MCQ Question Bank10l.in/is/adminnews/public/upload/news/pdf/Question_Bank...MCQ Question Bank M.Sc. Part I Semester I Choice Based Credit System ( Revised Course) Paper III- Organic

MCQ Question Bank

M.Sc. Part I Semester I

Choice Based Credit System ( Revised Course)

Paper III- Organic Chemistry

1. Which of the following statements regarding the use of catalysts is false?

a) Catalysts lower the activation energy for a reaction

b) Catalysts increase the proportion of molecules that possess sufficient energy to clear the activation energy barrier

c) Catalysts increase the number of reactions that can happen spontaneously

d) Catalysts provide an alternative reaction pathway from reactant to product

2. Which substituted benzoic acid is most acidic?

a)

b)

c)

d)

3. Which of (a)-(d) shows the increasing order of acidity of alcohols 1-4?

a) 1 < 2 < 3 < 4

b) 1 < 2 < 4 < 3

c) 1 < 3 < 2 < 4

d) 4 < 3 < 2 < 1

4. The rate of nucleophilic substitution reactions are higher in the presence of ___________ a) Electron withdrawing groups b) Electron releasing groups

c) Both electron withdrawing and releasing groups d) None of the mentione

5. Tertiary alkyl halides are practically inert to substitution by SN2 mechanism because of a. Instability

b. Insolubility

c. Steric hindrance

d. Inductive effect

6. SN2 reaction leads to

a. inversion of configuration

b. Retention of configuration

c. Partial racemisation

d. No racenisation

7. which one of the following ion is not ambident nucleofile?

a. Cyanide ion

b. Ethoxide ion

c. Nitrile ion

d. Enolate ion

8. The total of the oxidation number in an element is

a. charge b. volatility

c. reduction d. oxidation

9. The reduction is a gain of

a. electrons b. protons c. neutros d. oxygen

10. Which of the following is not a reducing agent?

a. CO2 b. SO2 c. NO2 d. ClO2

11. A number which is assigned to each atom or ion in a compound which explains its degree of

oxidation is called

a. oxidation state only b. oxidation number c. oxidation degree only d. oxidation state and number

12. The gain of oxygen is known as

a. oxidation b. reduction c. halogenation d. chlorination

13. Which of the following undergoes a maximum change in its oxidation number, when a

mixture of oxalic acid, potassium chlorate and sulphuric acid is heated?

a. S b. Cl c. H d. C

14. The oxidation number for oxygen will always be

a. 2 b. -2 c. 1

d. -1

15. The reduction is the decrease in

a. oxidation number b. charge c. solubility d. none of the above

16. What should be the free energy so that reaction is spontaneous? a) Positive b) Negative c) Neutral

d) None of the mentioned 17. What does hydrolysis of Alkyl Chlorides produce? a) Unsaturated compound b) Alcohol c) Aldehyde d) None of the mentioned

18. Which statement is false?

(a) If a reaction is thermodynamically spontaneous it may occur rapidly. (b) If a reaction is thermodynamically spontaneous it may occur slowly.

(c) Activation energy is a kinetic quantity rather than a thermodynamic quantity. (d) If a reaction is thermodynamically nonspontaneous, it will not occur spontaneously. (e) If a reaction is thermodynamically spontaneous, it must have a low activation energy.

19. When the concentration of reactant molecules is increased, the rate of reaction increases. The best explanation is: As the reactant concentration increases,

(a) the average kinetic energy of molecules increases. (b) the frequency of molecular collisions increases.

(c) the rate constant increases. (d) the activation energy increases. (e) the order of reaction increases

20. What is the relationship between the two groups in the following molecules?

a) They are equatorial to one another

b) They are axial to one another

c) They are cis to one another

d) They are trans to one another

21. What is the stereochemical relationship between the following two molecules?

a) Geometrical isomers

b) Enantiomers

c) Diastereomers

d) Identical

22. 7. Which of the following is an alkane which can exhibit optical activity?

a) Neopentane

b) Isopentane

c) 3–Methylpentane

d) 3–Methylhexane

23. Which of the following is the definition of chirality?

a) The superimposability of an object on its mirror image

b) A molecule with a mirror image

c) The non-superimposability an object on its mirror image

d) A molecule that has a carbon atom with four different substituents

.24. Which of the following compound(s) is/are chiral?

a) Only A and B b) Only B

c) Only B and C d) Only A

25. Which symmetry element makes the given compound achiral?

a) Plane of symmetry (POS) b) Center of symmetry (COS) c) Axis of symmetry (AOS) d) Alternating axis of symmetry (AAOS)

M.Sc. Part I Semester II

Credit Based Semester and Grading System ( Old Course)

& Choice Based Credit System ( Revised Course)

Paper III- Organic Chemistry

1) Alkylation of enolate with Alkyl halide followes:

a) free radical mechanism b) SN1 mechanism

c) elimination reaction d) SN2 mechanism

2) Ethyl acetoacetate can be prepared by

a) Rosenmund’s reaction b) Claisen condensation

c) Kolbe’s electrolytic method d) Grignard reagent

3) Reaction of sodium salt of acetoacetic ester with halogen derivative of an ester followed

by acidic hydrolysis produces

a) monocarboxylic acid b) tricarboxylic acid

c) dicarboxylic acid d) tetracarboxylic acid

4) Acetoacetic ester condenses with aldehydes and ketones in presence of pyridine. This

reaction is known as

a) Knoevenagal reaction b) Reimer Tiemann reaction

c) Wurtz reaction d) Kolbe’s reaction

5) Sodium salt of malonic ester on treatment with acetyl chloride followed by hydrolysis

And decarboxylation gives

a) butane b) acetone

b) acetyl acetic acid d) propionic acid

6) Barbituric acid is obtained by the the condensation in the presence of sodium ethoxide

between malonic ester and

a) oxalic acid b) urea

c) thiourea d) ethanethiol

7) What is product of following reaction

8) What is possible end product of reaction

OH

+ R2NH + C

HH

O H+

NR2

OH

NR2

OH

R2

OH

NR2

a)b)

c) d)

9) What is product of following reaction

N

H

+H

N

N

N

N

a)b)

c)d)

10) What is product of following reaction?

