 0 0GDF-UTF 0.24455 0 0 0 0 0LIN-UTF 0.073756 0 0 0 0 0

Actinomycin DTIME (days) 0.041237 0.082474 0.123711 0.164948 0.206185 0.247422COL-TST-sink 0 3743.024466 2029.433 1466.364 1197.855 1035.104FB-TST-sink 0 31042.23433 20248.65 17662.12 16607.65 15294.1FGF-TST-sink 0 187.3859892 391.5074 592.0654 770.7275 908.628FN-TST-sink 0 2.20E-08 1.48E-07 4.17E-07 8.21E-07 1.35E-06GAPDH-TST-sink 0 3.36E-10 1.56E-09 3.03E-09 4.52E-09 6.59E-09GDF-TST-sink 0 3.15E-10 1.48E-09 2.91E-09 4.37E-09 6.43E-09LIN-TST-sink 0 3.22E-10 1.51E-09 2.95E-09 4.42E-09 6.49E-09UTF-TST-sink 0 3.13E-10 1.47E-09 2.88E-09 4.33E-09 6.36E-09

TIME (days) 0.5 1.0 1.5 2.0 2.5 3.0COL-FB 1188.469 453.1125309 126.8936 31.45786 7.865444 1.471643COL-FGF 12003.29 746.8951108 102.3866 29.18396 9.40644 2.917135

COL-FN 690.4763 284.6250167 48.0985 11.67491 2.870116 0.321424COL-GAPDH 2.16E-06 2.79277E-05 0.000554 0.009193 0.161377 0.431829COL-GDF 6.61E-08 1.86572E-05 0.000489 0.0075 0.111675 0.573068COL-LIN 6.77E-08 2.04528E-05 0.000567 0.009229 0.146139 0.647744COL-UTF 6.77E-08 2.05082E-05 0.000592 0.010597 0.202418 1.427023FB-FGF 6.71E-08 2.06367E-05 0.000598 0.010416 0.175614 1.272228FB-FN 0 0 0 0 0 0FB-GAPDH 1.5 #REF! #REF! #REF! #REF! #REF!FB-GDF 287.5173 13.92041143 0 0 0 0FB-LIN 2137.107 12.0770006 0 0 0 0FB-UTF 167.6808 5.163892554 0 0 0 0FGF-FN 0.029778 0.029772873 0 0 0 0FGF-GAPDH 0.034814 0.03481121 0 0 0 0FGF-GDF 0.039481 0.039478008 0 0 0 0FGF-LIN 0.286785 0.286781666 0 0 0 0FGF-UTF 0.254604 0.254600195 0 0 0 0FN-GAPDH 0 0 0 0 0 0FN-GDF #REF! #REF! 0 0 0 0FN-LIN 37.67971 0 0 0 0 0FN-UTF 268.6481 0 0 0 0 0GAPDH-GDF 21.60558 0 0 0 0 0GAPDH-LIN 0.007444 0 0 0 0 0GAPDH-UTF 0.008703 0 0 0 0 0GDF-LIN 0.00987 0 0 0 0 0GDF-UTF 0.071696 0 0 0 0 0LIN-UTF 0.06365 0 0 0 0 0

TIME (days) 0.041237 0.082474 0.123711 0.164948 0.206185 0.247422COL-TLT-sink 0 15.18293945 7.645034 5.133805 3.877355 3.124868FB-TLT-sink 0 8.773847229 4.458659 3.023646 2.305678 1.876715FGF-TLT-sink 0 11.02615736 5.862986 4.021685 3.087705 2.523292FN-TLT-sink 0 0.002412594 0.018833 0.06187 0.14159 0.261569GAPDH-TLT-sink 0 -0.00343994 -0.02692 -0.08874 -0.20407 -0.38046GDF-TLT-sink 0 0.001070444 0.008328 0.028254 0.068547 0.139083LIN-TLT-sink 0 0.001827869 0.013997 0.046733 0.112213 0.228277UTF-TLT-sink 0 0.001293016 0.009825 0.032111 0.073864 0.13779

TIME (days) 0.5 1.0 1.5 2.0 2.5 3.0COL-FB 3.89395 1.002658188 0.608965 0.428637 0.294224 0.149393COL-FGF 2.310005 0.673243481 0.455287 0.350163 0.248333 0.088075COL-FN 3.036371 0.955518682 0.708523 0.639364 0.622208 0.612495COL-GAPDH 0.425329 0.905668485 0.589004 0.39963 0.256225 0.116833COL-GDF -0.68026 -1.80479717 -1.42644 -1.21777 -1.11774 -1.03726COL-LIN 0.590376 26.61276597 12.74182 4.531573 1.823066 0.35385COL-UTF 1.0491 39.16906967 14.41429 4.363799 1.661339 0.466754

FB-FGF 0.19342 0.694255185 1.193657 1.170983 0.836217 0.482552FB-FN 0 0 0 0 0 0FB-GAPDH 1.5 #REF! #REF! #REF! #REF! #REF!FB-GDF 0.917313 0.101212014 0 0 0 0FB-LIN 0.527386 0.03017784 0 0 0 0FB-UTF 0.971719 0.306403806 0 0 0 0FGF-FN 0.322952 0.101119298 0 0 0 0FGF-GAPDH -0.94794 -0.53376653 0 0 0 0FGF-GDF 6.069399 1.535542104 0 0 0 0FGF-LIN 8.419939 1.716911048 0 0 0 0FGF-UTF 0.476169 0.328223529 0 0 0 0FN-GAPDH 0 0 0 0 0 0FN-GDF #REF! #REF! 0 0 0 0FN-LIN 0.127316 0 0 0 0 0FN-UTF 0.069695 0 0 0 0 0GAPDH-GDF 0.159765 0 0 0 0 0GAPDH-LIN 0.053009 0 0 0 0 0GAPDH-UTF -0.18521 0 0 0 0 0GDF-LIN 0.950618 0 0 0 0 0GDF-UTF 1.267106 0 0 0 0 0LIN-UTF 0.100549 0 0 0 0 0

TIME (days) 0.041237 0.082474 0.123711 0.164948 0.206185 0.247422COL-TLT-FB 0 81.07933132 40.97233 27.63664 20.94263 16.93004FB-TLT-FB 0 102.2709506 51.7787 34.95031 26.53879 21.49893FGF-TLT-FB 0 -5.04896904 -3.69964 -2.8133 -2.27817 -1.93863FN-TLT-FB 0 4.53E-05 0.00035 0.001144 0.002631 0.004995GAPDH-TLT-FB 0 3.93E-06 3.04E-05 9.84E-05 0.000224 0.000423GDF-TLT-FB 0 2.05E-05 0.000156 0.000503 0.001144 0.002148LIN-TLT-FB 0 2.03E-05 0.000155 0.000504 0.001154 0.002179UTF-TLT-FB 0 2.61E-05 0.000199 0.000641 0.001459 0.002735

TIME (days) 0.5 1.0 1.5 2.0 2.5 3.0COL-FB 20.9941 5.648536661 3.577533 2.605587 1.783223 0.686017COL-FGF 26.60823 7.395611776 4.947138 3.992087 3.425621 2.87764COL-FN -2.00665 -0.9240687 -0.74924 -0.66019 -0.5743 -0.4855COL-GAPDH 0.013103 0.17675499 0.634399 1.206417 1.278135 0.710502COL-GDF 0.001065 0.012645549 0.037518 0.056472 0.041751 -0.00725COL-LIN 0.00537 0.06197016 0.17903 0.27945 0.271813 0.123638COL-UTF 0.005575 0.069180318 0.230504 0.449353 0.600112 0.541732FB-FGF 0.006777 0.076678194 0.226119 0.382892 0.447515 0.365194FB-FN 0 0 0 0 0 0FB-GAPDH 1.5 #REF! #REF! #REF! #REF! #REF!FB-GDF 4.679441 0.239001241 0 0 0 0FB-LIN 7.122046 1.454737999 0 0 0 0

FB-UTF -0.75752 -0.26906634 0 0 0 0FGF-FN 0.365558 0.333915225 0 0 0 0FGF-GAPDH 0.005684 0.003398344 0 0 0 0FGF-GDF 0.068326 0.057102506 0 0 0 0FGF-LIN 0.191664 0.179205184 0 0 0 0FGF-UTF 0.148051 0.134141838 0 0 0 0FN-GAPDH 0 0 0 0 0 0FN-GDF #REF! #REF! 0 0 0 0FN-LIN 0.614805 0 0 0 0 0FN-UTF 1.072098 0 0 0 0 0GAPDH-GDF -0.12832 0 0 0 0 0GAPDH-LIN 0.087434 0 0 0 0 0GAPDH-UTF 0.001135 0 0 0 0 0GDF-LIN 0.015679 0 0 0 0 0GDF-UTF 0.046359 0 0 0 0 0LIN-UTF 0.035274 0 0 0 0 0

Mitomycin CTIME (days) 0.041237 0.082474 0.123711 0.164948 0.206185 0.247422COL-TST-sink 0 2140.443173 1203.098 916.7181 782.9871 715.2084FB-TST-sink 0 1713.834947 977.4566 755.9152 657.3222 614.2742FGF-TST-sink 0 244.8191069 426.9542 513.5324 543.4007 550.9975FN-TST-sink 0 7.10E-08 4.46E-07 1.14E-06 2.07E-06 3.07E-06GAPDH-TST-sink 0 4.75E-08 2.93E-07 7.38E-07 1.31E-06 1.90E-06GDF-TST-sink 0 4.86E-08 3.11E-07 7.56E-07 1.28E-06 1.81E-06LIN-TST-sink 0 4.83E-08 3.09E-07 7.54E-07 1.28E-06 1.81E-06UTF-TST-sink 0 4.83E-08 3.09E-07 7.53E-07 1.28E-06 1.80E-06

TIME (days) 0.5 1.0 1.5 2.0 2.5 3.0COL-FB 796.7531 371.3054456 128.5026 106.4191 53.47757 3.983898COL-FGF 702.9109 557.211252 217.5085 139.203 41.87176 -0.98234COL-FN 455.1831 258.8833358 40.73305 7.833353 1.621909 0.243493COL-GAPDH 3.84E-06 5.33111E-05 0.000456 0.000625 0.006695 0.057672COL-GDF 2.09E-06 1.39353E-05 0.00012 0.000242 0.008326 0.203014COL-LIN 2.05E-06 1.69919E-05 0.00015 0.000273 0.004815 -0.04661COL-UTF 2.05E-06 1.69275E-05 0.000146 0.00025 0.002197 -0.1694FB-FGF 2.04E-06 1.68572E-05 0.000148 0.000265 0.004144 -0.07944FB-FN 0 0 0 0 0 0FB-GAPDH 1.5 #REF! #REF! #REF! #REF! #REF!FB-GDF 219.0708 24.39440402 0 0 0 0FB-LIN 242.8858 32.86548113 0 0 0 0FB-UTF 123.2053 4.194223644 0 0 0 0FGF-FN -0.0311 -0.03111306 0 0 0 0FGF-GAPDH 0.034939 0.03493597 0 0 0 0FGF-GDF -0.07053 -0.07053467 0 0 0 0

FGF-LIN -0.11858 -0.11858758 0 0 0 0FGF-UTF -0.11722 -0.11722678 0 0 0 0FN-GAPDH 0 0 0 0 0 0FN-GDF #REF! #REF! 0 0 0 0FN-LIN 30.43315 0 0 0 0 0FN-UTF 34.46891 0 0 0 0 0GAPDH-GDF 15.92494 0 0 0 0 0GAPDH-LIN -0.00778 0 0 0 0 0GAPDH-UTF 0.008734 0 0 0 0 0GDF-LIN -0.01763 0 0 0 0 0GDF-UTF -0.02965 0 0 0 0 0LIN-UTF -0.02931 0 0 0 0 0

TIME (days) 0.041237 0.082474 0.123711 0.164948 0.206185 0.247422COL-TLT-sink 0 148.5147013 78.87797 55.85901 44.52057 37.9176FB-TLT-sink 0 275.9050098 144.6967 101.0554 79.40891 66.61293FGF-TLT-sink 0 193.9522356 354.3207 452.2951 510.5392 553.1623FN-TLT-sink 0 1.71E-05 0.000119 0.000348 0.000717 0.001212GAPDH-TLT-sink 0 4.06E-06 2.87E-05 8.60E-05 0.000181 0.000313GDF-TLT-sink 0 3.08E-06 4.76E-06 4.54E-06 4.71E-06 4.97E-06LIN-TLT-sink 0 3.14E-06 4.83E-06 4.60E-06 4.76E-06 5.01E-06UTF-TLT-sink 0 3.11E-06 4.77E-06 4.52E-06 4.67E-06 4.90E-06

TIME (days) 0.5 1.0 1.5 2.0 2.5 3.0COL-FB 44.69734 23.64513907 23.47404 18.1372 10.30463 4.618294COL-FGF 79.3859 33.68357701 27.46959 20.24871 12.49515 3.906209COL-FN 483.6227 213.7037259 25.34983 6.321877 1.876199 0.392505COL-GAPDH 0.002007 0.008197507 0.009939 0.01526 0.029755 0.008447COL-GDF 0.000561 0.002872826 0.004367 0.00668 0.010116 -0.02265COL-LIN 5.09E-06 0.000438168 0.005639 0.012572 0.017049 -0.17281COL-UTF 5.11E-06 0.000438961 0.00581 0.0148 0.037855 0.098303FB-FGF 4.99E-06 0.00041415 0.005335 0.013376 0.034249 0.102885FB-FN 0 0 0 0 0 0FB-GAPDH 1.5 #REF! #REF! #REF! #REF! #REF!FB-GDF 16.30109 4.910674835 0 0 0 0FB-LIN 24.15634 5.311425868 0 0 0 0FB-UTF 119.0216 2.800516162 0 0 0 0FGF-FN -0.01034 -0.01204458 0 0 0 0FGF-GAPDH -0.02015 -0.02071781 0 0 0 0FGF-GDF -0.13187 -0.13194335 0 0 0 0FGF-LIN -0.05385 -0.05392883 0 0 0 0FGF-UTF -0.04748 -0.04754658 0 0 0 0FN-GAPDH 0 0 0 0 0 0FN-GDF #REF! #REF! 0 0 0 0FN-LIN 2.65147 0 0 0 0 0

FN-UTF 3.683471 0 0 0 0 0GAPDH-GDF 15.22776 0 0 0 0 0GAPDH-LIN -0.0028 0 0 0 0 0GAPDH-UTF -0.00511 0 0 0 0 0GDF-LIN -0.03298 0 0 0 0 0GDF-UTF -0.01347 0 0 0 0 0LIN-UTF -0.01188 0 0 0 0 0

TIME (days) 0.041237 0.082474 0.123711 0.164948 0.206185 0.247422COL-TLT-FB 0 124.9112725 67.54582 48.82035 39.68867 34.47461FB-TLT-FB 0 251.2520336 133.2452 94.30883 75.16992 64.02644FGF-TLT-FB 0 213.8269072 248.5232 222.027 196.6948 179.6689FN-TLT-FB 0 1.87E-05 0.000128 0.000368 0.000744 0.001234GAPDH-TLT-FB 0 4.28E-06 3.02E-05 8.99E-05 0.000188 0.000322GDF-TLT-FB 0 3.35E-06 9.07E-06 1.81E-05 3.11E-05 4.70E-05LIN-TLT-FB 0 3.35E-06 9.04E-06 1.80E-05 3.11E-05 4.69E-05UTF-TLT-FB 0 5.31E-06 1.41E-05 2.75E-05 4.66E-05 6.89E-05

TIME (days) 0.5 1.0 1.5 2.0 2.5 3.0COL-FB 40.23643 30.26834233 37.38457 14.48587 1.870988 -0.49126COL-FGF 75.80878 45.22291693 48.89626 18.21754 3.307156 0.475225COL-FN 171.7787 225.9223954 62.72408 7.897213 1.600683 0.369649COL-GAPDH 0.001864 0.005271676 0.004996 0.069575 0.412583 -0.27197COL-GDF 0.000544 0.00204057 0.002893 0.066251 1.700956 1.300223COL-LIN 5.53E-05 0.00010172 0.001739 0.035919 0.490677 -0.13857COL-UTF 5.52E-05 0.000100959 0.001654 0.029675 0.254018 -0.46177FB-FGF 7.7E-05 0.000120749 0.0017 0.030818 0.558314 0.250236FB-FN 0 0 0 0 0 0FB-GAPDH 1.5 #REF! #REF! #REF! #REF! #REF!FB-GDF 16.07966 4.328869256 0 0 0 0FB-LIN 26.07319 5.901238811 0 0 0 0FB-UTF 72.3392 6.055677897 0 0 0 0FGF-FN -0.05154 -0.05272694 0 0 0 0FGF-GAPDH 0.333914 0.333483664 0 0 0 0FGF-GDF -0.05194 -0.05196164 0 0 0 0FGF-LIN -0.15311 -0.15313752 0 0 0 0FGF-UTF 0.042512 0.042479216 0 0 0 0FN-GAPDH 0 0 0 0 0 0FN-GDF #REF! #REF! 0 0 0 0FN-LIN 2.551067 0 0 0 0 0FN-UTF 3.996803 0 0 0 0 0GAPDH-GDF 9.799359 0 0 0 0 0GAPDH-LIN -0.01303 0 0 0 0 0GAPDH-UTF 0.083425 0 0 0 0 0GDF-LIN -0.01299 0 0 0 0 0

GDF-UTF -0.03828 0 0 0 0 0LIN-UTF 0.010624 0 0 0 0 0

0.288659 0.329896 0.371133 0.41237 0.453607 0.494844 0.536081 0.577318 0.61855545.20745 41.74936 39.37329 37.80644 36.75694 36.13607 35.85836 35.86173 36.1156840.87361 37.69338 35.52019 34.06192 33.06751 32.45945 32.16882 32.11866 32.2817850.26763 45.52537 42.17732 39.87179 38.20239 37.05045 36.29312 35.83717 35.621820.001383 0.001859 0.002348 0.002815 0.003249 0.003629 0.003944 0.004187 0.0043560.000637 0.000864 0.0011 0.00133 0.001548 0.001744 0.001912 0.002049 0.0021510.000457 0.000628 0.000807 0.000984 0.001154 0.001308 0.001442 0.001552 0.0016380.000739 0.001009 0.001291 0.001565 0.001825 0.002057 0.002255 0.002415 0.0025350.000412 0.00057 0.00074 0.000909 0.001075 0.001229 0.001366 0.001484 0.001579

3.5 4.0 0.5 1 1.5 2 2.5-4.1984 -2.76909 COL-FB 59.13127 39.96571 70.98456 169.7593 301.6524

-5.51748 -3.46457 COL-FGF 53.47326 35.45351 61.59908 147.8528 267.14130.014135 -0.2019 COL-FN 62.42292 36.61756 30.99476 10.76284 2.735461-0.02071 -0.15626 COL-GAPDH0.001432 0.004074 0.001793 0.000336 9.43E-05-0.00673 -0.16895 COL-GDF 0.000674 0.002078 0.001017 0.000211 6.63E-050.005064 -0.08546 COL-LIN 0.000495 0.001627 0.000918 0.000186 5.45E-05-0.01376 -0.11234 COL-UTF 0.000789 0.002469 0.001307 0.000245 5.94E-05-0.0909 -0.43885 FB-FGF 0.000456 0.001616 0.000996 0.000215 5.61E-05

0 0 FB-FN 0 0 0 0 00 0 FB-GAPDH 1.5 0 0 0 00 0 FB-GDF 54.33607 0 0 0 00 0 FB-LIN 47.73326 0 0 0 00 0 FB-UTF 11.99926 0 0 0 00 0 FGF-FN -0.00666 0 0 0 00 0 FGF-GAPDH-0.00741 0 0 0 00 0 FGF-GDF -0.0005 0 0 0 00 0 FGF-LIN -0.00553 0 0 0 00 0 FGF-UTF -0.04241 0 0 0 00 0 FN-GAPDH 0 0 0 0 00 0 FN-GDF 0.125 0 0 0 00 0 FN-LIN 4.528006 0 0 0 00 0 FN-UTF 3.977772 0 0 0 00 0 GAPDH-GDF0.999938 0 0 0 00 0 GAPDH-LIN-0.00055 0 0 0 00 0 GAPDH-UTF-0.00062 0 0 0 00 0 GDF-LIN ### 0 0 0 00 0 GDF-UTF -0.00046 0 0 0 00 0 LIN-UTF -0.00353 0 0 0 0

0.288659 0.329896 0.371133 0.41237 0.453607 0.494844 0.536081 0.577318 0.61855575.40691 69.89555 66.15264 63.73933 62.16183 61.29374 61.01705 61.1426 61.6919474.06157 68.00383 63.79703 60.85791 58.79185 57.40429 56.55124 56.09347 55.9936868.22669 63.62834 60.66702 58.88813 57.89822 57.57984 57.76741 58.27891 59.13331

0.000397 0.00053 0.000663 0.000789 0.000903 0.001002 0.00108 0.001142 0.0011820.000189 0.000256 0.000325 0.000392 0.000455 0.000512 0.000561 0.000602 0.0006330.000197 0.000265 0.000333 0.000398 0.000459 0.000511 0.000555 0.000589 0.0006140.000165 0.000224 0.000286 0.000346 0.000404 0.000455 0.000499 0.000536 0.0005650.000276 0.000369 0.000462 0.000549 0.000628 0.000696 0.00075 0.000792 0.000821

3.5 4.0 0.5 1 1.5 2 2.50.28959 -0.20859 COL-FB 98.0562 67.95879 109.7287 165.9655 54.28538

0.076631 -0.12973 COL-FGF 97.61885 59.04305 83.67334 153.4364 54.24941-0.60402 -0.59595 COL-FN 76.33978 62.23074 42.79223 11.01765 1.8899160.051165 -0.05165 COL-GAPDH0.000403 0.001114 0.00057 0.000228 0.0055160.328416 0.113452 COL-GDF 0.000199 0.000631 0.000387 0.000154 0.0061430.20266 0.03005 COL-LIN 0.000203 0.000616 0.000446 0.00017 0.005859

-0.72153 -0.84822 COL-UTF 0.000175 0.000586 0.000455 0.000167 0.002652-0.04653 -0.24238 FB-FGF 0.000281 0.000805 0.000537 0.00018 0.004326

0 0 FB-FN 0 0 0 0 0#REF! 0 FB-GAPDH 1.5 #REF! #REF! #REF! #REF!

