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Measurement Uncertainty
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Measurement Uncertainty. Measurements Accuracy - hitting the center of the target Precision - tight pattern of hits Bias - all two inches high Uncertainty.

Jan 20, 2016

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Malcolm Bishop
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Page 1: Measurement Uncertainty. Measurements Accuracy - hitting the center of the target Precision - tight pattern of hits Bias - all two inches high Uncertainty.

Measurement Uncertainty

Page 2: Measurement Uncertainty. Measurements Accuracy - hitting the center of the target Precision - tight pattern of hits Bias - all two inches high Uncertainty.

Measurements

• Accuracy - hitting the center of the target

• Precision - tight pattern of hits

• Bias - all two inches high

• Uncertainty - circle containing 95% hits

Page 3: Measurement Uncertainty. Measurements Accuracy - hitting the center of the target Precision - tight pattern of hits Bias - all two inches high Uncertainty.
Page 4: Measurement Uncertainty. Measurements Accuracy - hitting the center of the target Precision - tight pattern of hits Bias - all two inches high Uncertainty.

Traceability

• Accuracy - close to system limitation

• Precision - range

• Bias - identified and corrected for

• Acceptable Uncertainty - 2 sigma

• Unbroken links to national standards

Page 5: Measurement Uncertainty. Measurements Accuracy - hitting the center of the target Precision - tight pattern of hits Bias - all two inches high Uncertainty.

Calibration Traceability

• Unbroken linkage to national standards

• Uncertainty - elements identified and quantified

• Strong QC/QA program

• Periodic MQA testing

Page 6: Measurement Uncertainty. Measurements Accuracy - hitting the center of the target Precision - tight pattern of hits Bias - all two inches high Uncertainty.

Measurement Traceability

• Starts with calibration uncertainty

• Identifies and quantifies all factors that affect the quality of a measurement

• Requires reproducibility

• Testing usually required to validate values

Page 7: Measurement Uncertainty. Measurements Accuracy - hitting the center of the target Precision - tight pattern of hits Bias - all two inches high Uncertainty.

How this affects you

• Did I make the measurement right?

• Is it reproducible?

• What uncertainty is involved?

• Can I cite them for a violation?

Page 8: Measurement Uncertainty. Measurements Accuracy - hitting the center of the target Precision - tight pattern of hits Bias - all two inches high Uncertainty.

2 cases, more than 2 results

• Package survey of radioactive material

• Mammography machine measurements

Page 9: Measurement Uncertainty. Measurements Accuracy - hitting the center of the target Precision - tight pattern of hits Bias - all two inches high Uncertainty.

Package

• 31x31x27 cm

• Bicron RSO-50E

• Calibrated by secondary laboratory

• Maximum surface dose rate measured is 0.4 uSv/h (0.4 mR/h)

• Traveling by air

Page 10: Measurement Uncertainty. Measurements Accuracy - hitting the center of the target Precision - tight pattern of hits Bias - all two inches high Uncertainty.
Page 11: Measurement Uncertainty. Measurements Accuracy - hitting the center of the target Precision - tight pattern of hits Bias - all two inches high Uncertainty.

IATA (ST-1 Requirements)

• Accuracy - so that correctly labeled

• Precision/uncertainty - based on package surface to detector center distance

• Bias - as high as a factor of 4 low

Page 12: Measurement Uncertainty. Measurements Accuracy - hitting the center of the target Precision - tight pattern of hits Bias - all two inches high Uncertainty.

ST-2 Measurement Guidance

a

D/P Distance Package Length CF

5 cm 20 - 40 cm

40 - 100 cm

>100 cm

2.3

1.6

1.0

Correction factors for package and detector sizes

Page 13: Measurement Uncertainty. Measurements Accuracy - hitting the center of the target Precision - tight pattern of hits Bias - all two inches high Uncertainty.