S

O

H3C

+ O

O O

S

H3C

O

O

SCH3

O

O

S

H3C

O

O

S

H3C

CH3

O

O

H3C

CH3

a)b)

c)d)

CH3

11) What is product of following reaction?

O

H3C

OH

Base

O

H3C

O

OH

O

H3C

OH

H3C

OH

a)

b)

c)

d)

12) What is product of following reaction?

O

H

HN3

O NHO

H

HN

HN

O

a) b)

c)d)

13) What is product of following reaction?

N3

NH2

O

Heat

Toluene

NH

HN

ONH

O

NH

HN

NH

HN

OH

a)

b)

c)

d)

14) What is product of following reaction?

CH3NH2

O

Br2

NaOH

a) CH3NH2 b) CH3CH2NH2

CH3CH2Brc)d) CH3CH2OH

15) What is product of following reaction?

OH

HBr

BrBr

OHOH

a)

b)

c)

d)

16) What is product of following reaction?

CH3Br + HN

CH3

CH3

NaOH

a) CH3 N

CH3

CH3

Br N

CH3

CH3

CH3 NH

CH3

HO N

CH3

CH3

b)

c)

d)

17) What is product of following reaction? O

CH3NH2

N CH3

HN CH3

NHN CH3

a)

b)

c)

d)

18) What is product of following reaction?

H

O O

KOH

EtOH

OO

OH OH

a)b)

c) d)

19) What is product of following reaction?

O

CH2N2

O

NH2

OOH

NH2

a)

b)

c)

d)

20) What is product of following reaction?

N CH3H3C

CH3Br

N CH3H3C

N CH3H3C

N CH3H3C N CH3H3C

CH3

H3C

BrBr

a)b)

c)d)

21) What is product of following reaction?

O

LDA

CH3Br

OO

OO

a)b)

c)

d)

22) ?

23) Isocyanate intermediate is not formed in

(a) Curtius (b) Lossen (c) Hoffmann (d) Backmann

24) ?

25) ?

26) In McMurry coupling product formed is

(a) Alkane (b) Alkene (c) Alkyne (d) Alkyl

27) ?

28) ?

29)

A = B =

A = B =

A = B =

A = B =

30) ?

31) ?

32) ?

33) ?

34) ?

35) ?

36)

37) The order of carbonyl stretching frequency in IR spectra of ketone, amide and anhydride

is:

a) Anhydride > ketone > amide b) ketone > Anhydride > amide

b) ketone > amide > Anhydride d) amide > Anhydride > ketone

38) In the IR spectrum, carbonyl absorption band for the following compound appears at

H

(a) 1810 cm -1 (b) 1770 cm -1 (c) 3000 cm -1 d) 1500 cm -1

39) In the IR spectrum the absorption band due to carbonyl group in phenyl acetate appears

at

(a) 1800 cm -1 b) 1760 cm -1 (c) 3300 cm -1 (d) 1200 cm -1

40) Among the compounds given in the option (a) to (d), the one that exhibits a sharp band

at around 3300 cm-1 in the IR spectrum is :

(a) 1, 2-butadiene b) 1, 3-butadiene (c) 1 - butyne (d) 2 - butyne

41) In IR spectra, the stretching frequency (in cm -1) of the carbonyl group of the following

compound is in the order

(a)A > B > C (b) C > B > A (c) B > C > A (d) B > A > C

42) Which of the following spectroscopic techniques will be useful to distinguish between

M-SCN and M-NCS binding modes.

(a) NMR (b) IR (c) APR (d) mass

43) In the IR spectrum of p-nitrophenyl acetate, the carbonyl absorption band appears at

(a) 3320 cm -1 b) 3200 cm -1 (c) 2330 cm -1 (d) 1770 cm -1

44) Among the following is not a chromophoric group:

(a) NO2 b) OH (c) Alkyne (d) Ketone

45) In the UV-visible absorption spectrum of α ,β – Unsaturated carbonyl compound with

increasing solvent polarity

(a) n-π* transitions undergo hypsochromic shift , π-π* transitions undergo

bathochromic shift

(b) n-π* transitions undergo bathochromic shift , π-π* transitions undergo

hypsochromic shift

(c) both n-π* and π-π* transitions undergo bathochromic shift

(d) both n-π* and π-π* transitions undergo hypsochromic shift

46) In the IR spectrum of acyl chloride carbonyl absorption band appears at

(a) 1800 cm -1 b) 2200 cm -1 (c) 3000 cm -1 (d) 1100 cm -1

47) Given the fact that 1,3 butadiene has a UV absorption of 217 nm , the absorption

wavelength in nm for the conjugated system shown below is

(Use these absorption values for auxochromic group : Alkyl : +5; exo-cyclic double bond :