0 0 FB-GDF 41.75107 0 0 0 00 0 FB-LIN 37.57768 0 0 0 00 0 FB-UTF 16.07086 0 0 0 00 0 FGF-FN 0.013302 0 0 0 00 0 FGF-GAPDH0.066088 0 0 0 00 0 FGF-GDF 0.040075 0 0 0 00 0 FGF-LIN -0.14405 0 0 0 00 0 FGF-UTF -0.01406 0 0 0 00 0 FN-GAPDH 0 0 0 0 00 0 FN-GDF #REF! 0 0 0 00 0 FN-LIN 3.479256 0 0 0 00 0 FN-UTF 3.131473 0 0 0 00 0 GAPDH-GDF1.339238 0 0 0 00 0 GAPDH-LIN0.001109 0 0 0 00 0 GAPDH-UTF0.005507 0 0 0 00 0 GDF-LIN 0.00334 0 0 0 00 0 GDF-UTF -0.012 0 0 0 00 0 LIN-UTF -0.00117 0 0 0 0

0.288659 0.329896 0.371133 0.41237 0.453607 0.494844 0.536081 0.577318 0.6185557.439614 6.460556 5.727128 5.157764 4.702634 4.330606 4.021414 3.760212 3.536743.703052 3.213453 2.846593 2.561509 2.333697 2.147154 1.992231 1.8616 1.7494783.556427 3.090913 2.740299 2.467348 2.248394 2.068399 1.91879 1.792187 1.6830390.030218 0.046035 0.065771 0.089391 0.116654 0.147039 0.17985 0.214298 0.249357-0.04812 -0.07454 -0.1084 -0.15005 -0.19954 -0.25659 -0.32035 -0.38979 -0.463510.032006 0.050935 0.076493 0.11003 0.153106 0.207412 0.274884 0.357823 0.4587590.053973 0.084198 0.123944 0.174597 0.237792 0.315358 0.409106 0.521188 0.6539490.047659 0.073307 0.105997 0.146072 0.193617 0.248324 0.30929 0.37526 0.444458

3.5 4.0 0.5 1 1.5 2 2.51.256591 1.291884 COL-FB 10.89714 3.05708 2.054649 1.668253 1.4660690.005396 -1.35524 COL-FGF 5.434265 1.508096 0.997804 0.78092 0.621060.06402 -0.10116 COL-FN 5.002975 1.444823 0.923523 0.665595 0.456121-0.1562 -0.23592 COL-GAPDH0.044067 0.346463 0.450657 0.306282 0.123966

-0.75835 -0.53455 COL-GDF -0.07412 -0.71414 -1.22037 -1.24823 -1.138760.620094 0.204318 COL-LIN 0.055303 1.198009 5.964652 6.551318 3.196464-0.05862 -0.21101 COL-UTF 0.087365 1.472219 4.67835 3.80741 1.55707-0.0236 -0.20941 FB-FGF 0.072292 0.654354 1.03964 1.002532 0.700326

0 0 FB-FN 0 0 0 0 0#REF! 0 FB-GAPDH 1.5 #REF! #REF! #REF! #REF!

0 0 FB-GDF 1.919437 0 0 0 00 0 FB-LIN 0.700635 0 0 0 00 0 FB-UTF 0.725707 0 0 0 00 0 FGF-FN 0.070022 0 0 0 00 0 FGF-GAPDH -0.5549 0 0 0 00 0 FGF-GDF 1.601894 0 0 0 00 0 FGF-LIN 0.978199 0 0 0 00 0 FGF-UTF 0.295025 0 0 0 00 0 FN-GAPDH 0 0 0 0 00 0 FN-GDF #REF! 0 0 0 00 0 FN-LIN 0.159953 0 0 0 00 0 FN-UTF 0.058386 0 0 0 00 0 GAPDH-GDF0.060476 0 0 0 00 0 GAPDH-LIN0.005835 0 0 0 00 0 GAPDH-UTF-0.04624 0 0 0 00 0 GDF-LIN 0.133491 0 0 0 00 0 GDF-UTF 0.081517 0 0 0 00 0 LIN-UTF 0.024585 0 0 0 0

0.288659 0.329896 0.371133 0.41237 0.453607 0.494844 0.536081 0.577318 0.618555932.626 862.6467 808.3873 765.0598 727.5463 693.5757 659.3588 625.408 588.579

13155.17 10364.4 7627.373 5426.538 3838.638 2772.587 2035.165 1534.329 1171.384991.8254 1018.5 985.9048 912.9318 815.5936 710.6461 607.8323 515.1711 433.76311.97E-06 2.64E-06 3.38E-06 4.17E-06 5.04E-06 6.00E-06 7.11E-06 8.41E-06 1.00E-051.06E-08 1.97E-08 4.13E-08 9.12E-08 2.00E-07 4.15E-07 8.15E-07 1.49E-06 2.58E-061.04E-08 1.96E-08 4.15E-08 9.25E-08 2.05E-07 4.27E-07 8.45E-07 1.55E-06 2.70E-061.05E-08 1.97E-08 4.17E-08 9.26E-08 2.05E-07 4.27E-07 8.43E-07 1.54E-06 2.69E-061.03E-08 1.94E-08 4.11E-08 9.16E-08 2.03E-07 4.24E-07 8.38E-07 1.54E-06 2.69E-06

3.5 4.0 0.5 1 1.5 2 2.5-0.15484 -0.48881 COL-FB 1188.469 453.1125 126.8936 31.45786 7.8654440.833278 0.196612 COL-FGF 12003.29 746.8951 102.3866 29.18396 9.40644

-0.40318 -0.59505 COL-FN 690.4763 284.625 48.0985 11.67491 2.870116-0.03675 -0.20893 COL-GAPDH2.16E-06 2.79E-05 0.000554 0.009193 0.1613770.025592 -0.30059 COL-GDF 6.61E-08 1.87E-05 0.000489 0.0075 0.1116750.050279 -0.38022 COL-LIN 6.77E-08 2.05E-05 0.000567 0.009229 0.1461391.020643 0.780106 COL-UTF 6.77E-08 2.05E-05 0.000592 0.010597 0.2024180.947704 0.648641 FB-FGF 6.71E-08 2.06E-05 0.000598 0.010416 0.175614

0 0 FB-FN 0 0 0 0 0#REF! 0 FB-GAPDH 1.5 #REF! #REF! #REF! #REF!

0 0 FB-GDF 150.7188 0 0 0 00 0 FB-LIN 1074.592 0 0 0 00 0 FB-UTF 86.42234 0 0 0 00 0 FGF-FN 0.029775 0 0 0 00 0 FGF-GAPDH0.034813 0 0 0 00 0 FGF-GDF 0.03948 0 0 0 00 0 FGF-LIN 0.286783 0 0 0 00 0 FGF-UTF 0.254602 0 0 0 00 0 FN-GAPDH 0 0 0 0 00 0 FN-GDF #REF! 0 0 0 00 0 FN-LIN 12.5599 0 0 0 00 0 FN-UTF 89.54935 0 0 0 00 0 GAPDH-GDF7.201861 0 0 0 00 0 GAPDH-LIN0.002481 0 0 0 00 0 GAPDH-UTF0.002901 0 0 0 00 0 GDF-LIN 0.00329 0 0 0 00 0 GDF-UTF 0.023899 0 0 0 00 0 LIN-UTF 0.021217 0 0 0 0

0.288659 0.329896 0.371133 0.41237 0.453607 0.494844 0.536081 0.577318 0.6185552.622947 2.263992 1.994608 1.784942 1.617117 1.479792 1.365157 1.26812 1.1847311.59021 1.385854 1.232456 1.113691 1.018435 0.94087 0.876093 0.821439 0.7746282.14716 1.87809 1.67693 1.520887 1.396424 1.295136 1.211295 1.140797 1.080816

0.415526 0.58522 0.746334 0.878026 0.969896 1.022667 1.043558 1.041019 1.023118-0.6138 -0.88472 -1.16239 -1.41444 -1.61852 -1.76556 -1.85895 -1.90773 -1.923090.25361 0.431647 0.702166 1.108037 1.715692 2.628075 4.009193 6.117931 9.357701

0.423581 0.742892 1.245697 2.002081 3.099637 4.672266 6.951276 10.33283 15.453740.218141 0.296022 0.351043 0.381643 0.400387 0.418917 0.442616 0.473455 0.511044

3.5 4.0 0.5 1 1.5 2 2.5-0.03383 -0.23284 COL-FB 3.89395 1.002658 0.608965 0.428637 0.294224-0.18956 -0.59016 COL-FGF 2.310005 0.673243 0.455287 0.350163 0.2483330.574565 0.51969 COL-FN 3.036371 0.955519 0.708523 0.639364 0.622208-0.01999 -0.12827 COL-GAPDH0.425329 0.905668 0.589004 0.39963 0.256225-0.89967 -0.70632 COL-GDF -0.68026 -1.8048 -1.42644 -1.21777 -1.11774-0.35187 -0.67193 COL-LIN 0.590376 26.61277 12.74182 4.531573 1.823066-0.04385 -0.2594 COL-UTF 1.0491 39.16907 14.41429 4.363799 1.661339

0.214305 0.040969 FB-FGF 0.19342 0.694255 1.193657 1.170983 0.8362170 0 FB-FN 0 0 0 0 0

#REF! 0 FB-GAPDH 1.5 #REF! #REF! #REF! #REF!0 0 FB-GDF 0.509263 0 0 0 00 0 FB-LIN 0.278782 0 0 0 00 0 FB-UTF 0.639061 0 0 0 00 0 FGF-FN 0.212036 0 0 0 00 0 FGF-GAPDH-0.74085 0 0 0 00 0 FGF-GDF 3.802471 0 0 0 00 0 FGF-LIN 5.068425 0 0 0 00 0 FGF-UTF 0.402196 0 0 0 00 0 FN-GAPDH 0 0 0 0 00 0 FN-GDF #REF! 0 0 0 00 0 FN-LIN 0.042439 0 0 0 00 0 FN-UTF 0.023232 0 0 0 00 0 GAPDH-GDF0.053255 0 0 0 00 0 GAPDH-LIN 0.01767 0 0 0 00 0 GAPDH-UTF-0.06174 0 0 0 00 0 GDF-LIN 0.316873 0 0 0 00 0 GDF-UTF 0.422369 0 0 0 00 0 LIN-UTF 0.033516 0 0 0 0

0.288659 0.329896 0.371133 0.41237 0.453607 0.494844 0.536081 0.577318 0.61855514.25589 12.33954 10.90665 9.79072 8.902297 8.173152 7.563593 7.049367 6.60849318.12776 15.72778 13.93481 12.5358 11.42314 10.51184 9.755461 9.11579 8.568359-1.70527 -1.53248 -1.40033 -1.29844 -1.21628 -1.14829 -1.0933 -1.04643 -1.007530.008402 0.01301 0.018951 0.026364 0.03533 0.046011 0.058514 0.072894 0.0892440.000705 0.001081 0.001559 0.002146 0.002847 0.003668 0.004609 0.005672 0.0068640.003576 0.005474 0.007875 0.010822 0.014317 0.018401 0.023065 0.028315 0.0341540.003648 0.005615 0.008127 0.011231 0.014947 0.019323 0.024371 0.030108 0.0365630.004544 0.006943 0.009966 0.013662 0.018032 0.023114 0.028894 0.035387 0.042573

3.5 4.0 0.5 1 1.5 2 2.5-1.14617 -4.63817 COL-FB 20.9941 5.648537 3.577533 2.605587 1.7832232.006018 0.208353 COL-FGF 26.60823 7.395612 4.947138 3.992087 3.425621-0.40262 -0.35695 COL-FN -2.00665 -0.92407 -0.74924 -0.66019 -0.57430.183449 -0.00592 COL-GAPDH0.013103 0.176755 0.634399 1.206417 1.278135-0.04491 -0.0428 COL-GDF 0.001065 0.012646 0.037518 0.056472 0.041751-0.05784 -0.11086 COL-LIN 0.00537 0.06197 0.17903 0.27945 0.2718130.273978 0.054783 COL-UTF 0.005575 0.06918 0.230504 0.449353 0.6001120.165669 0.022312 FB-FGF 0.006777 0.076678 0.226119 0.382892 0.447515

0 0 FB-FN 0 0 0 0 0#REF! 0 FB-GAPDH 1.5 #REF! #REF! #REF! #REF!

0 0 FB-GDF 2.459221 0 0 0 00 0 FB-LIN 4.288392 0 0 0 0

0 0 FB-UTF -0.51329 0 0 0 00 0 FGF-FN 0.349737 0 0 0 00 0 FGF-GAPDH0.004541 0 0 0 00 0 FGF-GDF 0.062714 0 0 0 00 0 FGF-LIN 0.185435 0 0 0 00 0 FGF-UTF 0.141096 0 0 0 00 0 FN-GAPDH 0 0 0 0 00 0 FN-GDF #REF! 0 0 0 00 0 FN-LIN 0.204935 0 0 0 00 0 FN-UTF 0.357366 0 0 0 00 0 GAPDH-GDF-0.04277 0 0 0 00 0 GAPDH-LIN0.029145 0 0 0 00 0 GAPDH-UTF0.000378 0 0 0 00 0 GDF-LIN 0.005226 0 0 0 00 0 GDF-UTF 0.015453 0 0 0 00 0 LIN-UTF 0.011758 0 0 0 0

0.288659 0.329896 0.371133 0.41237 0.453607 0.494844 0.536081 0.577318 0.618555676.4768 652.6866 639.1393 626.102 612.863 595.3138 570.2006 539.4049 502.1091596.0948 593.6147 603.9853 619.7879 640.5005 662.1442 678.1428 686.7561 684.6218550.2768 546.075 541.0222 531.271 517.18 496.6683 467.2871 430.9533 389.43974.08E-06 5.07E-06 5.98E-06 6.94E-06 7.96E-06 9.19E-06 1.08E-05 1.29E-05 1.59E-052.46E-06 2.96E-06 3.35E-06 3.70E-06 4.00E-06 4.29E-06 4.65E-06 5.09E-06 5.69E-062.32E-06 2.80E-06 3.22E-06 3.62E-06 4.01E-06 4.43E-06 4.94E-06 5.57E-06 6.40E-062.32E-06 2.80E-06 3.21E-06 3.62E-06 4.02E-06 4.43E-06 4.94E-06 5.57E-06 6.40E-062.31E-06 2.78E-06 3.20E-06 3.60E-06 3.99E-06 4.41E-06 4.91E-06 5.54E-06 6.36E-06

3.5 4.0 0.5 1.0 1.5 2.0 2.50.351071 -0.00136 COL-FB 796.8 371.3 128.5 106.4 53.5-1.92686 -1.28835 COL-FGF 702.9 557.2 217.5 139.2 41.9-0.03323 -0.0679 COL-FN 455.2 258.9 40.7 7.8 1.6-0.18486 -0.25395 COL-GAPDH 0.0 0.0 0.0 0.0 0.00.158681 0.048848 COL-GDF 0.0 0.0 0.0 0.0 0.0-0.36284 -0.4422 COL-LIN 0.0 0.0 0.0 0.0 0.0-0.59075 -0.66549 COL-UTF 0.0 0.0 0.0 0.0 0.0-0.52178 -0.81006 FB-FGF 0.0 0.0 0.0 0.0 0.0

0 0 FB-FN 0.0 0.0 0.0 0.0 0.0#REF! 0 FB-GAPDH 1.5 #REF! #REF! #REF! #REF!

0 0 FB-GDF 121.7 0.0 0.0 0.0 0.00 0 FB-LIN 137.9 0.0 0.0 0.0 0.00 0 FB-UTF 63.7 0.0 0.0 0.0 0.00 0 FGF-FN 0.0 0.0 0.0 0.0 0.00 0 FGF-GAPDH 0.0 0.0 0.0 0.0 0.00 0 FGF-GDF -0.1 0.0 0.0 0.0 0.0

0 0 FGF-LIN -0.1 0.0 0.0 0.0 0.00 0 FGF-UTF -0.1 0.0 0.0 0.0 0.00 0 FN-GAPDH 0.0 0.0 0.0 0.0 0.00 0 FN-GDF #REF! 0.0 0.0 0.0 0.00 0 FN-LIN 10.1 0.0 0.0 0.0 0.00 0 FN-UTF 11.5 0.0 0.0 0.0 0.00 0 GAPDH-GDF 5.3 0.0 0.0 0.0 0.00 0 GAPDH-LIN 0.0 0.0 0.0 0.0 0.00 0 GAPDH-UTF 0.0 0.0 0.0 0.0 0.00 0 GDF-LIN 0.0 0.0 0.0 0.0 0.00 0 GDF-UTF 0.0 0.0 0.0 0.0 0.00 0 LIN-UTF 0.0 0.0 0.0 0.0 0.0

0.288659 0.329896 0.371133 0.41237 0.453607 0.494844 0.536081 0.577318 0.61855533.59529 30.63856 28.53311 27.00034 25.87419 25.03672 24.42374 23.97674 23.680758.16546 52.24152 47.89879 44.59781 42.04113 40.00727 38.36562 37.01147 35.90917591.5146 624.8278 650.0381 655.7285 633.5212 583.5721 511.3308 430.3289 352.07360.001817 0.0025 0.00323 0.003978 0.004717 0.005426 0.006089 0.006695 0.0072270.000478 0.000673 0.000889 0.00112 0.001359 0.001601 0.001839 0.002072 0.0022925.16E-06 5.35E-06 5.61E-06 6.16E-06 7.29E-06 9.40E-06 1.33E-05 2.03E-05 3.26E-055.19E-06 5.38E-06 5.62E-06 6.17E-06 7.29E-06 9.40E-06 1.33E-05 2.03E-05 3.26E-055.07E-06 5.24E-06 5.47E-06 5.99E-06 7.06E-06 9.08E-06 1.28E-05 1.95E-05 3.13E-05

3.5 4.0 0.5 1 1.5 2 2.51.739936 0.653999 COL-FB 44.69734 23.64514 23.47404 18.1372 10.30463-0.0588 -0.32374 COL-FGF 79.3859 33.68358 27.46959 20.24871 12.49515

-0.10059 -0.23363 COL-FN 483.6227 213.7037 25.34983 6.321877 1.876199-0.0966 -0.11133 COL-GAPDH0.002007 0.008198 0.009939 0.01526 0.029755

-0.12586 -0.12127 COL-GDF 0.000561 0.002873 0.004367 0.00668 0.010116-0.68284 -0.76292 COL-LIN 5.09E-06 0.000438 0.005639 0.012572 0.017049-0.2219 -0.58201 COL-UTF 5.11E-06 0.000439 0.00581 0.0148 0.037855

-0.15491 -0.57149 FB-FGF 4.99E-06 0.000414 0.005335 0.013376 0.0342490 0 FB-FN 0 0 0 0 0

#REF! 0 FB-GAPDH 1.5 #REF! #REF! #REF! #REF!0 0 FB-GDF 10.60588 0 0 0 00 0 FB-LIN 14.73388 0 0 0 00 0 FB-UTF 60.91105 0 0 0 00 0 FGF-FN -0.01119 0 0 0 00 0 FGF-GAPDH-0.02043 0 0 0 00 0 FGF-GDF -0.13191 0 0 0 00 0 FGF-LIN -0.05389 0 0 0 00 0 FGF-UTF -0.04751 0 0 0 00 0 FN-GAPDH 0 0 0 0 00 0 FN-GDF #REF! 0 0 0 00 0 FN-LIN 0.883823 0 0 0 0

0 0 FN-UTF 1.227824 0 0 0 00 0 GAPDH-GDF5.075921 0 0 0 00 0 GAPDH-LIN-0.00093 0 0 0 00 0 GAPDH-UTF -0.0017 0 0 0 00 0 GDF-LIN -0.01099 0 0 0 00 0 GDF-UTF -0.00449 0 0 0 00 0 LIN-UTF -0.00396 0 0 0 0

0.288659 0.329896 0.371133 0.41237 0.453607 0.494844 0.536081 0.577318 0.61855531.21329 29.09269 27.71965 26.85033 26.35649 26.16399 26.20823 26.4497 26.8833556.85229 51.97813 48.60317 46.22536 44.57544 43.46854 42.79706 42.46651 42.46017169.0912 163.5962 161.8695 163.4467 167.8528 174.7471 184.2875 196.2806 210.23320.001809 0.00243 0.003059 0.003664 0.004217 0.004693 0.005082 0.00538 0.0055740.000487 0.000676 0.000878 0.001086 0.001289 0.001482 0.001656 0.001809 0.0019346.38E-05 7.96E-05 9.29E-05 0.000102 0.000108 0.000109 0.000106 0.0001 9.35E-056.37E-05 7.95E-05 9.28E-05 0.000102 0.000107 0.000108 0.000106 0.0001 9.32E-059.20E-05 0.000113 0.000129 0.00014 0.000145 0.000144 0.000138 0.000129 0.000118

3.5 4.0 0.5 1 1.5 2 2.5-0.70736 -0.59638 COL-FB 40.23643 30.26834 37.38457 14.48587 1.870988-0.01319 -0.06814 COL-FGF 75.80878 45.22292 48.89626 18.21754 3.3071560.07472 0.001793 COL-FN 171.7787 225.9224 62.72408 7.897213 1.600683

-0.43505 -0.41285 COL-GAPDH0.001864 0.005272 0.004996 0.069575 0.4125830.617185 0.314296 COL-GDF 0.000544 0.002041 0.002893 0.066251 1.700956-0.50521 -0.50809 COL-LIN 5.53E-05 0.000102 0.001739 0.035919 0.490677-0.82732 -0.83391 COL-UTF 5.52E-05 0.000101 0.001654 0.029675 0.254018-0.07183 -0.25948 FB-FGF 7.70E-05 0.000121 0.0017 0.030818 0.558314

0 0 FB-FN 0 0 0 0 0#REF! 0 FB-GAPDH 1.5 #REF! #REF! #REF! #REF!

