Martina Sahre 1 , Sreedharan Sabarinath 1 , PhD Maria Grant 2 , MD, Christoph Seubert 3 , MD, PhD, Carisa deAnda 4 , PharmD Hartmut Derendorf 1 , PhD University of Florida, College of Pharmacy, Departments of Pharmaceutics 1 , Therapeutics and Pharmacology 2 , Anesthesiology 3 , Trius Therapeutics 4 , San Diego, California Evaluation of Tissue Distribution Evaluation of Tissue Distribution of TR-700 in Healthy Volunteers of TR-700 in Healthy Volunteers Using Microdialysis Using Microdialysis
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Martina Sahre 1, Sreedharan Sabarinath 1, PhD Maria Grant 2, MD, Christoph Seubert 3, MD, PhD, Carisa deAnda 4, PharmD Hartmut Derendorf 1, PhD University.
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Martina Sahre1, Sreedharan Sabarinath1, PhD
Maria Grant2, MD, Christoph Seubert3, MD, PhD,
Carisa deAnda4, PharmDHartmut Derendorf1, PhD
University of Florida, College of Pharmacy, Departments of
Pharmaceutics1, Therapeutics and Pharmacology2, Anesthesiology3,
Trius Therapeutics4, San Diego, California
Evaluation of Tissue Distribution of TR-Evaluation of Tissue Distribution of TR-700 in Healthy Volunteers Using 700 in Healthy Volunteers Using
MicrodialysisMicrodialysis
OverviewOverviewIntroduction
TR-700 / TR-701RationaleMicrodialysis
Study DesignResultsConclusion
TR-700TR-700
Oxazolidinone classLimited water solubilityPhosphate ester prodrug (TR-701)Rapid conversion to active drug
N O
O
HN
O
F
N
O
Linezolid
N O
OH
O
F
N
NN
N
N
N O
O
F
N
NN
N
N
OP
O
ONa
ONaIn VivoPhosphatases
TR-700
TR-701
TR-700TR-700
Oxazolidinone classIndication complicated skin and skin