+5; every additional conjugated C=C : +30)

(a) 278 (b) 282 (c) 288 (d) 293

48)The absorption at λmax 279 nm (ϵ=15) in the UV spectrum of acetone is due to

(a) σ – σ* trnasition (b) n – σ* trnasition

(c) π – π* transition (d) n – π* trnasition

48) In the UV – Vis is spectrum, a diterpenoid exhibited at λmax 275 nm. The compound ,

among the choices given below is

49) Match the compounds in List – I with the stretching frequencies (cm-1) of principal

functional group given in List-II

(a) (A-iii), (B-iv), (C-i), (D-v) (c) (A-iv), (B-v), (C-ii), (D-i)

(b) (A-iii), (B-iv), (C-ii), (D-i) (d) (A-iv), (B-iii), (C-v), (D-i)

50) Match the item of column – I with the appropriate item in column –II

Column I Column II

Compounds Carbonyl stretching frequency (cm-1)

P) Cyclohexanone i) 1910

Q) Cyclopentanone ii) 1715

R) Cyclobutanone iii) 1813

S) Cyclopropanone iv) 1650

v) 1780

vi) 1745

(a) P-I , Q-ii , R-iii , S-iv (c) P-vi , Q-v , R-iv ,S-iii

(b) P-ii , Q-vi , R-v , S-iii (d) P-i , Q-v , R-iv , S-iii

51) The correct match of the 1HNMR chemical shift (δ) of following compound is

(a) I : 5.4; II : 7.2; III : 9.2 (b) I : 9.2; II : 7.2; III : 5.4

(c) I : 7.2; II : 9.2; III : 5.4 (d) I : 5.4; II : 7.2; III : 9.2

52) The number of signal that appear in the proton decoupled 13C NMR spectrum of

benzonitrile is :

(a) 4 (b) 5 (c) 6 (d) 7

53) The number of signal that appear in the broad-band decoupled 13C NMR spectrum of

ortho, meta and para-dichlorobenzene respectively are :

(a) 3,4 and 2 (b) 3,3 and 2 (c) 4,4 and 2 (d) 3,4 and 4

54) Methyl 4-oxopentanoate exhibited signals at δ 208,172,51,37,32 and 27 ppm in its 13C

NMR spectrum. The signals due to methoxy , C1,C4 and C5 carbons are

(a) OMe-32 , C1-208 , C4-172 , C5-51 (c) OMe-32 , C1-172 , C4-208 , C5-51

(b) OMe-51 , C1-208 , C4-172 , C5-32 (d) OMe-51 , C1-172 , C4-208 , C5-32

55) Match the following Compound 13C NMR Chemical Shift (δ ppm)

(A) Acetic acid (i) 95

(B) Acetonitrile (ii) 115

(C) Acetone (iii) 175

(D) Carbon tetrachloride (iv) 205

a) (A)-(iii), (B)-(ii), (C)-(iv), (D)-(i) b) (A)-(iii), (C)-(iv), (D)-(i), (B)-(ii)

c)(A)-(iii), (C)-(iv), (B)-(ii), (D)-(i) d) (B)-(ii), (C)-(iv), (D)-(i), (A)-(iii)

56) The number of signal that appear in the broad-band decoupled 13C NMR spectrum of

phenanthrene and anthracene respectively are :

(a) 10 and 4 (b) 10 and 10 (c) 7 and 4 (d) 7 and 7

57) 1H NMR spectrum of HD would show

(a) a singlet (b) a doublet

(c) a triplet with intensity ratio 1:2:1 (d) a triplet with intensity ratio 1:1:1

58) Match the observed principal absorptions in the visible spectrum shows in List I with

the bond that shows this absorption in list II

List I List II

(A) σ – σ* (i) C - C

(B) n – σ* (ii) C - O

(C) n – π* (iii) Ketone

(D) π – π* (iv) Alkene

(a) (A-i) (B-ii) (C-iii) (D-iv) (c) (A-i) (C-ii) (D-iv) (B-iii)

(b) (A-ii) (B-iii) (C-i) (D-iv) (d) (A-i) (B-iv) (C-iii) (D-ii)

59) Resonant frequencies for NMR is in the spectral region

(a) Radio frequency (b) Microwave

(c) Far – IR (d) Both a and b

60) 1H NMR spectrum of [18]-annulene shows

(a) Only one peak at δ 7.2(18H) (b) Only on peak at δ 5.0(18H)

(c) Two peaks at δ 9.0(12H) and δ -3.0 (6H) (d) Two peaks at δ 9.0(6H) and δ -3.0 (12H)

61) In the broad-band decoupled 13C NMR spectrum, the number of signals appearing for

the bicyclooctane A-C, respectively, are :

(a) Five, four and eight (c) Three , two and five

(b) Five, four and five (d) Three, two and eight

62) The Correct 13 C NMR chemical shifts (δ) values of carbons labeled a-e in the following

esters are

(a) a : 19; b : 143; c : 167; d : 125; e : 52 (c) a : 52; b : 167; c : 143; d :

125; e : 19

(b) a : 52; b : 143; c : 167; d : 125; e : 19 (d) a : 52; b : 167; c : 125; d :

143; e :19

63) The ratio of relative intensities of the carbon signals in the first order 13C NMR

spectrum of CD3Cl is :