0 0 FB-GDF 10.20427 0 0 0 00 0 FB-LIN 15.98721 0 0 0 00 0 FB-UTF 39.19744 0 0 0 00 0 FGF-FN -0.05213 0 0 0 00 0 FGF-GAPDH0.333699 0 0 0 00 0 FGF-GDF -0.05195 0 0 0 00 0 FGF-LIN -0.15312 0 0 0 00 0 FGF-UTF 0.042496 0 0 0 00 0 FN-GAPDH 0 0 0 0 00 0 FN-GDF #REF! 0 0 0 00 0 FN-LIN 0.850356 0 0 0 00 0 FN-UTF 1.332268 0 0 0 00 0 GAPDH-GDF3.266453 0 0 0 00 0 GAPDH-LIN-0.00434 0 0 0 00 0 GAPDH-UTF0.027808 0 0 0 00 0 GDF-LIN -0.00433 0 0 0 0

0 0 GDF-UTF -0.01276 0 0 0 00 0 LIN-UTF 0.003541 0 0 0 0

0.659792 0.701029 0.742266 0.783503 0.82474 0.865977 0.907214 0.948451 0.98968836.61757 37.31921 38.21767 39.31792 40.62491 42.12864 43.83839 45.77349 47.9149532.67582 33.23679 33.9643 34.87584 35.95524 37.21411 38.63837 40.26152 42.0508235.63483 35.79581 36.0709 36.43607 36.85377 37.27388 37.64137 37.92443 38.027520.004445 0.004466 0.004424 0.004324 0.004174 0.003988 0.003771 0.003532 0.0032830.002216 0.002247 0.002248 0.002218 0.002163 0.002086 0.001993 0.001885 0.0017690.001696 0.00173 0.001741 0.001732 0.001704 0.001661 0.001608 0.001544 0.0014740.002609 0.002647 0.00265 0.002621 0.002564 0.002486 0.002392 0.002284 0.0021690.001649 0.001696 0.001722 0.001727 0.001714 0.001686 0.001645 0.001593 0.001534

3 3.5 417.50722 -4.1984 -2.7690916.26123 -5.51748 -3.464570.645338 0.014135 -0.20190.089336 -0.02071 -0.156260.082653 -0.00673 -0.168950.071169 0.005064 -0.08546

0.0549 -0.01376 -0.112340.017447 -0.0909 -0.43885

0 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 0

0.659792 0.701029 0.742266 0.783503 0.82474 0.865977 0.907214 0.948451 0.98968862.6008 63.8526 65.37329 67.14745 69.27305 71.63683 74.26812 77.16924 80.33248

56.18402 56.66904 57.36622 58.24156 59.36248 60.66273 62.10882 63.74136 65.5419360.18427 61.38347 62.58112 63.67987 64.62006 65.20214 65.32653 64.85751 63.75427

COL-FB

COL-FGF

COL-FN

COL-GAPDH

COL-GDF

COL-LIN

COL-UTF

FB-FGFFB-FN

FB-GAPDH

FB-GDF

FB-LIN

FB-UTF

FGF-FN

FGF-GAPDH

FGF-GDF

FGF-LIN

FGF-UTF

FN-GAPDH

FN-GDF

FN-LIN

FN-UTF

GAPDH-GDF

GAPDH-LIN

GAPDH-UTF

GDF-LIN

GDF-UTF

LIN-UTF

-50

0

50

100

150

200

250

300

350

0.511.522.533.54

0.001204 0.001207 0.001196 0.001173 0.001136 0.001092 0.001041 0.000985 0.0009260.000655 0.000667 0.000672 0.00067 0.00066 0.000645 0.000625 0.000602 0.0005760.000631 0.00064 0.000642 0.000641 0.000635 0.000627 0.000618 0.000608 0.0005970.000586 0.0006 0.000609 0.000613 0.000613 0.00061 0.000606 0.0006 0.0005930.000838 0.000844 0.000842 0.000835 0.000822 0.000806 0.000789 0.00077 0.000751

3 3.5 44.937322 0.28959 -0.208592.964204 0.076631 -0.12973-0.22006 -0.60402 -0.595950.152285 0.051165 -0.051650.343676 0.328416 0.1134520.240898 0.20266 0.03005-0.16295 -0.72153 -0.848220.114097 -0.04653 -0.24238

0 0 0#REF! #REF! 0

0 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 0

0.659792 0.701029 0.742266 0.783503 0.82474 0.865977 0.907214 0.948451 0.9896883.343526 3.174775 3.026319 2.894769 2.777044 2.671698 2.576541 2.490238 2.4116771.652381 1.567636 1.493141 1.42692 1.367528 1.31453 1.266343 1.222652 1.1827141.588397 1.505422 1.432122 1.366805 1.307683 1.254592 1.206151 1.161737 1.1209550.284124 0.317512 0.348756 0.377143 0.402195 0.423572 0.44109 0.454813 0.464851-0.53983 -0.617 -0.69323 -0.76695 -0.83708 -0.90212 -0.96169 -1.0153 -1.062810.580722 0.726805 0.900534 1.105527 1.346423 1.625979 1.948757 2.317205 2.7326840.809582 0.990372 1.197998 1.433696 1.698778 1.990938 2.309103 2.648715 3.0031990.514675 0.583804 0.649612 0.710674 0.766029 0.81523 0.858425 0.896074 0.928714

COL-FB

COL-FGF

COL-FN

COL-GAPDH

COL-GDF

COL-LIN

COL-UTF

FB-FGFFB-FN

FB-GAPDH

FB-GDF

FB-LIN

FB-UTF

FGF-FN

FGF-GAPDH

FGF-GDF

FGF-LIN

FGF-UTF

FN-GAPDH

FN-GDF

FN-LIN

FN-UTF

GAPDH-GDF

GAPDH-LIN

GAPDH-UTF

GDF-LIN

GDF-UTF

LIN-UTF

-20

0

20

40

60

80

100

120

140

160

180

0.511.522.533.54

3 3.5 41.341582 1.256591 1.2918840.415315 0.005396 -1.355240.25258 0.06402 -0.10116

-0.03905 -0.1562 -0.23592-0.97029 -0.75835 -0.534551.432568 0.620094 0.2043180.405611 -0.05862 -0.211010.304161 -0.0236 -0.20941

0 0 0#REF! #REF! 0

0 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 0

0.659792 0.701029 0.742266 0.783503 0.82474 0.865977 0.907214 0.948451 0.989688550.8631 511.664 471.1416 431.2762 391.3452 353.3533 317.6058 283.8242 252.931920.1124 732.4451 592.417 487.1447 403.9687 339.2937 288.102 246.2059 212.1736365.4189 307.6105 259.7759 220.2181 187.3613 160.1132 137.4384 118.3875 102.40991.21E-05 1.46E-05 1.80E-05 2.23E-05 2.81E-05 3.56E-05 4.53E-05 5.83E-05 7.52E-054.14E-06 6.35E-06 9.35E-06 1.33E-05 1.85E-05 2.54E-05 3.43E-05 4.61E-05 6.15E-054.37E-06 6.76E-06 1.00E-05 1.43E-05 2.01E-05 2.77E-05 3.77E-05 5.10E-05 6.83E-054.36E-06 6.74E-06 1.00E-05 1.43E-05 2.01E-05 2.78E-05 3.78E-05 5.12E-05 6.88E-054.35E-06 6.74E-06 1.00E-05 1.44E-05 2.02E-05 2.79E-05 3.80E-05 5.16E-05 6.94E-05

3 3.5 41.471643 -0.15484 -0.488812.917135 0.833278 0.196612

COL-FB

COL-FGF

COL-FN

COL-GAPDH

COL-GDF

COL-LIN

COL-UTF

FB-FGFFB-FN

FB-GAPDH

FB-GDF

FB-LIN

FB-UTF

FGF-FN

FGF-GAPDH

FGF-GDF

FGF-LIN

FGF-UTF

FN-GAPDH

FN-GDF

FN-LIN

FN-UTF

GAPDH-GDF

GAPDH-LIN

GAPDH-UTF

GDF-LIN

GDF-UTF

LIN-UTF

-2

0

2

4

6

8

10

12

0.511.522.533.54

COL-FB

COL-FGF

COL-FN

COL-GAPDH

COL-GDF

COL-LIN

COL-UTF

FB-FGFFB-FN

FB-GAPDH

FB-GDF

FB-LIN

FB-UTF

FGF-FN

FGF-GAPDH

FGF-GDF

FGF-LIN

FGF-UTF

FN-GAPDH

FN-GDF

FN-LIN

FN-UTF

GAPDH-GDF

GAPDH-LIN

GAPDH-UTF

GDF-LIN

GDF-UTF

LIN-UTF

-2000

0

2000

4000

6000

8000

10000

12000

14000

0.511.522.533.54

0.321424 -0.40318 -0.595050.431829 -0.03675 -0.208930.573068 0.025592 -0.300590.647744 0.050279 -0.380221.427023 1.020643 0.7801061.272228 0.947704 0.648641

0 0 0#REF! #REF! 0

0 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 0

0.659792 0.701029 0.742266 0.783503 0.82474 0.865977 0.907214 0.948451 0.9896881.112252 1.048838 0.992685 0.942593 0.897739 0.857126 0.820295 0.786643 0.7557190.734047 0.698527 0.667259 0.639384 0.614492 0.592032 0.5717 0.553156 0.5361641.029173 0.98455 0.945467 0.91123 0.880916 0.854008 0.830053 0.808599 0.7893190.99599 0.963659 0.928988 0.893945 0.859339 0.825931 0.793953 0.763598 0.734923

-1.91501 -1.8914 -1.85822 -1.81971 -1.77856 -1.73678 -1.69549 -1.65548 -1.6171514.30507 21.53789 30.98199 40.49455 45.90898 44.9953 39.8645 33.6766 28.103523.24167 34.64591 49.44837 63.43659 69.20982 64.32581 54.06615 43.70269 35.213980.554668 0.603121 0.65531 0.709882 0.765947 0.82225 0.87778 0.931697 0.983293

3 3.5 40.149393 -0.03383 -0.232840.088075 -0.18956 -0.590160.612495 0.574565 0.519690.116833 -0.01999 -0.12827-1.03726 -0.89967 -0.706320.35385 -0.35187 -0.67193

0.466754 -0.04385 -0.2594

COL-FB

COL-FGF

COL-FN

COL-GAPDH

COL-GDF

COL-LIN

COL-UTF

FB-FGFFB-FN

FB-GAPDH

FB-GDF

FB-LIN

FB-UTF

FGF-FN

FGF-GAPDH

FGF-GDF

FGF-LIN

FGF-UTF

FN-GAPDH

FN-GDF

FN-LIN

FN-UTF

GAPDH-GDF

GAPDH-LIN

GAPDH-UTF

GDF-LIN

GDF-UTF

LIN-UTF

-2000

0

2000

4000

6000

8000

10000

12000

14000

0.511.522.533.54

COL-FB

COL-FGF

COL-FN

COL-GAPDH

COL-GDF

COL-LIN

COL-UTF

FB-FGFFB-FN

FB-GAPDH

FB-GDF

FB-LIN

FB-UTF

FGF-FN

FGF-GAPDH

FGF-GDF

FGF-LIN

FGF-UTF

FN-GAPDH

FN-GDF

FN-LIN

FN-UTF

GAPDH-GDF

GAPDH-LIN

GAPDH-UTF

GDF-LIN

GDF-UTF

LIN-UTF

-5

0

5

10

15

20

25

30

35

40

45

0.511.522.533.54

0.482552 0.214305 0.0409690 0 0

#REF! #REF! 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 0

0.659792 0.701029 0.742266 0.783503 0.82474 0.865977 0.907214 0.948451 0.9896886.225867 5.89005 5.59389 5.331139 5.094616 4.880313 4.686907 4.509863 4.3483418.095562 7.682705 7.319112 6.998669 6.710748 6.452601 6.220055 6.009781 5.818499-0.97372 -0.94405 -0.91782 -0.89474 -0.87473 -0.85669 -0.84106 -0.82618 -0.812570.107668 0.128266 0.151073 0.176042 0.203368 0.233144 0.265141 0.299543 0.3361640.008179 0.009614 0.011164 0.012832 0.014613 0.016493 0.018477 0.020541 0.022690.040564 0.047546 0.055075 0.063094 0.071617 0.080613 0.089993 0.099761 0.1098450.043724 0.051631 0.060266 0.069594 0.079701 0.090541 0.102064 0.11433 0.1272710.050451 0.059006 0.068219 0.078015 0.088459 0.099484 0.111014 0.123061 0.135576

3 3.5 40.686017 -1.14617 -4.638172.87764 2.006018 0.208353-0.4855 -0.40262 -0.35695

0.710502 0.183449 -0.00592-0.00725 -0.04491 -0.04280.123638 -0.05784 -0.110860.541732 0.273978 0.0547830.365194 0.165669 0.022312

0 0 0#REF! #REF! 0

0 0 00 0 0

COL-FB

COL-FGF

COL-FN

COL-GAPDH

COL-GDF

COL-LIN

COL-UTF

FB-FGFFB-FN

FB-GAPDH

FB-GDF

FB-LIN

FB-UTF

FGF-FN

FGF-GAPDH

FGF-GDF

FGF-LIN

FGF-UTF

FN-GAPDH

FN-GDF

FN-LIN

FN-UTF

GAPDH-GDF

GAPDH-LIN

GAPDH-UTF

GDF-LIN

GDF-UTF

LIN-UTF

-5

0

5

10

15

20

25

30

35

40

45

0.511.522.533.54

COL-FB

COL-FGF

COL-FN

COL-GAPDH

COL-GDF

COL-LIN

COL-UTF

FB-FGFFB-FN

FB-GAPDH

FB-GDF

FB-LIN

FB-UTF

FGF-FN

FGF-GAPDH

FGF-GDF

FGF-LIN

FGF-UTF

FN-GAPDH

FN-GDF

FN-LIN

FN-UTF

GAPDH-GDF

GAPDH-LIN

GAPDH-UTF

GDF-LIN

GDF-UTF

LIN-UTF

-10

-5

0

5

10

15

20

25

30

0.511.522.533.54

0 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 0

0.659792 0.701029 0.742266 0.783503 0.82474 0.865977 0.907214 0.948451 0.989688461.8922 419.9132 379.4575 339.9509 304.7082 272.8865 245.0473 220.5039 199.5911669.9695 642.9305 607.7703 563.2845 517.2731 471.4071 427.5563 386.6024 350.2207345.2778 301.0124 259.4919 221.3009 187.8922 159.0509 134.533 113.8379 96.523061.99E-05 2.53E-05 3.25E-05 4.24E-05 5.49E-05 7.11E-05 9.13E-05 0.000116 0.0001466.51E-06 7.64E-06 9.15E-06 1.13E-05 1.40E-05 1.76E-05 2.22E-05 2.81E-05 3.52E-057.49E-06 8.97E-06 1.09E-05 1.36E-05 1.72E-05 2.18E-05 2.76E-05 3.51E-05 4.43E-057.49E-06 8.97E-06 1.09E-05 1.36E-05 1.71E-05 2.17E-05 2.75E-05 3.49E-05 4.39E-057.45E-06 8.92E-06 1.09E-05 1.35E-05 1.70E-05 2.16E-05 2.74E-05 3.48E-05 4.38E-05

3.0 3.5 4.04.0 0.4 0.0-1.0 -1.9 -1.30.2 0.0 -0.10.1 -0.2 -0.30.2 0.2 0.00.0 -0.4 -0.4-0.2 -0.6 -0.7-0.1 -0.5 -0.80.0 0.0 0.0

#REF! #REF! 0.00.0 0.0 0.00.0 0.0 0.00.0 0.0 0.00.0 0.0 0.00.0 0.0 0.00.0 0.0 0.0

COL-FB

COL-FGF

COL-FN

COL-GAPDH

COL-GDF

COL-LIN

COL-UTF

FB-FGFFB-FN

FB-GAPDH

FB-GDF

FB-LIN

FB-UTF

FGF-FN

FGF-GAPDH

FGF-GDF

FGF-LIN

FGF-UTF

FN-GAPDH

FN-GDF

FN-LIN

FN-UTF

GAPDH-GDF

GAPDH-LIN

GAPDH-UTF

GDF-LIN

GDF-UTF

LIN-UTF

-10

-5

0

5

10

15

20

25

30

0.511.522.533.54

COL-FB

COL-FGF

COL-FN

COL-GAPDH

COL-GDF

COL-LIN

COL-UTF

FB-FGFFB-FN

FB-GAPDH

FB-GDF

FB-LIN

FB-UTF

FGF-FN

FGF-GAPDH

FGF-GDF

FGF-LIN

FGF-UTF

FN-GAPDH

FN-GDF

FN-LIN

FN-UTF

GAPDH-GDF

GAPDH-LIN

GAPDH-UTF

GDF-LIN

GDF-UTF

LIN-UTF

-100.0

0.0

100.0

200.0

300.0

400.0

500.0

600.0

700.0

800.0

900.0

0.51.01.52.02.53.03.54.0

0.0 0.0 0.00.0 0.0 0.00.0 0.0 0.00.0 0.0 0.00.0 0.0 0.00.0 0.0 0.00.0 0.0 0.00.0 0.0 0.00.0 0.0 0.00.0 0.0 0.00.0 0.0 0.00.0 0.0 0.0

0.659792 0.701029 0.742266 0.783503 0.82474 0.865977 0.907214 0.948451 0.98968823.49083 23.37472 23.34594 23.3637 23.4203 23.50639 23.61168 23.7198 23.8271334.98301 34.18275 33.51302 32.91376 32.38037 31.89721 31.44625 31.01114 30.58914284.3456 227.9592 183.1506 147.9658 120.4509 98.86129 81.90108 68.42549 57.65160.007687 0.008086 0.008402 0.008661 0.008866 0.00902 0.009134 0.009221 0.009283

