Mayo Clinic Acute and Chronic Leukemias 2013: A Case-Based Discussion Practical, Current and Evolving Therapy

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Mayo Clinic Education CenterPhoenix, Arizona

Mayo Clinic Acute and Chronic Leukemias 2013: A Case-Based Discussion

Practical, Current and Evolving Therapy

Saturday September 14, 2013

Course Directors: Lisa O. Sproat, M.D., M.S.W., Raoul Tibes, M.D., Ph.D., and Ruben A. Mesa, M.D.

In cooperation with:

Mayo School of Continuous Professional Development

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COURSE HIGHLIGHTSJoin us at the Mayo Clinic Education Center in Phoenix, Arizona, for this one day comprehensive workshop designed for physicians, physician assistants and nurse practitioners and nurses. Attendees will be part of a case-based analysis on the diagnosis and treatment of:• Chronic Myeloid Malignancies • Acute Myeloid Leukemia • Acute Lymphoid Leukemia • Practical Leukemia ManagementYou are invited to submit your questions or challenging cases on-line.

COURSE LEARNING OBJECTIVESUpon completion of this course, participants should be able to:• Recognize the standard of care for the diagnosis and treatment of:

acute myeloid leukemia, acute lymphoid leukemia, myelodysplastic syndromes, myeloproliferative neoplasms, chronic lymphocytic leukemia.

• Recognize significant molecular markers in acute and chronic leukemias and how to incorporate them into clinical practice.

• Review new treatment standards and recent changes to clinical practice for acute and chronic leukemias.

• Increase awareness of investigational agents and potential changes in the care of acute and chronic leukemia patients.

• Explain the importance of using asparaginase in the treatment of young adults diagnosed with Acute Lymphoblastic Leukemia.

• Prescribe that Leukemia and Acute Lymphoblastic Leukemia patients should be HLA-typed early in their diagnosis to facilitate allogeneic stem cell transplant.

INTENDED AUDIENCEPhysicians, Physician Assistants, Nurse Practitioners and Nurses

DISCLAIMERAttendance at this Mayo course does not indicate nor guarantee competence or proficiency in the performance of any procedures which may be discussed or taught in this course.

GRANTS AND EXHIBITS As of this printing, a complete listing of commercial supporters was not available. Appropriate acknowledgment will be given to all supporters at the meeting. Exhibits will be available for viewing at all scheduled breaks.

CREDIT College of Medicine, Mayo Clinic, is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.College of Medicine, Mayo Clinic, designates this live activity for a maximum of 7.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.Application for CME credit has been filed with the American Academy of Family Physicians. Determination of credit is pending. This program has been accredited by the American Osteopathic Association for 7.25 credits of AOA Category 2-A. Mayo Clinic in Arizona is an approved provider of continuing nursing education by the Arizona Nurses Association, an accredited approver by the American Nurses Credentialing Center’s Commission on Accreditation.A record of attendance will be provided to all registrants for requesting credits in accordance with state nursing boards, specialty societies, or other professional associations.

AMERICAN WITH DISABILITIES ACTCollege of Medicine, Mayo Clinic fully intends to comply with the legal requirements of the Americans with Disabilities Act. If you need assistance, please notify us at least two weeks prior to the activity. Email address: [email protected]

General Information

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Saturday, September 14, 2013

7:00 a.m. Registration/Continental Breakfast 7:50 Welcome Announcements CHRONIC MYELOID MALIGNANCIES – CASED-BASED DISCUSSION 8:00 Myelofibrosis/Polycythemia Vera/Essential Thrombocytosis Case

Ruben A. Mesa, M.D. 8:30 Myelodysplastic Syndrome and Myeloproliferative Neoplasms

Overlap Case Raoul Tibes, M.D., Ph.D.

9:00 Chronic Myeloid Leukemia Case James L. Slack, M.D.

9:15 Q & A Discussion 9:30 Challenging Myeloid Diagnosis Case

Riccardo Valdez, M.D. 9:45 Break ACUTE MYELOID LEUKEMIA – CASE BASED DISCUSSION 10:00 Suspected Acute Leukemia – Approach and Initial Work Up

Jane B. Palmer, RN, CNP10:15 Good Risk Acute Myeloid Leukemia Case

Lisa O. Sproat, M.D.10:30 Elderly Acute Myeloid Leukemia Case

Raoul Tibes, M.D., Ph.D.10:45 Acute Promyelocytic Leukemia Case

Lisa O. Sproat, M.D.11:00 Q&A Discussion 11:15 Drug Dosing Adjustments and Considerations

Jeffrey A. Betcher, R.Ph11:30 Allogeneic Stem Cell Transplant Case

Pierre Noel, M.D.11:45 Q & A Discussion Noon Lunch ACUTE MYELOID + LYMPHOID LEUKEMIA – CASE BASED DISCUSSION 12:45 p.m. Relapsed Acute Myeloid Leukemia Case

Sujith R. Kalmadi, M.D.; James L. Slack, M.D., Lisa O. Sproat, M.D., Raoul Tibes, M.D., Ph.D., Riccardo Valdez, M.D.

1:30 High Risk Chronic Lymphocytic Leukemia Case Jose F. Leis, M.D., Ph.D.

1:45 Elderly Chronic Lymphocytic Leukemia Case Jose F. Leis, M.D., Ph.D.