(a) 1 : 4 : 6 : 4 : 1 (c) 1 : 6 : 15 : 20 : 15 : 6 : 1

(b) 1 : 3 : 3 : 1 (d) 1 : 3 : 6 : 7 : 6 : 3

64) In the 400 MHz 1H NMR spectrum an organic compound exhibited a doublet. The two

lines of the doublet are at δ 2.35 and 2.38 ppm. The coupling constant (J) value is:

(a) 3 Hz (b) 6 Hz (c) 9 Hz (d) 12 Hz

65) An organic compound having the molecular formula C10H14 exhibited two singlets in

the 1H NMR spectrum and three signals in the 13C NMR spectrum. The Compound is

66) Ethene absorb at ~ 165 nm while butadiene absorb at ~ 214 nm in UV spectroscopy

a)Butadiene is the smaller the energy transition between its HOMO and LUMO

b) Butadiene is the larger the energy transition between its HOMO and LUMO

c)Ethene is the smaller the energy transition between its HOMO and LUMO

d)Butadiene and ethane have the energy transition between its HOMO and LUMO

67) The relative energies of their FMOs of hard nuclophilies

a)Have high energy of LUMOs b) Have low energy of LUMOs

c) Have high energy of HOMOs d) Have low energy of HOMOs

68) The relative energies of their FMOs of soft nuclophilies

a)Have high energy of LUMOs b) Have low energy of LUMOs

c)Have high energy of HOMOs d) Have low energy of HOMOs

69) The relative energies of their FMOs of hard electrophiles

a)Have high energy of LUMOs b) Have low energy of LUMOs

c)Have high energy of HOMOs d) Have low energy of HOMOs

70) The relative energies of their FMOs of soft electrophiles

a)Have high energy of LUMOs b) Have low energy of LUMOs

c)Have high energy of HOMOs d) Have low energy of HOMOs

71) Consider the SN1 reaction of tert-butyl chloride with iodide ion: (CH3)3C Cl + I

(CH3)3C I Cl + If the concentration of iodide ion is doubled, the rate of forming tert-butyl

iodide will: (hint: consider mechanism, i.e. how is the product formed?)

(A) Double (B) Increase 4 times

(C) Remain the same (D) Decrease

72) Which of the following alkyl halides would undergo SN2 reaction most rapidly?

(A) CH3CH2-Br (B) CH3CH2- Cl (C) CH3CH2-I (D) CH3CH2-F

Ans: c

73) Which of the following alkyl halides would you expect to undergo SN1 reaction most

rapidly ?

(A) CH3CH2CH2CH2CH2 Br (B) CH3CH2CH2CH Br CH3

(C) CH3CH2C Br CH3 CH3 (D) They will not undergo SN1 reaction

74) Which of the following alkyl halides would you expect to give the highest yield of

substitution product (SN2) with CH3CH2O - Na+ ?

(A) CH3CH2CH2CH2CH2 Br (B) CH3CH2CH2CH Br CH3

((C)CH3CH2C Br CH3 CH3 (D) They will give same yield of substitution products

75) Which standard is used in NMR spectroscopy …

a) CdCl3 b) DMSO c) Ether d) TMS

76) Which of following compound has highest chemical shift in NMR Spectroscopy..

a) CH3F b) CH3Cl c) CH3Br d) CH3I

77) How many number of signals are present in CH3CH2Br in NMR Spectroscopy..

a)1 b)2 c)3 d)4

78) The interaction of magnetic component of electromagnetic radiation with nuclei is known

as

a) IR Spectroscopy b) NMR Spectroscopy c) UV Spectroscopy d) Microwave spectroscopy

79) What is shielding in NMR?

a) Using a curved piece of metal to block an opponents attack

b) Putting metal around an Rf source

c) When the magnetic moment of an atom blocks the full induced magnetic field from

surrounding nuclei

d) Blocking parts of a molecule from Rf radiation

80) NMR spectroscopy is used for determining structure in which of the following materials?

a) Radioactive materials b) Insoluble chemical compounds c) Liquids d) Gases

81) The distance between the centers of the peaks of doublet is called as?

a) Coupling constant b) Spin constant c) Spin-spin coupling d) Chemical shift

82) NMR is the study of absorption of __________ by nuclei in a magnetic field?

a) Radioactive radiation b) IR radiation c) Radio frequency radiation d) Microwaves

83) NMR spectroscopy indicates the chemical nature of the __________ and spatial positions

of

a) Electrons, Protons b) Neutrons, electrons c) Nuclei, electrons d) Nuclei, neighbouring

nuclei

84) Which of the following organic compound with molecular formula C3H6 Cl2 exhibits

only one signal in the IH NMR spectrum?

a) 2, 2-dichloropropane b) 1, 2-dichloropropane c) 1, 3-dichloropropane d) 1, 1-

dichloropropane

85) The 1H NMR spectrum of CH3OCHCICH2Cl will exhibit _____

a) A three proton doublet. One proton singlet and a two proton doublet

b) A three proton singlet. One proton singlet and a two proton doublet

c) A three proton singlet. One proton triplet and a two proton doublet

d) A three proton triplet. One proton triplet and a two proton triplet

86) Which of the following 1H-NMR spectrum of compound with molecular formula

C4H9NO2 shows delta 5.30 (broad, IH), 4.10(q, 2H), 2.80 (d, 3H), 1.20 (t, 3H) ppm?