Mammography Measurements

• Exposure at skin entrance

• Half value layer

• Non-invasive kVp measurements

• Mean glandular dose calculation

Page 14: Measurement Uncertainty. Measurements Accuracy - hitting the center of the target Precision - tight pattern of hits Bias - all two inches high Uncertainty.

X-ray vs. Mammo Probes

Energy Response 10x5-6 vs 105-6M

0.8

0.85

0.9

0.95

1

1.05

0 0.5 1 1.5 2 2.5 3 3.5 4 4.5 5 5.5

HVL (mm Al)

Ind

ica

ted

vs.

Tru

e

10x5 -6 probe

10x5 -6M

Page 15: Measurement Uncertainty. Measurements Accuracy - hitting the center of the target Precision - tight pattern of hits Bias - all two inches high Uncertainty.

Phantom Variability

0.94

0.95

0.96

0.97

0.98

0.99

1.00

1.01

1.02

1.03

1.04

1.05

Normalization Factor

1202 2202 2203 1200 2790 8665 2791

Serial Number

Phantom Attenuation Variability

Page 16: Measurement Uncertainty. Measurements Accuracy - hitting the center of the target Precision - tight pattern of hits Bias - all two inches high Uncertainty.

Temperature Effects

MDH 1515 Temperature Effect

1860

1880

1900

1920

1940

1960

1980

2000

2020

0 10 20 30 40 50 60 70

Minutes since brought indoors

mR/

min

Page 17: Measurement Uncertainty. Measurements Accuracy - hitting the center of the target Precision - tight pattern of hits Bias - all two inches high Uncertainty.

HVL MeasurementsHVL Variation Due to Curve Fit

5.41

5.51

5.61

0.29 0.3 0.31 0.32 0.33 0.34 0.35 0.36 0.37 0.38 0.39 0.4 0.41

mm Al

ln o

f exp

osur

e

6 Points(FDA method - 0.3095 mm Al)

3 points (drop 0.2 mm Al - 0.3027 mmAl) (ACR method)

data points

MQSA method

ACR method

Page 18: Measurement Uncertainty. Measurements Accuracy - hitting the center of the target Precision - tight pattern of hits Bias - all two inches high Uncertainty.

Non Invasive kVp Measurements

kVp Filter Dependence

-2

-1.5

-1

-0.5

0

0.5

1

22 24 26 28 30 32

Measured kVp

kV C

orr

ect

ion 0.015 mm Mo

0.02 mm Mo

0.025 mm Mo

0.03 mm Mo

0.035 mm Mo

Page 19: Measurement Uncertainty. Measurements Accuracy - hitting the center of the target Precision - tight pattern of hits Bias - all two inches high Uncertainty.

Example of How Combined Uncertainties EffectMeasurement

0.03Machine Repro.

0.01Rate Dependence

0.01Energy Dependence

0.01Temp/Pressure

0.015Meter Calibration

Estimated Std. Dev.Component

(Cont.)

Page 20: Measurement Uncertainty. Measurements Accuracy - hitting the center of the target Precision - tight pattern of hits Bias - all two inches high Uncertainty.

Example of How Combined Uncertainties EffectMeasurement

0.0070.02kVp (+/- 1 kVp)

0.020.06HVL(+/-0.02mmAl)

0.020.06Phantom Variability

0.020.06Probe Placement

Estimated Std. Dev.

Estimated Max. Dev.Component

Estimate Std Deviation as Max Deviation/3 (NCRP Report 112)

(Cont.)

Page 21: Measurement Uncertainty. Measurements Accuracy - hitting the center of the target Precision - tight pattern of hits Bias - all two inches high Uncertainty.

Combined Uncertainty

• Total estimated uncertainty

• ( 1.52+ 12+ 12+12+ 32+ 22 + 22 + 22 + 0.72)1/2 = 5.2

• To estimate a confidence level of 95% use a coverage factor of 2 = 2 x 5.2 = 10.4 %