0.0025 0.002695 0.002872 0.003036 0.003185 0.00332 0.003443 0.003557 0.0036635.35E-05 8.87E-05 0.000146 0.000235 0.00037 0.000568 0.000844 0.001211 0.0016755.34E-05 8.86E-05 0.000146 0.000235 0.00037 0.000569 0.000845 0.001214 0.001685.12E-05 8.47E-05 0.000139 0.000224 0.000352 0.000539 0.000798 0.001143 0.001577

3 3.5 44.618294 1.739936 0.6539993.906209 -0.0588 -0.323740.392505 -0.10059 -0.233630.008447 -0.0966 -0.11133-0.02265 -0.12586 -0.12127-0.17281 -0.68284 -0.762920.098303 -0.2219 -0.582010.102885 -0.15491 -0.57149

0 0 0#REF! #REF! 0

0 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 0

COL-FB

COL-FGF

COL-FN

COL-GAPDH

COL-GDF

COL-LIN

COL-UTF

FB-FGFFB-FN

FB-GAPDH

FB-GDF

FB-LIN

FB-UTF

FGF-FN

FGF-GAPDH

FGF-GDF

FGF-LIN

FGF-UTF

FN-GAPDH

FN-GDF

FN-LIN

FN-UTF

GAPDH-GDF

GAPDH-LIN

GAPDH-UTF

GDF-LIN

GDF-UTF

LIN-UTF

-100.0

0.0

100.0

200.0

300.0

400.0

500.0

600.0

700.0

800.0

900.0

0.51.01.52.02.53.03.54.0

COL-FB

COL-FGF

COL-FN

COL-GAPDH

COL-GDF

COL-LIN

COL-UTF

FB-FGFFB-FN

FB-GAPDH

FB-GDF

FB-LIN

FB-UTF

FGF-FN

FGF-GAPDH

FGF-GDF

FGF-LIN

FGF-UTF

FN-GAPDH

FN-GDF

FN-LIN

FN-UTF

GAPDH-GDF

GAPDH-LIN

GAPDH-UTF

GDF-LIN

GDF-UTF

LIN-UTF

-100

0

100

200

300

400

500

600

0.511.522.533.54

0 0 00 0 00 0 00 0 00 0 00 0 00 0 0

0.659792 0.701029 0.742266 0.783503 0.82474 0.865977 0.907214 0.948451 0.98968827.46992 28.20861 29.09854 30.09786 31.21823 32.43639 33.72659 35.04894 36.3737442.70265 43.1739 43.85741 44.69842 45.70954 46.84998 48.06953 49.32103 50.56879225.6892 241.2283 254.7059 263.0788 263.5767 253.6638 233.8619 207.0559 177.4070.005679 0.005698 0.005636 0.00552 0.005354 0.005156 0.004941 0.004724 0.0045160.002033 0.002104 0.002148 0.002171 0.002172 0.002156 0.002131 0.002101 0.0020718.61E-05 7.97E-05 7.51E-05 7.38E-05 7.69E-05 8.66E-05 0.000106 0.00014 0.0001968.59E-05 7.93E-05 7.48E-05 7.34E-05 7.63E-05 8.58E-05 0.000105 0.000138 0.0001940.000107 9.73E-05 9.04E-05 8.75E-05 8.98E-05 9.97E-05 0.00012 0.000157 0.000216

3 3.5 4-0.49126 -0.70736 -0.596380.475225 -0.01319 -0.068140.369649 0.07472 0.001793-0.27197 -0.43505 -0.412851.300223 0.617185 0.314296-0.13857 -0.50521 -0.50809-0.46177 -0.82732 -0.833910.250236 -0.07183 -0.25948

0 0 0#REF! #REF! 0

0 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 0

COL-FB

COL-FGF

COL-FN

COL-GAPDH

COL-GDF

COL-LIN

COL-UTF

FB-FGFFB-FN

FB-GAPDH

FB-GDF

FB-LIN

FB-UTF

FGF-FN

FGF-GAPDH

FGF-GDF

FGF-LIN

FGF-UTF

FN-GAPDH

FN-GDF

FN-LIN

FN-UTF

GAPDH-GDF

GAPDH-LIN

GAPDH-UTF

GDF-LIN

GDF-UTF

LIN-UTF

-100

0

100

200

300

400

500

600

0.511.522.533.54

COL-FB

COL-FGF

COL-FN

COL-GAPDH

COL-GDF

COL-LIN

COL-UTF

FB-FGFFB-FN

FB-GAPDH

FB-GDF

FB-LIN

FB-UTF

FGF-FN

FGF-GAPDH

FGF-GDF

FGF-LIN

FGF-UTF

FN-GAPDH

FN-GDF

FN-LIN

FN-UTF

GAPDH-GDF

GAPDH-LIN

GAPDH-UTF

GDF-LIN

GDF-UTF

LIN-UTF

-50

0

50

100

150

200

250

0.511.522.533.54

0 0 00 0 0

COL-FB

COL-FGF

COL-FN

COL-GAPDH

COL-GDF

COL-LIN

COL-UTF

FB-FGFFB-FN

FB-GAPDH

FB-GDF

FB-LIN

FB-UTF

FGF-FN

FGF-GAPDH

FGF-GDF

FGF-LIN

FGF-UTF

FN-GAPDH

FN-GDF

FN-LIN

FN-UTF

GAPDH-GDF

GAPDH-LIN

GAPDH-UTF

GDF-LIN

GDF-UTF

LIN-UTF

-50

0

50

100

150

200

250

0.511.522.533.54

1.030925 1.072162 1.113399 1.154636 1.195873 1.23711 1.278347 1.319584 1.36082150.31901 52.98448 55.92003 59.14925 62.71092 66.58932 70.82553 75.49893 80.617444.06127 46.3016 48.77523 51.49336 54.50863 57.79395 61.38711 65.37687 69.751137.93852 37.58817 36.94307 35.97162 34.69139 33.10085 31.25313 29.23115 27.082010.003024 0.002764 0.002509 0.002264 0.002029 0.001809 0.001605 0.001416 0.0012420.001646 0.00152 0.001394 0.00127 0.001149 0.001035 0.000927 0.000826 0.0007310.001398 0.001317 0.001232 0.001144 0.001052 0.000959 0.000867 0.000774 0.0006860.002045 0.001915 0.001781 0.001643 0.001502 0.001362 0.001223 0.001085 0.0009550.001466 0.001393 0.001313 0.001229 0.001139 0.001047 0.000953 0.000857 0.000764

1.030925 1.072162 1.113399 1.154636 1.195873 1.23711 1.278347 1.319584 1.36082183.74814 87.46189 91.44901 95.68467 100.2641 105.1416 110.372 115.932 121.88467.48048 69.63008 71.93372 74.42653 77.1578 80.1273 83.40093 86.99184 90.9958161.93404 59.46751 56.36941 52.7984 48.92262 44.86195 40.77262 36.77659 32.9699

COL-FB

COL-FGF

COL-FN

COL-GAPDH

COL-GDF

COL-LIN

COL-UTF

FB-FGFFB-FN

FB-GAPDH

FB-GDF

FB-LIN

FB-UTF

FGF-FN

FGF-GAPDH

FGF-GDF

FGF-LIN

FGF-UTF

FN-GAPDH

FN-GDF

FN-LIN

FN-UTF

GAPDH-GDF

GAPDH-LIN

GAPDH-UTF

GDF-LIN

GDF-UTF

LIN-UTF

-50

0

50

100

150

200

250

300

350

0.511.522.533.54

0.000867 0.000806 0.000747 0.00069 0.000633 0.00058 0.000529 0.000482 0.0004370.000548 0.000519 0.000489 0.000459 0.000428 0.000398 0.000369 0.00034 0.0003130.000584 0.000569 0.000551 0.00053 0.000504 0.000474 0.000441 0.000408 0.0003730.000585 0.000573 0.000558 0.000538 0.000514 0.000485 0.000453 0.000419 0.0003840.00073 0.000706 0.000678 0.000647 0.00061 0.000569 0.000526 0.000481 0.000437

1.030925 1.072162 1.113399 1.154636 1.195873 1.23711 1.278347 1.319584 1.3608212.339891 2.27408 2.213526 2.157665 2.105884 2.05792 2.013335 1.971683 1.9328141.145996 1.112434 1.081271 1.052521 1.025565 1.000527 0.977177 0.955055 0.9342691.083275 1.048212 1.015468 0.984796 0.955961 0.928605 0.902749 0.878069 0.8544420.471493 0.474919 0.475589 0.473714 0.469574 0.463616 0.455925 0.446936 0.436705-1.1043 -1.14 -1.17032 -1.19565 -1.21656 -1.23342 -1.24672 -1.25695 -1.26443

3.194682 3.700266 4.242283 4.808677 5.385852 5.95189 6.484402 6.961138 7.3600243.364811 3.722245 4.065578 4.382502 4.661572 4.892981 5.069653 5.188544 5.2475760.956953 0.981296 1.00241 1.020505 1.035917 1.048789 1.059183 1.067278 1.073039

COL-FB

COL-FGF

COL-FN

COL-GAPDH

COL-GDF

COL-LIN

COL-UTF

FB-FGFFB-FN

FB-GAPDH

FB-GDF

FB-LIN

FB-UTF

FGF-FN

FGF-GAPDH

FGF-GDF

FGF-LIN

FGF-UTF

FN-GAPDH

FN-GDF

FN-LIN

FN-UTF

GAPDH-GDF

GAPDH-LIN

GAPDH-UTF

GDF-LIN

GDF-UTF

LIN-UTF

-20

0

20

40

60

80

100

120

140

160

180

0.511.522.533.54

1.030925 1.072162 1.113399 1.154636 1.195873 1.23711 1.278347 1.319584 1.360821225.0028 199.8174 177.3765 157.1722 139.3671 123.5766 109.7009 97.43803 86.61171184.1671 160.8357 141.2982 124.5731 110.3903 98.16811 87.665 78.52443 70.5266988.96956 77.51913 67.79738 59.44098 52.27707 46.08285 40.72923 36.06853 32.002659.72E-05 0.000126 0.000163 0.000211 0.000272 0.000351 0.000451 0.000578 0.0007388.16E-05 0.000108 0.000141 0.000185 0.00024 0.000311 0.0004 0.000513 0.0006569.10E-05 0.000121 0.000159 0.000209 0.000273 0.000355 0.00046 0.000592 0.000769.19E-05 0.000122 0.000161 0.000213 0.000279 0.000365 0.000474 0.000614 0.0007939.27E-05 0.000123 0.000163 0.000215 0.000282 0.000369 0.00048 0.000621 0.000801

COL-FB

COL-FGF

COL-FN

COL-GAPDH

COL-GDF

COL-LIN

COL-UTF

FB-FGFFB-FN

FB-GAPDH

FB-GDF

FB-LIN

FB-UTF

FGF-FN

FGF-GAPDH

FGF-GDF

FGF-LIN

FGF-UTF

FN-GAPDH

FN-GDF

FN-LIN

FN-UTF

GAPDH-GDF

GAPDH-LIN

GAPDH-UTF

GDF-LIN

GDF-UTF

LIN-UTF

-2

0

2

4

6

8

10

12

0.511.522.533.54

COL-FB

COL-FGF

COL-FN

COL-GAPDH

COL-GDF

COL-LIN

COL-UTF

FB-FGFFB-FN

FB-GAPDH

FB-GDF

FB-LIN

FB-UTF

FGF-FN

FGF-GAPDH

FGF-GDF

FGF-LIN

FGF-UTF

FN-GAPDH

FN-GDF

FN-LIN

FN-UTF

GAPDH-GDF

GAPDH-LIN

GAPDH-UTF

GDF-LIN

GDF-UTF

LIN-UTF

-2000

0

2000

4000

6000

8000

10000

12000

14000

0.511.522.533.54

1.030925 1.072162 1.113399 1.154636 1.195873 1.23711 1.278347 1.319584 1.3608210.727238 0.700833 0.676333 0.65349 0.632076 0.611958 0.592972 0.57505 0.5579970.520489 0.506002 0.492538 0.480026 0.468248 0.457164 0.446685 0.436726 0.4272150.772029 0.756452 0.742324 0.729638 0.718116 0.707679 0.698221 0.689665 0.68190.707821 0.682217 0.65801 0.635207 0.613526 0.593009 0.573512 0.554954 0.53721-1.58076 -1.54641 -1.51411 -1.48383 -1.45546 -1.42896 -1.4042 -1.38109 -1.3595123.57347 20.01648 17.24009 15.05158 13.29487 11.86974 10.69068 9.704259 8.86365928.71905 23.82289 20.10444 17.23488 14.97212 13.15959 11.67924 10.45161 9.4169411.031605 1.076273 1.116809 1.152821 1.184128 1.210519 1.232076 1.248803 1.260819

COL-FB

COL-FGF

COL-FN

COL-GAPDH

COL-GDF

COL-LIN

COL-UTF

FB-FGFFB-FN

FB-GAPDH

FB-GDF

FB-LIN

FB-UTF

FGF-FN

FGF-GAPDH

FGF-GDF

FGF-LIN

FGF-UTF

FN-GAPDH

FN-GDF

FN-LIN

FN-UTF

GAPDH-GDF

GAPDH-LIN

GAPDH-UTF

GDF-LIN

GDF-UTF

LIN-UTF

-2000

0

2000

4000

6000

8000

10000

12000

14000

0.511.522.533.54

COL-FB

COL-FGF

COL-FN

COL-GAPDH

COL-GDF

COL-LIN

COL-UTF

FB-FGFFB-FN

FB-GAPDH

FB-GDF

FB-LIN

FB-UTF

FGF-FN

FGF-GAPDH

FGF-GDF

FGF-LIN

FGF-UTF

FN-GAPDH

FN-GDF

FN-LIN

FN-UTF

GAPDH-GDF

GAPDH-LIN

GAPDH-UTF

GDF-LIN

GDF-UTF

LIN-UTF

-5

0

5

10

15

20

25

30

35

40

45

0.511.522.533.54

1.030925 1.072162 1.113399 1.154636 1.195873 1.23711 1.278347 1.319584 1.3608214.198853 4.060624 3.931879 3.811869 3.699737 3.593736 3.494563 3.399875 3.3104825.643593 5.482443 5.334494 5.198456 5.072145 4.955351 4.84684 4.745437 4.650523-0.80055 -0.78931 -0.77886 -0.76908 -0.75983 -0.75108 -0.74277 -0.73475 -0.727020.375146 0.416406 0.459842 0.505289 0.552514 0.601642 0.651891 0.703658 0.7561090.024901 0.027161 0.029474 0.031822 0.034169 0.036524 0.038863 0.04115 0.0433870.120195 0.130793 0.141575 0.152439 0.163351 0.174255 0.18505 0.195747 0.2061890.140912 0.155264 0.170276 0.1859 0.202145 0.218962 0.236228 0.254056 0.2722840.148511 0.161876 0.175595 0.18959 0.203843 0.218279 0.232807 0.247457 0.262083

COL-FB

COL-FGF

COL-FN

COL-GAPDH

COL-GDF

COL-LIN

COL-UTF

FB-FGFFB-FN

FB-GAPDH

FB-GDF

FB-LIN

FB-UTF

FGF-FN

FGF-GAPDH

FGF-GDF

FGF-LIN

FGF-UTF

FN-GAPDH

FN-GDF

FN-LIN

FN-UTF

GAPDH-GDF

GAPDH-LIN

GAPDH-UTF

GDF-LIN

GDF-UTF

LIN-UTF

-5

0

5

10

15

20

25

30

35

40

45

0.511.522.533.54

COL-FB

COL-FGF

COL-FN

COL-GAPDH

COL-GDF

COL-LIN

COL-UTF

FB-FGFFB-FN

FB-GAPDH

FB-GDF

FB-LIN

FB-UTF

FGF-FN

FGF-GAPDH

FGF-GDF

FGF-LIN

FGF-UTF

FN-GAPDH

FN-GDF

FN-LIN

FN-UTF

GAPDH-GDF

GAPDH-LIN

GAPDH-UTF

GDF-LIN

GDF-UTF

LIN-UTF

-10

-5

0

5

10

15

20

25

30

0.511.522.533.54

1.030925 1.072162 1.113399 1.154636 1.195873 1.23711 1.278347 1.319584 1.360821181.4967 166.0741 153.0522 141.7204 132.3535 124.3442 117.7031 112.1886 107.7441318.0178 290.0014 265.7217 244.4439 226.6355 211.1645 198.1087 187.0497 177.680582.03051 69.93772 59.80297 51.28269 44.13696 38.08 32.953 28.58941 24.861710.000182 0.000223 0.000268 0.00032 0.000374 0.000431 0.000488 0.000545 0.0005984.38E-05 5.39E-05 6.55E-05 7.88E-05 9.31E-05 0.000109 0.000125 0.000142 0.0001595.53E-05 6.82E-05 8.30E-05 9.99E-05 0.000118 0.000138 0.000158 0.000179 0.0001995.48E-05 6.74E-05 8.19E-05 9.84E-05 0.000116 0.000135 0.000154 0.000174 0.0001935.47E-05 6.74E-05 8.20E-05 9.86E-05 0.000116 0.000136 0.000156 0.000176 0.000195

COL-FB

COL-FGF

COL-FN

COL-GAPDH

COL-GDF

COL-LIN

COL-UTF

FB-FGFFB-FN

FB-GAPDH

FB-GDF

FB-LIN

FB-UTF

FGF-FN

FGF-GAPDH

FGF-GDF

FGF-LIN

FGF-UTF

FN-GAPDH

FN-GDF

FN-LIN

FN-UTF

GAPDH-GDF

GAPDH-LIN

GAPDH-UTF

GDF-LIN

GDF-UTF

LIN-UTF

-10

-5

0

5

10

15

20

25

30

0.511.522.533.54

COL-FB

COL-FGF

COL-FN

COL-GAPDH

COL-GDF

COL-LIN

COL-UTF

FB-FGFFB-FN

FB-GAPDH

FB-GDF

FB-LIN

FB-UTF

FGF-FN

FGF-GAPDH

FGF-GDF

FGF-LIN

FGF-UTF

FN-GAPDH

FN-GDF

FN-LIN

FN-UTF

GAPDH-GDF

GAPDH-LIN

GAPDH-UTF

GDF-LIN

GDF-UTF

LIN-UTF

-100.0

0.0

100.0

200.0

300.0

400.0

500.0

600.0

700.0

800.0

900.0

0.51.01.52.02.53.03.54.0

1.030925 1.072162 1.113399 1.154636 1.195873 1.23711 1.278347 1.319584 1.36082123.91204 23.98578 24.01951 24.01578 23.96962 23.87152 23.71151 23.50031 23.2306330.15977 29.73578 29.29153 28.83357 28.35654 27.85764 27.33011 26.78622 26.2211348.95311 41.86503 36.0432 31.23016 27.19869 23.81419 20.94293 18.49802 16.399670.009341 0.009385 0.00944 0.009506 0.009585 0.009689 0.009828 0.009994 0.0101990.003765 0.003861 0.003958 0.004056 0.004157 0.004263 0.004378 0.004501 0.0046340.002229 0.002853 0.003518 0.004194 0.004856 0.005487 0.006085 0.006645 0.0071790.002238 0.002869 0.003545 0.004236 0.004921 0.005582 0.006219 0.006828 0.0074230.002093 0.002673 0.003293 0.003923 0.004544 0.005141 0.005714 0.006261 0.006793

COL-FB

COL-FGF

COL-FN

COL-GAPDH

COL-GDF

COL-LIN

COL-UTF

FB-FGFFB-FN

FB-GAPDH

FB-GDF

FB-LIN

FB-UTF

FGF-FN

FGF-GAPDH

FGF-GDF

FGF-LIN

FGF-UTF

FN-GAPDH

FN-GDF

FN-LIN

FN-UTF

GAPDH-GDF

GAPDH-LIN

GAPDH-UTF

GDF-LIN

GDF-UTF

LIN-UTF

-100.0

0.0

100.0

200.0

300.0

400.0

500.0

600.0

700.0

800.0

900.0

0.51.01.52.02.53.03.54.0

COL-FB

COL-FGF

COL-FN

COL-GAPDH

COL-GDF

COL-LIN

COL-UTF

FB-FGFFB-FN

FB-GAPDH

FB-GDF

FB-LIN

FB-UTF

FGF-FN

FGF-GAPDH

FGF-GDF

FGF-LIN

FGF-UTF

FN-GAPDH

FN-GDF

FN-LIN

FN-UTF

GAPDH-GDF

GAPDH-LIN

GAPDH-UTF

GDF-LIN

GDF-UTF

LIN-UTF

-100

0

100

200

300

400

500

600

0.511.522.533.54

1.030925 1.072162 1.113399 1.154636 1.195873 1.23711 1.278347 1.319584 1.36082137.62791 38.77874 39.70588 40.32229 40.59063 40.38745 39.6838 38.46137 36.762351.71381 52.69416 53.38438 53.67635 53.51105 52.77073 51.40453 49.42348 46.87958148.4332 122.242 99.94089 81.50224 66.57238 54.56907 44.94747 37.21426 30.988160.004333 0.004178 0.004071 0.004023 0.004038 0.004141 0.004347 0.004681 0.0051750.002048 0.002037 0.002047 0.002086 0.00216 0.002285 0.002476 0.002754 0.0031460.000285 0.000417 0.0006 0.00083 0.001093 0.001373 0.001664 0.00198 0.0023430.00028 0.000409 0.000586 0.000807 0.001059 0.001324 0.001599 0.001893 0.00223