a) CH3NHCOOCH2CH3

b) CH3CH2NHCOOCH3

c) CH3OCH2CONHCH3

d) CH3CH2OCH2CONH2

87) when energy is absorbed by the sample, the absorption can be observed as a change in

signal developed by which of the following components?

a) Amplifier b) Photodetector c) GM counter d) Radiofrequency detector

88)The fundamental modes of vibration for CO2 molecules is…..

a)1 b)4 c)3 d)6

89) Finger print region is in between…..

a) 4000-2500cm_1 b) 2500-2000_1 c) 1500-1250 _1 d) 1250-625_1

90) Triple bond absorbed in IR radiation in between…

a) 1740-1850 cm _1 b) 2000-2100 cm _1 c)2100-2260 cm _ 1 d)2000-1900 cm _1

91) Monosubstituted benzene absorbed in IR radiation…

a) 690-710 cm _1 b) 735-770 cm _1 c) 750-810 cm _1 d) 790-850 cm _1

92) Which factor increases IR frequencies…..

a) Inductive effect b) Resonance effect c) Hydrogen bonding d) All of above

93) The IR Spectroscopy is used for……

a) Determination of structure b) Study of chemical reaction c) Detection of Hydrogen

bonding d) All of above

94) The site of unsaturation for C4H7BrO2 is...

a)1 b)2 c) 3 d)4

95) ?

96) + ?

97) + + ?

98) Enamines are

(a) α, β unsaturated aldehyde (b) α, β unsaturated ester

(c) α, β unsaturated ketone (d) α, β unsaturated amine

99) Carbanion act as

(a) Electrophile (b) Nucleophile (c) Intermediate (d) Acid

100) + ?

101) ?

102) + ?

103) ?

104) ?

105) Stability of carbanion

(a) 3º > 2º > 1º (b) 2º > 3º > 1º (c) 1º > 2º > 3º (d) None

106) ?

107) ?

108) ?

109) ?

M. Sc. Organic Chemistry

Semester III

Course Code PSCHO301

Theoretical organic chemistry-I

MCQ on Organic reaction mechanisms

1. Which carbocation is the most stable?

(a) (b) (c) (d)

2. The order of decreasing stability of the following cations is?

(I) CH3C+HCH3 (II) CH3C+HOCH3 (III) CH3C+HCOCH3

a) III > II > I

b) I > II > III

c) II > I > III

d) I > III > II

3. Arrange the following intermediate into decreasing order of stability.

OH

CH2

(I)

NH2

CH2

(II)

CH3

CH2

(III)

Cl

CH2

(IV)

a) I > II > III > IV

b) II > IV > III > I

c) II > I > IV > III

d) II > I > III > IV

4. Which of the following would react most rapidly with sodium ethoxide to produce an ether?

(a) Chorobencene

(b) 2- nitrotolune

(c) P-nitrobenzene

(d) m (choromethyl)- tolune

5. In the given reaction

OTs

OTs

(i) HS (1.0eq.)

(ii) KOHZ

Z will be

(a)

OTs

S (b)

S

S

(c )

S

(d)

S

6. For the following reaction, pick out the best term which describe its mechanisum

H3CS Br NaCN

H3CS CN

(a) SN1

(b) SN2

(c) SN2 with NGP

(d) addition followed by substitution

7. Which of the following reaction is an elimination

(a) (CH3)3CCl (CH3)2C=CH2 HCl

(b)

CH3COOH NH3 CH3COO NH4

(c) CH2O H2O CH2(OH)2

(d) CH3COOH CH3OH CH3COOCH3 H2O

8. A photochemical reaction takes place by the absorption of

(a) visible and ultraviolet radiations

(b) Infrared radiations

(c) heat energy

(d) Microwave radiations

9. “It is only the absorbed light radiations that are effective in producing a chemical reaction.”

This is the statement of

(a) Lambert law

(b) Lambert-Beer law

(c) Grothus-Draper law

(d) Stark-Einstein law

10 . The number of molecules reacted or formed per photon of light absorbed is called

(a) yield of the reaction

(b) quantum efficiency

(c) quantum yield

(d) quantum productivity

11. The energy per einstein depends upon the wavelength of photon. The higher the

wavelength, the _______ will be the energy per einstein.

(a) higher

(b) smaller

(c) zero

(d) infinity

12. A species which can both absorb and transfer radiant energy for activation of the reactant

molecule is called

(a) radioactive substance

(b) an ioniser

(c) a photochemical substance

(d) a photosensitizer

13. The substances that when exposed to light radiations of short wavelength emit light of

longer wavelength are called

(a) photosensitized substances

(b) phosphorescent substances

(c) fluorescent substances

(d) dark substances

14. _______ stops as soon as the incident radiation is cut off

(a) fluorescence

(b) phosphorescence

(d) chemiluminescence

(d) photoluminance

15. The emission of light as a result of chemical action is called _______

(a) phosphorescence

(b) fluorescence

(c) chemiluminescence

(d) photoluminance

16. The reactions which are caused by heat and in absence of light are called

(a) photochemical reactions

(b) catalytic reactions

(c) exothermic reactions

(d) thermal or dark reactions

17. The substances which initiate a photochemical reaction but itself does not undergo any

chemical change is called

(a) catalysis

(b) fluorescent

(c) sensitizer

(d) dark substances

19. Organic dyes like eosin, chlorophyll, ultrarine etc. show _______ in the visible or UV region

(a) fluorescence

(b) phosphorescence

(c) chemiluminescence

(d) photoluminance

20. In photochemical reactions, the absorption of light takes place in

(a) primary processes only

(b) secondary processes only

(c) either primary or secondary process

(d) both primary and secondary process

21. Which of the following are the reactions in which molecules absorbing light do not

themselves react but induce other molecules to react?

a) Free radical reactions

b) Chain reactions

c) Reversible reactions

d) Photosensitized reactions

22. Which of the following dienes cannot undergo Diels-Alder reactions?

(a) (b) (c) (d)

23. Which of phenols (a)-(d) is the main product of the following thermal rearrangement?

O Heat

(a)

OH

(b)

OH

(c)

OH

(d)

OH

24. Which of unsaturated aldehydes (a)-(d) is the sigmatropic rearrangement product obtained by

heating the following ether?

