www.cellsignal.com/cstmapk For pathway key and background please visit: Histone H3 CREB SRF PPARγ ER Elk-1 Stat1/3 c-Myc/ N-Myc MSK1/2 p90RSK p90RSK p90RSK Erk1/2 Erk1/2 Erk1/2 MNK1/2 cPLA 2 nNos PLD1 MEK1/2 PP1/ PP2At B-Raf B-Raf PKA c-Raf c-Raf PKC PLCγ Src PYK2 PAK LKB1 AMPK Spry Spred Tpl2/Cot1 PI3K FAK GRB2 GRB2 Ras Rac Rap1 CRK 14-3-3 Integrins MEK1 MP1 Erk1 LAMTOR2 C-TAK1 IMP RACK1 ATF1 c-Fos Ets Pax6 UBF MKP-1/2 cdc25 MKP-3 KSR 1/2 c-Fos FoxO3 ERα ATF4 MITF Mad1 Nur77 ETV1 TIF1A eIF4B METTL1 eEF2K GSK-3 rpS6 TCPβ IκBα BAD DAPK C/EBPβ Myt1 BUB1 Filamin A Raptor ER81 HMGN1 YB1 TIF1A p27 KIP1 TSC2 WAVE-2 Bim Tal Shc FRS2 IRS SOS SOS SOS EPAC Ion Channels [Ca 2+ ] RTKs RTKs C3G CAS Fyn Pax PEA-15 [cAMP] [Ca 2+ ] Translation Control Ion Channels, Receptors Nucleus Cytoplasm Heterodimer FMK SL0101 BI-D1870 Transcription PD98059 U0126 AZD6244 Late Endosome Cell Adhesion Migration Ca 2+ -regulated Exocytosis mTOR Signaling Cytoplasmic Anchoring MAP Kinase Signaling MAPK/Erk in Growth and Differentiation Pathway
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MAPK/Erk in Growth and Differentiation Pathway Kinase Signaling.pdf · o patwa ke an ackgon please isit Histone H3 CREB SRF PPARγ ER Elk-1 Stat1/3 c-Myc/ N-Myc MSK1/2 p90RSK p90RSK
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www.cellsignal.com/cstmapkFor pathway key and background please visit:
HistoneH3
CREB SRF
PPARγ
ER Elk-1
Stat1/3 c-Myc/N-Myc
MSK1/2p90RSK
p90RSK
p90RSK
Erk1/2
Erk1/2
Erk1/2MNK1/2
cPLA2
nNos
PLD1
MEK1/2
PP1/PP2At
B-RafB-Raf
PKAc-Raf
c-RafPKC
PLCγ
SrcPYK2 PAK
LKB1
AMPK
Spry
Spred
Tpl2/Cot1
PI3KFAKG
RB
2
GR
B2
Ras
Rac
Rap1
CR
K
14-3-3
Integrins
MEK1
MP1
Erk1
LAMTOR2
C-TAK1
IMP
RACK1
ATF1 c-FosEts
Pax6
UBF
MKP-1/2
cdc25
MKP-3
KSR1/2
c-Fos
FoxO3 ERα
ATF4
MITF
Mad1
Nur77
ETV1 TIF1A
eIF4B
METTL1
eEF2K GSK-3
rpS6 TCPβ
IκBα
BAD
DAPK
C/EBPβ
Myt1
BUB1
Filamin A
Raptor
ER81
HMGN1 YB1
TIF1A
p27 KIP1
TSC2
WAVE-2
Bim
Tal
Shc
FRS2
IRS SOS
SOS
SOS
EPAC
Ion Channels[Ca2+]
RTKs
RTKs
C3GCASFyn Pax
PEA-15
[cAMP][Ca2+]
TranslationControl
Ion Channels,Receptors
Nucleus
Cytoplasm
Heterodimer
FMKSL0101
BI-D1870
Transcription
PD98059U0126
AZD6244
Late Endosome
Cell AdhesionMigration
Ca2+-regulated Exocytosis
mTORSignaling
Cytoplasmic Anchoring
MAP Kinase Signaling
MAPK/Erk in Growth and Differentiation Pathway
15FL
YMAP
K_RE
FM10
5ENG
_00
www.cellsignal.com/cstmapkFor Research Use Only. Not For Use In Diagnostic Procedures. For Research Use Only. Not For Use In Diagnostic Procedures.
Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (D13.14.4E) XP® Rabbit mAb #4370: Confocal IF analysis of C2C12 cells, treated with U0126 #9903 (10 μM, 1 hr; top) or TPA #9905 (200 nM, 15 min; bottom), using #4370 (green). Actin filaments were labeled with Alexa Fluor® 555 Phalloidin #8953 (red). Blue pseudocolor = DRAQ5® #4084 (fluo-rescent DNA dye).
Visit www.cellsignal.com/mapklist for full listing of antibodies, related kits, and reagents.
Phospho-p38 MAPK (Thr180/Tyr182) (D3F9) XP® Rabbit mAb #4511: WB analysis (A) of extracts from COS and 239 cells, untreated (-) or UV-treated (+) using #4511 (upper) or p38 MAPK Antibody #9212 (lower). Flow cytometric analysis (B) of Jurkat cells, untreated (blue) or treated with An-isomycin #2222 (green), using #4511 compared to a nonspecific negative control antibody (red).
kDa
Phospho-p38 MAPK
p38 MAPK
UV
COS10080
6050
4030
20
10
10080
6050
4030
10
20
293
– +– +
A
Even
ts
Phospho-p38 MAPK (Thr180/Tyr182)
B
Phospho-c-Jun (Ser73) (D47G9) XP® Rabbit mAb #3270: IHC analysis of paraffin-embedded human lung carcinoma using #3270.
APPLICATIONS & REACTIVITY KEY: WB Western Blotting / IP Immunoprecipitation / IHC Immunohistochemistry / IF Immunofluorescence / F Flow Cytometry / ChIP Chromatin Immunoprecipitation / -IC Immunocytochemistry / -P Paraffin / -F Frozen / E-P Peptide ELISA / H human / M mouse / R rat / Hm hamster / Mk monkey / C chicken / Mi mink / Dm D. melanogaster / X Xenopus / Z zebra fish / B bovine / Dg dog / Pg pig / Sc S. cerevisiae / All all species expected / ( ) 100% sequence homology