Materials and Engineering Science ANSTO website: Suzanne V Smith [email protected].

Materials and Engineering ScienceMaterials and Engineering ScienceANSTOANSTO

website:website:http://www.ansto.gov.au/ansto/matengsci/index.htmlhttp://www.ansto.gov.au/ansto/matengsci/index.html

Suzanne V SmithSuzanne V Smith

[email protected]@ansto.gov.au

Radioanalytical and Chemical Radioanalytical and Chemical AnalysisAnalysis

Expertise

• Experience in development of targetry,

design and execution of radiotracer studies.

• Development of routine methods and training

in use of relevant techniques is also

available.

Radioanalytical and Chemical Radioanalytical and Chemical AnalysisAnalysis

Facilities

• Gamma counter – (0 - 2000 keV; small and large sampling)

• Alpha, beta and gamma spectrometry – (28 and 50% efficiency)

• Graphite furnace atomic absorption spectroscopy

• Inductively coupled plasma-mass spectrometry (ICP-MS), and

• Clean room facilities.

Nanotechnology Nanotechnology Controlled Release of Drugs.Controlled Release of Drugs.

≈ 20 m

Novel technology for production nanoparticles.

Encapsulation and release of molecules under controlled conditions≈ 0.05 m

Selective Inorganic SorbentsSelective Inorganic Sorbents

Microporous inorganic adsorbents that have unique metal ion binding affinity.

Investigating their application for radioisotope separation.

Images: Alexandra Bush

Image: Victor Luca

MicrobiologyMicrobiology

• Research/synthesis of bio-inorganic

composites (live rocks).• Characterisation of biological systems.

• Culturing of fastidious microbes -

magnetotactic bacteria

• Novel bioreactors – culturing cells requiring

high pO2

– E.g hepatocytes

Top: magnetotactic bacterium with a chain of magnetosomes (dark inclusions).

Bottom: higher magnification of the magnetosomes in the cell. Images from Tony Taylor

Integrated Suite of Characterisation Integrated Suite of Characterisation Capabilities and ExpertiseCapabilities and Expertise

• Scanning electron microscopy (SEM)• spatial/topological info., resolution 3.5 nm• chemical info., spatial limit ~1 micron

• Transmission electron microscopy (TEM)• spatial/structural/topological info., resolution 0.1 nm• chemical/valence/bonding info., spatial limit ~10 nm

• Structure and texture analysis•X-ray diffraction (XRD) •Neutron diffraction

• Nuclear Magnetic Resonance Spectroscopy (NMR)

•Atomic force microscopy (AFM)

International Collaborations International Collaborations Radiometal tracersRadiometal tracers

Apply ANU/ANSTO patent - radiolabelling technology – Harvard Medical School, USA – Humanized

Antibodies– Cambridge University, UK – Humanized

Antibodies– TRIUMF, Canada – RNA

Apply ANSTO Radioplatinum Patent Technology– Paterson Cancer Institute, UK– Harvard Medical School, USA– NECSA, South Africa