O Heat

(a)

O

(b)

O

(c)

O

(d)

O

25. Which of the following reaction is an elimination

(a) (CH3)3CCl (CH3)2C=CH2 HCl

(b)

CH3COOH NH3 CH3COO NH4

( c ) CH2O H2O CH2(OH)2

(d) CH3COOH CH3OH CH3COOCH3 H2O

M.Sc. Semester III Organic Chemistry( Revised course)

Paper III - Synthetic Organic Chemistry-I

Q1. …………… is act as Mukaiyama Reagent

a. 2- choloro-1-methyl piperidine chloride

b. 2-chloro-1-methyl pyridinium iodide

c. 2-chloro-1methyl piperidine iodide

d. 3-chloro-1-methyl pyridinium chloride

Q2.

Q3.

The above reaction is named as……….

a.Ritter Reaction b. Ugi 4cc

c.Yamagachi Esterification d. Mitsunobu Reaction

Q4.

Q5. The reaction in which nitrile is transformed into N-alkyl amide by using

electrophilic alkylating reagent is named as………

a.Yamaguchi Reaction b. Mitsunobu Reaction

c. Domino Reaction d. Ritter Reaction

Q6.

Q7. In Yamaguchi esterification which of the following reactant get esterified

a. Aliphatic ketone b. Aromatic carboxylic acid

c. Aliphatic carboxylic acid d. Aromatic ketone

Q8.

Q9. In Peterson’s olefination formation of using α-silyl carbanion with ketone

which undergoes elimination to form alkene.

a. α-hydroxy silyl ketone b. β-hydroxy silane

c. β -hydroxy silyl ketone d. α-hydroxy silane

Q10.

Q11. …………..Reaction in organic chemistry used for the synthesis of

cyclopentanones.

a. Peterson’s olefination b. Mitsunobu cyclization

c. Nazaraov cyclization d. None of the above

Q12.

a. Lewis Acid b. Lewis Base

c. Oxidizing Reagent d. Reducing Reagent

Q13.

The above synthesis is named as ………….

a. Hantzsh pyridine synthesis b. Hantzsh piperidine synthesis

c. Ugi-4 component synthesis d. Ugi pyridine synthesis

Q14.

Q15.

Q16. In pictet spengler tetrahydroquinoline synthesis condensation of ……….

and carbonyl compound takes place by cyclisation.

a. α-aryl ethyl amine b. α-aryl butyl amine

c. β - aryl butyl amine d. β - aryl ethyl amine

Q17.

Q18. α-aminoacyl derivative is formed by condensation of an aldehyde, an

amine carboxylic acid isocyanide is called as …………

a. Pictet spengler condensation b. Biginelli Reaction

c. Ugi 4 component condensation d. None of the above

Q19. Bigibelli reaction is ……. component reaction.

a. 2 b. 3 c. 4 d. 5

Q20.

Q21.

Q22. Cycloaddition between azide and alkyne to give 1,2,3 triazole is called as

………

a. Mitsunobu cycloaddition b. Strecker synthesis

c. Haisgen cycloaddition d. Ugi cycloaddition

Q23. Domino reactions are also known as ………

a. Cascade reaction b. Tendem reaction

c. A and b Both d. None of the above

Q24. ……….. is an organic reaction that converts alcohol into variety of

functional group.

a. Mitsunobu reaction b. Cascade reaction

c. Ugi reaction d. Tendem reaction

Q25. Nazarov reaction involves activation of ……….. using stoichiometric

lewis acid as parameter.

a. Vinyl ketone b. Divinyl ketone

c. Aryl ketone d. Ethyl methyl ketone

Q26.

27.

Q28.

Q29.

Q30. Dialkyl peroxide is homolysed by heat or light to give two …….. radical.

a. Cation b. Anion

c. Oxy d. Alkoxy

Q31. Free radical chain oxidation of organic molecule by molecular oxygen is

often referred as ……..

a. Oxidation b. Reduction

c. Autoreductant d. Autoxidant

Q32. The substitution of aryldiazonium salt with halides or pseudohalides is

known as …………

a. Sandmeyer reaction b. Hunsdiecker reaction

c. Acyloin condensation d. Mcmurry coupling

Q33.

Q34. In Mcmurry coupling, carbonyl compound using ……….. complexes to

form corresponding alkenes.

a. Copper b. Iron

c. Titanium d. Rhodium

Q35. Acyloins are formed by treating …… with highly dispersed sodium in the

hot xylene.

a. Aromatic ester b. Aliphatic ether

c. Aromatic ether d. Aliphatic ester

Q36.

Q37. Acid catalysed transformation of vicinal diols is known as ……….

a. Pinacol rearrangement b. Aldol condensation

c. Mcmurry coupling d. Acyloin condensation

Q38.