0.000309 0.000446 0.000632 0.000862 0.001118 0.001386 0.001658 0.001948 0.002279

COL-FB

COL-FGF

COL-FN

COL-GAPDH

COL-GDF

COL-LIN

COL-UTF

FB-FGFFB-FN

FB-GAPDH

FB-GDF

FB-LIN

FB-UTF

FGF-FN

FGF-GAPDH

FGF-GDF

FGF-LIN

FGF-UTF

FN-GAPDH

FN-GDF

FN-LIN

FN-UTF

GAPDH-GDF

GAPDH-LIN

GAPDH-UTF

GDF-LIN

GDF-UTF

LIN-UTF

-100

0

100

200

300

400

500

600

0.511.522.533.54

COL-FB

COL-FGF

COL-FN

COL-GAPDH

COL-GDF

COL-LIN

COL-UTF

FB-FGFFB-FN

FB-GAPDH

FB-GDF

FB-LIN

FB-UTF

FGF-FN

FGF-GAPDH

FGF-GDF

FGF-LIN

FGF-UTF

FN-GAPDH

FN-GDF

FN-LIN

FN-UTF

GAPDH-GDF

GAPDH-LIN

GAPDH-UTF

GDF-LIN

GDF-UTF

LIN-UTF

-50

0

50

100

150

200

250

0.511.522.533.54

COL-FB

COL-FGF

COL-FN

COL-GAPDH

COL-GDF

COL-LIN

COL-UTF

FB-FGFFB-FN

FB-GAPDH

FB-GDF

FB-LIN

FB-UTF

FGF-FN

FGF-GAPDH

FGF-GDF

FGF-LIN

FGF-UTF

FN-GAPDH

FN-GDF

FN-LIN

FN-UTF

GAPDH-GDF

GAPDH-LIN

GAPDH-UTF

GDF-LIN

GDF-UTF

LIN-UTF

-50

0

50

100

150

200

250

0.511.522.533.54

1.402058 1.443295 1.484532 1.525769 1.567006 1.608243 1.64948 1.690717 1.73195486.17815 92.19374 98.82793 106.0609 113.9864 122.607 132.1862 142.6234 154.310874.52915 79.72648 85.48417 91.78278 98.72615 106.3207 114.7814 124.036 134.401724.88369 22.68895 20.56453 18.54327 16.65534 14.91343 13.3248 11.88652 10.592910.001086 0.000946 0.00082 0.000708 0.000609 0.000522 0.000445 0.000378 0.0003190.000645 0.000567 0.000496 0.000432 0.000375 0.000324 0.000278 0.000238 0.0002030.000602 0.000526 0.000456 0.000393 0.000338 0.000289 0.000246 0.000209 0.0001760.000833 0.000722 0.000622 0.000532 0.000454 0.000385 0.000325 0.000274 0.0002290.000676 0.000594 0.000517 0.000449 0.000387 0.000332 0.000284 0.000242 0.000204

1.402058 1.443295 1.484532 1.525769 1.567006 1.608243 1.64948 1.690717 1.731954128.1773 134.8322 141.7977 148.991 156.3653 163.5285 170.214 176.0709 180.172895.44577 100.4382 106.0517 112.3941 119.611 127.6726 136.68 146.6061 156.931129.40206 26.11206 23.11963 20.41502 17.99368 15.83338 13.91424 12.21481 10.71008

0.000395 0.000357 0.000322 0.000291 0.000263 0.000239 0.000219 0.000203 0.0001920.000286 0.000261 0.000238 0.000216 0.000195 0.000177 0.000161 0.000147 0.0001360.000339 0.000307 0.000276 0.000248 0.000223 0.0002 0.00018 0.000163 0.0001490.00035 0.000316 0.000284 0.000255 0.000227 0.000203 0.000182 0.000163 0.000148

0.000394 0.000353 0.000315 0.00028 0.000248 0.00022 0.000196 0.000175 0.000158

1.402058 1.443295 1.484532 1.525769 1.567006 1.608243 1.64948 1.690717 1.7319541.896439 1.8623 1.830249 1.800083 1.771596 1.744744 1.719383 1.695279 1.6725310.914626 0.895987 0.878221 0.861351 0.845047 0.829479 0.814492 0.799889 0.7858510.831793 0.809989 0.788915 0.768403 0.748538 0.729092 0.710119 0.691465 0.6731680.425466 0.413364 0.400588 0.387244 0.373385 0.359183 0.344605 0.329741 0.314754-1.26956 -1.27264 -1.27392 -1.27368 -1.27209 -1.26933 -1.26555 -1.26087 -1.255417.664701 7.864547 7.957367 7.947134 7.846195 7.666393 7.424991 7.138205 6.8190495.248708 5.197265 5.098768 4.96126 4.792104 4.598053 4.386728 4.163398 3.9336521.07645 1.077502 1.076353 1.072801 1.067128 1.059119 1.048883 1.036651 1.022134

1.402058 1.443295 1.484532 1.525769 1.567006 1.608243 1.64948 1.690717 1.73195477.03035 68.56022 61.06986 54.43634 48.55201 43.3181 38.68256 34.55771 30.8678663.48406 57.25992 51.74637 46.84227 42.45516 38.51692 34.98987 31.82121 28.9383428.43716 25.30856 22.54885 20.11511 17.95733 16.04311 14.34117 12.82556 11.470680.000942 0.001198 0.001521 0.001926 0.002434 0.003072 0.003867 0.004863 0.0061140.000834 0.001058 0.001337 0.001684 0.002115 0.002652 0.003314 0.004132 0.0051510.000972 0.001239 0.001572 0.00199 0.002512 0.003165 0.003975 0.004981 0.006240.001019 0.001306 0.001669 0.002127 0.002705 0.003434 0.004348 0.005496 0.0069470.00103 0.001319 0.001684 0.002143 0.002721 0.003448 0.004356 0.005492 0.006923

1.402058 1.443295 1.484532 1.525769 1.567006 1.608243 1.64948 1.690717 1.7319540.541782 0.526356 0.511492 0.497299 0.4836 0.470349 0.45754 0.445113 0.4329540.418084 0.409376 0.40089 0.39268 0.384665 0.376833 0.369094 0.361464 0.3538980.67489 0.668544 0.662818 0.657661 0.65303 0.648837 0.645099 0.641735 0.638772

0.520255 0.503999 0.488324 0.473239 0.458668 0.444512 0.430804 0.417451 0.404422-1.33936 -1.32055 -1.30298 -1.28658 -1.27125 -1.2569 -1.24349 -1.23093 -1.219178.139427 7.507926 6.949657 6.452256 6.003993 5.596487 5.223218 4.879285 4.5592928.534005 7.771882 7.104836 6.517229 5.993834 5.523979 5.09978 4.71397 4.3613961.268237 1.271363 1.270426 1.265528 1.257162 1.245596 1.230957 1.213639 1.193867

1.402058 1.443295 1.484532 1.525769 1.567006 1.608243 1.64948 1.690717 1.7319543.22429 3.141938 3.062554 2.986286 2.912196 2.840789 2.770356 2.701633 2.633952

4.560642 4.477267 4.398462 4.324107 4.253904 4.187494 4.124039 4.063224 4.005814-0.71978 -0.7125 -0.70533 -0.69829 -0.69137 -0.68427 -0.67749 -0.67071 -0.663760.809704 0.863458 0.917133 0.969997 1.022096 1.072147 1.120841 1.166693 1.2097030.045543 0.047634 0.049587 0.051362 0.053035 0.05448 0.055805 0.056875 0.0577010.216472 0.226378 0.23591 0.244943 0.25351 0.261442 0.268833 0.275558 0.2815290.290999 0.309908 0.329113 0.348368 0.36769 0.386887 0.40603 0.424922 0.4433560.276744 0.291186 0.305456 0.319363 0.332916 0.345986 0.358571 0.370581 0.381858

1.402058 1.443295 1.484532 1.525769 1.567006 1.608243 1.64948 1.690717 1.731954104.1588 101.504 99.69171 98.61045 98.32301 98.70558 99.79419 101.6187 104.0295169.7969 163.3243 158.1574 153.8267 150.5183 147.9045 145.9497 144.3814 142.932721.66264 18.91416 16.54486 14.48576 12.70343 11.14996 9.796652 8.610413 7.5712640.000646 0.000685 0.000715 0.000734 0.00074 0.000734 0.000717 0.000689 0.0006540.000175 0.00019 0.000203 0.000215 0.000224 0.000231 0.000235 0.000238 0.0002380.000218 0.000235 0.00025 0.000262 0.000271 0.000276 0.000278 0.000277 0.0002740.000211 0.000227 0.00024 0.00025 0.000257 0.000261 0.000261 0.000258 0.0002530.000214 0.000231 0.000245 0.000256 0.000264 0.000269 0.000271 0.00027 0.000266

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1.773191 1.814428 1.855665 1.896902 1.938139 1.979376 2.020613 2.06185 2.103087182.0258 180.5177 175.5079 166.3665 153.652 138.1735 121.3861 104.2823 88.02398167.3557 176.0172 181.7033 181.7537 174.5951 159.9168 139.7433 116.8761 94.564819.378877 8.202996 7.162657 6.244077 5.43064 4.711312 4.074092 3.50906 3.008649

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3.628856 3.670093 3.71133 3.752567 3.793804 3.835041 3.876278 3.917515 3.9587520.01441 0.004627 -0.00347 -0.01015 -0.0156 -0.02007 -0.02367 -0.02654 -0.02879

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-0.49846 -0.48988 -0.48079 -0.4713 -0.4615 -0.45149 -0.44135 -0.43115 -0.42093-0.81366 -0.80132 -0.78806 -0.77408 -0.7595 -0.74448 -0.72912 -0.71355 -0.69785-0.21494 -0.22541 -0.23516 -0.24419 -0.25258 -0.26029 -0.26742 -0.27392 -0.27984

3.999989-1.86797-2.31544-0.2207

-0.17923-0.24177-0.1269

-0.14101-0.57511

3.999989-0.21204-0.11231-0.48823

-0.054440.055716-0.0069

-0.72726-0.26639

3.9999891.166842-2.54911-0.15366-0.22964-0.338310.054612-0.18166-0.19747

3.999989-0.452070.053189-0.54575-0.2208

-0.34482-0.477270.6488120.492584

3.999989-0.26534-0.672190.418282-0.14043-0.51222-0.66754-0.28197-0.01934

3.999989-6.09194-1.07966-0.29895-0.03001-0.03139-0.0898

0.001666-0.00585

3.999989-0.03052-0.92086-0.05647-0.219240.016838-0.3627

-0.53842-0.73129

3.9999890.349828-0.21923-0.21863-0.08496-0.08831-0.6286

-0.57971-0.62901

3.999989-0.46413

-0.055-0.00939-0.336140.195549-0.41075-0.6821

-0.28518

Actinomycin DTLT TST TLT-sink-1 TST-sink-1

COL, C 28.41653 20.0104 COL 2.81833334 1.24033333COL, 1 31.23487 21.25073 FB 2.07353334 0.21313333COL, 2 27.89727 24.06173 FGF 10.9615 0.36083333COL, 3 30.21043 26.46307 FN 5.37743333 0.21336666FB, C 25.27113 22.2466 GAPDH 5.92786667 0.5189FB, 1 27.34467 22.03347 H19 1.35153333 0.24523333FB, 2 25.62433 23.69737 LIN 2.26653334 0.3266FB, 3 26.72317 18.5853 UTF 0.7639 0.70976667FGF, C 26.7536 24.13073FGF, 1 37.7151 23.7699 TLT-sink-2 TST-sink-2FGF, 2 21.99833 23.34973 COL 3.3376 2.811FGF, 3 30.1051 25.7185 FB 1.72033334 1.6639FN, C 24.87367 16.54367 FGF 15.71676667 0.42016667FN, 1 30.2511 16.75703 FN 1.23345 3.4001FN, 2 23.49003 18.5676 GAPDH 6.9773 1.58543334FN, 3 26.57243 21.7501 H19 0.90578333 0.72803333GAPDH, C 25.3902 16.69983 LIN 3.85096667 0.7518GAPDH, 1 31.31807 17.21873 UTF 0.89106667 0.09823333GAPDH, 2 24.34077 18.80417GAPDH, 3 33.44477 22.2186 TLT-sink-3 TST-sink-3H19, C 35.196 32.5028 COL 2.31316666 2.40133334H19, 1 36.54753 32.74803 FB 1.09883334 5.11206667H19, 2 35.64175 32.02 FGF 8.10676667 2.36876667H19, 3 34.4083 35.4201 FN 3.0824 3.1825LIN, C 30.30073 27.31673 GAPDH 9.104 3.41443333LIN, 1 32.56727 27.64333 H19 1.23345 3.4001LIN, 2 28.7163 26.89153 LIN 1.6133 8.34473334LIN, 3 30.3296 35.23627 UTF 0.2631 5.77793334UTF, C 30.4093 29.13453UTF, 1 29.6454 29.8443UTF, 2 28.75433 29.94253UTF, 3 29.01743 35.72047

FF-1 TLT-sink-TOT FB-1 TST-sink-10 2.81833334 9.98413334 COL 1.24 COL0 2.07353334 5.3112 FB 0.21 FB0 10.9615 13.9452 FGF 0.36 FGF0 5.37743333 13.49406667 FN 0.21 FN0 5.92786667 14.09933334 GAPDH 0.52 GAPDH0 1.35153333 3.7995 H19 0.25 H190 2.26653334 4.92393334 LIN 0.33 LIN

0.1989 0.9628 0 UTF 0.71 UTF

FF-2 TLT-sink-TOT FB-2 TST-sink-20 3.3376 3.83553334 COL 2.81 COL0 1.72033334 1.92696666 FB 1.66 FB

1.3514 17.06816667 11.22616667 FGF 0.42 FGF1.0118 2.24525 0 FN 3.40 FN

0 6.9773 5.5366 GAPDH 1.59 GAPDH0 0.90578333 3.62175 H19 0.73 H190 3.85096667 1.82476667 LIN 0.75 LIN

1.1882 2.07926667 0 UTF 0.10 UTF

FF-3 TLT-sink-TOT FB-3 TST-sink-30 2.31316666 3.74736666 COL 2.40 COL0 1.09883334 8.13786667 FB 5.11 FB0 8.10676667 4.3866 FGF 2.37 FGF0 3.0824 4.82233333 FN 3.18 FN0 9.104 11.22616667 GAPDH 3.41 GAPDH

1.0118 2.24525 0 H19 3.40 H194.90666667 6.51996667 0 LIN 8.34 LIN6.70303334 6.96613334 0 UTF 5.78 UTF

COL FB FGF FN GAPDH H19 LIN UTF0.00

3.00

6.00

9.00

TST-sink-1TST-sink-2TST-sink-3

COL FB FGF FN GAPDH H19 LIN UTF0.00

2.00

4.00

6.00

8.00

FF-1FF-2FF-3

COL FB FGF FN GAPDH H19 LIN UTF0.00

6.00

12.00

18.00

TLT-sink-1TLT-sink-2TLT-sink-3

COL FB FGF FN GAPDH H19 LIN UTF0.00

4.00

8.00

12.00

16.00

FB-1FB-2FB-3

COL FB FGF FN GAPDH H19 LIN UTF0.00

4.00

8.00

12.00

16.00

FB-1FB-2FB-3

FF-1 TLT-sink-TOT FB-10.00 COL 2.82 COL 9.98 COL0.00 FB 2.07 FB 5.31 FB0.00 FGF 10.96 FGF 13.95 FGF0.00 FN 5.38 FN 13.49 FN0.00 GAPDH 5.93 GAPDH 14.10 GAPDH0.00 H19 1.35 H19 3.80 H190.00 LIN 2.27 LIN 4.92 LIN0.20 UTF 0.96 UTF 0.00 UTF

FF-2 TLT-sink-TOT FB-20.00 COL 3.34 COL 3.84 COL0.00 FB 1.72 FB 1.93 FB1.35 FGF 17.07 FGF 11.23 FGF1.01 FN 2.25 FN 0.00 FN0.00 GAPDH 6.98 GAPDH 5.54 GAPDH0.00 H19 0.91 H19 3.62 H190.00 LIN 3.85 LIN 1.82 LIN1.19 UTF 2.08 UTF 0.00 UTF

FF-3 TLT-sink-TOT FB-30.00 COL 2.31 COL 3.75 COL0.00 FB 1.10 FB 8.14 FB0.00 FGF 8.11 FGF 4.39 FGF0.00 FN 3.08 FN 4.82 FN0.00 GAPDH 9.10 GAPDH 11.23 GAPDH1.01 H19 2.25 H19 0.00 H194.91 LIN 6.52 LIN 0.00 LIN6.70 UTF 6.97 UTF 0.00 UTF

COLFBFGFFNGAPDHH19LINUTF

COL FB FGF FN GAPDH H19 LIN UTF0.00

3.00

6.00

9.00

TST-sink-1TST-sink-2TST-sink-3

COL FB FGF FN GAPDH H19 LIN UTF0.00

2.00

4.00

6.00

8.00

FF-1FF-2FF-3

COL FB FGF FN GAPDH H19 LIN UTF0.00

6.00

12.00

18.00

TLT-sink-1TLT-sink-2TLT-sink-3

COL FB FGF FN GAPDH H19 LIN UTF0.00

4.00

8.00

12.00

16.00

FB-1FB-2FB-3

COL FB FGF FN GAPDH H19 LIN UTF0.00

4.00

8.00

12.00

16.00

FB-1FB-2FB-3

TST-sink-1 TST-sink-2 TST-sink-3 delta-TST-sink-1-21.24 2.81 2.40 FN0.21 1.66 5.11 hEAG0.36 0.42 2.37 HOTTIP0.21 3.40 3.18 KCNQ10.52 1.59 3.41 MH2A10.25 0.73 3.40 MH2A30.33 0.75 8.34 XIST0.71 0.10 5.78 GAPDH

FF-1 FF-2 FF-30.00 0.00 0.00 FN0.00 0.00 0.00 hEAG0.00 1.35 0.00 HOTTIP0.00 1.01 0.00 KCNQ10.00 0.00 0.00 MH2A10.00 0.00 1.01 MH2A30.00 0.00 4.91 XIST0.20 1.19 6.70 GAPDH

TLT-sink-1 TLT-sink-2 TLT-sink-3 delta-TLT-sink-1-22.82 3.34 2.31 FN2.07 1.72 1.10 hEAG

10.96 17.07 8.11 HOTTIP5.38 2.25 3.08 KCNQ15.93 6.98 9.10 MH2A11.35 0.91 2.25 MH2A32.27 3.85 6.52 XIST0.96 2.08 6.97 GAPDH

FB-1 FB-2 FB-39.98 3.84 3.75 FN5.31 1.93 8.14 hEAG

13.95 11.23 4.39 HOTTIP13.49 0.00 4.82 KCNQ114.10 5.54 11.23 MH2A13.80 3.62 0.00 MH2A34.92 1.82 0.00 XIST0.00 0.00 0.00 GAPDH

delta-TST-sink-1-2delta-TST-sink-2-31.57 -0.411.45 3.450.06 1.953.19 -0.221.07 1.830.48 2.670.43 7.59

