Mass Spectrometry/ Mass Spectrometry: Techniques and Applications of Tandem Mass Spectrometry Kenneth L Busch Department of Chemistry, Indiana University, Bloomington, IN 47405 Gary L. Clish and Scott A. McLuckey Analytical Chemistry Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831 VCH
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Mass Spectrometry/ Mass Spectrometry:
Techniques and Applications of Tandem
Mass Spectrometry
Kenneth L Busch Department of Chemistry, Indiana University, Bloomington, IN 47405
Gary L. Clish and Scott A. McLuckey Analytical Chemistry Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831
VCH
Table of Contents
Acknowledgments v
Preface vii
1. Introduction to Mass Spectrometry/Mass Spectrometry 1 1.1. History of mass spectrometry/mass spectrometry 1 1.2. Concepts and principles 3 1.3. Nomenclature 12
2.2.1. Electric sectors 17 2.2.2. Magnetic sectors 17 2.2.3. Quadrupole mass filters 18 2.2.4. Time-of-fiight analysis 19 2.2.5. The Wien filter 19 2.2.6. Fourier transform-ion cyclotron resonance 20 2.2.7. Ion trap mass spectrometers 21
4.3. Reaction mechanisms 123 4.3.1. Unimolecular reactions in the ion source 124 4.3.2. Unimolecular reactions in reaction regions 126 4.3.3. Bimolecular reactions in the ion source 131 4.3.4. Bimolecular reactions in a reaction region 132
4.4. Thermochemistry 137 4.4.1. Energy gain/loss measurements 137 4.4.2. Kinetic energy release measurements 144 4.4.3. Relative product ion abundances 145
4.4.3.1. Thermochemical information from ion-bound dimers 145 4.4.3.2. Ion internal energies from ion abundances 149
5. Characteristics of MS/MS for Analytical Applications 153 5.1. Sample considerations 153