Q39.

Q40.

Q41.

Q42.

Q43.

Q44.

Q45.

Q46.

Q47. Cobalt complex can be reduced by single electron transfer to give

……….. complexes.

a. Co(I) b. Co(II) c. Co(III) d. Co(IV)

Q48.

Q49. In Kolbe’s electrolysis of carboxylic acid generate radicals which combine

to give ………..

a. Ester b. Ether

c. Alkenes d. Dimers

Q50. One electro reduction of α-dicarbonyl compounds give radical anion

known as ………..

a. Diones b. Semidiones

c. Dianion d. Dication

Q51. An enamine is also called as ……..

a. Alkyl amine b. Aryl amine

c. Vinyl amine d. Acyl amine

Q52.

w

Q53.

Q54.

Q55.

Q56.

Q57.

Q58.

This reaction is called as ……………….

a. Witting reaction b. Enamine formation

c. Olefination d. Hoffman elimination

Q59.

Q60.

The above reaction is called as ………..

a. Michael addition reaction b. Bamford steven reaction

c. Ramberg reaction d. Hoffman elimination

reaction

Q61.

Q62. The coupling reaction between diazo compound and thioketone through

diazo intermediate of alkene to form alkene is called as …………

a. Witting reaction b. Ramberg reaction

c. Olefination d. Barton kellogg reaction

Q63. Steven rearrangement involves the rearrangement of ………. Ylide.

a. Sulphur b. Phosphorus

c. Nitrogen d. Oxygen

Q64. Hydrogenation is highly ……….. and ……….

a. Stereoselective & Stereospecific b. Regioselective &

Enantioselective

c. A & B Both d. Regioselective &

Stereospecific

Q65. Hydration via oxymercuration - demercuration followa ………

a. Markownikoff’s rule b. Antimarkownikoff’s rule

c. Hoffman rule d. Bredt’s rule

Q66. Boron prefers to go to the …… carbon atom due to electronic and steric

factor.

a. More substituted b. Less substituted

c. Halogenated d. Aryl

Q67. Silicon has empty ……… orbital which can receive a pair of electron.

a. s b. p c. d d. f

Q68.

Q69.

Q70.

Q71.

Q72.

Q73. ……………… micronutrient whose absent from diet causes cardiac

muscle and skeletal dysfunction.

a. Organotin b. Organoselenium

c. Organosilicon d. Mercury

Q74.

Q75. 9-BBN is highly ……. reagent which is commercially available.

a. Regioselective b. Regiospecific

c. Enantioselective d. Enantiospecific

M.Sc. Semester IV Organic Chemistry( Old course)

Paper IV -Medicinal, bioorganic and green chemistry

1. What value does the regression coefficient have for a perfect fit?

a] 0.1 b] 1 c] 10 d] 100

2. What does MR represent in a QSAR equation?

a] Molar refractivity is a steric factor.

b] Molar refractivity is an electronic factor.

c] Molar refractivity is a hydrophobic factor.

d] Molar refractivity is a stereoelectronic factor

3. What does a negative value of σ signify for a substituent?

a)It is electron donating b) It is electron withdrawing c) It is neutral

d) It is hydrophobic

4. Which of the following statements is true?

a)Hydrophobic compounds have a high value of P

b) Hydrophilic compounds have a high value of P

c)Acidic compounds have a high value of P

d) Basic compounds have a high value of P

5. What does Es represent in a QSAR equation?

a)The electronic influence of a stubstituent as an electron withdrawing

group

b) The electronic influence of a stubstituent as an electron donating

group

c)The entropy associated with a substituent

d) Taft’s steric factor

6. What symbol is used to represent molar refractivity as a steric factor in a

QSAR equation?

a)MR b) F c) R d) Es

7. Which of the following will not be a limitation for prodrug design?

a)Formation of toxic product

b) An inert carrier can be cleaved off forming toxic product

c)Product cleaving off before reaching the target site

d) The cleaving of the carrier is also site-specific

8. A prodrug is

a)The prototype member of a class of drugs

b) The oldest member of a class of drugs

c)An inactive drug that is transformed in the body to an active

metabolite

d) A drug that is stored in body tissues and is then gradually released

in the circulation

9. A soft drug is

a)Pharmacologically active b) Pharmacologically inactive c)

Metabolically active

d) Metabolically inactive

10. Fluconazole is ______________drug.

a)Anti-bacterial b) Anti-fungal c) Anti-cancer d) Anti- allergic

11. Diclofenac is __________drug.

a)Anti- allergic b) Anti-cancer c) Anti-fungal d) Anti-

inflammetry

12. Esomeprazol is __________.

a)Proton pump inhibitor b) Anti- histamine c) Anti-cancer d)

Calcium channel blocker

13. Labetalol is used in ________.

a)Hypertension b) Diabetes c) Alzheimer d) Arthritis

14. Which of following is modern method for drug design?

a)CADD b) NMR c) QSAR d) ESR

15. Which enzyme inhibitors represent the most common used in clinical

agents?

a)Reversible inhibitors b) Irreversible inhibitors c) suicide substrate

d) Transition-state inhibitors

16. What two molecules form the basis of NAD+?

a)ADP & ATP b) ATP & Vitamin B3 c) Vitamin B3 & AMP d)

Nicotine & ATP

17. Which form of nicotinamide adenine dinucleotide acts as a hydrogen and

electron donor?

