MAKE WAY FOR THE FIRST ACTIVE HEMOSTATIC POWDER … · the first active hemostatic powder 3 ingredients for a synergistic and simultaneous effect1 a unique and innovative formulation2,3

MAKE WAY FOR THE FIRST ACTIVE HEMOSTATIC POWDER

E-MR-288-V1

THE FIRST ACTIVE HEMOSTATIC POWDER3 INGREDIENTS FOR

A SYNERGISTIC AND SIMULTANEOUS EFFECT1

A UNIQUE AND INNOVATIVE FORMULATION2,3

1. biom’up, internal data. 2. HEMOBLAST™ Bellows IFU. 3. Patented formulation.

CHONDROITIN SULFATE

CLOT STABILIZATION

COLLAGEN POWDER

PLATELET AGGREGATIONCLOTTING CASCADE

INITIATION

POOLED THROMBIN

CLOT FORMATIONCONVERSION OF

FIBRINOGEN INTO FIBRIN FORMATION OF A FIBRIN

NETWORKAPPLICATION

COHESIVE AND STABLE CLOT

Red blood cell

HEMOBLAST™ Bellows

Triple collagen helix

Chondroitin sulfate

Inactivated platelet

Activated platelet

Fibrin

Red blood cell

HEMOBLAST™ Bellows

Triple collagen helix

Chondroitin sulfate

Platelet

Activated platelet

Fibrin

0 10 20 30 40 50 60 70

DEVELOPED BY AND FOR SURGEONS

EFFICIENT1

COHESIVE & STABLE CLOT MAINTAINED VISIBILITY AFTER APPLICATION

READY AND EASY TO USE1

NO PREPARATION TIME NEEDEDERGONOMIC AND INTUITIVE APPLICATOR

COST EFFECTIVE2

ON-DEMAND USAGE CROSS-OVER PRODUCT SAVES TRAINING TIME

THE ACTIVE HEMOSTAT WITH THE LARGEST COVERAGE AREA3

1. biom’up, internal data. Data derived from preclinical animal studies. Results may differ in clinical use. 2. biom’up, company data. Data derived from clinical use of 125 cases in Germany and France (PME report). 3. biom’up, company data. HEMOBLAST™ Bellows or one of its competitors was uniformly applied on the slice until the operator deemed the device as emptied. Macroscopic picture(s) were taken for each assay with a camera mounted on a support (similar position and distance from the liver slice and same magnification between assays). Three devices were used for each product.

MEAN (+/- SD) AREA COVERED3

cm2

Flowabe Gelatin +Thrombin (5 mL)

Collagen patch+ Thrombin + Fibrinogen

(9.5 cm*4.8 cm)

HEMOBLAST™ BellowsThe first active hemostatic

powder (1.65 g)

-19%52.69 cm2 (± 2.22)

64.96 cm2 (± 5.75)

30.38 cm2 (± 3.3) -53%

EXPERIENCED IN THE CLINICAL SETTING

SPINE SURGERYExample of indications:LaminectomyCorporectomyDiscectomy

Professor POINTILLART CHU Bordeaux (Bordeaux, France)Discectomy and cervical arthrodesis (anterior approach)

HEPATIC SURGERYExample of indications:

HepatectomyTumorectomy

Liver transplant

Professor LAURENTCHU Bordeaux

(Bordeaux, France)Hepatectomy (cirrhotic)

HERNIA SURGERYExample of indications:

Incisional herniaStomial hernia

Doctor DABROWSKIClinique Saint Omer (Lille, France)

Incisional hernia

CARDIOVASCULAR SURGERYExample of indications: Coronary artery bypassHeart transplantReoperative proceduresValve replacements and repairs

Doctor EL BATTIHEGP (Paris, France)Abdominal Aorta

www.hemoblast.com

OF SURGEONS STATED HEMOBLAST™ BELLOWS COULD REPLACE ANOTHER HEMOSTATIC AGENT.1

OF SURGEONS WHO TRIED HEMOBLAST™ BELLOWS WERE SATISFIED WITH HOW IT PERFORMED AND WOULD RECOMMEND

THAT THEIR HOSPITAL BUY IT.*1

* Including 58% «Very satisfied» and 36% «Satisfied». 1. biomup, internal data. Data derived from clinical use of 125 cases in Germany and France (PME report).Legal Information : HEMOBLAST™ Bellows - Implantable Medical device Class III for surgery reserved for use by qualified healthcare professionals, reimbursement depends on each country - NOT FOR SALE IN THE USA. Read the instructions for use on the packaging carefully before use. CE0086: BSI - Manufacturer : biom’up SA France.

88%

93%

QUANTITY PER BELLOWS (G) PER PACK REFERENCE

1.65 1 BELLOWS AND A SHORT 10CM CANNULA BQF02

GOOD VISIBILITY AFTER APPLICATION

EASY AND READY TO USE

THE CLOT IS STABLE

SIMPLE APPLICATION

GOOD BLEEDING SITE

ACCESSIBILITY

An active hemostat is one that has a directbiological action on the coagulation cascade