2:00 Q & A Discussion 2:15 Break 2:30 Acute Lymphoid Leukemia Case

James L. Slack, M.D. 2:45 Young Adult Acute Lymphoid Leukemia Case

Roberta H. Adams, M.D. 3:00 Q & A Discussion 3:15 Challenging Lymphoid Leukemia Diagnosis Case

Annette C. Fontaine, M.D., Roberta H. Adams, M.D., Jose F. Leis, M.D., Ph.D., Lisa O. Sproat, M.D., Raoul Tibes, M.D., Riccardo Valdez, M.D.

4:00 Infectious Disease Prophylaxis and Febrile Neutropenia H. R. Vikram, M.D.

4:15 Q & A Final Analysis 4:30 Adjourn

Program

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General InformationMEETING LOCATION Mayo Clinic Education Center is located on the Mayo Clinic Hospital campus at 5777 East Mayo Blvd., Phoenix Arizona, 85054.

ACCOMMODATIONS Residence Inn Phoenix Desert View at Mayo Clinic 5665 E. Mayo Blvd. • Phoenix, AZ 85054Hotel rooms near the Education Center at Mayo Clinic Hospital in Arizona are limited. You are urged to make reservations at the Residence Inn early. To make your reservation, call (800) 331-3131 or (480) 563-1500, ask for Mayo Clinic’s corporate rate. Hotel Website: www.marriott.com/phxmh Attendees are responsible for their own reservations. The standard hotel reservation cancellation policy will apply to individual reservations unless otherwise specified.

RECREATION/LEISURE ACTIVITIESVisit www.visitphoenix.com or www.scottsdalecvb.com for additional recreation and leisure activities.

TRANSPORTATION Ground Transportation: Hertz is offering a reduced daily rate for participants attending the course. Call (800) 654-2240 and refer to CV Number #03NR0008 when making reservations.Supershuttle vans offer airport transportation to and from the hotel. To make reservations, call (800) 258-3826 or (602) 244-9000.

FacultyMAYO CLINIC

Roberta H. Adams, M.D.

Jeffrey A. Betcher, R.Ph.

Jose F. Leis, M.D.

Ruben A. Mesa, M.D.*

Pierre Noel, M.D.

Jane B. Palmer, RN, CNP

James L. Slack, M.D.

Lisa O. Sproat, M.D., MSW*

Raoul Tibes, M.D., Ph.D.*

Riccardo Valdez, M.D.

H.R. Vikram, M.D.

GUEST FACULTYAnnette C. Fontaine, M.D.

New Mexico Cancer Center Albuquerque, New Mexico

Sujith Kalmadi, M.D. Ironwood Cancer & Research Centers

Chandler, Arizona

*Course Directors

FACULTY DISCLOSURE: As a provider accredited by ACCME, College of Medicine, Mayo Clinic (Mayo School of CPD) must ensure balance, independence, objectivity and scientific rigor in its educational activities. Course Director(s), Planning Committee Members, Faculty, and all others who are in a position to control the content of this educational activity are required to disclose all relevant financial relationships with any commercial interest related to the subject matter of the educational activity. Safeguards against commercial bias have been put in place. Faculty will also disclose any off-label and/or investigational use of pharmaceuticals or instruments discussed in their presentation. Disclosure of this information will be published in course materials so those participants in the activity may formulate their own judgments regarding the presentation.

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REGISTRATION FORM

Mayo Clinic Acute and Chronic Leukemias 2013 September 14, 2013

Registration at the standard fee may be completed using this form and faxing it to (480) 301-9176. Or you can mail it to: Mayo Clinic, Mayo School of CPD, 13400 East Shea Boulevard, Scottsdale, Arizona 85259.

An email confirmation will be sent upon receipt of payment and completed registration. If you do not receive your confirmation, or if you have any questions, please email us at [email protected] or call (480) 301-4580.

No refund will be granted unless a written notice of cancellation is received. If registration must be canceled, tuition less a $75 administrative fee, will be refunded when notification is received on or before (August 26, 2013). No refunds will be made after this date.

Although it is not Mayo Clinic’s policy to limit the number of registrants for a course, conference room facilities may necessitate closure of enrollment. Early registration is strongly recommended. Walk-in registrations cannot be guaranteed.

Mayo Clinic will not be responsible for expenses incurred by individuals who are not confirmed for courses with a closed registration status. Costs incurred by the registrant such as airline/ hotel fees or penalties are the responsibility of the registrant.

ONLINE SYLLABUS: Your registration fee includes access to a detailed online syllabus, emailed one week prior to the course. This allows you to view, save, or print the syllabus before attending the course. If you want to order a paper copy (additional fee), check the box at the bottom of this registration form.

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Standard Fee Online Fee Physicians Active in Practice $225 $150 $ ______________ Other (resident, retired and allied health) $185 $110 $ ______________ Note: Please refer to course agenda for included meals and refreshment breaks. Paper copy of the syllabus $25 $ ______________ Note: Due to printing deadlines, this option will not be available after August 26, 2013.

$75 DISCOUNT FOR ONLINE REGISTRATION! Go to www.mayo.edu/cme (offer expires August 23, 2013)

Note: When registering online, please be sure to “check-out” after your profile is completed/updated.

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