-0.61 5.68

delta-FF-1-2 delta-FF-2-30.00 0.000.00 0.001.35 -1.351.01 -1.010.00 0.000.00 1.010.00 4.910.99 5.51

delta-TLT-sink-1-2delta-TLT-sink-2-30.52 -1.02

-0.35 -0.626.11 -8.96

-3.13 0.841.05 2.13

-0.45 1.341.58 2.671.12 4.89

delta-FB-1-2 delta-FB-2-3-6.15 -0.09-3.38 6.21-2.72 -6.84

-13.49 4.82-8.56 5.69-0.18 -3.62-3.10 -1.820.00 0.00

FNhEAG

HOTTIP

KCNQ1

MH2A1

MH2A3

XIST

GAPDH

-5.00

0.00

5.00

10.00

delta-TST-sink-1-2delta-TST-sink-2-3

FN hEAG HOTTIPKCNQ1 MH2A1 MH2A3 XIST GAPDH

-2.00

0.00

2.00

4.00

6.00

delta-FF-1-2delta-FF-2-3

FNhEAG

HOTTIP

KCNQ1MH2A1MH2A3

XIST

GAPDH

-12.00

-9.00

-6.00

-3.00

0.00

3.00

6.00

9.00

delta-TLT-sink-1-2delta-TLT-sink-2-3

FN hEAG HOTTIPKCNQ1 MH2A1 MH2A3 XIST GAPDH

-15.00

-12.00

-9.00

-6.00

-3.00

0.00

3.00

6.00

9.00

delta-FB-1-2delta-FB-2-3

FN hEAG HOTTIPKCNQ1 MH2A1 MH2A3 XIST GAPDH

-15.00

-12.00

-9.00

-6.00

-3.00

0.00

3.00

6.00

9.00

delta-FB-1-2delta-FB-2-3

FNhEAG

HOTTIP

KCNQ1

MH2A1

MH2A3

XIST

GAPDH

-5.00

0.00

5.00

10.00

delta-TST-sink-1-2delta-TST-sink-2-3

FN hEAG HOTTIPKCNQ1 MH2A1 MH2A3 XIST GAPDH

-2.00

0.00

2.00

4.00

6.00

delta-FF-1-2delta-FF-2-3

FNhEAG

HOTTIP

KCNQ1MH2A1MH2A3

XIST

GAPDH

-12.00

-9.00

-6.00

-3.00

0.00

3.00

6.00

9.00

delta-TLT-sink-1-2delta-TLT-sink-2-3

FN hEAG HOTTIPKCNQ1 MH2A1 MH2A3 XIST GAPDH

-15.00

-12.00

-9.00

-6.00

-3.00

0.00

3.00

6.00

9.00

delta-FB-1-2delta-FB-2-3

FN hEAG HOTTIPKCNQ1 MH2A1 MH2A3 XIST GAPDH

-15.00

-12.00

-9.00

-6.00

-3.00

0.00

3.00

6.00

9.00

delta-FB-1-2delta-FB-2-3

Mitomycin CTLT TST TLT-sink-1 TST-sink-1

COL, C 27.33607 30.26357 COL 0.5392 5.21376666COL, 1d 27.87527 35.47733 FB 0.46923333 0.8249COL, 2d 28.36717 35.72393 FGF 2.43913333 3.41956667COL, 4d 27.6911 26.99787 FN 0.40736667 1.57546667FB, C 23.68657 26.77273 GAPDH 0.37473334 2.06623333FB, 1d 24.1558 27.59763 H19 0.58473333 0.3347FB, 2d 24.05053 28.05237 LIN 0.24576667 0.35906667FB, 4d 28.0212 27.11113 UTF 0.0009 1.1826FGF4, C 33.24857 31.03073FGF4, 1d 35.6877 34.4503 TLT-sink-2 TST-sink-2FGF4, 2d 35.5412 35.1896 COL 0.4919 0.2466FGF4, 4d 33.039 27.89245 FB 0.10526667 0.45473334FN, C 25.7127 28.73303 FGF 0.1465 0.7393FN, 1d 26.12007 30.3085 FN 0.59123334 1.73996666FN, 2d 26.28237 30.26823 GAPDH 4.51456667 0.1197FN, 4d 26.00137 31.69197 H19 0.31406666 0.63153333GAPDH, C 28.93097 31.59757 LIN 0.44503333 0.0833GAPDH, 1d 28.55623 33.6638 UTF 1.6341 1.26426666GAPDH, 2d 33.0708 33.5441GAPDH, 4d 32.70983 24.36227 TLT-sink-3 TST-sink-3H19, C 34.5861 33.2038 COL 0.67606667 8.72606666H19, 1d 34.00137 33.5385 FB 3.97066667 0.94123334H19, 2d 34.31543 32.90697 FGF 2.5022 7.29715H19, 4d 34.90667 34.64693 FN 0.281 1.42373334LIN28, C 27.95747 27.7752 GAPDH 0.36096667 9.18183333LIN28, 1d 27.7117 28.13427 H19 0.59123334 1.73996666LIN28, 2d 28.15673 28.05097 LIN 1.00643333 0.88746666LIN28, 4d 27.1503 28.93843 UTF 2.8805 0.08246666UTF, C 37.37687 34.68413UTF, 1d 37.37777 33.50153UTF, 2d 39.01187 32.23727UTF, 4d 36.13137 32.31973

FF-1 TLT-sink-TOT FB-1 TST-sink-17.60206666 8.14126666 0 COL 5.21 COL3.44183333 3.91106666 0 FB 0.82 FB

0 2.43913333 1.2374 FGF 3.42 FGF4.18843333 4.5958 0 FN 1.58 FN5.10756667 5.48230001 0 GAPDH 2.07 GAPDH

0 0.58473333 0.462867 H19 0.33 H190.42256667 0.66833334 0 LIN 0.36 LIN

0 0.0009 3.876233 UTF 1.18 UTF

FF-2 TLT-sink-TOT FB-2 TST-sink-27.35676666 7.84866666 0 COL 0.25 COL4.00183334 4.10710001 0 FB 0.45 FB

0 0.1465 8.347567 FGF 0.74 FGF0 0.59123334 0.3516 FN 1.74 FN

0.4733 4.98786667 0 GAPDH 0.12 GAPDH0 0.31406666 1.408467 H19 0.63 H190 0.44503333 0.105767 LIN 0.08 LIN0 1.6341 6.7746 UTF 1.26 UTF

FF-3 TLT-sink-TOT FB-3 TST-sink-30 0.67606667 0.693233 COL 8.73 COL0 3.97066667 0.910067 FB 0.94 FB0 2.5022 5.14655 FGF 7.30 FGF

5.6906 5.9716 0 FN 1.42 FN0 0.36096667 8.347567 GAPDH 9.18 GAPDH0 0.59123334 0.259733 H19 1.74 H19

1.78813333 2.79456666 0 LIN 0.89 LIN0 2.8805 3.811633 UTF 0.08 UTF

COL FB FGF FN GAPDH H19 LIN UTF0.00

5.00

10.00

TST-sink-1TST-sink-2TST-sink-3

COL FB FGF FN GAPDH H19 LIN UTF0.00

2.00

4.00

6.00

8.00

FF-1FF-2FF-3

COL FB FGF FN GAPDH H19 LIN UTF0.00

3.00

6.00

9.00

TLT-sink-1TLT-sink-2TLT-sink-3

COL FB FGF FN GAPDH H19 LIN UTF0.00

3.00

6.00

9.00

FB-1FB-2FB-3

COL FB FGF FN GAPDH H19 LIN UTF0.00

3.00

6.00

9.00

FB-1FB-2FB-3

FF-1 TLT-sink-TOT FB-17.60 COL 8.14 COL 0.00 COL3.44 FB 3.91 FB 0.00 FB0.00 FGF 2.44 FGF 1.24 FGF4.19 FN 4.60 FN 0.00 FN5.11 GAPDH 5.48 GAPDH 0.00 GAPDH0.00 H19 0.58 H19 0.46 H190.42 LIN 0.67 LIN 0.00 LIN0.00 UTF 0.00 UTF 3.88 UTF

FF-2 TLT-sink-TOT FB-27.36 COL 7.85 COL 0.00 COL4.00 FB 4.11 FB 0.00 FB0.00 FGF 0.15 FGF 8.35 FGF0.00 FN 0.59 FN 0.35 FN0.47 GAPDH 4.99 GAPDH 0.00 GAPDH0.00 H19 0.31 H19 1.41 H190.00 LIN 0.45 LIN 0.11 LIN0.00 UTF 1.63 UTF 6.77 UTF

FF-3 TLT-sink-TOT FB-30.00 COL 0.68 COL 0.69 COL0.00 FB 3.97 FB 0.91 FB0.00 FGF 2.50 FGF 5.15 FGF5.69 FN 5.97 FN 0.00 FN0.00 GAPDH 0.36 GAPDH 8.35 GAPDH0.00 H19 0.59 H19 0.26 H191.79 LIN 2.79 LIN 0.00 LIN0.00 UTF 2.88 UTF 3.81 UTF

COLFBFGFFNGAPDHH19LINUTF

COL FB FGF FN GAPDH H19 LIN UTF0.00

5.00

10.00

TST-sink-1TST-sink-2TST-sink-3

COL FB FGF FN GAPDH H19 LIN UTF0.00

2.00

4.00

6.00

8.00

FF-1FF-2FF-3

COL FB FGF FN GAPDH H19 LIN UTF0.00

3.00

6.00

9.00

TLT-sink-1TLT-sink-2TLT-sink-3

COL FB FGF FN GAPDH H19 LIN UTF0.00

3.00

6.00

9.00

FB-1FB-2FB-3

COL FB FGF FN GAPDH H19 LIN UTF0.00

3.00

6.00

9.00

FB-1FB-2FB-3

TST-sink-1 TST-sink-2 TST-sink-3 delta-TST-sink-1-25.21 0.25 8.73 FN0.82 0.45 0.94 hEAG3.42 0.74 7.30 HOTTIP1.58 1.74 1.42 KCNQ12.07 0.12 9.18 MH2A10.33 0.63 1.74 MH2A30.36 0.08 0.89 XIST1.18 1.26 0.08 GAPDH

FF-1 FF-2 FF-37.60 7.36 0.00 FN3.44 4.00 0.00 hEAG0.00 0.00 0.00 HOTTIP4.19 0.00 5.69 KCNQ15.11 0.47 0.00 MH2A10.00 0.00 0.00 MH2A30.42 0.00 1.79 XIST0.00 0.00 0.00 GAPDH

TLT-sink-1 TLT-sink-2 TLT-sink-3 delta-TLT-sink-1-28.14 7.85 0.68 FN3.91 4.11 3.97 hEAG2.44 0.15 2.50 HOTTIP4.60 0.59 5.97 KCNQ15.48 4.99 0.36 MH2A10.58 0.31 0.59 MH2A30.67 0.45 2.79 XIST0.00 1.63 2.88 GAPDH

FB-1 FB-2 FB-30.00 0.00 0.69 FN0.00 0.00 0.91 hEAG1.24 8.35 5.15 HOTTIP0.00 0.35 0.00 KCNQ10.00 0.00 8.35 MH2A10.46 1.41 0.26 MH2A30.00 0.11 0.00 XIST3.88 6.77 3.81 GAPDH

delta-TST-sink-1-2 delta-TST-sink-2-3-4.97 8.48-0.37 0.49-2.68 6.560.16 -0.32-1.95 9.060.30 1.11-0.28 0.800.08 -1.18

delta-FF-1-2 delta-FF-2-3-0.25 -7.360.56 -4.000.00 0.00-4.19 5.69-4.63 -0.470.00 0.00-0.42 1.790.00 0.00

delta-TLT-sink-1-2 delta-TLT-sink-2-3-0.29 -7.170.20 -0.14-2.29 2.36-4.00 5.38-0.49 -4.63-0.27 0.28-0.22 2.351.63 1.25

delta-FB-1-2 delta-FB-2-30.00 0.690.00 0.917.11 -3.200.35 -0.350.00 8.350.95 -1.150.11 -0.112.90 -2.96

FNhEAG

HOTTIP

KCNQ1MH2A1MH2A3

XIST

GAPDH

-10.00

-5.00

0.00

5.00

10.00

15.00

delta-TST-sink-1-2delta-TST-sink-2-3

FN hEAG HOTTIPKCNQ1 MH2A1 MH2A3 XIST GAPDH

-10.00

-8.00

-6.00

-4.00

-2.00

0.00

2.00

4.00

6.00

8.00

delta-FF-1-2delta-FF-2-3

FN hEAG HOTTIPKCNQ1 MH2A1 MH2A3 XIST GAPDH

-6.00

-3.00

0.00

3.00

6.00

9.00

12.00

delta-FB-1-2delta-FB-2-3

FN hEAG HOTTIPKCNQ1 MH2A1 MH2A3 XIST GAPDH

-12.00

-9.00

-6.00

-3.00

0.00

3.00

6.00

9.00

12.00

15.00

delta-FB-1-2delta-FB-2-3

FN hEAG HOTTIPKCNQ1 MH2A1 MH2A3 XIST GAPDH

-12.00

-9.00

-6.00

-3.00

0.00

3.00

6.00

9.00

12.00

15.00

delta-FB-1-2delta-FB-2-3

FNhEAG

HOTTIP

KCNQ1MH2A1MH2A3

XIST

GAPDH

-10.00

-5.00

0.00

5.00

10.00

15.00

delta-TST-sink-1-2delta-TST-sink-2-3

FN hEAG HOTTIPKCNQ1 MH2A1 MH2A3 XIST GAPDH

-10.00

-8.00

-6.00

-4.00

-2.00

0.00

2.00

4.00

6.00

8.00

delta-FF-1-2delta-FF-2-3

FN hEAG HOTTIPKCNQ1 MH2A1 MH2A3 XIST GAPDH

-6.00

-3.00

0.00

3.00

6.00

9.00

12.00

delta-FB-1-2delta-FB-2-3

FN hEAG HOTTIPKCNQ1 MH2A1 MH2A3 XIST GAPDH

-12.00

-9.00

-6.00

-3.00

0.00

3.00

6.00

9.00

12.00

15.00

delta-FB-1-2delta-FB-2-3

FN hEAG HOTTIPKCNQ1 MH2A1 MH2A3 XIST GAPDH

-12.00

-9.00

-6.00

-3.00

0.00

3.00

6.00

9.00

12.00

15.00

delta-FB-1-2delta-FB-2-3

SaporinTLT TST TLT-sink-1

FN, C 25.159 38.5484 FN 4.475FN, 1d 29.634 28.80105 hEAG 1.2206FN, 2d 27.4364 27.45755 HOTTIP 4.66665hEAG, C 30.56715 31.255 KCNQ1 0.70215hEAG, 1d 29.34655 37.42145 MH2A1 3.7632hEAG, 2d 28.9231 33.27755 MH2A3 0.52705HOTTIP, C 34.6905 32.61405 XIST 1.89315HOTTIP, 1d 30.02385 30.78995 GAPDH 7.6509HOTTIP, 2d 29.236 29.6526KCNQ1, C 27.8909 33.13545 TLT-sink-2KCNQ1, 1d 27.18875 32.37495 FN 2.1976KCNQ1, 2d 24.5299 27.64705 hEAG 0.42345MH2A1, C 28.1864 37.37365 HOTTIP 0.78785MH2A1, 1d 31.9496 33.79135 KCNQ1 2.65885MH2A1, 2d 31.66665 31.7634 MH2A1 0.28295MH2A3, C 27.1892 32.4004 MH2A3 10.1536MH2A3, 1d 26.66215 28.0048 XIST 1.65355MH2A3, 2d 36.81575 27.19915 GAPDH 3.5975XIST, C 28.3168 34.05765XIST, 1d 26.42365 27.8525XIST, 2d 24.7701 28.38505GAPDH, C 25.1364 32.026GAPDH, 1d 32.7873 31.71795GAPDH, 2d 29.1898 27.1213

TST-sink-1 FF-1 TLT-sink-TOT FB-19.74735 0 4.475 0.83295 FN6.16645 8.0749 9.2955 0 hEAG1.8241 0.7661 5.43275 0 HOTTIP0.7605 5.1862 5.88835 0 KCNQ13.5823 1.84175 5.60495 0 MH2A14.3956 1.34265 1.8697 0 MH2A3

6.20515 1.42885 3.322 0 XIST0.30805 0 7.6509 1.06935 GAPDH

TST-sink-2 FF-2 TLT-sink-TOT FB-21.3435 0.02115 2.21875 0 FN4.1439 4.35445 4.7779 0 hEAG

1.13735 0.4166 1.20445 0 HOTTIP4.7279 3.11715 5.776 0 KCNQ1

2.02795 0.09675 0.3797 0 MH2A10.80565 0 10.1536 9.6166 MH2A30.53255 3.61495 5.2685 0 XIST4.59665 0 3.5975 2.0685 GAPDH

FNhEAGHOTTIPKCNQ1MH2A1MH2A3XISTGAPDH

FNhEAGHOTTIPKCNQ1MH2A1MH2A3XISTGAPDH

TST-sink-1 TST-sink-29.75 1.346.17 4.141.82 1.140.76 4.733.58 2.034.40 0.816.21 0.530.31 4.60

FF-1 FF-20.00 0.028.07 4.350.77 0.425.19 3.121.84 0.101.34 0.001.43 3.610.00 0.00

TLT-sink-1 TLT-sink-24.48 2.201.22 0.424.67 0.790.70 2.663.76 0.280.53 10.151.89 1.657.65 3.60

FB-1 FB-20.83 0.000.00 0.000.00 0.000.00 0.000.00 0.000.00 9.620.00 0.001.07 2.07

FN hEAG HOTTIP KCNQ1 MH2A1 MH2A3 XIST GAPDH0.00

5.00

10.00

15.00

TST-sink-1TST-sink-2

FN hEAG HOTTIP KCNQ1 MH2A1 MH2A3 XIST GAPDH0.00

2.00

4.00

6.00

8.00

10.00

FF-1FF-2

FN hEAG HOTTIP KCNQ1 MH2A1 MH2A3 XIST GAPDH0.00

3.00

6.00

9.00

12.00

TLT-sink-1TLT-sink-2

FN hEAG HOTTIP KCNQ1 MH2A1 MH2A3 XIST GAPDH0.00

3.00

6.00

9.00

12.00

FB-1FB-2

FN hEAG HOTTIP KCNQ1 MH2A1 MH2A3 XIST GAPDH0.00

3.00

6.00

9.00

12.00

FB-1FB-2

delta-TST-sinkFN -8.40hEAG -2.02HOTTIP -0.69KCNQ1 3.97MH2A1 -1.55MH2A3 -3.59XIST -5.67GAPDH 4.29

delta-FFFN 0.02hEAG -3.72HOTTIP -0.35KCNQ1 -2.07MH2A1 -1.75MH2A3 -1.34XIST 2.19GAPDH 0.00

delta-TLT-sinkFN -2.28hEAG -0.80HOTTIP -3.88KCNQ1 1.96MH2A1 -3.48MH2A3 9.63XIST -0.24GAPDH -4.05

delta-FBFN -0.83hEAG 0.00HOTTIP 0.00KCNQ1 0.00MH2A1 0.00MH2A3 9.62XIST 0.00GAPDH 1.00

FN hEAG HOTTIP KCNQ1 MH2A1 MH2A3 XIST GAPDH0.00

5.00

10.00

15.00

TST-sink-1TST-sink-2

FN hEAG HOTTIP KCNQ1 MH2A1 MH2A3 XIST GAPDH0.00

2.00

4.00

6.00

8.00

10.00

FF-1FF-2

FN hEAG HOTTIP KCNQ1 MH2A1 MH2A3 XIST GAPDH0.00

3.00

6.00

9.00

12.00

TLT-sink-1TLT-sink-2

FN hEAG HOTTIP KCNQ1 MH2A1 MH2A3 XIST GAPDH0.00

3.00

6.00

9.00

12.00

FB-1FB-2

FNhEAG

HOTTIP

KCNQ1

MH2A1

MH2A3

XIST

GAPDH

-10.00

-5.00

0.00

5.00

10.00

delta-TST-sink

FN hEAG HOTTIP KCNQ1 MH2A1 MH2A3 XIST GAPDH

-6.00

-4.00

-2.00

0.00

2.00

4.00

delta-FF

FNhEAG

HOTTIP

KCNQ1

MH2A1

MH2A3

XIST

GAPDH

-6.00

-3.00

0.00

3.00

6.00

9.00

12.00

delta-TLT-sink

FN hEAG HOTTIP KCNQ1 MH2A1 MH2A3 XIST GAPDH

-3.00

0.00

3.00

6.00

9.00

12.00

delta-FB

FN hEAG HOTTIP KCNQ1 MH2A1 MH2A3 XIST GAPDH0.00

3.00

6.00

9.00

12.00

FB-1FB-2

FN hEAG HOTTIP KCNQ1 MH2A1 MH2A3 XIST GAPDH

-3.00

0.00

3.00

6.00

9.00

12.00

delta-FB

FNhEAG

HOTTIP

KCNQ1

MH2A1

MH2A3

XIST

GAPDH

-10.00

-5.00

0.00

5.00

10.00

delta-TST-sink

FN hEAG HOTTIP KCNQ1 MH2A1 MH2A3 XIST GAPDH

-6.00

-4.00

-2.00

0.00

2.00

4.00

delta-FF

FNhEAG

HOTTIP

KCNQ1

MH2A1

MH2A3

XIST

GAPDH

-6.00

-3.00

0.00

3.00

6.00

9.00

12.00

delta-TLT-sink

FN hEAG HOTTIP KCNQ1 MH2A1 MH2A3 XIST GAPDH

-3.00

0.00

3.00

6.00

9.00

12.00

delta-FB

FN hEAG HOTTIP KCNQ1 MH2A1 MH2A3 XIST GAPDH

-3.00

0.00

3.00

6.00

9.00

12.00

delta-FB

SaporinTLT TST TLT-sink-1

COL, C 34.54237 18.61341 COL 3.67387COL, 1 30.8685 20.69792 FB 10.44904COL, 2 32.26968 19.84636 FGF 1.04819COL, 3 32.69973 20.55972 FN 5.9993FB, C 29.47498 19.31066 GAPDH 7.079FB, 1 19.02594 21.40111 GDF 8.35192FB, 2 18.46028 21.33172 LIN 1.56586FB, 3 21.19565 22.19875 UTF 1.98822FGF, C 28.94709 26.74731FGF, 1 27.8989 27.42938 TLT-sink-2FGF, 2 28.76208 23.86297 COL 1.40118FGF, 3 28.59528 26.15959 FB 0.56566FN, C 29.53512 20.65628 FGF 0.86318FN, 1 23.53582 23.6705 FN 1.04283FN, 2 23.54935 23.04995 GAPDH 0.27512FN, 3 26.24309 20.14764 GDF 1.78916GAPDH, C 34.77905 21.12369 LIN 0.12261GAPDH, 1 27.70005 22.74588 UTF 3.26502GAPDH, 2 27.97517 21.68374GAPDH, 3 29.95253 18.29384 TLT-sink-3GDF, C 36.88221 29.08792 COL 0.43005GDF, 1 28.53029 29.62936 FB 2.73537GDF, 2 30.31945 25.47403 FGF 0.1668GDF, 3 29.27662 28.06838 FN 2.69374LIN, C 31.54602 24.27131 GAPDH 1.97736LIN, 1 29.98016 27.96661 GDF 1.04283LIN, 2 30.10277 24.11547 LIN 0.10108LIN, 3 30.20385 26.41879 UTF 5.37505UTF, C 32.97995 29.25005UTF, 1 34.96817 31.20142UTF, 2 31.70315 29.32261UTF, 3 37.0782 29.43281

