Mannich Reaction

• 1. Mannich Reaction

2. 3. 4. 5. 6. 7. 8. Nucleophilic Nitrogen Electrophilic Nitrogen 9. Substitution by Nucleophilic Nitrogen at Saturated Carbon

• Treatment of RX with NH 3gives a mixture of primary, secondary, tertiary and quarternary ammonium salts

• Reaction of primary amine with primary alkylhalide gives secondary amine but reaction of primary amine with tertiary alkylhalide gives an elimination product

10. Addition of Nucleophilic Nitrogen to Unsaturated Carbon Reactions with Aldehydes and Ketones 11. 12. Reactions of Electrophilic Nitrogen 13. Nitration 14. Synthesis of Amino Acids Via Hell-Volhard Zelensky Reaction 15. Via Gabriel Procedure Via Nitrosation 16. Via Strecker Method 17.