Patterns of red blood cell transfusion use and outcomes in patients undergoing percutaneous coronary intervention in contemporary clinical practice: Insights from the NCDR ® Matthew W. Sherwood, Yongfei Wang, Jeptha P. Curtis, Eric D. Peterson, Sunil V. Rao
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Matthew W. Sherwood, Yongfei Wang, Jeptha P. Curtis, Eric D. Peterson, Sunil V. Rao
Patterns of red blood cell transfusion use and outcomes in patients undergoing percutaneous coronary intervention in contemporary clinical practice: Insights from the NCDR ®. Matthew W. Sherwood, Yongfei Wang, Jeptha P. Curtis, Eric D. Peterson, Sunil V. Rao. Disclosures. - PowerPoint PPT Presentation
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Patterns of red blood cell transfusion use and outcomes in patients undergoing percutaneous coronary intervention in contemporary clinical practice: Insights
from the NCDR®
Matthew W. Sherwood, Yongfei Wang, Jeptha P. Curtis, Eric D.
Peterson, Sunil V. Rao
DisclosuresMatthew W. Sherwood – None Yongfei Wang – NoneJeptha P. Curtis – None Eric D. Peterson – Research Support >10K :
Eli Lilly, Janssen Pharm., PI of Data Analytic Center for ACCSunil V. Rao – Research grants - Ikaria, sanofi-aventis;
Funding Support and Disclaimer This research was supported by the American College of Cardiology Foundation’s National Cardiovascular Data Registry (NCDR). The views expressed in this presentation represent those of the author(s), and do not necessarily represent the official views of the NCDR or its associated professional societies identified at www.ncdr.com.
Background• Prior studies have shown that there is marked
variation in the use of red blood cell transfusion (RBCT) among patients with acute coronary syndromes
• Contemporary post-procedure RBCT patterns in patients undergoing PCI are unclear
• Documenting variation in RBCT practice is important since RBCT has been independently associated with morbidity and mortality in patients with ischemic heart disease
Objectives• To determine the variability in use of RBCT in
hospitals across the United States• To determine patient factors associated with
RBCT• To determine whether RBCT has an
independent association with patient outcomes– Is an association of transfusion with outcomes
• Definition – Bleeding Events– Hemoglobin drop of ≥3 g/dL– Transfusion of whole blood or packed red blood cells– Procedural intervention/surgery at the bleeding site to
reverse/stop or correct the bleeding
Analyses• Rates of transfusion by site were determined and
then risk adjusted rates were calculated• Patient clinical characteristics and in-hospital
outcomes were compared between patients who did and did not receive RBCT
• Logistic regression was used to determine the adjusted association between RBCT and in-hospital death, MI, or stroke– Secondary analyses performed to determine whether any
adverse effect of transfusion was independent of bleeding events