TST-sink-1 FF-1 TLT-sink-TOT FB-12.0845153 0 3.67387 10.17057555 COL2.09045057 2.37517402 12.82421402 0 FB0.68206936 0 1.04819 0.46952153 FGF3.01422274 0.1346822 6.1339822 0 FN1.62219602 0 7.079 4.95416577 GAPDH0.5414359 1.09906807 9.45098807 0 GDF3.69529448 0 1.56586 2.01355341 LIN1.95136423 0 1.98822 3.76675206 UTF

TST-sink-2 FF-2 TLT-sink-TOT FB-20.85156212 0 1.40118 12.42331767 COL0.06939285 2.87144117 3.43710117 0 FB3.56640663 0 0.86318 11.65868616 FGF2.59435341 0 1.04283 4.89910816 FN1.062144 0 0.27512 6.29142977 GAPDH

4.15533148 0 1.78916 4.84542341 GDF3.85113788 0 0.12261 5.98730129 LIN1.87881197 0 3.26502 2.38054403 UTF

TST-sink-3 FF-3 TLT-sink-TOT FB-30.71335873 0 0.43005 12.14000894 COL0.86703009 1.00310126 3.73847126 0 FB2.29661591 0 0.1668 2.43569225 FGF2.90230646 0 2.69374 6.09544511 FN3.38989639 0 1.97736 11.65868616 GAPDH2.59435341 0 1.04283 1.20824 GDF2.30331856 0 0.10108 3.78506273 LIN0.11020271 0 5.37505 7.64539132 UTF

COLFBFGFFNGAPDHGDFLINUTF

TST-sink-1 TST-sink-2 TST-sink-32.08 0.85 0.712.09 0.07 0.870.68 3.57 2.303.01 2.59 2.901.62 1.06 3.390.54 4.16 2.593.70 3.85 2.301.95 1.88 0.11

FF-1 FF-2 FF-30.00 0.00 0.002.38 2.87 1.000.00 0.00 0.000.13 0.00 0.000.00 0.00 0.001.10 0.00 0.000.00 0.00 0.000.00 0.00 0.00

TLT-sink-1 TLT-sink-2 TLT-sink-33.67 1.40 0.43

10.45 0.57 2.741.05 0.86 0.176.00 1.04 2.697.08 0.28 1.988.35 1.79 1.041.57 0.12 0.101.99 3.27 5.38

FB-1 FB-2 FB-310.17 12.42 12.140.00 0.00 0.000.47 11.66 2.440.00 4.90 6.104.95 6.29 11.660.00 4.85 1.212.01 5.99 3.793.77 2.38 7.65

COL FB FGF FN GAPDH GDF LIN UTF0.00

5.00

TST-sink-1TST-sink-2TST-sink-3

COL FB FGF FN GAPDH GDF LIN UTF0.00

2.00

4.00

FF-1FF-2FF-3

COL FB FGF FN GAPDH GDF LIN UTF0.00

3.00

6.00

9.00

12.00

TLT-sink-1TLT-sink-2TLT-sink-3

COL FB FGF FN GAPDH GDF LIN UTF0.00

3.00

6.00

9.00

12.00

15.00

FB-1FB-2FB-3

COL FB FGF FN GAPDH GDF LIN UTF0.00

3.00

6.00

9.00

12.00

15.00

FB-1FB-2FB-3

FNhEAGHOTTIPKCNQ1MH2A1MH2A3XISTGAPDH

FNhEAGHOTTIPKCNQ1MH2A1MH2A3XISTGAPDH

FNhEAGHOTTIPKCNQ1MH2A1MH2A3XISTGAPDH

FNhEAGHOTTIPKCNQ1MH2A1MH2A3XISTGAPDH

COL FB FGF FN GAPDH GDF LIN UTF0.00

5.00

TST-sink-1TST-sink-2TST-sink-3

COL FB FGF FN GAPDH GDF LIN UTF0.00

2.00

4.00

FF-1FF-2FF-3

COL FB FGF FN GAPDH GDF LIN UTF0.00

3.00

6.00

9.00

12.00

TLT-sink-1TLT-sink-2TLT-sink-3

COL FB FGF FN GAPDH GDF LIN UTF0.00

3.00

6.00

9.00

12.00

15.00

FB-1FB-2FB-3

COL FB FGF FN GAPDH GDF LIN UTF0.00

3.00

6.00

9.00

12.00

15.00

FB-1FB-2FB-3

delta-TST-sink-1-2 delta-TST-sink-2-3-1.23 -0.14-2.02 0.802.88 -1.27

-0.42 0.31-0.56 2.333.61 -1.560.16 -1.55

-0.07 -1.77

delta-FF-1-2 delta-FF-2-30.00 0.000.50 -1.870.00 0.00

-0.13 0.000.00 0.00

-1.10 0.000.00 0.000.00 0.00

delta-TLT-sink-1-2 delta-TLT-sink-2-3-2.27 -0.97-9.88 2.17-0.19 -0.70-4.96 1.65-6.80 1.70-6.56 -0.75-1.44 -0.021.28 2.11

delta-FB-1-2 delta-FB-2-32.25 -0.280.00 0.00

11.19 -9.224.90 1.201.34 5.374.85 -3.643.97 -2.20

-1.39 5.26

FNhEAG

HOTTIP

KCNQ1

MH2A1

MH2A3

XIST

GAPDH

-5.00

0.00

5.00

delta-TST-sink-1-2delta-TST-sink-2-3

FN hEAG HOTTIPKCNQ1 MH2A1 MH2A3 XIST GAPDH

-2.00

0.00

2.00

delta-FF-1-2delta-FF-2-3

FNhEAG

HOTTIP

KCNQ1MH2A1MH2A3

XIST

GAPDH

-12.00

-9.00

-6.00

-3.00

0.00

3.00

delta-TLT-sink-1-2delta-TLT-sink-2-3

FN hEAG HOTTIPKCNQ1 MH2A1 MH2A3 XIST GAPDH

-12.00

-9.00

-6.00

-3.00

0.00

3.00

6.00

9.00

12.00

15.00

delta-FB-1-2delta-FB-2-3

FN hEAG HOTTIPKCNQ1 MH2A1 MH2A3 XIST GAPDH

-12.00

-9.00

-6.00

-3.00

0.00

3.00

6.00

9.00

12.00

15.00

delta-FB-1-2delta-FB-2-3

FNhEAG

HOTTIP

KCNQ1

MH2A1

MH2A3

XIST

GAPDH

-5.00

0.00

5.00

delta-TST-sink-1-2delta-TST-sink-2-3

FN hEAG HOTTIPKCNQ1 MH2A1 MH2A3 XIST GAPDH

-2.00

0.00

2.00

delta-FF-1-2delta-FF-2-3

FNhEAG

HOTTIP

KCNQ1MH2A1MH2A3

XIST

GAPDH

-12.00

-9.00

-6.00

-3.00

0.00

3.00

delta-TLT-sink-1-2delta-TLT-sink-2-3

FN hEAG HOTTIPKCNQ1 MH2A1 MH2A3 XIST GAPDH

-12.00

-9.00

-6.00

-3.00

0.00

3.00

6.00

9.00

12.00

15.00

delta-FB-1-2delta-FB-2-3

FN hEAG HOTTIPKCNQ1 MH2A1 MH2A3 XIST GAPDH

-12.00

-9.00

-6.00

-3.00

0.00

3.00

6.00

9.00

12.00

15.00

delta-FB-1-2delta-FB-2-3

Saporin Actinomycin DTLT-sink-1 TST-sink-1 TLT-sink-1 TST-sink-1

COL, 1 3.67387 2.0845153 COL, 1 2.81833334 1.24033333FB, 1 10.44904 2.09045057 FB, 1 2.07353334 0.21313333FGF, 1 1.04819 0.68206936 FGF, 1 10.9615 0.36083333FN, 1 5.9993 3.01422274 FN, 1 5.37743333 0.21336666GAPDH, 1 7.079 1.62219602 GAPDH, 1 5.92786667 0.5189GDF, 1 8.35192 0.5414359 H19, 1 1.35153333 0.24523333LIN, 1 1.56586 3.69529448 LIN, 1 2.26653334 0.3266UTF, 1 1.98822 1.95136423 UTF, 1 0.7639 0.70976667

TLT-sink-2 TST-sink-2 TLT-sink-2 TST-sink-2COL, 2 1.40118 0.85156212 COL, 2 3.3376 2.811FB, 2 0.56566 0.06939285 FB, 2 1.72033334 1.6639FGF, 2 0.86318 3.56640663 FGF, 2 15.71676667 0.42016667FN, 2 1.04283 2.59435341 FN, 2 1.23345 3.4001GAPDH, 2 0.27512 1.062144 GAPDH, 2 6.9773 1.58543334GDF, 2 1.78916 4.15533148 H19, 2 0.90578333 0.72803333LIN, 2 0.12261 3.85113788 LIN, 2 3.85096667 0.7518UTF, 2 3.26502 1.87881197 UTF, 2 0.89106667 0.09823333

TLT-sink-3 TST-sink-3 TLT-sink-3 TST-sink-3COL, 3 0.43005 0.71335873 COL, 3 2.31316666 2.40133334FB, 3 2.73537 0.86703009 FB, 3 1.09883334 5.11206667FGF, 3 0.1668 2.29661591 FGF, 3 8.10676667 2.36876667FN, 3 2.69374 2.90230646 FN, 3 3.0824 3.1825GAPDH, 3 1.97736 3.38989639 GAPDH, 3 9.104 3.41443333GDF, 3 1.04283 2.59435341 H19, 3 1.23345 3.4001LIN, 3 0.10108 2.30331856 LIN, 3 1.6133 8.34473334UTF, 3 5.37505 0.11020271 UTF, 3 0.2631 5.77793334

Mitomycin C Observed (Mean)TLT-sink-1 TST-sink-1 Saporin

COL, 1 0.5392 5.21376666FB, 1 0.46923333 0.8249 COLFGF, 1 2.43913333 3.41956667 FBFN, 1 0.40736667 1.57546667 FNGAPDH, 1 0.37473334 2.06623333 FGFH19, 1 0.58473333 0.3347 UTFLIN, 1 0.24576667 0.35906667 LINUTF, 1 0.0009 1.1826 GDF

TLT-sink-2 TST-sink-2 GAPDHCOL, 2 0.4919 0.2466FB, 2 0.10526667 0.45473334 Observed (Additive)FGF, 2 0.1465 0.7393 SaporinFN, 2 0.59123334 1.73996666GAPDH, 2 4.51456667 0.1197 COLH19, 2 0.31406666 0.63153333 FBLIN, 2 0.44503333 0.0833 FNUTF, 2 1.6341 1.26426666 FGF

TLT-sink-3 TST-sink-3 UTFCOL, 3 0.67606667 8.72606666 LINFB, 3 3.97066667 0.94123334 GDFFGF, 3 2.5022 7.29715 GAPDHFN, 3 0.281 1.42373334GAPDH, 3 0.36096667 9.18183333H19, 3 0.59123334 1.73996666LIN, 3 1.00643333 0.88746666UTF, 3 2.8805 0.08246666

Observed (Mean)Actinomycin D Mitomycin C

TST TLT TST TLT1.8350333333 1.2164787167 COL 2.8230333333 2.15088889 COL4.5833566667 1.0089578367 FB 1.6309000067 2.3297 FB0.6927233333 2.1816973 FN 11.595011113 1.0499222233 FN

3.24529 2.83696087 FGF 3.2310944433 2.26532222 FGF3.1104933333 2.02474547 UTF 7.33638889 1.83958889 UTF

3.72797 2.4303735967 LIN 1.1635888867 1.4577888867 LIN0.5965166667 3.2832503067 H19 2.5769333367 3.1410444467 H193.5427633333 1.3134596367 GAPDH 0.6393555567 2.1953111133 GAPDH

Observed (Additive)Actinomycin D Mitomycin C

TST TLT TST TLT5.5051 3.64943615 COL 8.4691 6.45266667 COL

13.75007 3.02687351 FB 4.89270002 6.9891 FB2.07817 6.5450919 FN 34.78503334 3.14976667 FN9.73587 8.51088261 FGF 9.69328333 6.79596666 FGF9.33148 6.07423641 UTF 22.00916667 5.51876667 UTF

11.18391 7.29112079 LIN 3.49076666 4.37336666 LIN1.78955 9.84975092 H19 7.73080001 9.42313334 H19

10.62829 3.94037891 GAPDH 1.91806667 6.58593334 GAPDH

Predicted (linear regression)Mitomycin C Saporin Actinomycin D

TST TLT TST TLT TST0.56905556 4.7288111 COL 0.6856 0.9156 COL 0.58051.51505556 0.7402889 FB 0.6117 1.0849 FB 2.44951.69594444 3.8186722 FN 2.9583 1.3536 FN 1.48460.42653334 1.5797222 FGF -0.8073 0.3482 FGF 1.36481.75008889 3.7892556 UTF 0.9206 1.055 UTF 2.53410.49667778 0.9020667 LIN 0.696 0.1118 LIN 4.00910.56574444 0.4432778 GDF -1.0265 0.3732 H19 1.57741.50516667 0.8431111 GAPDH 2.506 1.1262 GAPDH 1.4478

Mitomycin CTST TLT1.70716667 14.1864334.54516667 2.22086675.08783333 11.4560171.27960001 4.73916675.25026668 11.3677671.49003333 2.70621.69723333 1.3298333

4.5155 2.5293333

Mitomycin CTLT TST TLT-0.2526 COL -4.2397 -0.09213.3065 FB -0.2433 1.9327-1.1475 FN 0.6917 -0.0593-1.4274 FGF -3.2789 -1.32440.5175 UTF 0.5542 -0.6232-0.3266 LIN 0.4021 -0.2807-1.2925 H19 -0.5909 0.45271.5881 GAPDH -4.6508 2.0768

MMC (Mitomycin C) AD (Actinomycin D)TLT z TST z TLTFB 23.3095 -1.55134 COL 26.1478 -1.35751 COL, CFB 24.0069 -1.40006 COL 31.624 0.185048 COL, CFB 23.7433 -1.45724 COL 33.0189 0.577968 COL, CFB 24.0086 -1.39969 COL 34.0175 0.859257 COL, 1FB 24.2017 -1.35781 COL 35.7938 1.359612 COL, 1FB 24.2571 -1.34579 COL 36.6207 1.592536 COL, 1FB 24.0368 -1.39358 COL 35.0106 1.138998 COL, 2FB 23.8838 -1.42677 COL 35.5937 1.303247 COL, 2FB 24.231 -1.35145 COL 36.5675 1.577551 COL, 2FB 24.8855 -1.20949 COL 26.9357 -1.13557 COL, 3FB 34.2019 0.811327 COL 28.1034 -0.80665 COL, 3FB 24.9762 -1.18981 COL 25.9545 -1.41196 COL, 3COL 27.3193 -0.68157 FB 26.1624 -1.3534 FN, CCOL 27.0976 -0.72966 FB 26.8312 -1.16501 FN, CCOL 27.5913 -0.62257 FB 27.3246 -1.02602 FN, CCOL 27.5813 -0.62474 FB 27.7292 -0.91205 FN, 1COL 27.8328 -0.57019 FB 27.9168 -0.85921 FN, 1COL 28.2117 -0.488 FB 27.1469 -1.07608 FN, 1COL 28.1829 -0.49425 FB 28.0654 -0.81735 FN, 2COL 28.5892 -0.40612 FB 28.0327 -0.82656 FN, 2COL 28.3294 -0.46247 FB 28.059 -0.81915 FN, 2COL 28.0286 -0.52772 FB 26.8936 -1.14743 FN, 3COL 27.6617 -0.6073 FB 27.0929 -1.09129 FN, 3COL 27.383 -0.66776 FB 27.3469 -1.01974 FN, 3UTF 36.5804 1.327245 FGF 30.0141 -0.26843 FGF, CUTF 39.1734 1.889691 FGF 30.5801 -0.109 FGF, CUTF 36.3768 1.283083 FGF 32.498 0.431239 FGF, CUTF 33.5413 0.668036 FGF 34.2206 0.916467 FGF, 1UTF 36.3183 1.270394 FGF 33.773 0.790386 FGF, 1UTF 42.2737 2.562175 FGF 35.3573 1.236657 FGF, 1UTF 37.1647 1.453986 FGF 35.4732 1.269304 FGF, 2UTF 40.1915 2.110527 FGF 35.621 1.310937 FGF, 2UTF 39.6794 1.999447 FGF 34.4746 0.988015 FGF, 2UTF 36.554 1.321519 FGF 30.967 ### FGF, 3UTF 36.2382 1.253019 FGF 27.3651 -1.01461 FGF, 3UTF 35.6019 1.115 FGF 28.4198 -0.71752 FGF, 3LIN28 29.5033 -0.20784 FN 27.0835 -1.09394 FB, CLIN28 27.0765 -0.73424 FN 30.0624 -0.25483 FB, CLIN28 27.2926 -0.68736 FN 29.0532 -0.5391 FB, CLIN28 27.6862 -0.60199 FN 30.3854 -0.16385 FB, 1LIN28 27.8252 -0.57184 FN 30.2057 -0.21446 FB, 1LIN28 27.6237 -0.61555 FN 30.3344 -0.17821 FB, 1LIN28 27.9983 -0.53429 FN 30.4533 -0.14472 FB, 2

