1 Management of Management of Rectourethral Rectourethral Fistula (RUF) Fistula (RUF) Herman Kwan R5 Herman Kwan R5 Urology Grand Rounds Dec 21, Urology Grand Rounds Dec 21, 2005 2005 Summary of Iatrogenic RUF Summary of Iatrogenic RUF Non Non- radiation radiation RUF RUF Numerous surgical Numerous surgical approaches to excision approaches to excision + repair + repair Presence of healthy Presence of healthy tissue tissue…results in results in reasonable success reasonable success Radiation RUF Radiation RUF Minimal literature on this Minimal literature on this entity and it entity and it’ s s management management Local repairs will fail Local repairs will fail Ultimately need anterior Ultimately need anterior exenteration exenteration, , ileal ileal loop loop diversion, colostomy for diversion, colostomy for durable cure durable cure
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Management of Management of RectourethralRectourethral Fistula (RUF)Fistula (RUF)
Herman Kwan R5Herman Kwan R5Urology Grand Rounds Dec 21, Urology Grand Rounds Dec 21,
20052005
Summary of Iatrogenic RUFSummary of Iatrogenic RUFNonNon--radiation radiation RUFRUF
Numerous surgical Numerous surgical approaches to excision approaches to excision + repair+ repair
Presence of healthy Presence of healthy tissuetissue……results in results in reasonable successreasonable success
Radiation RUFRadiation RUF
Minimal literature on this Minimal literature on this entity and itentity and it’’s s managementmanagement
Local repairs will failLocal repairs will fail
Ultimately need anterior Ultimately need anterior exenterationexenteration, , ilealileal loop loop diversion, colostomy for diversion, colostomy for durable curedurable cure
Presentation postPresentation post--radiationradiationMay initially present w/ May initially present w/ severe rectal severe rectal pain from mucosal ulcerationpain from mucosal ulcerationDramatically resolves when rectal wall Dramatically resolves when rectal wall breaks open and breaks open and fistulizesfistulizes
DiagnosisDiagnosis
RadiologicRadiologic options:options:CTCTBarium enemaBarium enemaVCUGVCUGMethyleneMethylene blue in bladderblue in bladder
Symptoms despite Symptoms despite abxabx + urinary diversion+ urinary diversionPersistent Persistent fecaluriafecaluria despite TPN/ low residue despite TPN/ low residue diet in presence of sepsisdiet in presence of sepsis**Radiation induced fistulas****Radiation induced fistulas**
Surgical Principles of Local Surgical Principles of Local RepairsRepairs
Proper positioning/incisionProper positioning/incisionExcision of fistula tractExcision of fistula tractNonNon--overlapping suture linesoverlapping suture lines……no tensionno tensionSeparation of urethral/rectal suture line by Separation of urethral/rectal suture line by interposition of pedicle flapinterposition of pedicle flap
Numerous procedures describedNumerous procedures described……. . reflects uncertainty in approachreflects uncertainty in approach
Surgical approachesSurgical approaches
Posterior Posterior vsvs anterioranteriorTransphinctericTransphincteric vsvsnon non transphincterictransphinctericMidline or Midline or saggitalsaggitalOpen or Open or endoscopicendoscopic
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Types of repairsTypes of repairsA. TransA. Trans--abdominal abdominal
approachapproachB. B. KraskeKraske (posterior (posterior
Of 16 RUF from various iatrogenic Of 16 RUF from various iatrogenic etiologies:etiologies:
7 colostomy as initial 7 colostomy as initial mxmx……all all reqreq’’dd surgerysurgery13 underwent surgical excision13 underwent surgical excision
9 were 9 were ““curedcured””3 3 gracilisgracilis flapsflaps……all all ““curedcured””4 failures4 failures……permanent fecal diversion w/ permanent fecal diversion w/ ““good palliation of good palliation of sxsx’’ss””No anterior No anterior extenterationextenteration
77 male intermediate risk 77 male intermediate risk CaPCaPBT 2002BT 2002Rectal bleeding 2004Rectal bleeding 2004Colonoscopy rectal Colonoscopy rectal proctitisproctitisMarch 2005 rectal ulcer 15mmMarch 2005 rectal ulcer 15mmJune June ’’05, 05, dysuriadysuria, , pneumaturiapneumaturia, frequency , frequency x10x10
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Pt is now admitted under Gen Pt is now admitted under Gen SurgSurg w/ w/ fevers to 39C, fevers to 39C, fecaluriafecaluria, , pneumaturiapneumaturiaDRE: fistula easily admits fingerDRE: fistula easily admits fingerCystoCysto: large fistula prostate, mild radiation : large fistula prostate, mild radiation cystitiscystitis
How would you manage this pt?How would you manage this pt?
