mechanics of cell division - Pécsi Tudományegyetem ÁOKbiofizika2.aok.pte.hu/tantargyak/files/cytoskeleton/2012-2013/...4/3/13 1 Mechanics of Cell Division László Grama 2 April,

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Mechanics of Cell Division

László Grama 2 April, 2013

The Cell Cycle

Alberts. Molecular Biology of the Cell. 4th Edition

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Cytoskeletal Machines Perform Both Mitosis and Cytokinesis


M Phase in Animal Cells Depends on Centrosome Duplication in the

Preceding Interphase


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M Phase in Animal Cells Depends on Centrosome Duplication in the Preceding Interphase


M Phase Is Traditionally Divided into Six Stages A

lber

ts. M

olec

ular

Bio

logy

of t

he C

ell.

4th E

ditio

n

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Three Classes of Spindle Microtubules

Microtubule Instability Increases Greatly at M Phase


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Interactions Between Opposing Motor Proteins and Microtubules of Opposite Polarity Drive Spindle

Assembly


Kinetochores Attach Chromosomes to the Mitotic Spindle


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Microtubules Are Highly Dynamic in the

Metaphase Spindle


Opposing forces may drive chromosomes to the metaphase plate


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Sister Chromatids Separate Suddenly at Anaphase


Kinetochore Microtubules Disassemble at Both Ends During Anaphase A


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Both Pushing and Pulling Forces Contribute to Anaphase B


Actin and Myosin II in the Contractile Ring Generate the Force for Cytokinesis


mechanics of cell division - Pécsi Tudományegyetem ÁOKbiofizika2.aok.pte.hu/tantargyak/files/cytoskeleton/2012-2013/...4/3/13 1 Mechanics of Cell Division László Grama 2 April,

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