LIN28 28.363 -0.45519 FN 30.1434 -0.23201 FB, 2LIN28 28.1089 -0.5103 FN 30.208 -0.21382 FB, 2LIN28 27.266 -0.69313 FN 25.6863 -1.48751 FB, 3LIN28 27.1315 -0.72231 FN 24.4625 -1.83223 FB, 3LIN28 27.0534 -0.73925 FN 44.9271 3.932313 FB, 3FGF4 34.1026 0.789788 H19 30.967 ### LIN28, CFGF4 29.1867 -0.27652 H19 33.201 0.629263 LIN28, CFGF4 36.4564 1.300349 H19 33.2066 0.63084 LIN28, CFGF4 34.4045 0.855272 H19 34.2048 0.912017 LIN28, 1FGF4 37.2935 1.481923 H19 33.4502 0.699458 LIN28, 1FGF4 35.3651 1.063636 H19 32.9605 0.561518 LIN28, 1FGF4 35.9105 1.181938 H19 33.3087 0.6596 LIN28, 2FGF4 35.3457 1.059428 H19 32.3393 0.386536 LIN28, 2FGF4 35.3674 1.064134 H19 33.0729 0.593179 LIN28, 2FGF4 33.0107 0.552944 H19 34.9704 1.127674 LIN28, 3FGF4 32.467 0.435011 H19 34.5005 0.995311 LIN28, 3FGF4 33.6393 0.689293 H19 34.4699 0.986691 LIN28, 3FN 26.4368 -0.873 LIN 27.8033 -0.89118 UTF, CFN 25.998 -0.96818 LIN 27.9339 -0.85439 UTF, CFN 24.7033 -1.24901 LIN 27.5884 -0.95171 UTF, CFN 26.0668 -0.95325 LIN 28.1006 -0.80744 UTF, 1FN 26.2785 -0.90733 LIN 28.017 -0.83099 UTF, 1FN 26.0149 -0.96451 LIN 28.2852 -0.75544 UTF, 1FN 26.1229 -0.94108 LIN 28.2374 -0.7689 UTF, 2FN 26.4 -0.88098 LIN 28.2093 -0.77682 UTF, 2FN 26.3242 -0.89742 LIN 27.7062 -0.91853 UTF, 2FN 27.8597 -0.56436 LIN 29.0697 -0.53446 UTF, 3FN 25.5064 -1.07481 LIN 28.3984 -0.72355 UTF, 3FN 24.638 -1.26317 LIN 29.3472 -0.45629 UTF, 3H19 34.466 0.868612 UTF 33.8085 0.800386 H19, CH19 34.5246 0.881323 UTF 35.4654 1.267107 H19, CH19 34.7677 0.934054 UTF 34.7785 1.073619 H19, CH19 34.529 0.882278 UTF 33.4433 0.697515 H19, 1H19 33.8475 0.734454 UTF 32.9827 0.567771 H19, 1H19 33.6276 0.686756 UTF 34.0786 0.876468 H19, 1H19 34.1742 0.805318 UTF 31.5642 0.168203 H19, 2H19 34.5333 0.88321 UTF 32.5109 0.434873 H19, 2H19 34.2388 0.819331 UTF 32.6367 0.470309 H19, 2H19 34.4471 0.864513 UTF 31.976 0.2842 H19, 3H19 35.7264 1.142005 UTF 32.1365 0.329411 H19, 3H19 34.5465 0.886074 UTF 32.8467 0.529462 H19, 3GAPDH 28.994 -0.31832 GAPDH 32.1343 0.328791 GAPDH, CGAPDH 28.1934 -0.49197 GAPDH 31.0909 0.034882 GAPDH, CGAPDH 29.6055 -0.18568 GAPDH 31.5675 0.169133 GAPDH, CGAPDH 28.0696 -0.51883 GAPDH 33.5527 0.728331 GAPDH, 1

GAPDH 28.4622 -0.43367 GAPDH 33.9515 0.840666 GAPDH, 1GAPDH 29.1369 -0.28732 GAPDH 33.4872 0.709881 GAPDH, 1GAPDH 32.6019 0.464272 GAPDH 32.9348 0.554279 GAPDH, 2GAPDH 32.5923 0.462189 GAPDH 33.9534 0.841202 GAPDH, 2GAPDH 34.0182 0.77148 GAPDH 33.7441 0.782245 GAPDH, 2GAPDH 32.9108 0.531275 GAPDH 24.1914 -1.90859 GAPDH, 3GAPDH 32.0657 0.347965 GAPDH 24.6319 -1.78451 GAPDH, 3GAPDH 33.153 0.58381 GAPDH 24.2635 -1.88828 GAPDH, 3

AD (Actinomycin D) SAP (Saporin)z TST z TLT

28.2584 -0.20203 COL, C 19.2799 -0.96437 COL, C 34.3396328.4421 -0.15746 COL, C 19.8911 -0.86021 COL, C 36.1375428.5491 -0.1315 COL, C 20.8602 -0.69505 COL, C 33.1494831.2522 0.524286 COL, 1 21.3076 -0.61881 COL, 1 30.9932731.2791 0.530812 COL, 1 21.2361 -0.63099 COL, 1 31.4619431.1733 0.505144 COL, 1 21.2085 -0.6357 COL, 1 30.6654527.7478 -0.3259 COL, 2 23.5833 -0.23098 COL, 2 30.5578327.8211 -0.30812 COL, 2 24.2407 -0.11895 COL, 2 33.9813828.1229 -0.2349 COL, 2 24.3612 -0.09841 COL, 2 32.269630.5969 0.365306 COL, 3 27.1189 0.37155 COL, 3 32.9041930.1298 0.251985 COL, 3 27.0956 0.367579 COL, 3 32.1897929.9046 0.197351 COL, 3 25.1747 0.040221 COL, 3 33.0049924.4158 -1.13426 FN, C 16.288 -1.47424 FB, C 29.2550624.998 -0.99302 FN, C 16.6738 -1.4085 FB, C 29.7324525.2072 -0.94227 FN, C 16.6692 -1.40928 FB, C 29.4381227.3438 -0.42391 FN, 1 16.4868 -1.44036 FB, 1 18.9440436.2122 1.72761 FN, 1 16.8333 -1.38131 FB, 1 19.1266627.1973 -0.45946 FN, 1 16.951 -1.36126 FB, 1 19.0083523.3038 -1.40404 FN, 2 18.1851 -1.15094 FB, 2 19.1079523.3619 -1.38995 FN, 2 18.6532 -1.07117 FB, 2 17.1848523.8044 -1.28259 FN, 2 18.8645 -1.03516 FB, 2 19.0830926.315 -0.67351 FN, 3 21.2468 -0.62917 FB, 3 18.4007127.1266 -0.47661 FN, 3 21.5348 -0.58009 FB, 3 27.780926.2757 -0.68304 FN, 3 22.4687 -0.42093 FB, 3 17.5091625.8886 -0.77695 FGF, C 23.7074 -0.20983 FN, C 30.0852626.8929 -0.5333 FGF, C 24.4115 -0.08984 FN, C 29.2003127.4793 -0.39104 FGF, C 24.2733 -0.11339 FN, C 29.3200429.091 ### FGF, 1 23.3819 -0.26531 FN, 1 22.7296545.4086 3.958709 FGF, 1 24.1392 -0.13625 FN, 1 23.2390830.0216 0.225735 FGF, 1 23.7886 -0.196 FN, 1 24.6340422.0257 -1.71412 FGF, 2 22.7635 -0.37069 FN, 2 22.2537122.0074 -1.71855 FGF, 2 23.5675 -0.23368 FN, 2 24.5930921.9619 -1.72959 FGF, 2 23.7182 -0.20799 FN, 2 23.8034136.8213 1.875381 FGF, 3 24.9387 2.31E-06 FN, 3 31.5114227.1156 -0.47928 FGF, 3 25.2637 0.055389 FN, 3 24.2479526.3784 -0.65813 FGF, 3 26.1733 0.210402 FN, 3 22.9680925.5941 -0.8484 FB, C 22.1883 -0.46872 FGF, C 31.2617925.1418 -0.95813 FB, C 21.8768 -0.5218 FGF, C 31.5594325.0775 -0.97373 FB, C 22.6747 -0.38583 FGF, C 36.1177832.2279 0.760996 FB, 1 21.4377 -0.59664 FGF, 1 31.1909325.779 -0.80354 FB, 1 22.1233 -0.4798 FGF, 1 31.6183424.0271 -1.22856 FB, 1 22.5394 -0.40888 FGF, 1 42.0941524.1247 -1.20489 FB, 2 23.4889 -0.24707 FGF, 2 29.85332

26.3128 -0.67404 FB, 2 23.7292 -0.20612 FGF, 2 33.5539926.4355 -0.64427 FB, 2 23.874 -0.18144 FGF, 2 31.7036526.45 -0.64075 FB, 3 17.8023 -1.21618 FGF, 3 32.91907

27.1614 -0.46817 FB, 3 17.725 -1.22935 FGF, 3 33.1965626.5581 -0.61453 FB, 3 20.2286 -0.80269 FGF, 3 45.1151830.3094 0.295557 LIN, C 27.3303 0.407577 UTF, C 31.2617230.8111 0.417273 LIN, C 27.0113 0.353213 UTF, C 31.5593329.7817 0.167534 LIN, C 27.6086 0.455005 UTF, C 36.1178332.1731 0.747702 LIN, 1 28.0044 0.522456 UTF, 1 31.2059931.9175 0.685692 LIN, 1 27.4784 0.432816 UTF, 1 31.6186733.6112 1.096593 LIN, 1 27.4472 0.427499 UTF, 1 42.0943428.6017 -0.11874 LIN, 2 27.0505 0.359894 UTF, 2 29.8521829.091 ### LIN, 2 26.5743 0.27874 UTF, 2 33.5539928.8309 -0.06314 LIN, 2 27.0498 0.359774 UTF, 2 31.7030830.7075 0.392139 LIN, 3 37.2073 2.090807 UTF, 3 32.9189229.9517 0.208777 LIN, 3 39.2724 2.44274 UTF, 3 33.1966429.091 ### LIN, 3 29.2291 0.731169 UTF, 3 45.1151830.1454 0.25577 UTF, C 29.2306 0.731424 LIN, C 31.6813329.091 ### UTF, C 29.077 0.705248 LIN, C 31.4418730.6732 0.383817 UTF, C 29.096 0.708486 LIN, C 31.5136831.3028 0.536562 UTF, 1 29.7484 0.819668 LIN, 1 30.3899929.1486 0.013941 UTF, 1 29.7678 0.822974 LIN, 1 29.5692828.4848 -0.1471 UTF, 1 30.0167 0.865391 LIN, 1 29.9796328.7465 -0.08361 UTF, 2 29.7823 0.825445 LIN, 2 28.9504528.9792 -0.02716 UTF, 2 29.7598 0.82161 LIN, 2 31.2530528.5373 -0.13436 UTF, 2 30.2855 0.9112 LIN, 2 30.1042229.2262 0.032767 UTF, 3 32.7354 1.32871 LIN, 3 30.7735429.2148 0.030001 UTF, 3 41.7351 2.862431 LIN, 3 30.2757528.6113 -0.11641 UTF, 3 32.6909 1.321126 LIN, 3 29.5643735.0131 1.436702 H19, C 32.4304 1.276732 GDF, C 43.943335.3789 1.525447 H19, C 32.5325 1.294132 GDF, C 31.4402529.091 ### H19, C 32.5455 1.296347 GDF, C 35.2652435.6572 1.592964 H19, 1 32.6235 1.30964 GDF, 1 28.5187835.8954 1.650753 H19, 1 33.4487 1.45027 GDF, 1 29.157538.09 2.183175 H19, 1 32.1719 1.232678 GDF, 1 27.91508

35.3282 1.513147 H19, 2 31.6944 1.151303 GDF, 2 33.0593435.9553 1.665285 H19, 2 31.8863 1.184007 GDF, 2 28.1847229.091 ### H19, 2 32.4793 1.285065 GDF, 2 29.8963829.091 ### H19, 3 35.5572 1.809599 GDF, 3 29.1789934.3579 1.277746 H19, 3 34.9119 1.699627 GDF, 3 28.9941534.4587 1.302201 H19, 3 35.7912 1.849477 GDF, 3 29.6600925.4354 -0.8869 GAPDH, C 16.4239 -1.45108 GAPDH, C 34.9177925.6343 -0.83865 GAPDH, C 16.94 -1.36313 GAPDH, C 35.7471425.1009 -0.96805 GAPDH, C 16.7356 -1.39796 GAPDH, C 33.6486129.8915 0.194172 GAPDH, 1 16.5067 -1.43697 GAPDH, 1 27.05264

34.0248 1.196934 GAPDH, 1 17.8111 -1.21468 GAPDH, 1 28.6240230.0379 0.22969 GAPDH, 1 17.3384 -1.29523 GAPDH, 1 27.4252724.3869 -1.14127 GAPDH, 2 18.7961 -1.04681 GAPDH, 2 27.3434324.3615 -1.14744 GAPDH, 2 18.8438 -1.03869 GAPDH, 2 27.7523524.2739 -1.16869 GAPDH, 2 18.7726 -1.05082 GAPDH, 2 28.8254339.9562 2.635926 GAPDH, 3 21.8798 -0.52129 GAPDH, 3 27.495927.6317 -0.35407 GAPDH, 3 21.9206 -0.51434 GAPDH, 3 27.1516532.7464 0.886787 GAPDH, 3 22.8554 -0.35503 GAPDH, 3 27.21104

z TST z0.800542 COL, C 18.97863 -0.664371.131493 COL, C 18.3493 -0.764040.581466 COL, C 11.83968 -1.794970.18456 COL, 1 19.16108 -0.63547

0.270832 COL, 1 24.03649 0.136650.124218 COL, 1 23.64029 0.0739030.104406 COL, 2 12.3826 -1.708990.734597 COL, 2 18.72815 -0.704040.419501 COL, 2 23.56156 0.0614340.536314 COL, 3 18.56167 -0.73040.404811 COL, 3 19.55583 -0.572960.554869 COL, 3 21.36405 -0.28659-0.1354 FB, C 19.97344 -0.50682

-0.04752 FB, C 18.64789 -0.71675-0.1017 FB, C 20.64266 -0.40083-2.0334 FB, 1 21.40336 -0.28036

-1.99979 FB, 1 22.15979 -0.16056-2.02156 FB, 1 3.490758 -3.11719-2.00323 FB, 2 3.835541 -3.06259-2.35723 FB, 2 2.881705 -3.21365-2.00781 FB, 2 21.9215 -0.1983-2.13342 FB, 3 21.11227 -0.32646-0.40676 FB, 3 23.21798 0.007022-2.29753 FB, 3 22.85838 -0.049930.017418 FN, C 20.61733 -0.40485-0.14548 FN, C 20.69523 -0.39251-0.12344 FN, C 20.60291 -0.40713-1.33657 FN, 1 27.04927 0.613785-1.24279 FN, 1 23.35865 0.0293-0.98602 FN, 1 25.37662 0.348887-1.42418 FN, 2 21.69392 -0.23435-0.99355 FN, 2 22.07931 -0.17331-1.13891 FN, 2 21.29471 -0.297570.27994 FN, 3 19.24464 -0.62224

-1.05708 FN, 3 19.90299 -0.51798-1.29268 FN, 3 19.87955 -0.521690.233988 FGF, C 25.59285 0.3831310.288776 FGF, C 27.90196 0.7488261.127855 FGF, C 30.57143 1.1715920.220945 FGF, 1 26.75072 0.5665040.29962 FGF, 1 24.96763 0.284115

2.227957 FGF, 1 23.50484 0.052452-0.02528 FGF, 2 24.48259 0.207299

0.655925 FGF, 2 24.60189 0.2261920.315324 FGF, 2 25.88085 0.4287420.539053 FGF, 3 26.12881 0.4680110.590131 FGF, 3 25.47006 0.3636852.784052 FGF, 3 27.19224 0.6364270.233976 UTF, C 28.16208 0.7900210.288758 UTF, C 30.33841 1.1346891.127865 UTF, C 35.39623 1.9356980.223717 UTF, 1 29.1113 0.940350.299681 UTF, 1 29.09635 0.9379822.227992 UTF, 1 33.04431 1.563223-0.02549 UTF, 2 26.93435 0.5955860.655925 UTF, 2 27.99067 0.7628750.315219 UTF, 2 29.52727 1.0062280.539025 UTF, 3 27.71429 0.7191040.590147 UTF, 3 31.06003 1.2489722.784052 UTF, 3 30.23256 1.1179240.311214 LIN, C 22.18244 -0.156980.267137 LIN, C 26.36737 0.5057930.280355 LIN, C 27.27842 0.6500760.073511 LIN, 1 26.94976 0.598026-0.07756 LIN, 1 29.66792 1.028502-0.00203 LIN, 1 25.95189 0.439992-0.19147 LIN, 2 22.19101 -0.155620.23238 LIN, 2 24.19 0.160961

0.020908 LIN, 2 26.71846 0.5613940.144114 LIN, 3 25.93412 0.4371780.052483 LIN, 3 26.60531 0.543474-0.07846 LIN, 3 27.18047 0.6345632.56834 GDF, C 30.09127 1.095549

0.266838 GDF, C 28.0821 0.7773540.970924 GDF, C 30.2674 1.123442-0.27093 GDF, 1 28.60052 0.859457-0.15336 GDF, 1 30.01843 1.084013-0.38206 GDF, 1 29.4911 1.0004990.564873 GDF, 2 22.85094 -0.05111-0.33242 GDF, 2 2.677809 -3.24594-0.01735 GDF, 2 28.1402 0.786556-0.1494 GDF, 3 27.90048 0.748592

-0.18343 GDF, 3 28.16604 0.790649-0.06084 GDF, 3 27.52194 0.6886420.906967 GAPDH, C 20.85471 -0.367251.059629 GAPDH, C 21.39099 -0.282320.673343 GAPDH, C 21.42842 -0.27639-0.54081 GAPDH, 1 24.06582 0.141295

-0.25156 GAPDH, 1 22.73826 -0.06895-0.47222 GAPDH, 1 24.63743 0.23182-0.48728 GAPDH, 2 3.862191 -3.05837-0.41201 GAPDH, 2 20.40552 -0.43839-0.21448 GAPDH, 2 20.36081 -0.44547-0.45922 GAPDH, 3 18.35392 -0.7633-0.52259 GAPDH, 3 16.17045 -1.1091-0.51165 GAPDH, 3 19.62262 -0.56238

Gene Condition Condition Ct valueKCNQ1 C (Untreated) TST 32.0588KCNQ1 C (Untreated) TST 34.2121KCNQ1 1d TST 30.7073KCNQ1 1d TST 34.0426KCNQ1 2d TST 27.0491KCNQ1 2d TST 28.245KCNQ1 C (Untreated) TLT 27.0736KCNQ1 C (Untreated) TLT 28.7082KCNQ1 1d TLT 27.4925KCNQ1 1d TLT 26.885KCNQ1 2d TLT 25.2194KCNQ1 2d TLT 23.8404MH2A1 C (Untreated) TST 37.768MH2A1 C (Untreated) TST 36.9793MH2A1 1d TST 33.889MH2A1 1d TST 33.6937MH2A1 2d TST 32.1502MH2A1 2d TST 31.3766MH2A1 C (Untreated) TLT 28.5028MH2A1 C (Untreated) TLT 27.87MH2A1 1d TLT 32.407MH2A1 1d TLT 31.4922MH2A1 2d TLT 32.1362MH2A1 2d TLT 31.1971hEAG C (Untreated) TST 31.2119hEAG C (Untreated) TST 31.2981hEAG 1d TST 29.854hEAG 1d TST 44.9889hEAG 2d TST 30.0746hEAG 2d TST 36.4805hEAG C (Untreated) TLT 30.4315hEAG C (Untreated) TLT 30.7028hEAG 1d TLT 29.6667hEAG 1d TLT 29.0264hEAG 2d TLT 28.688hEAG 2d TLT 29.1582MH2A3 C (Untreated) TST 33.795MH2A3 C (Untreated) TST 31.0058MH2A3 1d TST 30.7596MH2A3 1d TST 25.25MH2A3 2d TST 27.2778MH2A3 2d TST 27.1205MH2A3 C (Untreated) TLT 27.4462MH2A3 C (Untreated) TLT 26.9322

MH2A3 1d TLT 27.2124MH2A3 1d TLT 26.1119MH2A3 2d TLT 27.4745MH2A3 2d TLT 46.157XIST C (Untreated) TST 29.0792XIST C (Untreated) TST 39.0361XIST 1d TST 27.522XIST 1d TST 28.183XIST 2d TST 27.0339XIST 2d TST 29.7362XIST C (Untreated) TLT 27.3801XIST C (Untreated) TLT 29.2535XIST 1d TLT 26.8057XIST 1d TLT 26.0416XIST 2d TLT 26.6516XIST 2d TLT 22.8886HOTTIP C (Untreated) TST 32.7608HOTTIP C (Untreated) TST 32.4673HOTTIP 1d TST 30.5738HOTTIP 1d TST 31.0061HOTTIP 2d TST 29.4563HOTTIP 2d TST 29.8489HOTTIP C (Untreated) TLT 29.2861HOTTIP C (Untreated) TLT 40.0949HOTTIP 1d TLT 29.696HOTTIP 1d TLT 30.3517HOTTIP 2d TLT 29.0641HOTTIP 2d TLT 29.4079FN C (Untreated) TST 44.9615FN C (Untreated) TST 32.1353FN 1d TST 27.9923FN 1d TST 29.6098FN 2d TST 27.6898FN 2d TST 27.2253FN C (Untreated) TLT 24.9771FN C (Untreated) TLT 25.3409FN 1d TLT 28.3912FN 1d TLT 30.8768FN 2d TLT 27.2406FN 2d TLT 27.6322GAPDH C TST 32.026GAPDH C TST 32.026GAPDH 1d TST 31.7937GAPDH 1d TST 31.6422GAPDH 2d TST 27.0164

GAPDH 2d TST 27.2262GAPDH C (Untreated) TLT 25.2098GAPDH C (Untreated) TLT 25.063GAPDH 1d TLT 30.2851GAPDH 1d TLT 35.2895GAPDH 2d TLT 30.4631GAPDH 2d TLT 27.9165