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M. Pharm. (Pharmacology) Syllabus Applicable w.e.f. Academic Session 2011-12 (22022012) Page 1 of 20
Study & Evaluation Scheme
of
Master of Pharmacy
(Pharmacology) [Applicable w.e.f. Academic Session 2011-12 till revised]
[With amendments in Credit scheme, MPL 251,351& 451 vide approval dated 17th Nov 2012]
TEERTHANKER MAHAVEER UNIVERSITY N.H.-24, Delhi Road, Moradabad, Uttar Pradesh-244001
Website: www.tmu.ac.in
M. Pharm. (Pharmacology) Syllabus Applicable w.e.f. Academic Session 2011-12 (22022012) Page 2 of 20
To qualify the course a student is required to secure a minimum of 40% marks in aggregate in the end
semester examination and teachers continuous evaluation (i.e. both internal and external). A candidate who
secures less than of 40% of marks in a course shall be deemed to have failed in that course. The student
should have overall 50% marks in a semester to clear the semester. In case a student has more than 40% in
each course but less than 50% overall in a semester he/she shall re-appear in one or two course(s) to improve
the percentage. There will be three Class Tests in a semester and an average of the marks obtained in best two
tests will be computed (cumulatively) for the final result.
The class tests would comprise of five questions. Student shall have to answer three questions out of which one question will be compulsory. Each question would be of five marks.
Question Paper Structure:
1. The question paper shall consist of eight questions. Out of which first question shall be of short
answer type (not exceeding 50 words) and will be compulsory. Question No. 1 shall contain 8 parts
representing all units of the syllabus and students shall have to answer any five (weightage 4 marks
each).
2. Out of the remaining seven questions, a student shall be required to attempt any five questions.
There will be minimum one and maximum two questions from each unit of the syllabus. The
weightage of Question No. 2 to 8 shall be 10 marks each.
M. Pharm. (Pharmacology) Syllabus Applicable w.e.f. Academic Session 2011-12 (22022012) Page 3 of 20
Research Project shall be carried out in different stages. It will commence with submission and approval of
synopsis in second semester. The experimental work shall be carried out in two phases i.e. in III & IV
semesters.
Note: L – Lecture T- Tutorial P- Practical C- Credits
1L = 1Hr 1T= 1 Hr 1P=1 Hr 1C =1Hr of Theory paper
= 2Hrs of Practical
M. Pharm. (Pharmacology) Syllabus Applicable w.e.f. Academic Session 2011-12 (22022012) Page 4 of 20
M. Pharm. Semester I
MODERN ANALYTICAL TECHNIQUES (MAT)
Course Code: MPA101 L-4, T-2, P-0, C-5 Objective: The basic objective of this course is to get familiar with Principle, theory & instrumentation of sophisticated pharmaceutical analysis instruments and the interpretation of their spectra.
Unit - 1
Principle, Theory & Instrumentation of UV-Visible spectroscopy. Its utility in structural qualitative and
quantitative analysis of drug molecules, woodward fischer rules and use of shiff’s reagents for
elucidation of structure. (8 Hours)
Unit – 2
Infrared spectroscopy, I.R radiation and its interaction with organic molecules, vibrational mode of
bonds, instrumentation and application, effect of hydrogen bonding and conjugation on absorption bands,
interpretation of IR Spectra, FTIR and ATR. (8 Hours)
Unit – 3
Nuclear magnetic resonance spectroscopy: chemical shift concept, isotopic nuclei, reference standards
and solvents. 1H NMR spectra, coupling constants, interpretation of spectra, decoupling-double
resonance and shift reagent methods.
Principles of FT-NMR with reference to 13C NMR, free induction decay. Spin-spin and spin-lattice
relaxation phenomenon. Nuclear overhauser enhanced 13C NMR spectra, their interpretation and
application. (8 Hours)
Unit – 4
Mass spectrometry: Basic principles and brief outline of instrumentation. Ion formation, molecular ion,
metastable ion, fragmentation process in relation to molecular structure and functional groups. Relative
abundance of isotopes, chemical ionization, GC-MS and LC/MS. Interpretation of spectra of simple
molecules. (8 Hours)
Unit – 5
Chromatographic techniques: Principles of separation and application of Column, Paper, Thin layer and
Gas chromatography, HPLC, HPTLC, Electrophoresis. Instrumentation of HPLC, Reverse phase
columns.
Pharmaceutical evaluation of drug in biological fluids- bioassays. Radioimmunoassay.
(8 Hours)
Recommended Books
1. Willard, H.H., Merrit, L.L., Dean, J.A., Settle, P.A., Instrumental Methods of Analysis, Van
4. Ardrey, R.E., Pharmaceutical Mass Spectra, Pharmaceutical Press, London.
5. Sethi, P.D., Quantitative Analysis of Pharmaceutical Formulations, CBS Publishers, New Delhi. 6. Kalsi, P.S., Spectroscopy of Organic Compounds, New Age Publishers, New Delhi.
7. Gross J.H., Mass Spectrometry, Springer Berlin, Heidelberg.
8. Haffmann D. H., Advances in Chromatography, Marcel Dekker.
9. Robert D. Braun, Introduction to Instrumental Analysis, McGraw-Hill.
10. Wilfried, M.A. Niessen- Liquid Chromatography-Mass Spectrometry, Marcel Dekker.
*Latest editions of all the suggested books are recommended. .
M. Pharm. (Pharmacology) Syllabus Applicable w.e.f. Academic Session 2011-12 (22022012) Page 5 of 20
Semester I
PHARMACEUTICAL BIOSTATICS AND COMPUTER APPLICATIONS
Course Code: MPL101 L-4, T-2, P-0, C-5
Objective: The basic objective of this course is to get familiar with pharmaceutical biostatics and computer applications.
Unit - 1
Methods of collection of data, classifications and graphical representation of data. Binomial and
normal probability distribution. Polygon, histogram, measure of central tendency. Significance of
statistical methods, probability, degree of freedom, measures of variation - Standard deviation,
Standard error. (8 Hours)
Unit - 2
Sampling, sample size and power. Statistical inference and hypothesis. Tests for statistical
Linear regression and correlation. Analysis of Variance (one way and two way). Factorial designs
(including fraction factorial design). Theory of probability, Permutation and Combination, Ratios, Percentage and Proportion. Two way ANOVA and Multiple comparison procedures. (8 Hours)
Unit - 4
Non-parametric tests, Experimental design in clinical trials, Statistical quality control, Validation, Optimization techniques and Screening design. Correlation and regression, least square method,
significance of coefficient of correlation, nonlinear regression. (8 Hours)
Unit - 5
Bioassays-calculations of doses response relationships, LD50, ED50.
Applications of software for statistical calculation viz. SPSS, foxtron. (8 Hours)