Fecal diversion?Fecal diversion?Urinary drainage?Urinary drainage?Urinary diversion?Urinary diversion?Local repair and excision of fistula?Local repair and excision of fistula?
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MxMx of RUF postof RUF post--BTBT
Few publicationsFew publicationsBJU Aug 2004, BJU Aug 2004, Devastating Complications Devastating Complications after after BrachytherapyBrachytherapy in in txtx of of CaPCaPRetrospective chart reviewRetrospective chart review20002000--’’03, 11pts w/ RUF post BT03, 11pts w/ RUF post BT
MxMx of RUF post of RUF post brachytherapybrachytherapy
All pts initially All pts initially txtx w/ diverting colostomyw/ diverting colostomy4 had simultaneous SPT diversion4 had simultaneous SPT diversion
2 management arms:2 management arms:1. Severe radiation damage + severe symptoms 1. Severe radiation damage + severe symptoms
w/ LARGE fistula (7)w/ LARGE fistula (7)2. Minor radiation damage + CONTINENT (4)2. Minor radiation damage + CONTINENT (4)
SummarySummaryAll received colostomy as initial All received colostomy as initial txtx……unsuccesfulunsuccesfulPts w/ MAJOR radiation damage +LARGE Pts w/ MAJOR radiation damage +LARGE fistulafistula
Pts w/ MINOR radiation damagePts w/ MINOR radiation damageYork Mason procedure +/York Mason procedure +/-- GracilisGracilis muscle muscle flap +/flap +/--dartosdartos flapsflapsAll All continentcontinent following surgeryfollowing surgery
Urinary Fistulas following external radiation Urinary Fistulas following external radiation or permanent or permanent brachytherapybrachytherapy for for CaPCaP
JU June 2005JU June 2005
51pts 51pts ’’7272--02, 02, h/oh/o radiation treatment w/ radiation treatment w/ subequentsubequent fistula formationfistula formationEBRT or BT or combinedEBRT or BT or combinedExcluded previous RRP, Excluded previous RRP, diverticulitisdiverticulitis, , crohncrohn’’ss (any predisposing RF)(any predisposing RF)
11 RUF11 RUF
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conclusionsconclusions
Majority of pts have large fistulas into Majority of pts have large fistulas into necrotic/infected prostates, even after necrotic/infected prostates, even after fecal diversionfecal diversionSubjective/objective cure only from both Subjective/objective cure only from both urinary (urinary (ilealileal loop) and fecal diversionloop) and fecal diversionbladder sparing diversionbladder sparing diversion……
Treatment principles of postTreatment principles of post--radiation RUFradiation RUF
Fecal diversion is mandatoryFecal diversion is mandatoryBladder drainage unlikely to contribute to Bladder drainage unlikely to contribute to cure except w/ small fistula + minimal cure except w/ small fistula + minimal radiation damageradiation damageHighest rate of success w/ FD + Highest rate of success w/ FD + cystoprostatectomycystoprostatectomy w/ w/ ilealileal loop diversionloop diversionBladder sparing approach may not be best Bladder sparing approach may not be best choicechoice
Back to the caseBack to the case……
Symptomatic despite oral Symptomatic despite oral abxabx +IDC+IDCInitial diverting colostomy + SPTInitial diverting colostomy + SPTPt now resolved from symptomsPt now resolved from symptomsUndergoing Hyperbaric OxygenUndergoing Hyperbaric OxygenGeneral Surgeon still unsure of final repairGeneral Surgeon still unsure of final repair
Permanent colostomy Permanent colostomy vsvs CystoprostatectomyCystoprostatectomyRectal pull down w/ Rectal pull down w/ coloanalcoloanal anastomosisanastomosis