a)NAD+ b) NADH c) Nicotine d) ATP

18. In which of the following processes is NADH not formed?

a)glycolysis b) fermentation c) citric acid cycle d) pyruvate

oxidation

19. Thiamine pyrophosphate which is active form of _____.

a)Vitamin B12 b) Vitamin B1 c) Vitamin C d) Vitamin D

20. Which of the following vitamin is involved in transamination of amino

acids?

a)Niacin b) Vitamin B6 c) Thiamine d) Vitamin B3

21. Which of the following is a function of biotin?

a)Synthesis of TMP (thymidine monophosphate)

b) Synthesis of methionine from homocysteine

c)Synthesis of methylene tetrahydrofolate

d) Carboxylation of pyruvate to oxalo acetate

22. FAD is a prosthetic group, _____________________.

a)___it is readily exchanged with the solvent

b) ___it is loosely associated with the protein

c)___it is an artificial substitute for NADH

d) ___it is tightly bound to the enzyme

23. The coenzyme _________is the oxidizing agent in glycosis.

a)NADH b) NADPH c) NAD+ d) FAD

24. The group transferring coenzyme _____.

a)CoA b) NADP+ c) NAD+ d) FAD+

25. Lipoic acid exists in_________.

a)Oxidized form b) reduced form c) Oxidized and reduced form both

d) free form

26. Which metal ion is specifically bound by vitamin B12?

a)Cobalt b) copper c) zinc d) iron

27. Which of the following compounds belong to vitamin B6 group?

a)Pyridoxal b) pyridoxine c) pyridoxamine d) all of these

28. Which of the following statements is not true about cytochrome P450

enzyme?

a)They contain haem & magnesium

b) They belong to a general class of enzymes called monooxygenases

c)These are over 30 different cytochrome P450 enzymes

d) Cytochrome P450 enzyme is least susceptible to quaternary carbon

atom

29. Cytochrome P 450 is member of superfamiliy of ________.

a)Haemoprotein b) haemoferrous c) oxyferrous d) ferroprotein

30. Cyotochrome in oxygen activation activates ___________.

a)Monooxygen b) Dioxygen c) Quaternary carbon d) Tetraoxygen

31. Which of the following enzyme is responsible for glycogen breakdown?

a)Glycogen phosphorylase b) Glycogen phosphatase

b) Glycogen hydrolase d) Glycogen phosphor glycosidase

32. All the following enzymes are involved in glycogen synthesis except?

a)hexokinase b) phosphor glucomutase c) glucose-1-P- uridylyl

transferase

d) glycogen synthetase

33. The enzyme which catalyses only the hydrolysis of urea is____.

a)Hydrolase b) Urease c) Lipase d) Transferase

34. To what main class of enzyme does the enzymes that catalyses the

conversion of lactose to glalactose & glucose belong?

a)oxidoreductase b) transferase c) hydrolase d) lyase

35. Which of the following is not true about enzymes?

a)Enzymes catalyse the reaction in only the forward direction

b) Enzymes are often very specific for their substrates

c)Enzymes activation can often be regulated

d) Enzymes typically catalyze reactions at much higher rates than

chemical catalysis

36. Which of the following enzyme is used in oxidation-reduction reaction.

a)Transferase b) Lyases c) Ligases d) oxidoreductase

37. The enzyme which is used in the hydroxylation reaction is called ______.

a)Hyroxylases b) lipases c) oxidoreductase d) lyases

38. Fermentation of glucose molecule has the potential to produce a net

number of ______ATPs.

a) 4 b) 2 c) 40 d) 0

39. The final electron acceptor in lactic acid fermentation is __________.

a)Oxygen b) lactic acid c) pyruvate d) NAD

40. What do both glycolysis & fermentation have in common?

a)They require oxygen

b) They produce lactic acid & ethyl alcohol

c)They require light energy

d) They produce ATP

41. Green chemistry reduces the ______ and protects the environment.

a) Pollution b) Temperature c) Air d) Water

42. Which of the following is not one of the twelve principles of green

chemistry?

a) Using high temperatures to speed up reactions

b) Minimising toxic reagents used in a synthesis

c) Maximisation of atom economy

d) Minimising the use of solvents

43. Which of the following is the green reagent?

a)Dimethyl carbonate b) Diethyl sulfonate c) Dimethyl sulfonate d)

Dimethyl fumarate

44. The green solvent maximizes the atom ……..

a)Molecular weight b) Electronic configuration c) Velocity d)

Efficiency

45. Which of the following is NOT a property of ionic liquids?

a) High viscosity b) High thermal stability

c) High electrical conductivity d) Low melting points

46. What is meant by solid phase synthesis?

a) Reactions are carried out without solvent

b) Reagents and reactants are attached to a solid phase support

c) Reagents are used in the solid phase

d) Molecules are constructed on a solid phase support

47. ----------- are greener than the conventional methods.

a)Micro waves b) Electromagnetic waves c) Ultra violet waves d)

Radio waves

48. -------------is the fundamental advantage of the ultrasound assisted

reactions without solvents.

a)High yields b) High energy requirements c) Use of solvents d)

High wastes

49. What is the starting material for nylon 6-6 is _________.

a) acetic anhydride b) 2-methyl propyl benzene c) adipic acid d)

Nitric acid

50. In green synthetic methods, the high quality product with no ________ are

produced.

a) Good products b) Catalyst c) Reaction d) Contamination